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O88626

- GALR3_RAT

UniProt

O88626 - GALR3_RAT

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Protein

Galanin receptor type 3

Gene
Galr3, Galnr3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin and spexin-1.

GO - Molecular functioni

  1. galanin receptor activity Source: MGI

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  2. negative regulation of adenylate cyclase activity Source: InterPro
  3. negative regulation of cAMP biosynthetic process Source: RGD
  4. neuropeptide signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:Galr3
Synonyms:Galnr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi2658. Galr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Extracellular Reviewed predictionAdd
BLAST
Transmembranei21 – 4121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini42 – 5716Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9618Extracellular Reviewed predictionAdd
BLAST
Transmembranei97 – 11822Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini119 – 13820Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini160 – 18425Extracellular Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini206 – 23631Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini258 – 2592Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini281 – 37090Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Galanin receptor type 3PRO_0000069471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 172 By similarity
Lipidationi308 – 3081S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiO88626.

Expressioni

Gene expression databases

GenevestigatoriO88626.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliO88626.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 2258Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000087530.
HOVERGENiHBG101447.
KOiK04232.
OrthoDBiEOG7327PK.
PhylomeDBiO88626.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88626-1 [UniParc]FASTAAdd to Basket

« Hide

MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW    50
QEPRSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL 100
LIYLTMYASS FTLAAVSLDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA 150
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV 200
SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP 250
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA 300
RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR 350
GDALRGGGET RLTLSPRGPQ 370
Length:370
Mass (Da):40,410
Last modified:November 1, 1998 - v1
Checksum:iCE5B39E6147AFAD4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541R → S in AAC35943. 1 Publication
Sequence conflicti127 – 1271P → Q in AAC26145. 1 Publication
Sequence conflicti183 – 1831A → R in AAC26145. 1 Publication
Sequence conflicti311 – 3111R → C in AAC26145. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079844 mRNA. Translation: AAC34590.1.
AF031522 mRNA. Translation: AAC26145.1.
AF073798 mRNA. Translation: AAC35943.1.
RefSeqiNP_062046.1. NM_019173.1.
XP_006242034.1. XM_006241972.1.
UniGeneiRn.30069.

Genome annotation databases

EnsembliENSRNOT00000014349; ENSRNOP00000014349; ENSRNOG00000027060.
GeneIDi29235.
KEGGirno:29235.
UCSCiRGD:2658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079844 mRNA. Translation: AAC34590.1 .
AF031522 mRNA. Translation: AAC26145.1 .
AF073798 mRNA. Translation: AAC35943.1 .
RefSeqi NP_062046.1. NM_019173.1.
XP_006242034.1. XM_006241972.1.
UniGenei Rn.30069.

3D structure databases

ProteinModelPortali O88626.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi O88626.
GuidetoPHARMACOLOGYi 245.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O88626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014349 ; ENSRNOP00000014349 ; ENSRNOG00000027060 .
GeneIDi 29235.
KEGGi rno:29235.
UCSCi RGD:2658. rat.

Organism-specific databases

CTDi 8484.
RGDi 2658. Galr3.

Phylogenomic databases

GeneTreei ENSGT00620000087530.
HOVERGENi HBG101447.
KOi K04232.
OrthoDBi EOG7327PK.
PhylomeDBi O88626.

Miscellaneous databases

NextBioi 608494.
PROi O88626.

Gene expression databases

Genevestigatori O88626.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues."
    Waters S.M., Krause J.E.
    Neuroscience 95:265-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hypothalamus.
  2. "Molecular cloning of the rat galanin receptor type 3."
    Wang S., He C., Hashemi T., Bayne M.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
    Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
    J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiGALR3_RAT
AccessioniPrimary (citable) accession number: O88626
Secondary accession number(s): O54914, Q9QWZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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