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O88627

- S28A2_MOUSE

UniProt

O88627 - S28A2_MOUSE

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Protein

Sodium/nucleoside cotransporter 2

Gene

Slc28a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (By similarity).By similarity

GO - Molecular functioni

  1. nucleoside:sodium symporter activity Source: InterPro
  2. nucleoside binding Source: InterPro
  3. purine nucleoside transmembrane transporter activity Source: MGI

GO - Biological processi

  1. purine nucleoside transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_247934. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 2
Alternative name(s):
Concentrative nucleoside transporter 2
Short name:
CNT 2
Na(+)/nucleoside cotransporter 2
Sodium-coupled nucleoside transporter 2
Sodium/purine nucleoside cotransporter
Short name:
SPNT
Solute carrier family 28 member 2
Gene namesi
Name:Slc28a2
Synonyms:Cnt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1913105. Slc28a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei106 – 12520HelicalSequence AnalysisAdd
BLAST
Transmembranei150 – 16819HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence AnalysisAdd
BLAST
Transmembranei297 – 31620HelicalSequence AnalysisAdd
BLAST
Transmembranei338 – 35720HelicalSequence AnalysisAdd
BLAST
Transmembranei364 – 38320HelicalSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST
Transmembranei531 – 55121HelicalSequence AnalysisAdd
BLAST
Transmembranei569 – 58921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Sodium/nucleoside cotransporter 2PRO_0000070451Add
BLAST

Proteomic databases

PaxDbiO88627.
PRIDEiO88627.

PTM databases

PhosphoSiteiO88627.

Expressioni

Gene expression databases

BgeeiO88627.
ExpressionAtlasiO88627. baseline and differential.
GenevestigatoriO88627.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996278.

Structurei

3D structure databases

ProteinModelPortaliO88627.
SMRiO88627. Positions 176-587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1972.
GeneTreeiENSGT00390000016025.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiO88627.
KOiK11536.
OMAiSRLIMTY.
OrthoDBiEOG7RV9FR.
TreeFamiTF314131.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequencei

Sequence statusi: Complete.

O88627-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKSKGRKSV SQATVENCME NPGLELMEGG NLEQRYTQEE VTQGHSLEDG
60 70 80 90 100
LGHSSLWSRR IFQPFTKARS FFERHAGLFR KILLGLLCLA YAAYFLAACI
110 120 130 140 150
LNFQRALALF VITCLVIFIL ACHFLKKFFP KEQLRCLKPL ENTHLNLWAK
160 170 180 190 200
RVFVGLSVVG LILWLALDTA QRPEQLISFA GICMFILILF ACSKHHSAVC
210 220 230 240 250
WRTVFWGLGL QFIFGILVIR TEPGFNAFQW LGDQIQIFLA YTVEGSSFVF
260 270 280 290 300
GDTLVQNVFA FQSLPIIIFF GCVMSILYYL GLVQWVIQKV AWFLQITMGT
310 320 330 340 350
TAAETLAVAG NIFVGMTEAP LLIRPYLADM TISEIHAVMT GGFATIAGTV
360 370 380 390 400
LGAFISFGID ASSLISASVM AAPCALALSK LVYPEVEESK FKSKEGLKLP
410 420 430 440 450
RGEERNILEA ASNGATDAIS LVANVAANLI AFLAVLAFIN ATLSWLGEMV
460 470 480 490 500
DIHGLSFQVI CSYVLRPMVF MMGVQWADCP LVAEIVGVKF FINEFVAYQQ
510 520 530 540 550
LSQYKNKRLS GVEEWINGEK QWISVKAEII TTFSLCGFAN LSSIGITLGG
560 570 580 590 600
LTSMIPQRKS DLCKIVVRAL FTGACVSFIS ACMAGILYVP RGAETDCVSF
610 620 630 640 650
LNTNFTNRTY ETYVCCRELF QSTSLNGTNM PSFSGPWQDN VSSLRNLASC
660
CDLYTSTVCA
Length:660
Mass (Da):72,916
Last modified:July 27, 2011 - v2
Checksum:i64522D068A2138EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21E → K in AAC28858. (PubMed:10721696)Curated
Sequence conflicti14 – 141T → R in AAC28858. (PubMed:10721696)Curated
Sequence conflicti18 – 181C → G in AAC28858. (PubMed:10721696)Curated
Sequence conflicti80 – 801R → K in AAC28858. (PubMed:10721696)Curated
Sequence conflicti92 – 921A → T in AAC28858. (PubMed:10721696)Curated
Sequence conflicti154 – 1541V → I in AAC28858. (PubMed:10721696)Curated
Sequence conflicti337 – 3371A → T in AAC28858. (PubMed:10721696)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079853 mRNA. Translation: AAC28858.1.
AK080957 mRNA. Translation: BAC38094.1.
AK152776 mRNA. Translation: BAE31488.1.
AL844566 Genomic DNA. Translation: CAM16323.1.
CCDSiCCDS16663.1.
RefSeqiNP_766568.1. NM_172980.2.
XP_006499663.1. XM_006499600.1.
XP_006499664.1. XM_006499601.1.
UniGeneiMm.29510.

Genome annotation databases

EnsembliENSMUST00000028652; ENSMUSP00000028652; ENSMUSG00000027219.
ENSMUST00000110524; ENSMUSP00000106153; ENSMUSG00000027219.
ENSMUST00000110525; ENSMUSP00000106154; ENSMUSG00000027219.
GeneIDi269346.
KEGGimmu:269346.
UCSCiuc008mas.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079853 mRNA. Translation: AAC28858.1 .
AK080957 mRNA. Translation: BAC38094.1 .
AK152776 mRNA. Translation: BAE31488.1 .
AL844566 Genomic DNA. Translation: CAM16323.1 .
CCDSi CCDS16663.1.
RefSeqi NP_766568.1. NM_172980.2.
XP_006499663.1. XM_006499600.1.
XP_006499664.1. XM_006499601.1.
UniGenei Mm.29510.

3D structure databases

ProteinModelPortali O88627.
SMRi O88627. Positions 176-587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996278.

Chemistry

ChEMBLi CHEMBL1287613.

PTM databases

PhosphoSitei O88627.

Proteomic databases

PaxDbi O88627.
PRIDEi O88627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028652 ; ENSMUSP00000028652 ; ENSMUSG00000027219 .
ENSMUST00000110524 ; ENSMUSP00000106153 ; ENSMUSG00000027219 .
ENSMUST00000110525 ; ENSMUSP00000106154 ; ENSMUSG00000027219 .
GeneIDi 269346.
KEGGi mmu:269346.
UCSCi uc008mas.1. mouse.

Organism-specific databases

CTDi 9153.
MGIi MGI:1913105. Slc28a2.

Phylogenomic databases

eggNOGi COG1972.
GeneTreei ENSGT00390000016025.
HOGENOMi HOG000267658.
HOVERGENi HBG054073.
InParanoidi O88627.
KOi K11536.
OMAi SRLIMTY.
OrthoDBi EOG7RV9FR.
TreeFami TF314131.

Enzyme and pathway databases

Reactomei REACT_247934. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

NextBioi 392797.
PROi O88627.
SOURCEi Search...

Gene expression databases

Bgeei O88627.
ExpressionAtlasi O88627. baseline and differential.
Genevestigatori O88627.

Family and domain databases

InterProi IPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view ]
PANTHERi PTHR10590. PTHR10590. 1 hit.
Pfami PF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00804. nupC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, genomic organization and chromosomal localization of the gene encoding the murine sodium-dependent, purine-selective, concentrative nucleoside transporter (CNT2)."
    Patel D.H., Crawford C.R., Naeve C.W., Belt J.A.
    Gene 242:51-58(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Bone marrow.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiS28A2_MOUSE
AccessioniPrimary (citable) accession number: O88627
Secondary accession number(s): Q8BJP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3