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O88623

- UBP2_MOUSE

UniProt

O88623 - UBP2_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 2

Gene

Usp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Cofactori

    Binds 1 zinc ion.By similarity

    Enzyme regulationi

    Cleavage is inhibited by ubiquitin in a dosage-dependent manner. Cleavage is blocked by ubiquitin aldehyde By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei284 – 2841NucleophilePROSITE-ProRule annotation
    Metal bindingi433 – 4331ZincBy similarity
    Metal bindingi436 – 4361ZincBy similarity
    Metal bindingi484 – 4841ZincBy similarity
    Metal bindingi487 – 4871ZincBy similarity
    Active sitei565 – 5651Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. identical protein binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW
    4. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. muscle organ development Source: UniProtKB-KW
    3. negative regulation of skeletal muscle tissue development Source: Ensembl
    4. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. positive regulation of mitotic cell cycle Source: UniProtKB
    6. positive regulation of skeletal muscle tissue development Source: Ensembl
    7. protein deubiquitination Source: UniProtKB
    8. protein stabilization Source: UniProtKB
    9. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Myogenesis, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC19.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 2 (EC:3.4.19.12)
    Alternative name(s):
    41 kDa ubiquitin-specific protease
    Deubiquitinating enzyme 2
    Ubiquitin thioesterase 2
    Ubiquitin-specific-processing protease 2
    Gene namesi
    Name:Usp2
    Synonyms:Ubp41
    ORF Names:MNCb-0190
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1858178. Usp2.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmperinuclear region By similarity
    Note: Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.By similarity
    Isoform 2 : Nucleus By similarity

    GO - Cellular componenti

    1. cell cortex Source: MGI
    2. centrosome Source: Ensembl
    3. cytoplasm Source: MGI
    4. nucleus Source: UniProtKB-SubCell
    5. perinuclear region of cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613Ubiquitin carboxyl-terminal hydrolase 2PRO_0000080617Add
    BLAST

    Proteomic databases

    MaxQBiO88623.
    PRIDEiO88623.

    PTM databases

    PhosphoSiteiO88623.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed in heart, liver, kidney, pancreas and to a lower extent in skeletal muscle, brain and testis (at protein level). Expressed in testis, brain, heart and skeletal muscle.1 Publication

    Developmental stagei

    No stage-dependent developmental pattern of expression is detected. First detected throughout 7.5 dpc embryos.1 Publication

    Gene expression databases

    ArrayExpressiO88623.
    BgeeiO88623.
    CleanExiMM_USP2.
    GenevestigatoriO88623.

    Interactioni

    Subunit structurei

    Found in trimeric complex with MDM2 and MDM4 and UPB2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C-terminus) with MDM2. Interacts with MDM4 By similarity. Homooligomer.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi207299. 12 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO88623.
    SMRiO88623. Positions 271-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini275 – 607333USPAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 207207Necessary for interaction with MDM4By similarityAdd
    BLAST
    Regioni411 – 511101Necessary for interaction with MDM4By similarityAdd
    BLAST

    Domaini

    The different N-terminus extensions of isoform 1 and isoform 2 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity By similarity.By similarity

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP2 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    GeneTreeiENSGT00750000117710.
    HOGENOMiHOG000231498.
    HOVERGENiHBG011164.
    InParanoidiO88623.
    KOiK11833.
    OMAiSASHRSY.
    OrthoDBiEOG7FR7GN.
    PhylomeDBiO88623.
    TreeFamiTF106277.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88623-1) [UniParc]FASTAAdd to Basket

