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Protein

Galanin receptor type 3

Gene

Galr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin and spexin-1.

GO - Molecular functioni

  • galanin receptor activity Source: MGI
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  • negative regulation of adenylate cyclase activity Source: InterPro
  • negative regulation of cAMP biosynthetic process Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.
REACT_339234. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:Galr3
Synonyms:Galnr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2658. Galr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini42 – 5716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 18425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini206 – 23631CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 2592ExtracellularSequence Analysis
Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini281 – 37090CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Galanin receptor type 3PRO_0000069471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308 – 3081S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiO88626.

Expressioni

Gene expression databases

GenevestigatoriO88626.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliO88626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 2258Poly-Ala

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG101447.
InParanoidiO88626.
KOiK04232.
OrthoDBiEOG7327PK.
PhylomeDBiO88626.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPRSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSLDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV
210 220 230 240 250
SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA
310 320 330 340 350
RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR
360 370
GDALRGGGET RLTLSPRGPQ
Length:370
Mass (Da):40,410
Last modified:November 1, 1998 - v1
Checksum:iCE5B39E6147AFAD4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541R → S in AAC35943 (PubMed:9722565).Curated
Sequence conflicti127 – 1271P → Q in AAC26145 (Ref. 2) Curated
Sequence conflicti183 – 1831A → R in AAC26145 (Ref. 2) Curated
Sequence conflicti311 – 3111R → C in AAC26145 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079844 mRNA. Translation: AAC34590.1.
AF031522 mRNA. Translation: AAC26145.1.
AF073798 mRNA. Translation: AAC35943.1.
RefSeqiNP_062046.1. NM_019173.1.
XP_006242034.1. XM_006241972.2.
UniGeneiRn.30069.

Genome annotation databases

GeneIDi29235.
KEGGirno:29235.
UCSCiRGD:2658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079844 mRNA. Translation: AAC34590.1.
AF031522 mRNA. Translation: AAC26145.1.
AF073798 mRNA. Translation: AAC35943.1.
RefSeqiNP_062046.1. NM_019173.1.
XP_006242034.1. XM_006241972.2.
UniGeneiRn.30069.

3D structure databases

ProteinModelPortaliO88626.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiO88626.
GuidetoPHARMACOLOGYi245.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO88626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29235.
KEGGirno:29235.
UCSCiRGD:2658. rat.

Organism-specific databases

CTDi8484.
RGDi2658. Galr3.

Phylogenomic databases

HOVERGENiHBG101447.
InParanoidiO88626.
KOiK04232.
OrthoDBiEOG7327PK.
PhylomeDBiO88626.

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.
REACT_339234. G alpha (i) signalling events.

Miscellaneous databases

NextBioi608494.
PROiO88626.

Gene expression databases

GenevestigatoriO88626.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues."
    Waters S.M., Krause J.E.
    Neuroscience 95:265-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hypothalamus.
  2. "Molecular cloning of the rat galanin receptor type 3."
    Wang S., He C., Hashemi T., Bayne M.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
    Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
    J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiGALR3_RAT
AccessioniPrimary (citable) accession number: O88626
Secondary accession number(s): O54914, Q9QWZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 27, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.