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O88626

- GALR3_RAT

UniProt

O88626 - GALR3_RAT

Protein

Galanin receptor type 3

Gene

Galr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Receptor for the hormone galanin and spexin-1.

    GO - Molecular functioni

    1. galanin receptor activity Source: MGI
    2. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
    2. negative regulation of adenylate cyclase activity Source: InterPro
    3. negative regulation of cAMP biosynthetic process Source: RGD
    4. neuropeptide signaling pathway Source: RGD
    5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 3
    Short name:
    GAL3-R
    Short name:
    GALR-3
    Gene namesi
    Name:Galr3
    Synonyms:Galnr3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi2658. Galr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Galanin receptor type 3PRO_0000069471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
    Lipidationi308 – 3081S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiO88626.

    Expressioni

    Gene expression databases

    GenevestigatoriO88626.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliO88626.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini42 – 5716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 18425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 23631CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2592ExtracellularSequence Analysis
    Topological domaini281 – 37090CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi218 – 2258Poly-Ala

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00620000087530.
    HOVERGENiHBG101447.
    KOiK04232.
    OrthoDBiEOG7327PK.
    PhylomeDBiO88626.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000405. Galanin_rcpt.
    IPR003908. Galnin_3_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01420. GALANIN3R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW    50
    QEPRSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL 100
    LIYLTMYASS FTLAAVSLDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA 150
    ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV 200
    SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP 250
    HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA 300
    RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR 350
    GDALRGGGET RLTLSPRGPQ 370
    Length:370
    Mass (Da):40,410
    Last modified:November 1, 1998 - v1
    Checksum:iCE5B39E6147AFAD4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541R → S in AAC35943. (PubMed:9722565)Curated
    Sequence conflicti127 – 1271P → Q in AAC26145. 1 PublicationCurated
    Sequence conflicti183 – 1831A → R in AAC26145. 1 PublicationCurated
    Sequence conflicti311 – 3111R → C in AAC26145. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079844 mRNA. Translation: AAC34590.1.
    AF031522 mRNA. Translation: AAC26145.1.
    AF073798 mRNA. Translation: AAC35943.1.
    RefSeqiNP_062046.1. NM_019173.1.
    XP_006242034.1. XM_006241972.1.
    UniGeneiRn.30069.

    Genome annotation databases

    EnsembliENSRNOT00000014349; ENSRNOP00000014349; ENSRNOG00000027060.
    GeneIDi29235.
    KEGGirno:29235.
    UCSCiRGD:2658. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079844 mRNA. Translation: AAC34590.1 .
    AF031522 mRNA. Translation: AAC26145.1 .
    AF073798 mRNA. Translation: AAC35943.1 .
    RefSeqi NP_062046.1. NM_019173.1.
    XP_006242034.1. XM_006241972.1.
    UniGenei Rn.30069.

    3D structure databases

    ProteinModelPortali O88626.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi O88626.
    GuidetoPHARMACOLOGYi 245.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O88626.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014349 ; ENSRNOP00000014349 ; ENSRNOG00000027060 .
    GeneIDi 29235.
    KEGGi rno:29235.
    UCSCi RGD:2658. rat.

    Organism-specific databases

    CTDi 8484.
    RGDi 2658. Galr3.

    Phylogenomic databases

    GeneTreei ENSGT00620000087530.
    HOVERGENi HBG101447.
    KOi K04232.
    OrthoDBi EOG7327PK.
    PhylomeDBi O88626.

    Miscellaneous databases

    NextBioi 608494.
    PROi O88626.

    Gene expression databases

    Genevestigatori O88626.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000405. Galanin_rcpt.
    IPR003908. Galnin_3_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01420. GALANIN3R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues."
      Waters S.M., Krause J.E.
      Neuroscience 95:265-271(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Hypothalamus.
    2. "Molecular cloning of the rat galanin receptor type 3."
      Wang S., He C., Hashemi T., Bayne M.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
      Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
      J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiGALR3_RAT
    AccessioniPrimary (citable) accession number: O88626
    Secondary accession number(s): O54914, Q9QWZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3