Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O88676

- MMP23_MOUSE

UniProt

O88676 - MMP23_MOUSE

Protein

Matrix metalloproteinase-23

Gene

Mmp23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Enzyme regulationi

    Inhibited by TIMP2.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei79 – 802Cleavage; by furin-like proteaseSequence Analysis
    Metal bindingi212 – 2121Zinc; catalyticPROSITE-ProRule annotation
    Active sitei213 – 2131PROSITE-ProRule annotation
    Metal bindingi216 – 2161Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi222 – 2221Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: UniProtKB
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. proteolysis Source: UniProtKB
    2. reproduction Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM10.022.
    TCDBi8.B.14.2.1. the sea anemone peptide toxin, class 1 (bgk) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrix metalloproteinase-23 (EC:3.4.24.-)
    Short name:
    MMP-23
    Alternative name(s):
    CAMP metalloproteinase
    Short name:
    CA-MMP
    Cleaved into the following chain:
    Gene namesi
    Name:Mmp23
    Synonyms:Cammp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1347361. Mmp23.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity. Membrane 1 Publication; Single-pass type II membrane protein 1 Publication
    Note: A secreted form produced by proteolytic cleavage may also exist.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. extracellular matrix Source: InterPro
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Matrix metalloproteinase-23PRO_0000259915Add
    BLAST
    Propeptidei1 – 7979Sequence AnalysisPRO_0000259916Add
    BLAST
    Chaini80 – 391312Matrix metalloproteinase-23, soluble formPRO_0000259917Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi256 ↔ 290By similarity
    Disulfide bondi263 ↔ 283By similarity
    Disulfide bondi272 ↔ 287By similarity
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi322 ↔ 371By similarity

    Post-translational modificationi

    N-glycosylated.By similarity
    Proteolytic cleavage might yield an active form.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiO88676.

    PTM databases

    PhosphoSiteiO88676.

    Expressioni

    Tissue specificityi

    Expressed at relatively high level in heart, lung and spleen. Not detected in brain, liver, skeletal muscle, kidney and testis.1 Publication

    Developmental stagei

    Expressed at relatively high level at 7 days old embryo compared to those at stadges day 11, 15 and 17.1 Publication

    Gene expression databases

    BgeeiO88676.
    CleanExiMM_MMP23.
    GenevestigatoriO88676.

    Structurei

    3D structure databases

    ProteinModelPortaliO88676.
    SMRiO88676. Positions 88-255, 311-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini40 – 391352LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini256 – 29035ShKTPROSITE-ProRule annotationAdd
    BLAST
    Domaini298 – 38386Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi76 – 794Poly-Arg

    Domaini

    The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the peptidase M10A family.Curated
    Contains 1 ShKT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG245056.
    GeneTreeiENSGT00730000110410.
    HOGENOMiHOG000231157.
    HOVERGENiHBG053177.
    InParanoidiO88676.
    KOiK08001.
    OMAiGFYPVNH.
    OrthoDBiEOG7KSX8P.
    PhylomeDBiO88676.
    TreeFamiTF315428.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR024079. MetalloPept_cat_dom.
    IPR028687. MMP23.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR006026. Peptidase_Metallo.
    IPR003582. ShKT_dom.
    [Graphical view]
    PANTHERiPTHR10201:SF7. PTHR10201:SF7. 1 hit.
    PfamiPF00413. Peptidase_M10. 1 hit.
    PF01549. ShK. 1 hit.
    [Graphical view]
    PRINTSiPR00138. MATRIXIN.
    SMARTiSM00409. IG. 1 hit.
    SM00254. ShKT. 1 hit.
    SM00235. ZnMc. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51670. SHKT. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88676-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGCRACLRPE ASGAVQGRWL GAALSGLCLL SALALLEWLG APTETAWRAA    50
    QGNVDAPNVG SSTAQVPRLL TMSVTRRRRY TLTPARLRWD HFNLTYRVLS 100
    FPRNLLSPEE TRRGLAAAFR MWSDVSPFSF REVAPERPSD LKIGFYPVNH 150
    TDCLVSAVHH CFDGPTGELA HAFFPPHGGI HFDDSEYWVL GPTRYSWKKG 200
    VWLTNLVHVA AHEIGHALGL MHSQQDQALM HLNATLRGWK ALSQDELWGL 250
    HRLYGCLDRI FVCASWARKG FCDVRQRLMK RLCPRSCDFC YEFPFPTVAT 300
    TTSPTRTKTR LVREGRNMTF HCGQKILHKK GKVYWYKDQE PLEFSYPGYL 350
    ALGEAQLSII ANAVNEGTYT CVVRRHQRVL STYSWRVRVR N 391
    Length:391
    Mass (Da):44,451
    Last modified:November 1, 1998 - v1
    Checksum:i8C9675020F02F632
    GO
    Isoform 2 (identifier: O88676-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         144-157: Missing.

