Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O88665 (BRD7_MOUSE)

Last modified December 15, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Bromodomain-containing protein 7
Alternative name(s):
    75 kDa bromodomain protein
Gene names
Name: Brd7
Synonyms: Bp75
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length651 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Ref.3

Subunit structure

Interacts with IRF2 and HNRPUL1. Associates with histones and HNRPUL1 By similarity. Interacts with PTPN13 and DVL1.

Subcellular location

Nucleus Ref.1.

Tissue specificity

Ubiquitous. Ref.1

Developmental stage

Expressed ubiquitously from 10.5 to 18.5 dpc. Ref.1

Sequence similarities

Contains 1 bromo domain.

Hide | Top

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentNucleus
   DomainBromodomain
Coiled coil
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processWnt receptor signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus Ref.1

Inferred from physical interaction. Source: MGI

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Pik3r1P264502EBI-643930,EBI-641764
Pik3r2O089083EBI-643930,EBI-643570

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 651651Bromodomain-containing protein 7
PRO_0000227665

Regions

Domain148 – 21871Bromo
Coiled coil536 – 56732 Potential
Compositional bias57 – 9135Lys-rich

Amino acid modifications

Modified residue2791Phosphoserine Ref.4

Experimental info

Sequence conflict1021D → G in BAE23823. Ref.2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
O88665-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 5D34B4F14FD51350

FASTA65174,000
        10         20         30         40         50         60 
MGKKHKKHKS DRHFYEEYVE KPLKLVLKVG GSEVTELSTG SSGHDSSLFE DRSDHDKHKD 

        70         80         90        100        110        120 
RKRKKRKKGE KQAPGEEKGR KRRRVKEDKK KRDRDRAENE VDRDLQCHVP IRLDLPPEKP 

       130        140        150        160        170        180 
LTSSLAKQEE VEQTPLQEAL NQLMRQLQRK DPSAFFSFPV TDFIAPGYSM IIKHPMDFST 

       190        200        210        220        230        240 
MKEKIKNNDY QSIEELKDNF KLMCTNAMIY NKPETIYYKA AKKLLHSGMK ILSQERIQSL 

       250        260        270        280        290        300 
KQSIDFMSDL QKTRKQKERT DACQSGEDSG CWQREREDSG DAETQAFRSP AKDNKRKDKD 

       310        320        330        340        350        360 
VLEDKWRSSN SEREHEQIER VVQESGGKLT RRLANSQCEF ERRKPDGTTT LGLLHPVDPI 

       370        380        390        400        410        420 
VGEPGYCPVR LGMTTGRLQS GVNTLQGFKE DKRNRVTPVL YLNYGPYSSY APHYDSTFAN 

       430        440        450        460        470        480 
ISKDDSDLIY STYGEDSDLP NNFSISEFLA TCQDYPYVMA DSLLDVLTKG GHSRSLQDLD 

       490        500        510        520        530        540 
MSSPEDEGQT RALDTAKEAE ITQIEPTGRL ESSSQDRLTA LQAVTTFGAP AEVFDSEEAE 

       550        560        570        580        590        600 
VFQRKLDETT RLLRELQEAQ NERLSTRPPP NMICLLGPSY REMYLAEQVT NNLKELTQQV 

       610        620        630        640        650 
TPGDVVSIHG VRKAMGISVP SPIVGNSFVD LTGECEEPKE TSTAECGPDA S

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Identification and molecular characterization of BP75, a novel bromodomain-containing protein."
Cuppen E., van Ham M., Pepers B., Wieringa B., Hendriks W.
FEBS Lett. 459:291-298(1999) [PubMed: 10526152] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PTPN13, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
Strain: BALB/c.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-293 AND 478-651.
Strain: C57BL/6J.
Tissue: Aorta, Embryo, Fetal head and Vein.
[3]"BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta."
Kim S., Lee J., Park J., Chung J.
Cancer Res. 63:4792-4795(2003) [PubMed: 12941796] [Abstract]
Cited for: FUNCTION, INTERACTION WITH DVL1.
[4]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, MASS SPECTROMETRY.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF084259 mRNA. Translation: AAC33302.1.
AK004429 mRNA. Translation: BAB23299.1.
AK138934 mRNA. Translation: BAE23823.1. Different initiation.
AK142758 mRNA. Translation: BAE25187.1.
IPIIPI00133099.
RefSeqNP_036177.1.
UniGeneMm.5400

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO88665. 2 interactions.
STRINGO88665.

PTM databases

PhosphoSiteO88665.

Proteomic databases

PRIDEO88665.

Genome annotation databases

EnsemblENSMUST00000034085; ENSMUSP00000034085; ENSMUSG00000031660; Mus musculus. [Genome view]
GeneID26992.
KEGGmmu:26992.
UCSCuc009mrn.1. mouse.

Organism-specific databases

CTD26992.
MGIMGI:1349766. Brd7.

Phylogenomic databases

HOGENOMHBG444928.
HOVERGENO88665.
InParanoidO88665.
OMASNNLERE.
OrthoDBEOG9HHRMV.

Gene expression databases

ArrayExpressO88665.
BgeeO88665.
CleanExMM_BRD7.
GenevestigatorO88665.
GermOnlineENSMUSG00000031660. Mus musculus.

Family and domain databases

InterProIPR001487. Bromodomain.
[Graphical view]
Gene3DG3DSA:1.20.920.10. Bromodomain. 1 hit.
PfamPF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 1 hit.
[Graphical view]
PROSITEPS00633. BROMODOMAIN_1. False negative.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio304935.
SOURCESearch...

Hide | Top

Entry information

Entry nameBRD7_MOUSE
AccessionPrimary (citable) accession number: O88665
Secondary accession number(s): Q3UQ56, Q3UU06, Q9CT78
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1998
Last modified: December 15, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents