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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

Arpc1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

  • Arp2/3 complex-mediated actin nucleation Source: RGD
  • response to estradiol Source: RGD
  • response to estrogen Source: RGD

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-3928662 EPHB-mediated forward signaling
R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:Arpc1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2155 Arpc1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508571 – 372Actin-related protein 2/3 complex subunit 1BAdd BLAST372

Proteomic databases

PaxDbiO88656
PeptideAtlasiO88656
PRIDEiO88656

PTM databases

iPTMnetiO88656
PhosphoSitePlusiO88656

Expressioni

Gene expression databases

BgeeiENSRNOG00000000991
GenevisibleiO88656 RN

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88656, 1 interactor
STRINGi10116.ENSRNOP00000001315

Structurei

3D structure databases

ProteinModelPortaliO88656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 45WD 1Add BLAST40
Repeati50 – 89WD 2Add BLAST40
Repeati94 – 135WD 3Add BLAST42
Repeati140 – 179WD 4Add BLAST40
Repeati242 – 280WD 5Add BLAST39
Repeati324 – 367WD 6Add BLAST44

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiO88656
KOiK05757
OMAiVLFTYDS
OrthoDBiEOG091G096H
PhylomeDBiO88656

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030141 ARC1B
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF10 PTHR10709:SF10, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O88656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWNKVHELKE
60 70 80 90 100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SAGGSRVAWV SHDSTVCLVD AEKKMAVATL ASETLPLLAI
260 270 280 290 300
TFITENSLVA AGHDCFPVLF TYDNAAGTLS FGGRLDVPKQ NSQRGLTARE
310 320 330 340 350
RFQNLDKKAS SEGGAATGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVK SLESALKDLK IR
Length:372
Mass (Da):41,057
Last modified:January 23, 2007 - v3
Checksum:iA538CF67C8610E25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083269 mRNA Translation: AAC32605.1
BC062027 mRNA Translation: AAH62027.1
RefSeqiNP_062162.1, NM_019289.2
UniGeneiRn.2090

Genome annotation databases

EnsembliENSRNOT00000001315; ENSRNOP00000001315; ENSRNOG00000000991
GeneIDi54227
KEGGirno:54227

Similar proteinsi

Entry informationi

Entry nameiARC1B_RAT
AccessioniPrimary (citable) accession number: O88656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health