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Protein

Ragulator complex protein LAMTOR3

Gene

Lamtor3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.2 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-165159. mTOR signalling.
R-MMU-166208. mTORC1-mediated signalling.
R-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-MMU-5628897. TP53 Regulates Metabolic Genes.
R-MMU-5674135. MAP2K and MAPK activation.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8943724. Regulation of PTEN gene transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR3
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
MEK-binding partner 1
Short name:
Mp1
Mitogen-activated protein kinase kinase 1-interacting protein 1
Mitogen-activated protein kinase scaffold protein 1
Gene namesi
Name:Lamtor3
Synonyms:Map2k1ip1, Mapbp, Mapksp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929467. Lamtor3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210061 – 124Ragulator complex protein LAMTOR3Add BLAST124

Proteomic databases

EPDiO88653.
PaxDbiO88653.
PeptideAtlasiO88653.
PRIDEiO88653.
TopDownProteomicsiO88653.

PTM databases

iPTMnetiO88653.
PhosphoSitePlusiO88653.

Expressioni

Gene expression databases

BgeeiENSMUSG00000091512.
ExpressionAtlasiO88653. baseline and differential.
GenevisibleiO88653. MM.

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR2; the interaction is direct (PubMed:11266467, PubMed:15263099, PubMed:19177150). Interacts with MAP2K1/MEK1 and MAPK2 (PubMed:9733512). Interacts with MORG1 (PubMed:15118098).By similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

CORUMiO88653.
IntActiO88653. 11 interactors.
MINTiMINT-4102054.
STRINGi10090.ENSMUSP00000136999.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 12Combined sources8
Helixi13 – 15Combined sources3
Beta strandi19 – 26Combined sources8
Beta strandi31 – 36Combined sources6
Helixi42 – 45Combined sources4
Helixi47 – 50Combined sources4
Helixi52 – 60Combined sources9
Beta strandi63 – 65Combined sources3
Beta strandi68 – 74Combined sources7
Beta strandi76 – 85Combined sources10
Beta strandi88 – 95Combined sources8
Helixi100 – 117Combined sources18
Turni118 – 121Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VETX-ray1.90A1-124[»]
1VEUX-ray2.15A1-124[»]
ProteinModelPortaliO88653.
SMRiO88653.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88653.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 70Required for interaction with LAMTOR21 PublicationAdd BLAST14

Sequence similaritiesi

Belongs to the LAMTOR3 family.Curated

Phylogenomic databases

eggNOGiENOG410IWYZ. Eukaryota.
ENOG4111KCU. LUCA.
GeneTreeiENSGT00390000013159.
HOVERGENiHBG052480.
InParanoidiO88653.
KOiK04370.
OMAiYQVIQMN.
OrthoDBiEOG091G0TYL.
PhylomeDBiO88653.
TreeFamiTF324889.

Family and domain databases

InterProiView protein in InterPro
IPR015019. LAMTOR3.
PANTHERiPTHR13378. PTHR13378. 1 hit.
PfamiView protein in Pfam
PF08923. MAPKK1_Int. 1 hit.
SMARTiView protein in SMART
SM01278. MAPKK1_Int. 1 hit.

Sequencei

Sequence statusi: Complete.

O88653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDSA PEHALRPGFL
60 70 80 90 100
STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT
110 120
GLIVSLEKEL APLFEELIKV VEVS
Length:124
Mass (Da):13,553
Last modified:November 1, 1998 - v1
Checksum:i3B9C8A0241D806A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082526 mRNA. Translation: AAC34591.1.
BC016417 mRNA. Translation: AAH16417.1.
BC083155 mRNA. Translation: AAH83155.1.
CCDSiCCDS51078.1.
RefSeqiNP_064304.1. NM_019920.2.
UniGeneiMm.331392.

Genome annotation databases

EnsembliENSMUST00000168345; ENSMUSP00000130811; ENSMUSG00000091512.
ENSMUST00000197064; ENSMUSP00000142512; ENSMUSG00000091512.
GeneIDi56692.
KEGGimmu:56692.
UCSCiuc008rms.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLTOR3_MOUSE
AccessioniPrimary (citable) accession number: O88653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1998
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families