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Protein

Protein BTG3

Gene

Btg3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.By similarity

GO - Biological processi

  • negative regulation of cell proliferation Source: UniProtKB
  • response to oxidative stress Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG3
Short name:
rBTG3
Alternative name(s):
BTG family member 3
Gene namesi
Name:Btg3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2226 Btg3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438091 – 252Protein BTG3Add BLAST252

Proteomic databases

PaxDbiO88677
PRIDEiO88677

PTM databases

iPTMnetiO88677
PhosphoSitePlusiO88677

Expressioni

Tissue specificityi

Highly expressed in the brain.1 Publication

Inductioni

By 12-O-tetradecanoylphorbol-13-acetate (TPA). Induced at higher levels by TPA and cycloheximide together. Also induced by redox changes after stimulation by hydrogen peroxide or menadione.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002121

Structurei

3D structure databases

ProteinModelPortaliO88677
SMRiO88677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Ser6
Compositional biasi180 – 234Pro-richAdd BLAST55

Sequence similaritiesi

Belongs to the BTG family.Sequence analysis

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
HOGENOMiHOG000234823
HOVERGENiHBG004332
InParanoidiO88677
KOiK14443
PhylomeDBiO88677

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTQILQE KYKNHWYPEK
60 70 80 90 100
PSKGQAYRCI RVNKFQRVDP DVLKACEDSC ILYSDLGLPK ELTLWVDPCE
110 120 130 140 150
VCCRYGKKNN AFIVASFENE DENKDEISKK VSRALDKVTS DYHSGSSSSD
160 170 180 190 200
EDTSKEVEVK PSAVATTPSP VYQISELIFP PLPMWHPLPR KKPGMYRGGG
210 220 230 240 250
HQSHYPPPVP FAYPSPGRKN KAFRPIPVTW VPPPGMHCDR NHWINPHMLA

PH
Length:252
Mass (Da):28,914
Last modified:November 1, 1998 - v1
Checksum:iD66C22A659F9A3FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087037 mRNA Translation: AAC34894.1
RefSeqiNP_062163.1, NM_019290.1
UniGeneiRn.8897

Genome annotation databases

GeneIDi54230
KEGGirno:54230
UCSCiRGD:2226 rat

Similar proteinsi

Entry informationi

Entry nameiBTG3_RAT
AccessioniPrimary (citable) accession number: O88677
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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