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O88668

- CREG1_MOUSE

UniProt

O88668 - CREG1_MOUSE

Protein

Protein CREG1

Gene

Creg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R By similarity.By similarity

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. oxidoreductase activity Source: InterPro
    3. transcription factor binding Source: MGI

    GO - Biological processi

    1. regulation of growth Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: MGI

    Keywords - Biological processi

    Growth regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CREG1
    Alternative name(s):
    Cellular repressor of E1A-stimulated genes 1
    Gene namesi
    Name:Creg1
    Synonyms:Creg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1344382. Creg1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 220189Protein CREG1PRO_0000006204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO88668.
    PaxDbiO88668.
    PRIDEiO88668.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Developmental stagei

    Found at low level from E7 embryo and increased during embryonic development.1 Publication

    Inductioni

    Induced during differentiation.1 Publication

    Gene expression databases

    ArrayExpressiO88668.
    BgeeiO88668.
    CleanExiMM_CREG1.
    GenevestigatoriO88668.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation By similarity.By similarity

    Protein-protein interaction databases

    IntActiO88668. 1 interaction.
    MINTiMINT-1846777.

    Structurei

    3D structure databases

    ProteinModelPortaliO88668.
    SMRiO88668. Positions 49-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CREG family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG294476.
    GeneTreeiENSGT00390000005914.
    HOGENOMiHOG000239875.
    HOVERGENiHBG051115.
    InParanoidiO88668.
    OMAiDEMEHER.
    OrthoDBiEOG7ZWD33.
    PhylomeDBiO88668.
    TreeFamiTF324680.

    Family and domain databases

    Gene3Di2.30.110.10. 1 hit.
    InterProiIPR014631. CREG.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view]
    PIRSFiPIRSF036911. CREG. 1 hit.
    SUPFAMiSSF50475. SSF50475. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88668-1 [UniParc]FASTAAdd to Basket

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    MAARAPELAR SLLAALLAPA LVALLVSPAS GRGGRDHGDW DVDRRLPPLP    50
    PREDGPRVAR FVTHVSDWGS LATISTIKEV RGWPFADIIS ISDGPPGEGT 100
    GEPYMYLSPL QQAVSDLQEN PEATLTMSLA QTVYCRNHGF DPQSPLCVHI 150
    MMSGTVTKVN KTEEDYARDS LFVRHPEMKH WPSSHNWFFA KLKISRIWVL 200
    DYFGGPKVVT PEEYFNVTLQ 220
    Length:220
    Mass (Da):24,452
    Last modified:November 1, 1998 - v1
    Checksum:iEF3A8CFD3186163D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621V → M in BAC39549. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084524 mRNA. Translation: AAC34862.1.
    AK005388 mRNA. Translation: BAB23994.1.
    AK010947 mRNA. Translation: BAB27285.1.
    AK085844 mRNA. Translation: BAC39549.1.
    AK144101 mRNA. Translation: BAE25699.1.
    BC027426 mRNA. Translation: AAH27426.1.
    CCDSiCCDS35759.1.
    RefSeqiNP_035934.1. NM_011804.2.
    XP_006496993.1. XM_006496930.1.
    UniGeneiMm.294885.
    Mm.468745.

    Genome annotation databases

    EnsembliENSMUST00000111432; ENSMUSP00000107060; ENSMUSG00000040713.
    GeneIDi433375.
    KEGGimmu:433375.
    UCSCiuc007djm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084524 mRNA. Translation: AAC34862.1 .
    AK005388 mRNA. Translation: BAB23994.1 .
    AK010947 mRNA. Translation: BAB27285.1 .
    AK085844 mRNA. Translation: BAC39549.1 .
    AK144101 mRNA. Translation: BAE25699.1 .
    BC027426 mRNA. Translation: AAH27426.1 .
    CCDSi CCDS35759.1.
    RefSeqi NP_035934.1. NM_011804.2.
    XP_006496993.1. XM_006496930.1.
    UniGenei Mm.294885.
    Mm.468745.

    3D structure databases

    ProteinModelPortali O88668.
    SMRi O88668. Positions 49-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88668. 1 interaction.
    MINTi MINT-1846777.

    Proteomic databases

    MaxQBi O88668.
    PaxDbi O88668.
    PRIDEi O88668.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111432 ; ENSMUSP00000107060 ; ENSMUSG00000040713 .
    GeneIDi 433375.
    KEGGi mmu:433375.
    UCSCi uc007djm.1. mouse.

    Organism-specific databases

    CTDi 8804.
    MGIi MGI:1344382. Creg1.

    Phylogenomic databases

    eggNOGi NOG294476.
    GeneTreei ENSGT00390000005914.
    HOGENOMi HOG000239875.
    HOVERGENi HBG051115.
    InParanoidi O88668.
    OMAi DEMEHER.
    OrthoDBi EOG7ZWD33.
    PhylomeDBi O88668.
    TreeFami TF324680.

    Miscellaneous databases

    ChiTaRSi CREG1. mouse.
    NextBioi 408624.
    PROi O88668.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88668.
    Bgeei O88668.
    CleanExi MM_CREG1.
    Genevestigatori O88668.

    Family and domain databases

    Gene3Di 2.30.110.10. 1 hit.
    InterProi IPR014631. CREG.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view ]
    PIRSFi PIRSF036911. CREG. 1 hit.
    SUPFAMi SSF50475. SSF50475. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F."
      Veal E., Eisenstein M., Tseng Z.H., Gill G.
      Mol. Cell. Biol. 18:5032-5041(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart, Kidney, Liver and Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Mammary tumor.
    4. "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells."
      Veal E., Groisman R., Eisenstein M., Gill G.
      Oncogene 19:2120-2128(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCREG1_MOUSE
    AccessioniPrimary (citable) accession number: O88668
    Secondary accession number(s): Q3UNP8, Q8C3I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3