    Also known as: Usp2-69

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQLSSTLKR YTESSRYTDA PYAKPGYGTY TPSSYGANLA ASFLEKEKLG    50
    FKPVSPTSFL PRPRTYGPSS ILDCDRGRPL LRSDIIGSSK RSESQTRGNE 100
    RPSGSGLNGG SGFSYGVSSN SLSYLPMNAR DQGVTLSQKK SNSQSDLARD 150
    FSSLRTSDGY RTSEGFRIDP GNLGRSPMLA RTRKELCALQ GLYQAASRSE 200
    YLTDYLENYG RKGSAPQVLT QAPPPSRVPE VLSPTYRPSG RYTLWEKSKG 250
    QASGPSRSSS PGRDTMNSKS AQGLAGLRNL GNTCFMNSIL QCLSNTRELR 300
    DYCLQRLYMR DLGHTSSAHT ALMEEFAKLI QTIWTSSPND VVSPSEFKTQ 350
    IQRYAPRFMG YNQQDAQEFL RFLLDGLHNE VNRVAARPKA SPETLDHLPD 400
    EEKGRQMWRK YLEREDSRIG DLFVGQLKSS LTCTDCGYCS TVFDPFWDLS 450
    LPIAKRGYPE VTLMDCMRLF TKEDILDGDE KPTCCRCRAR KRCIKKFSVQ 500
    RFPKILVLHL KRFSESRIRT SKLTTFVNFP LRDLDLREFA SENTNHAVYN 550
    LYAVSNHSGT TMGGHYTAYC RSPVTGEWHT FNDSSVTPMS SSQVRTSDAY 600
    LLFYELASPP SRM 613
    Length:613
    Mass (Da):68,845
    Last modified:September 5, 2006 - v2
    Checksum:i7B5DD3594A42C445
    GO
    Isoform 2 (identifier: O88623-2) [UniParc]FASTAAdd to Basket

    Also known as: Usp2-45

    The sequence of this isoform differs from the canonical sequence as follows:
         1-217: Missing.
         218-266: VLTQAPPPSR...RSSSPGRDTM → MRTSYTVTLP...FVGLLLNKAK

    Show »
    Length:396
    Mass (Da):45,238
    Checksum:i14CC674DC08FFF93
    GO
    Isoform 3 (identifier: O88623-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         154-154: L → LRTSDGY

    Show »
    Length:619
    Mass (Da):69,525
    Checksum:i93A6F2B9269316F8
    GO
    Isoform 4 (identifier: O88623-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-220: Missing.
         221-268: QAPPPSRVPE...SSPGRDTMNS → MRTSYTVTLP...TFVGLLLNKA

    Note: No experimental confirmation available.

    Show »
    Length:393
    Mass (Da):44,908
    Checksum:iF4715ABDE436573B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 2 (identifier: O88623-2)
    Sequence conflicti44 – 441L → M in AAC28393. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 220220Missing in isoform 4. 1 PublicationVSP_020130Add
    BLAST
    Alternative sequencei1 – 217217Missing in isoform 2. 2 PublicationsVSP_020131Add
    BLAST
    Alternative sequencei154 – 1541L → LRTSDGY in isoform 3. 3 PublicationsVSP_020132
    Alternative sequencei218 – 26649VLTQA…GRDTM → MRTSYTVTLPEEPPAAHFPA LAKELRPRSPLSPSLLLSTF VGLLLNKAK in isoform 2. 2 PublicationsVSP_020133Add
    BLAST
    Alternative sequencei221 – 26848QAPPP…DTMNS → MRTSYTVTLPEEPPAAHFPA LAKELRPRSPLSPSLLLSTF VGLLLNKA in isoform 4. 1 PublicationVSP_020134Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY255637 mRNA. Translation: AAQ83301.1.
    AY255638 mRNA. Translation: AAQ83302.1.
    AY255639 mRNA. Translation: AAQ83303.1.
    AY255640 mRNA. Translation: AAQ83304.1.
    AB041799 mRNA. Translation: BAA95110.1.
    AK138799 mRNA. Translation: BAE23782.1.
    BC017517 mRNA. Translation: AAH17517.1.
    AF079565 mRNA. Translation: AAC28393.1.
    CCDSiCCDS23094.1. [O88623-3]
    CCDS23095.1. [O88623-2]
    RefSeqiNP_058088.2. NM_016808.2. [O88623-3]
    NP_932759.1. NM_198091.2. [O88623-2]
    NP_932760.2. NM_198092.2. [O88623-3]
    XP_006510543.1. XM_006510480.1. [O88623-3]
    XP_006510544.1. XM_006510481.1. [O88623-3]
    XP_006510545.1. XM_006510482.1. [O88623-3]
    XP_006510546.1. XM_006510483.1. [O88623-3]
    UniGeneiMm.272770.

    Genome annotation databases

    EnsembliENSMUST00000034508; ENSMUSP00000034508; ENSMUSG00000032010. [O88623-3]
    ENSMUST00000065461; ENSMUSP00000070264; ENSMUSG00000032010. [O88623-2]
    ENSMUST00000114830; ENSMUSP00000110479; ENSMUSG00000032010. [O88623-3]
    ENSMUST00000176416; ENSMUSP00000135482; ENSMUSG00000032010. [O88623-4]
    ENSMUST00000177054; ENSMUSP00000135018; ENSMUSG00000032010. [O88623-3]
    GeneIDi53376.
    KEGGimmu:53376.
    UCSCiuc009pbn.1. mouse. [O88623-3]
    uc009pbp.1. mouse. [O88623-2]
    uc012grp.1. mouse. [O88623-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY255637 mRNA. Translation: AAQ83301.1 .
    AY255638 mRNA. Translation: AAQ83302.1 .
    AY255639 mRNA. Translation: AAQ83303.1 .
    AY255640 mRNA. Translation: AAQ83304.1 .
    AB041799 mRNA. Translation: BAA95110.1 .
    AK138799 mRNA. Translation: BAE23782.1 .
    BC017517 mRNA. Translation: AAH17517.1 .
    AF079565 mRNA. Translation: AAC28393.1 .
    CCDSi CCDS23094.1. [O88623-3 ]
    CCDS23095.1. [O88623-2 ]
    RefSeqi NP_058088.2. NM_016808.2. [O88623-3 ]
    NP_932759.1. NM_198091.2. [O88623-2 ]
    NP_932760.2. NM_198092.2. [O88623-3 ]
    XP_006510543.1. XM_006510480.1. [O88623-3 ]
    XP_006510544.1. XM_006510481.1. [O88623-3 ]
    XP_006510545.1. XM_006510482.1. [O88623-3 ]
    XP_006510546.1. XM_006510483.1. [O88623-3 ]
    UniGenei Mm.272770.

    3D structure databases

    ProteinModelPortali O88623.
    SMRi O88623. Positions 271-608.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207299. 12 interactions.

    Protein family/group databases

    MEROPSi C19.013.

    PTM databases

    PhosphoSitei O88623.

    Proteomic databases

    MaxQBi O88623.
    PRIDEi O88623.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034508 ; ENSMUSP00000034508 ; ENSMUSG00000032010 . [O88623-3 ]
    ENSMUST00000065461 ; ENSMUSP00000070264 ; ENSMUSG00000032010 . [O88623-2 ]
    ENSMUST00000114830 ; ENSMUSP00000110479 ; ENSMUSG00000032010 . [O88623-3 ]
    ENSMUST00000176416 ; ENSMUSP00000135482 ; ENSMUSG00000032010 . [O88623-4 ]
    ENSMUST00000177054 ; ENSMUSP00000135018 ; ENSMUSG00000032010 . [O88623-3 ]
    GeneIDi 53376.
    KEGGi mmu:53376.
    UCSCi uc009pbn.1. mouse. [O88623-3 ]
    uc009pbp.1. mouse. [O88623-2 ]
    uc012grp.1. mouse. [O88623-4 ]

    Organism-specific databases

    CTDi 9099.
    MGIi MGI:1858178. Usp2.

    Phylogenomic databases

    eggNOGi COG5533.
    GeneTreei ENSGT00750000117710.
    HOGENOMi HOG000231498.
    HOVERGENi HBG011164.
    InParanoidi O88623.
    KOi K11833.
    OMAi SASHRSY.
    OrthoDBi EOG7FR7GN.
    PhylomeDBi O88623.
    TreeFami TF106277.

    Miscellaneous databases

    NextBioi 310185.
    PROi O88623.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88623.
    Bgeei O88623.
    CleanExi MM_USP2.
    Genevestigatori O88623.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene structure, alternate splicing, tissue distribution, cellular localization, and developmental expression pattern of mouse deubiquitinating enzyme isoforms Usp2-45 and Usp2-69."
      Gousseva N., Baker R.T.
      Gene Expr. 11:163-179(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, SUBUNIT.
      Strain: C57BL/6.
      Tissue: Kidney and Retina.
    2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6.
      Tissue: Retina.
    5. "Cloning and expression of the human and mouse UBP41."
      Gong L., Yeh E.T.H.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-613 (ISOFORM 2).
      Tissue: Liver.

    Entry informationi

    Entry nameiUBP2_MOUSE
    AccessioniPrimary (citable) accession number: O88623
    Secondary accession number(s): Q6X4T9
    , Q6X4U1, Q8VD74, Q9JJ87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3