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Protein

Galanin receptor type 3

Gene

Galr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin and spexin-1.By similarity1 Publication

GO - Molecular functioni

  • galanin receptor activity Source: MGI
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:Galr3
Synonyms:Galnr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2658 Galr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 96ExtracellularSequence analysisAdd BLAST18
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 138CytoplasmicSequence analysisAdd BLAST20
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184ExtracellularSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 236CytoplasmicSequence analysisAdd BLAST31
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 259ExtracellularSequence analysis2
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 370CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694711 – 370Galanin receptor type 3Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88626

PTM databases

PhosphoSitePlusiO88626

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014349

Chemistry databases

BindingDBiO88626

Structurei

3D structure databases

ProteinModelPortaliO88626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 225Poly-Ala8

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG101447
InParanoidiO88626
KOiK04232
PhylomeDBiO88626

Family and domain databases

InterProiView protein in InterPro
IPR000405 Galanin_rcpt
IPR003908 Galnin_3_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01420 GALANIN3R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPRSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSLDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV
210 220 230 240 250
SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA
310 320 330 340 350
RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR
360 370
GDALRGGGET RLTLSPRGPQ
Length:370
Mass (Da):40,410
Last modified:November 1, 1998 - v1
Checksum:iCE5B39E6147AFAD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54R → S in AAC35943 (PubMed:9722565).Curated1
Sequence conflicti127P → Q in AAC26145 (Ref. 2) Curated1
Sequence conflicti183A → R in AAC26145 (Ref. 2) Curated1
Sequence conflicti311R → C in AAC26145 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079844 mRNA Translation: AAC34590.1
AF031522 mRNA Translation: AAC26145.1
AF073798 mRNA Translation: AAC35943.1
RefSeqiNP_062046.1, NM_019173.1
XP_006242034.1, XM_006241972.2
XP_017450186.1, XM_017594697.1
UniGeneiRn.30069

Genome annotation databases

GeneIDi29235
KEGGirno:29235
UCSCiRGD:2658 rat

Similar proteinsi

Entry informationi

Entry nameiGALR3_RAT
AccessioniPrimary (citable) accession number: O88626
Secondary accession number(s): O54914, Q9QWZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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