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O88627

- S28A2_MOUSE

UniProt

O88627 - S28A2_MOUSE

Protein

Sodium/nucleoside cotransporter 2

Gene

Slc28a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) By similarity.By similarity

    GO - Molecular functioni

    1. nucleoside:sodium symporter activity Source: InterPro
    2. nucleoside binding Source: InterPro
    3. purine nucleoside transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. purine nucleoside transmembrane transport Source: MGI

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/nucleoside cotransporter 2
    Alternative name(s):
    Concentrative nucleoside transporter 2
    Short name:
    CNT 2
    Na(+)/nucleoside cotransporter 2
    Sodium-coupled nucleoside transporter 2
    Sodium/purine nucleoside cotransporter
    Short name:
    SPNT
    Solute carrier family 28 member 2
    Gene namesi
    Name:Slc28a2
    Synonyms:Cnt2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1913105. Slc28a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 660660Sodium/nucleoside cotransporter 2PRO_0000070451Add
    BLAST

    Proteomic databases

    PaxDbiO88627.
    PRIDEiO88627.

    PTM databases

    PhosphoSiteiO88627.

    Expressioni

    Gene expression databases

    BgeeiO88627.
    GenevestigatoriO88627.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4996278.

    Structurei

    3D structure databases

    ProteinModelPortaliO88627.
    SMRiO88627. Positions 176-587.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 16819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei364 – 38320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei531 – 55121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei569 – 58921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1972.
    GeneTreeiENSGT00390000016025.
    HOGENOMiHOG000267658.
    HOVERGENiHBG054073.
    InParanoidiQ8BJP1.
    KOiK11536.
    OMAiSRLIMTY.
    OrthoDBiEOG7RV9FR.
    TreeFamiTF314131.

    Family and domain databases

    InterProiIPR008276. C_nuclsd_transpt.
    IPR018270. C_nuclsd_transpt_met_bac.
    IPR011657. CNT_C_dom.
    IPR002668. CNT_N_dom.
    IPR011642. Nucleoside_recog_Gate.
    [Graphical view]
    PANTHERiPTHR10590. PTHR10590. 1 hit.
    PfamiPF07670. Gate. 1 hit.
    PF07662. Nucleos_tra2_C. 1 hit.
    PF01773. Nucleos_tra2_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00804. nupC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O88627-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKSKGRKSV SQATVENCME NPGLELMEGG NLEQRYTQEE VTQGHSLEDG    50
    LGHSSLWSRR IFQPFTKARS FFERHAGLFR KILLGLLCLA YAAYFLAACI 100
    LNFQRALALF VITCLVIFIL ACHFLKKFFP KEQLRCLKPL ENTHLNLWAK 150
    RVFVGLSVVG LILWLALDTA QRPEQLISFA GICMFILILF ACSKHHSAVC 200
    WRTVFWGLGL QFIFGILVIR TEPGFNAFQW LGDQIQIFLA YTVEGSSFVF 250
    GDTLVQNVFA FQSLPIIIFF GCVMSILYYL GLVQWVIQKV AWFLQITMGT 300
    TAAETLAVAG NIFVGMTEAP LLIRPYLADM TISEIHAVMT GGFATIAGTV 350
    LGAFISFGID ASSLISASVM AAPCALALSK LVYPEVEESK FKSKEGLKLP 400
    RGEERNILEA ASNGATDAIS LVANVAANLI AFLAVLAFIN ATLSWLGEMV 450
    DIHGLSFQVI CSYVLRPMVF MMGVQWADCP LVAEIVGVKF FINEFVAYQQ 500
    LSQYKNKRLS GVEEWINGEK QWISVKAEII TTFSLCGFAN LSSIGITLGG 550
    LTSMIPQRKS DLCKIVVRAL FTGACVSFIS ACMAGILYVP RGAETDCVSF 600
    LNTNFTNRTY ETYVCCRELF QSTSLNGTNM PSFSGPWQDN VSSLRNLASC 650
    CDLYTSTVCA 660
    Length:660
    Mass (Da):72,916
    Last modified:July 27, 2011 - v2
    Checksum:i64522D068A2138EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21E → K in AAC28858. (PubMed:10721696)Curated
    Sequence conflicti14 – 141T → R in AAC28858. (PubMed:10721696)Curated
    Sequence conflicti18 – 181C → G in AAC28858. (PubMed:10721696)Curated
    Sequence conflicti80 – 801R → K in AAC28858. (PubMed:10721696)Curated
    Sequence conflicti92 – 921A → T in AAC28858. (PubMed:10721696)Curated
    Sequence conflicti154 – 1541V → I in AAC28858. (PubMed:10721696)Curated
    Sequence conflicti337 – 3371A → T in AAC28858. (PubMed:10721696)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079853 mRNA. Translation: AAC28858.1.
    AK080957 mRNA. Translation: BAC38094.1.
    AK152776 mRNA. Translation: BAE31488.1.
    AL844566 Genomic DNA. Translation: CAM16323.1.
    CCDSiCCDS16663.1.
    RefSeqiNP_766568.1. NM_172980.2.
    XP_006499663.1. XM_006499600.1.
    XP_006499664.1. XM_006499601.1.
    UniGeneiMm.29510.

    Genome annotation databases

    EnsembliENSMUST00000028652; ENSMUSP00000028652; ENSMUSG00000027219.
    ENSMUST00000110524; ENSMUSP00000106153; ENSMUSG00000027219.
    ENSMUST00000110525; ENSMUSP00000106154; ENSMUSG00000027219.
    GeneIDi269346.
    KEGGimmu:269346.
    UCSCiuc008mas.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079853 mRNA. Translation: AAC28858.1 .
    AK080957 mRNA. Translation: BAC38094.1 .
    AK152776 mRNA. Translation: BAE31488.1 .
    AL844566 Genomic DNA. Translation: CAM16323.1 .
    CCDSi CCDS16663.1.
    RefSeqi NP_766568.1. NM_172980.2.
    XP_006499663.1. XM_006499600.1.
    XP_006499664.1. XM_006499601.1.
    UniGenei Mm.29510.

    3D structure databases

    ProteinModelPortali O88627.
    SMRi O88627. Positions 176-587.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996278.

    Chemistry

    ChEMBLi CHEMBL1287613.

    PTM databases

    PhosphoSitei O88627.

    Proteomic databases

    PaxDbi O88627.
    PRIDEi O88627.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028652 ; ENSMUSP00000028652 ; ENSMUSG00000027219 .
    ENSMUST00000110524 ; ENSMUSP00000106153 ; ENSMUSG00000027219 .
    ENSMUST00000110525 ; ENSMUSP00000106154 ; ENSMUSG00000027219 .
    GeneIDi 269346.
    KEGGi mmu:269346.
    UCSCi uc008mas.1. mouse.

    Organism-specific databases

    CTDi 9153.
    MGIi MGI:1913105. Slc28a2.

    Phylogenomic databases

    eggNOGi COG1972.
    GeneTreei ENSGT00390000016025.
    HOGENOMi HOG000267658.
    HOVERGENi HBG054073.
    InParanoidi Q8BJP1.
    KOi K11536.
    OMAi SRLIMTY.
    OrthoDBi EOG7RV9FR.
    TreeFami TF314131.

    Miscellaneous databases

    NextBioi 392797.
    PROi O88627.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88627.
    Genevestigatori O88627.

    Family and domain databases

    InterProi IPR008276. C_nuclsd_transpt.
    IPR018270. C_nuclsd_transpt_met_bac.
    IPR011657. CNT_C_dom.
    IPR002668. CNT_N_dom.
    IPR011642. Nucleoside_recog_Gate.
    [Graphical view ]
    PANTHERi PTHR10590. PTHR10590. 1 hit.
    Pfami PF07670. Gate. 1 hit.
    PF07662. Nucleos_tra2_C. 1 hit.
    PF01773. Nucleos_tra2_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00804. nupC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, genomic organization and chromosomal localization of the gene encoding the murine sodium-dependent, purine-selective, concentrative nucleoside transporter (CNT2)."
      Patel D.H., Crawford C.R., Naeve C.W., Belt J.A.
      Gene 242:51-58(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Spleen.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Adipose tissue and Bone marrow.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiS28A2_MOUSE
    AccessioniPrimary (citable) accession number: O88627
    Secondary accession number(s): Q8BJP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3