Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-like protein 3

Gene

Dll3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: RGD

GO - Biological processi

  • cell fate determination Source: RGD
  • central nervous system development Source: RGD
  • negative regulation of astrocyte differentiation Source: RGD
  • negative regulation of Notch signaling pathway Source: RGD
  • Notch signaling pathway Source: UniProtKB-KW
  • positive regulation of neurogenesis Source: RGD
  • skeletal system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like protein 3
Alternative name(s):
Drosophila Delta homolog 3
Short name:
Delta3
Gene namesi
Name:Dll3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70953. Dll3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 494462ExtracellularSequence analysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence analysisAdd
BLAST
Topological domaini516 – 58974CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232By similarityAdd
BLAST
Chaini33 – 589557Delta-like protein 3PRO_0000007511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi222 ↔ 233PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Disulfide bondi241 ↔ 250PROSITE-ProRule annotation
Disulfide bondi280 ↔ 291PROSITE-ProRule annotation
Disulfide bondi285 ↔ 300PROSITE-ProRule annotation
Disulfide bondi302 ↔ 311PROSITE-ProRule annotation
Disulfide bondi318 ↔ 329PROSITE-ProRule annotation
Disulfide bondi323 ↔ 341PROSITE-ProRule annotation
Disulfide bondi343 ↔ 352PROSITE-ProRule annotation
Disulfide bondi359 ↔ 370PROSITE-ProRule annotation
Disulfide bondi364 ↔ 379PROSITE-ProRule annotation
Disulfide bondi381 ↔ 390PROSITE-ProRule annotation
Disulfide bondi397 ↔ 408PROSITE-ProRule annotation
Disulfide bondi402 ↔ 417PROSITE-ProRule annotation
Disulfide bondi419 ↔ 428PROSITE-ProRule annotation
Disulfide bondi435 ↔ 446PROSITE-ProRule annotation
Disulfide bondi440 ↔ 455PROSITE-ProRule annotation
Disulfide bondi457 ↔ 466PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.By similarity

Keywords - PTMi

Disulfide bond, Ubl conjugation

Proteomic databases

PaxDbiO88671.
PRIDEiO88671.

Interactioni

Subunit structurei

Can bind and activate Notch-1 or another Notch receptor.By similarity

GO - Molecular functioni

  • Notch binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026182.

Structurei

3D structure databases

ProteinModelPortaliO88671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 21340DSLAdd
BLAST
Domaini218 – 25134EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini276 – 31237EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini314 – 35340EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini355 – 39137EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini393 – 42937EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini431 – 46737EGF-like 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi503 – 5119Poly-Ala

Domaini

The DSL domain is required for binding to the Notch receptor.

Sequence similaritiesi

Contains 1 DSL domain.Curated
Contains 6 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiO88671.
KOiK06051.
PhylomeDBiO88671.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PfamiPF00008. EGF. 2 hits.
PF12661. hEGF. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 6 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLQVSSLP QTLILAFLLP QALPAGVFEL QIHSFGPGPG PGTPRSPCNA
60 70 80 90 100
RGPCRLFFRV CLKPGVSQEA AESLCALGAA LSTSGPVYTE QPGVPAAALS
110 120 130 140 150
LPDGLVRVPF LDAWPGTFSL IIETWREQLG ERAAGPAWNL LARVAGRRRL
160 170 180 190 200
AAGAPWARDV QRTGAWELHF SYRARCEPPA VGAACARLCR SRSAPSRCGP
210 220 230 240 250
GLRPCTPFPD ECEAPRESLT VCRAGCSPEH GYCEEPDECH CLEGWTGPLC
260 270 280 290 300
TVPVSTSSCL NSRVSGPAGT GCLLPGPGPC DGNPCANGGS CSETPGSFEC
310 320 330 340 350
ACPRGFYGPR CEVSGVTCAD GPCFNGGLCV GGEDPDSAYV CHCPPAFQGS
360 370 380 390 400
NCERRVDRCS LQPCQNGGLC LDLGHALRCR CRAGFAGPRC EHDLDDCAGR
410 420 430 440 450
ACANGGTCVE GGGARRCSCA LGFGGRDCRE RADPCASRPC AHGGRCYAHF
460 470 480 490 500
SGLVCACAPG YMGVRCEFAV RPDGADAVPA APRGLRQADS QRFLLPPALG
510 520 530 540 550
LLAAAALAGA ALLLIHVRRR GPGRDTGTRL LSGTREPSVH TLPDALNNLR
560 570 580
LQDGAGDGPT SSADWNHPED GDSRSIYVIP APSIYAREA
Length:589
Mass (Da):61,425
Last modified:November 1, 1998 - v1
Checksum:iA17B3BF9B95EC17F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084576 mRNA. Translation: AAC33303.1.
RefSeqiNP_446118.1. NM_053666.1.
UniGeneiRn.23105.

Genome annotation databases

GeneIDi114125.
KEGGirno:114125.
UCSCiRGD:70953. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084576 mRNA. Translation: AAC33303.1.
RefSeqiNP_446118.1. NM_053666.1.
UniGeneiRn.23105.

3D structure databases

ProteinModelPortaliO88671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026182.

Proteomic databases

PaxDbiO88671.
PRIDEiO88671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114125.
KEGGirno:114125.
UCSCiRGD:70953. rat.

Organism-specific databases

CTDi10683.
RGDi70953. Dll3.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiO88671.
KOiK06051.
PhylomeDBiO88671.

Miscellaneous databases

PROiO88671.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PfamiPF00008. EGF. 2 hits.
PF12661. hEGF. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 6 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rattus norvegicus mRNA for Delta 3: a putative ligand for Notch."
    Boulter J., Greenfield A., Weinmaster G.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDLL3_RAT
AccessioniPrimary (citable) accession number: O88671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.