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Protein

Sodium/nucleoside cotransporter 2

Gene

Slc28a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • purine nucleoside transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 2
Alternative name(s):
Concentrative nucleoside transporter 2
Short name:
CNT 2
Na(+)/nucleoside cotransporter 2
Sodium-coupled nucleoside transporter 2
Sodium/purine nucleoside cotransporter
Short name:
SPNT
Solute carrier family 28 member 2
Gene namesi
Name:Slc28a2
Synonyms:Cnt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913105. Slc28a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei106 – 125HelicalSequence analysisAdd BLAST20
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Transmembranei338 – 357HelicalSequence analysisAdd BLAST20
Transmembranei364 – 383HelicalSequence analysisAdd BLAST20
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1287613.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704511 – 660Sodium/nucleoside cotransporter 2Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88627.
PaxDbiO88627.
PRIDEiO88627.

PTM databases

iPTMnetiO88627.
PhosphoSitePlusiO88627.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027219.
GenevisibleiO88627. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996278.
STRINGi10090.ENSMUSP00000028652.

Structurei

3D structure databases

ProteinModelPortaliO88627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3747. Eukaryota.
COG1972. LUCA.
GeneTreeiENSGT00390000016025.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiO88627.
KOiK11536.
OMAiTGIENPG.
OrthoDBiEOG091G05D5.
TreeFamiTF314131.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030212. CNT1/CNT2.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Gate_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF11. PTHR10590:SF11. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequencei

Sequence statusi: Complete.

O88627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSKGRKSV SQATVENCME NPGLELMEGG NLEQRYTQEE VTQGHSLEDG
60 70 80 90 100
LGHSSLWSRR IFQPFTKARS FFERHAGLFR KILLGLLCLA YAAYFLAACI
110 120 130 140 150
LNFQRALALF VITCLVIFIL ACHFLKKFFP KEQLRCLKPL ENTHLNLWAK
160 170 180 190 200
RVFVGLSVVG LILWLALDTA QRPEQLISFA GICMFILILF ACSKHHSAVC
210 220 230 240 250
WRTVFWGLGL QFIFGILVIR TEPGFNAFQW LGDQIQIFLA YTVEGSSFVF
260 270 280 290 300
GDTLVQNVFA FQSLPIIIFF GCVMSILYYL GLVQWVIQKV AWFLQITMGT
310 320 330 340 350
TAAETLAVAG NIFVGMTEAP LLIRPYLADM TISEIHAVMT GGFATIAGTV
360 370 380 390 400
LGAFISFGID ASSLISASVM AAPCALALSK LVYPEVEESK FKSKEGLKLP
410 420 430 440 450
RGEERNILEA ASNGATDAIS LVANVAANLI AFLAVLAFIN ATLSWLGEMV
460 470 480 490 500
DIHGLSFQVI CSYVLRPMVF MMGVQWADCP LVAEIVGVKF FINEFVAYQQ
510 520 530 540 550
LSQYKNKRLS GVEEWINGEK QWISVKAEII TTFSLCGFAN LSSIGITLGG
560 570 580 590 600
LTSMIPQRKS DLCKIVVRAL FTGACVSFIS ACMAGILYVP RGAETDCVSF
610 620 630 640 650
LNTNFTNRTY ETYVCCRELF QSTSLNGTNM PSFSGPWQDN VSSLRNLASC
660
CDLYTSTVCA
Length:660
Mass (Da):72,916
Last modified:July 27, 2011 - v2
Checksum:i64522D068A2138EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2E → K in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti14T → R in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti18C → G in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti80R → K in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti92A → T in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti154V → I in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti337A → T in AAC28858 (PubMed:10721696).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079853 mRNA. Translation: AAC28858.1.
AK080957 mRNA. Translation: BAC38094.1.
AK152776 mRNA. Translation: BAE31488.1.
AL844566 Genomic DNA. Translation: CAM16323.1.
CCDSiCCDS16663.1.
RefSeqiNP_766568.1. NM_172980.2.
XP_006499664.1. XM_006499601.3.
XP_011237878.1. XM_011239576.2.
UniGeneiMm.29510.

Genome annotation databases

EnsembliENSMUST00000028652; ENSMUSP00000028652; ENSMUSG00000027219.
ENSMUST00000110524; ENSMUSP00000106153; ENSMUSG00000027219.
ENSMUST00000110525; ENSMUSP00000106154; ENSMUSG00000027219.
GeneIDi269346.
KEGGimmu:269346.
UCSCiuc008mas.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079853 mRNA. Translation: AAC28858.1.
AK080957 mRNA. Translation: BAC38094.1.
AK152776 mRNA. Translation: BAE31488.1.
AL844566 Genomic DNA. Translation: CAM16323.1.
CCDSiCCDS16663.1.
RefSeqiNP_766568.1. NM_172980.2.
XP_006499664.1. XM_006499601.3.
XP_011237878.1. XM_011239576.2.
UniGeneiMm.29510.

3D structure databases

ProteinModelPortaliO88627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4996278.
STRINGi10090.ENSMUSP00000028652.

Chemistry databases

ChEMBLiCHEMBL1287613.

PTM databases

iPTMnetiO88627.
PhosphoSitePlusiO88627.

Proteomic databases

EPDiO88627.
PaxDbiO88627.
PRIDEiO88627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028652; ENSMUSP00000028652; ENSMUSG00000027219.
ENSMUST00000110524; ENSMUSP00000106153; ENSMUSG00000027219.
ENSMUST00000110525; ENSMUSP00000106154; ENSMUSG00000027219.
GeneIDi269346.
KEGGimmu:269346.
UCSCiuc008mas.1. mouse.

Organism-specific databases

CTDi9153.
MGIiMGI:1913105. Slc28a2.

Phylogenomic databases

eggNOGiKOG3747. Eukaryota.
COG1972. LUCA.
GeneTreeiENSGT00390000016025.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiO88627.
KOiK11536.
OMAiTGIENPG.
OrthoDBiEOG091G05D5.
TreeFamiTF314131.

Enzyme and pathway databases

ReactomeiR-MMU-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

PROiO88627.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027219.
GenevisibleiO88627. MM.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030212. CNT1/CNT2.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Gate_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF11. PTHR10590:SF11. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS28A2_MOUSE
AccessioniPrimary (citable) accession number: O88627
Secondary accession number(s): Q8BJP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.