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Protein

Olfactory receptor 51E2

Gene

Or51e2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure. May also be activated by steroid hormones and regulate cell proliferation. May also function as an olfactory receptor being activated by beta-ionone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51E2
Alternative name(s):
G-protein coupled receptor RA1c
Olfactory receptor 59
Gene namesi
Name:Or51e2
Synonyms:Olr59, Psgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628858. Olr59.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence analysis
Transmembranei54 – 7421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini75 – 9824ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 19536ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 27215ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 32027CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 51E2PRO_0000150752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88628.
PRIDEiO88628.

Expressioni

Tissue specificityi

Expressed in brain and liver. Expressed only in some areas of the brain and in the olfactory epithelium.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025097.

Structurei

3D structure databases

ProteinModelPortaliO88628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGD6. Eukaryota.
ENOG41120HT. LUCA.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiO88628.
KOiK04257.
PhylomeDBiO88628.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCNFTHAT FMLIGIPGLE EAHFWFGFPL LSMYAVALFG NCIVVFIVRT
60 70 80 90 100
ERSLHAPMYL FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ITFDACLAQM
110 120 130 140 150
FFIHALSAIE STILLAMAFD RYVAICHPLR HAAVLNNTVT VQIGMVALVR
160 170 180 190 200
GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH QDVMKLAYTD TLPNVVYGLT
210 220 230 240 250
AILLVMGVDV MFISLSYFLI IRAVLQLPSK SERAKAFGTC VSHIGVVLAF
260 270 280 290 300
YVPLIGLSVV HRFGNSLDPI VHVLMGDVYL LLPPVINPII YGAKTKQIRT
310 320
RVLAMFKISC DKDIEAGGNT
Length:320
Mass (Da):35,505
Last modified:November 1, 1998 - v1
Checksum:iE7FF78F5FFD5BF94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079864 mRNA. Translation: AAD12761.1.
RefSeqiNP_775415.1. NM_173293.1.
UniGeneiRn.12541.

Genome annotation databases

GeneIDi170816.
KEGGirno:170816.
UCSCiRGD:628858. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079864 mRNA. Translation: AAD12761.1.
RefSeqiNP_775415.1. NM_173293.1.
UniGeneiRn.12541.

3D structure databases

ProteinModelPortaliO88628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025097.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO88628.
PRIDEiO88628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170816.
KEGGirno:170816.
UCSCiRGD:628858. rat.

Organism-specific databases

CTDi170816.
RGDi628858. Olr59.

Phylogenomic databases

eggNOGiENOG410IGD6. Eukaryota.
ENOG41120HT. LUCA.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiO88628.
KOiK04257.
PhylomeDBiO88628.

Miscellaneous databases

PROiO88628.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51E2_RAT
AccessioniPrimary (citable) accession number: O88628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.