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Protein

Protein BTG3

Gene

Btg3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.By similarity

GO - Biological processi

  • negative regulation of cell proliferation Source: UniProtKB
  • response to oxidative stress Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG3
Short name:
rBTG3
Alternative name(s):
BTG family member 3
Gene namesi
Name:Btg3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2226. Btg3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Protein BTG3PRO_0000143809Add
BLAST

Proteomic databases

PaxDbiO88677.
PRIDEiO88677.

PTM databases

iPTMnetiO88677.
PhosphoSiteiO88677.

Expressioni

Tissue specificityi

Highly expressed in the brain.1 Publication

Inductioni

By 12-O-tetradecanoylphorbol-13-acetate (TPA). Induced at higher levels by TPA and cycloheximide together. Also induced by redox changes after stimulation by hydrogen peroxide or menadione.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002121.

Structurei

3D structure databases

ProteinModelPortaliO88677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi144 – 1496Poly-Ser
Compositional biasi180 – 23455Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BTG family.Sequence analysis

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
HOGENOMiHOG000234823.
HOVERGENiHBG004332.
InParanoidiO88677.
KOiK14443.
PhylomeDBiO88677.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTQILQE KYKNHWYPEK
60 70 80 90 100
PSKGQAYRCI RVNKFQRVDP DVLKACEDSC ILYSDLGLPK ELTLWVDPCE
110 120 130 140 150
VCCRYGKKNN AFIVASFENE DENKDEISKK VSRALDKVTS DYHSGSSSSD
160 170 180 190 200
EDTSKEVEVK PSAVATTPSP VYQISELIFP PLPMWHPLPR KKPGMYRGGG
210 220 230 240 250
HQSHYPPPVP FAYPSPGRKN KAFRPIPVTW VPPPGMHCDR NHWINPHMLA

PH
Length:252
Mass (Da):28,914
Last modified:November 1, 1998 - v1
Checksum:iD66C22A659F9A3FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087037 mRNA. Translation: AAC34894.1.
RefSeqiNP_062163.1. NM_019290.1.
UniGeneiRn.8897.

Genome annotation databases

GeneIDi54230.
KEGGirno:54230.
UCSCiRGD:2226. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087037 mRNA. Translation: AAC34894.1.
RefSeqiNP_062163.1. NM_019290.1.
UniGeneiRn.8897.

3D structure databases

ProteinModelPortaliO88677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002121.

PTM databases

iPTMnetiO88677.
PhosphoSiteiO88677.

Proteomic databases

PaxDbiO88677.
PRIDEiO88677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54230.
KEGGirno:54230.
UCSCiRGD:2226. rat.

Organism-specific databases

CTDi10950.
RGDi2226. Btg3.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
HOGENOMiHOG000234823.
HOVERGENiHBG004332.
InParanoidiO88677.
KOiK14443.
PhylomeDBiO88677.

Miscellaneous databases

PROiO88677.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of rat BTG3 gene, Rbtg3, is regulated by redox changes."
    Seo M.S., Lee M.S., Lim I.K.
    Gene 240:165-173(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: FischerImported.
    Tissue: Fibroblast1 Publication.

Entry informationi

Entry nameiBTG3_RAT
AccessioniPrimary (citable) accession number: O88677
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.