Galanin receptor type 3 - Rattus norvegicus (Rat)

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O88626 (GALR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Galanin receptor type 3
Short name=GAL3-R
Short name=GALR-3

Gene names

Name:	Galr3
Synonyms:	Galnr3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the hormone galanin.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Inferred from mutant phenotype PubMed 1847683. Source: RGD negative regulation of cAMP biosynthetic process Inferred from mutant phenotype PubMed 1847683. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	galanin receptor activity Inferred from direct assay Ref.3. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 370

370

Galanin receptor type 3

PRO_0000069471

Regions

Topological domain

1 – 20

Extracellular Potential

Transmembrane

21 – 41

Helical; Name=1; Potential

Topological domain

42 – 57

Cytoplasmic Potential

Transmembrane

58 – 78

Helical; Name=2; Potential

Topological domain

79 – 96

Extracellular Potential

Transmembrane

97 – 118

Helical; Name=3; Potential

Topological domain

119 – 138

Cytoplasmic Potential

Transmembrane

139 – 159

Helical; Name=4; Potential

Topological domain

160 – 184

Extracellular Potential

Transmembrane

185 – 205

Helical; Name=5; Potential

Topological domain

206 – 236

Cytoplasmic Potential

Transmembrane

237 – 257

Helical; Name=6; Potential

Topological domain

258 – 259

Extracellular Potential

Transmembrane

260 – 280

Helical; Name=7; Potential

Topological domain

281 – 370

Cytoplasmic Potential

Compositional bias

218 – 225

Poly-Ala

Amino acid modifications

Lipidation

308

S-palmitoyl cysteine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

95 ↔ 172

By similarity

Experimental info

Sequence conflict

R → S in AAC35943. Ref.3

Sequence conflict

127

P → Q in AAC26145. Ref.2

Sequence conflict

183

A → R in AAC26145. Ref.2

Sequence conflict

311

R → C in AAC26145. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

O88626 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: CE5B39E6147AFAD4
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FASTA

370

40,410

        10         20         30         40         50         60 
MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW QEPRSTTDLF 

        70         80         90        100        110        120 
ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL LIYLTMYASS FTLAAVSLDR 

       130        140        150        160        170        180 
YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR 

       190        200        210        220        230        240 
RRALDVATFA AGYLLPVAVV SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV 

       250        260        270        280        290        300 
AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA 

       310        320        330        340        350        360 
RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR GDALRGGGET 

       370 
RLTLSPRGPQ

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References

[1]	"Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues." Waters S.M., Krause J.E. Neuroscience 95:265-271(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Hypothalamus.
[2]	"Molecular cloning of the rat galanin receptor type 3." Wang S., He C., Hashemi T., Bayne M. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels." Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A. J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF079844 mRNA. Translation: AAC34590.1. AF031522 mRNA. Translation: AAC26145.1. AF073798 mRNA. Translation: AAC35943.1.
IPI	IPI00327526.
RefSeq	NP_062046.1. NM_019173.1.
UniGene	Rn.30069.
3D structure databases
ProteinModelPortal	O88626.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O88626.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000014349; ENSRNOP00000014349; ENSRNOG00000027060.
GeneID	29235.
KEGG	rno:29235.
UCSC	RGD:2658. rat.
Organism-specific databases
CTD	8484.
RGD	2658. Galr3.
Phylogenomic databases
GeneTree	ENSGT00620000087530.
HOVERGEN	HBG101447.
KO	K04232.
Gene expression databases
Genevestigator	O88626.
Family and domain databases
InterPro	IPR000405. Galanin_rcpt. IPR003908. Galnin_3_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01420. GALANIN3R. PR00663. GALANINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O88626.
NextBio	608494.

Entry information

Entry name

GALR3_RAT

Accession

Primary (citable) accession number: O88626
Secondary accession number(s): O54914, Q9QWZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents