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O88627

- S28A2_MOUSE

UniProt

O88627 - S28A2_MOUSE

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Protein
Sodium/nucleoside cotransporter 2
Gene
Slc28a2, Cnt2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) By similarity.

GO - Molecular functioni

  1. nucleoside binding Source: InterPro
  2. nucleoside:sodium symporter activity Source: InterPro
  3. purine nucleoside transmembrane transporter activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. purine nucleoside transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 2
Alternative name(s):
Concentrative nucleoside transporter 2
Short name:
CNT 2
Na(+)/nucleoside cotransporter 2
Sodium-coupled nucleoside transporter 2
Sodium/purine nucleoside cotransporter
Short name:
SPNT
Solute carrier family 28 member 2
Gene namesi
Name:Slc28a2
Synonyms:Cnt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1913105. Slc28a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Transmembranei106 – 12520Helical; Reviewed prediction
Add
BLAST
Transmembranei150 – 16819Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei202 – 22221Helical; Reviewed prediction
Add
BLAST
Transmembranei235 – 25521Helical; Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Reviewed prediction
Add
BLAST
Transmembranei297 – 31620Helical; Reviewed prediction
Add
BLAST
Transmembranei338 – 35720Helical; Reviewed prediction
Add
BLAST
Transmembranei364 – 38320Helical; Reviewed prediction
Add
BLAST
Transmembranei425 – 44521Helical; Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Reviewed prediction
Add
BLAST
Transmembranei531 – 55121Helical; Reviewed prediction
Add
BLAST
Transmembranei569 – 58921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Sodium/nucleoside cotransporter 2
PRO_0000070451Add
BLAST

Proteomic databases

PaxDbiO88627.
PRIDEiO88627.

PTM databases

PhosphoSiteiO88627.

Expressioni

Gene expression databases

BgeeiO88627.
GenevestigatoriO88627.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996278.

Structurei

3D structure databases

ProteinModelPortaliO88627.
SMRiO88627. Positions 176-587.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1972.
GeneTreeiENSGT00390000016025.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiQ8BJP1.
KOiK11536.
OMAiSRLIMTY.
OrthoDBiEOG7RV9FR.
TreeFamiTF314131.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequencei

Sequence statusi: Complete.

O88627-1 [UniParc]FASTAAdd to Basket

« Hide

MEKSKGRKSV SQATVENCME NPGLELMEGG NLEQRYTQEE VTQGHSLEDG    50
LGHSSLWSRR IFQPFTKARS FFERHAGLFR KILLGLLCLA YAAYFLAACI 100
LNFQRALALF VITCLVIFIL ACHFLKKFFP KEQLRCLKPL ENTHLNLWAK 150
RVFVGLSVVG LILWLALDTA QRPEQLISFA GICMFILILF ACSKHHSAVC 200
WRTVFWGLGL QFIFGILVIR TEPGFNAFQW LGDQIQIFLA YTVEGSSFVF 250
GDTLVQNVFA FQSLPIIIFF GCVMSILYYL GLVQWVIQKV AWFLQITMGT 300
TAAETLAVAG NIFVGMTEAP LLIRPYLADM TISEIHAVMT GGFATIAGTV 350
LGAFISFGID ASSLISASVM AAPCALALSK LVYPEVEESK FKSKEGLKLP 400
RGEERNILEA ASNGATDAIS LVANVAANLI AFLAVLAFIN ATLSWLGEMV 450
DIHGLSFQVI CSYVLRPMVF MMGVQWADCP LVAEIVGVKF FINEFVAYQQ 500
LSQYKNKRLS GVEEWINGEK QWISVKAEII TTFSLCGFAN LSSIGITLGG 550
LTSMIPQRKS DLCKIVVRAL FTGACVSFIS ACMAGILYVP RGAETDCVSF 600
LNTNFTNRTY ETYVCCRELF QSTSLNGTNM PSFSGPWQDN VSSLRNLASC 650
CDLYTSTVCA 660
Length:660
Mass (Da):72,916
Last modified:July 27, 2011 - v2
Checksum:i64522D068A2138EC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21E → K in AAC28858. 1 Publication
Sequence conflicti14 – 141T → R in AAC28858. 1 Publication
Sequence conflicti18 – 181C → G in AAC28858. 1 Publication
Sequence conflicti80 – 801R → K in AAC28858. 1 Publication
Sequence conflicti92 – 921A → T in AAC28858. 1 Publication
Sequence conflicti154 – 1541V → I in AAC28858. 1 Publication
Sequence conflicti337 – 3371A → T in AAC28858. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079853 mRNA. Translation: AAC28858.1.
AK080957 mRNA. Translation: BAC38094.1.
AK152776 mRNA. Translation: BAE31488.1.
AL844566 Genomic DNA. Translation: CAM16323.1.
CCDSiCCDS16663.1.
RefSeqiNP_766568.1. NM_172980.2.
XP_006499663.1. XM_006499600.1.
XP_006499664.1. XM_006499601.1.
UniGeneiMm.29510.

Genome annotation databases

EnsembliENSMUST00000028652; ENSMUSP00000028652; ENSMUSG00000027219.
ENSMUST00000110524; ENSMUSP00000106153; ENSMUSG00000027219.
ENSMUST00000110525; ENSMUSP00000106154; ENSMUSG00000027219.
GeneIDi269346.
KEGGimmu:269346.
UCSCiuc008mas.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079853 mRNA. Translation: AAC28858.1 .
AK080957 mRNA. Translation: BAC38094.1 .
AK152776 mRNA. Translation: BAE31488.1 .
AL844566 Genomic DNA. Translation: CAM16323.1 .
CCDSi CCDS16663.1.
RefSeqi NP_766568.1. NM_172980.2.
XP_006499663.1. XM_006499600.1.
XP_006499664.1. XM_006499601.1.
UniGenei Mm.29510.

3D structure databases

ProteinModelPortali O88627.
SMRi O88627. Positions 176-587.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4996278.

Chemistry

ChEMBLi CHEMBL1287613.

PTM databases

PhosphoSitei O88627.

Proteomic databases

PaxDbi O88627.
PRIDEi O88627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028652 ; ENSMUSP00000028652 ; ENSMUSG00000027219 .
ENSMUST00000110524 ; ENSMUSP00000106153 ; ENSMUSG00000027219 .
ENSMUST00000110525 ; ENSMUSP00000106154 ; ENSMUSG00000027219 .
GeneIDi 269346.
KEGGi mmu:269346.
UCSCi uc008mas.1. mouse.

Organism-specific databases

CTDi 9153.
MGIi MGI:1913105. Slc28a2.

Phylogenomic databases

eggNOGi COG1972.
GeneTreei ENSGT00390000016025.
HOGENOMi HOG000267658.
HOVERGENi HBG054073.
InParanoidi Q8BJP1.
KOi K11536.
OMAi SRLIMTY.
OrthoDBi EOG7RV9FR.
TreeFami TF314131.

Miscellaneous databases

NextBioi 392797.
PROi O88627.
SOURCEi Search...

Gene expression databases

Bgeei O88627.
Genevestigatori O88627.

Family and domain databases

InterProi IPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view ]
PANTHERi PTHR10590. PTHR10590. 1 hit.
Pfami PF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00804. nupC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, genomic organization and chromosomal localization of the gene encoding the murine sodium-dependent, purine-selective, concentrative nucleoside transporter (CNT2)."
    Patel D.H., Crawford C.R., Naeve C.W., Belt J.A.
    Gene 242:51-58(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Bone marrow.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiS28A2_MOUSE
AccessioniPrimary (citable) accession number: O88627
Secondary accession number(s): Q8BJP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi