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O88626 (GALR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 3

Short name=GAL3-R
Short name=GALR-3
Gene names
Name:Galr3
Synonyms:Galnr3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the hormone galanin.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Galanin receptor type 3
PRO_0000069471

Regions

Topological domain1 – 2020Extracellular Potential
Transmembrane21 – 4121Helical; Name=1; Potential
Topological domain42 – 5716Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 9618Extracellular Potential
Transmembrane97 – 11822Helical; Name=3; Potential
Topological domain119 – 13820Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 18425Extracellular Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 23631Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 2592Extracellular Potential
Transmembrane260 – 28021Helical; Name=7; Potential
Topological domain281 – 37090Cytoplasmic Potential
Compositional bias218 – 2258Poly-Ala

Amino acid modifications

Lipidation3081S-palmitoyl cysteine By similarity
Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 172 By similarity

Experimental info

Sequence conflict541R → S in AAC35943. Ref.3
Sequence conflict1271P → Q in AAC26145. Ref.2
Sequence conflict1831A → R in AAC26145. Ref.2
Sequence conflict3111R → C in AAC26145. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O88626 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: CE5B39E6147AFAD4

FASTA37040,410
        10         20         30         40         50         60 
MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW QEPRSTTDLF 

        70         80         90        100        110        120 
ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL LIYLTMYASS FTLAAVSLDR 

       130        140        150        160        170        180 
YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR 

       190        200        210        220        230        240 
RRALDVATFA AGYLLPVAVV SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV 

       250        260        270        280        290        300 
AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA 

       310        320        330        340        350        360 
RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR GDALRGGGET 

       370 
RLTLSPRGPQ 

« Hide

References

[1]"Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues."
Waters S.M., Krause J.E.
Neuroscience 95:265-271(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Hypothalamus.
[2]"Molecular cloning of the rat galanin receptor type 3."
Wang S., He C., Hashemi T., Bayne M.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF079844 mRNA. Translation: AAC34590.1.
AF031522 mRNA. Translation: AAC26145.1.
AF073798 mRNA. Translation: AAC35943.1.
RefSeqNP_062046.1. NM_019173.1.
XP_006242034.1. XM_006241972.1.
UniGeneRn.30069.

3D structure databases

ProteinModelPortalO88626.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBO88626.
GuidetoPHARMACOLOGY245.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO88626.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014349; ENSRNOP00000014349; ENSRNOG00000027060.
GeneID29235.
KEGGrno:29235.
UCSCRGD:2658. rat.

Organism-specific databases

CTD8484.
RGD2658. Galr3.

Phylogenomic databases

GeneTreeENSGT00620000087530.
HOVERGENHBG101447.
KOK04232.
OrthoDBEOG7327PK.
PhylomeDBO88626.

Gene expression databases

GenevestigatorO88626.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608494.
PROO88626.

Entry information

Entry nameGALR3_RAT
AccessionPrimary (citable) accession number: O88626
Secondary accession number(s): O54914, Q9QWZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries