##gff-version 3
O88643	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Chain	2	545	.	.	.	ID=PRO_0000086461;Note=Serine/threonine-protein kinase PAK 1	
O88643	UniProtKB	Domain	75	88	.	.	.	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057	
O88643	UniProtKB	Domain	270	521	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
O88643	UniProtKB	Region	1	75	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O88643	UniProtKB	Region	70	140	.	.	.	Note=Autoregulatory region;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Region	75	105	.	.	.	Note=GTPase-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Region	150	198	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O88643	UniProtKB	Region	210	250	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O88643	UniProtKB	Compositional bias	21	38	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O88643	UniProtKB	Compositional bias	42	75	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O88643	UniProtKB	Compositional bias	150	167	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O88643	UniProtKB	Compositional bias	216	236	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O88643	UniProtKB	Active site	389	389	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027	
O88643	UniProtKB	Binding site	276	284	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
O88643	UniProtKB	Binding site	299	299	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
O88643	UniProtKB	Modified residue	2	2	.	.	.	Note=N-acetylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	21	21	.	.	.	Note=Phosphoserine%3B by PKB and autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	57	57	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	84	84	.	.	.	Note=Phosphothreonine%3B by OXSR1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35465	
O88643	UniProtKB	Modified residue	115	115	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	131	131	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	142	142	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	144	144	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35465	
O88643	UniProtKB	Modified residue	149	149	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35465	
O88643	UniProtKB	Modified residue	153	153	.	.	.	Note=Phosphotyrosine%3B by JAK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	174	174	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	185	185	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	199	199	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35465	
O88643	UniProtKB	Modified residue	201	201	.	.	.	Note=Phosphotyrosine%3B by JAK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	204	204	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35465	
O88643	UniProtKB	Modified residue	212	212	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:12176334,ECO:0007744|PubMed:21183079;Dbxref=PMID:12176334,PMID:21183079	
O88643	UniProtKB	Modified residue	219	219	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	220	220	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
O88643	UniProtKB	Modified residue	223	223	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
O88643	UniProtKB	Modified residue	225	225	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
O88643	UniProtKB	Modified residue	229	229	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
O88643	UniProtKB	Modified residue	230	230	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
O88643	UniProtKB	Modified residue	285	285	.	.	.	Note=Phosphotyrosine%3B by JAK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13153	
O88643	UniProtKB	Modified residue	423	423	.	.	.	Note=Phosphothreonine%3B by autocatalysis%2C BRSK2 and PDPK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22669945;Dbxref=PMID:22669945	
O88643	UniProtKB	Mutagenesis	83	83	.	.	.	Note=When expressed in hippocampal neurons%2C strongly decreases the number of dendritic spines%3B when associated with L-86 and R-299. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193	
O88643	UniProtKB	Mutagenesis	86	86	.	.	.	Note=When expressed in hippocampal neurons%2C strongly decreases the number of dendritic spines%3B when associated with L-83 and R-299. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193	
O88643	UniProtKB	Mutagenesis	299	299	.	.	.	Note=When expressed in hippocampal neurons%2C decreases the number of dendritic spines. Strong decrease in the number of dendritic spines%3B when associated with L-83 and L-86. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193	
O88643	UniProtKB	Mutagenesis	423	423	.	.	.	Note=When expressed in hippocampal neurons%2C increases the density of both spines and dendritic protrusions. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193