    Show »
    Length:377
    Mass (Da):42,946
    Checksum:i8C30623283790A72
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei144 – 15714Missing in isoform 2. 1 PublicationVSP_021561Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085742 mRNA. Translation: AAC34886.1.
    AK146510 mRNA. Translation: BAE27223.1.
    BC107357 mRNA. Translation: AAI07358.1.
    BC107358 mRNA. Translation: AAI07359.1.
    CCDSiCCDS19034.1. [O88676-1]
    RefSeqiNP_036115.1. NM_011985.2. [O88676-1]
    XP_006538945.1. XM_006538882.1. [O88676-1]
    XP_006538946.1. XM_006538883.1. [O88676-2]
    UniGeneiMm.29373.

    Genome annotation databases

    EnsembliENSMUST00000030937; ENSMUSP00000030937; ENSMUSG00000029061. [O88676-1]
    GeneIDi26561.
    KEGGimmu:26561.
    UCSCiuc008wed.1. mouse. [O88676-1]
    uc012dqs.1. mouse. [O88676-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085742 mRNA. Translation: AAC34886.1 .
    AK146510 mRNA. Translation: BAE27223.1 .
    BC107357 mRNA. Translation: AAI07358.1 .
    BC107358 mRNA. Translation: AAI07359.1 .
    CCDSi CCDS19034.1. [O88676-1 ]
    RefSeqi NP_036115.1. NM_011985.2. [O88676-1 ]
    XP_006538945.1. XM_006538882.1. [O88676-1 ]
    XP_006538946.1. XM_006538883.1. [O88676-2 ]
    UniGenei Mm.29373.

    3D structure databases

    ProteinModelPortali O88676.
    SMRi O88676. Positions 88-255, 311-375.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M10.022.
    TCDBi 8.B.14.2.1. the sea anemone peptide toxin, class 1 (bgk) family.

    PTM databases

    PhosphoSitei O88676.

    Proteomic databases

    PRIDEi O88676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030937 ; ENSMUSP00000030937 ; ENSMUSG00000029061 . [O88676-1 ]
    GeneIDi 26561.
    KEGGi mmu:26561.
    UCSCi uc008wed.1. mouse. [O88676-1 ]
    uc012dqs.1. mouse. [O88676-2 ]

    Organism-specific databases

    CTDi 26561.
    MGIi MGI:1347361. Mmp23.

    Phylogenomic databases

    eggNOGi NOG245056.
    GeneTreei ENSGT00730000110410.
    HOGENOMi HOG000231157.
    HOVERGENi HBG053177.
    InParanoidi O88676.
    KOi K08001.
    OMAi GFYPVNH.
    OrthoDBi EOG7KSX8P.
    PhylomeDBi O88676.
    TreeFami TF315428.

    Miscellaneous databases

    NextBioi 304627.
    PROi O88676.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88676.
    CleanExi MM_MMP23.
    Genevestigatori O88676.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR024079. MetalloPept_cat_dom.
    IPR028687. MMP23.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR006026. Peptidase_Metallo.
    IPR003582. ShKT_dom.
    [Graphical view ]
    PANTHERi PTHR10201:SF7. PTHR10201:SF7. 1 hit.
    Pfami PF00413. Peptidase_M10. 1 hit.
    PF01549. ShK. 1 hit.
    [Graphical view ]
    PRINTSi PR00138. MATRIXIN.
    SMARTi SM00409. IG. 1 hit.
    SM00254. ShKT. 1 hit.
    SM00235. ZnMc. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51670. SHKT. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CA-MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch."
      Pei D.
      FEBS Lett. 457:262-270(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Spleen.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Stomach.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiMMP23_MOUSE
    AccessioniPrimary (citable) accession number: O88676
    Secondary accession number(s): Q3KNC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2006
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3