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Protein

Galanin receptor type 3

Gene

Galr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin and spexin-1.By similarity1 Publication

GO - Molecular functioni

  • galanin receptor activity Source: MGI
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:Galr3
Synonyms:Galnr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2658. Galr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 96ExtracellularSequence analysisAdd BLAST18
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 138CytoplasmicSequence analysisAdd BLAST20
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184ExtracellularSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 236CytoplasmicSequence analysisAdd BLAST31
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 259ExtracellularSequence analysis2
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 370CytoplasmicSequence analysisAdd BLAST90

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694711 – 370Galanin receptor type 3Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88626.

PTM databases

PhosphoSitePlusiO88626.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014349.

Chemistry databases

BindingDBiO88626.

Structurei

3D structure databases

ProteinModelPortaliO88626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 225Poly-Ala8

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG101447.
InParanoidiO88626.
KOiK04232.
PhylomeDBiO88626.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPRSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSLDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV
210 220 230 240 250
SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA
310 320 330 340 350
RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR
360 370
GDALRGGGET RLTLSPRGPQ
Length:370
Mass (Da):40,410
Last modified:November 1, 1998 - v1
Checksum:iCE5B39E6147AFAD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54R → S in AAC35943 (PubMed:9722565).Curated1
Sequence conflicti127P → Q in AAC26145 (Ref. 2) Curated1
Sequence conflicti183A → R in AAC26145 (Ref. 2) Curated1
Sequence conflicti311R → C in AAC26145 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079844 mRNA. Translation: AAC34590.1.
AF031522 mRNA. Translation: AAC26145.1.
AF073798 mRNA. Translation: AAC35943.1.
RefSeqiNP_062046.1. NM_019173.1.
XP_006242034.1. XM_006241972.2.
XP_017450186.1. XM_017594697.1.
UniGeneiRn.30069.

Genome annotation databases

GeneIDi29235.
KEGGirno:29235.
UCSCiRGD:2658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079844 mRNA. Translation: AAC34590.1.
AF031522 mRNA. Translation: AAC26145.1.
AF073798 mRNA. Translation: AAC35943.1.
RefSeqiNP_062046.1. NM_019173.1.
XP_006242034.1. XM_006241972.2.
XP_017450186.1. XM_017594697.1.
UniGeneiRn.30069.

3D structure databases

ProteinModelPortaliO88626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014349.

Chemistry databases

BindingDBiO88626.
GuidetoPHARMACOLOGYi245.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO88626.

Proteomic databases

PaxDbiO88626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29235.
KEGGirno:29235.
UCSCiRGD:2658. rat.

Organism-specific databases

CTDi8484.
RGDi2658. Galr3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG101447.
InParanoidiO88626.
KOiK04232.
PhylomeDBiO88626.

Miscellaneous databases

PROiO88626.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALR3_RAT
AccessioniPrimary (citable) accession number: O88626
Secondary accession number(s): O54914, Q9QWZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.