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O88668 (CREG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CREG1
Alternative name(s):
Cellular repressor of E1A-stimulated genes 1
Gene names
Name:Creg1
Synonyms:Creg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R By similarity.

Subunit structure

Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Widely expressed. Ref.4

Developmental stage

Found at low level from E7 embryo and increased during embryonic development. Ref.4

Induction

Induced during differentiation. Ref.4

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the CREG family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 220189Protein CREG1
PRO_0000006204

Amino acid modifications

Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict621V → M in BAC39549. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O88668 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: EF3A8CFD3186163D

FASTA22024,452
        10         20         30         40         50         60 
MAARAPELAR SLLAALLAPA LVALLVSPAS GRGGRDHGDW DVDRRLPPLP PREDGPRVAR 

        70         80         90        100        110        120 
FVTHVSDWGS LATISTIKEV RGWPFADIIS ISDGPPGEGT GEPYMYLSPL QQAVSDLQEN 

       130        140        150        160        170        180 
PEATLTMSLA QTVYCRNHGF DPQSPLCVHI MMSGTVTKVN KTEEDYARDS LFVRHPEMKH 

       190        200        210        220 
WPSSHNWFFA KLKISRIWVL DYFGGPKVVT PEEYFNVTLQ 

« Hide

References

« Hide 'large scale' references
[1]"A cellular repressor of E1A-stimulated genes that inhibits activation by E2F."
Veal E., Eisenstein M., Tseng Z.H., Gill G.
Mol. Cell. Biol. 18:5032-5041(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart, Kidney, Liver and Placenta.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and FVB/N.
Tissue: Mammary tumor.
[4]"The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells."
Veal E., Groisman R., Eisenstein M., Gill G.
Oncogene 19:2120-2128(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF084524 mRNA. Translation: AAC34862.1.
AK005388 mRNA. Translation: BAB23994.1.
AK010947 mRNA. Translation: BAB27285.1.
AK085844 mRNA. Translation: BAC39549.1.
AK144101 mRNA. Translation: BAE25699.1.
BC027426 mRNA. Translation: AAH27426.1.
RefSeqNP_035934.1. NM_011804.2.
XP_006496993.1. XM_006496930.1.
UniGeneMm.294885.
Mm.468745.

3D structure databases

ProteinModelPortalO88668.
SMRO88668. Positions 49-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO88668. 1 interaction.
MINTMINT-1846777.

Proteomic databases

PaxDbO88668.
PRIDEO88668.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111432; ENSMUSP00000107060; ENSMUSG00000040713.
GeneID433375.
KEGGmmu:433375.
UCSCuc007djm.1. mouse.

Organism-specific databases

CTD8804.
MGIMGI:1344382. Creg1.

Phylogenomic databases

eggNOGNOG294476.
GeneTreeENSGT00390000005914.
HOGENOMHOG000239875.
HOVERGENHBG051115.
InParanoidO88668.
OMAKVNETEM.
OrthoDBEOG7ZWD33.
PhylomeDBO88668.
TreeFamTF324680.

Gene expression databases

ArrayExpressO88668.
BgeeO88668.
CleanExMM_CREG1.
GenevestigatorO88668.

Family and domain databases

Gene3D2.30.110.10. 1 hit.
InterProIPR014631. CREG.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PIRSFPIRSF036911. CREG. 1 hit.
SUPFAMSSF50475. SSF50475. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCREG1. mouse.
NextBio408624.
PROO88668.
SOURCESearch...

Entry information

Entry nameCREG1_MOUSE
AccessionPrimary (citable) accession number: O88668
Secondary accession number(s): Q3UNP8, Q8C3I1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot