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O88602

- CCG2_MOUSE

UniProt

O88602 - CCG2_MOUSE

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Protein

Voltage-dependent calcium channel gamma-2 subunit

Gene

Cacng2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. membrane depolarization Source: MGI
  2. membrane hyperpolarization Source: MGI
  3. neurological system process Source: MGI
  4. neuromuscular junction development Source: MGI
  5. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  6. regulation of membrane potential Source: MGI
  7. transmission of nerve impulse Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-2 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-2 subunit
Stargazin
Transmembrane AMPAR regulatory protein gamma-2
Short name:
TARP gamma-2
Gene namesi
Name:Cacng2
Synonyms:Stg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1316660. Cacng2.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi321 – 3211T → A: Abolishes phosphorylation. 1 Publication
Mutagenesisi321 – 3211T → D or E: No interaction with DLG1 and DLG4. 1 Publication
Mutagenesisi323 – 3231V → A: No interaction with DLG1 and DLG4. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Voltage-dependent calcium channel gamma-2 subunitPRO_0000164674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Modified residuei271 – 2711Phosphotyrosine1 Publication
Modified residuei321 – 3211Phosphothreonine; by PKA1 Publication

Post-translational modificationi

Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO88602.
PRIDEiO88602.

PTM databases

PhosphoSiteiO88602.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiO88602.
ExpressionAtlasiO88602. baseline and differential.
GenevestigatoriO88602.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198444. 2 interactions.
DIPiDIP-32457N.
IntActiO88602. 2 interactions.
STRINGi10090.ENSMUSP00000019290.

Structurei

3D structure databases

ProteinModelPortaliO88602.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43469.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiO88602.
KOiK04867.
OMAiSMSENET.
OrthoDBiEOG7TQV1Q.
PhylomeDBiO88602.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005422. VDCC_g2su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01602. VDCCGAMMA2.

Sequencei

Sequence statusi: Complete.

O88602-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KTKSVSENET
60 70 80 90 100
SKKNEEVMTH SGLWRTCCLE GNFKGLCKQI DHFPEDADYE ADTAEYFLRA
110 120 130 140 150
VRASSIFPIL SVILLFMGGL CIAASEFYKT RHNIILSAGI FFVSAGLSNI
160 170 180 190 200
IGIIVYISAN AGDPSKSDSK KNSYSYGWSF YFGALSFIIA EMVGVLAVHM
210 220 230 240 250
FIDRHKQLRA TARATDYLQA SAITRIPSYR YRYQRRSRSS SRSTEPSHSR
260 270 280 290 300
DASPVGVKGF NTLPSTEISM YTLSRDPLKA ATTPTATYNS DRDNSFLQVH
310 320
NCIQKDSKDS LHANTANRRT TPV
Length:323
Mass (Da):35,895
Last modified:November 1, 1998 - v1
Checksum:iAA9D475606A0FBA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077739 mRNA. Translation: AAC40201.1.
CCDSiCCDS27608.1.
RefSeqiNP_031609.1. NM_007583.2.
UniGeneiMm.277338.
Mm.400802.

Genome annotation databases

EnsembliENSMUST00000019290; ENSMUSP00000019290; ENSMUSG00000019146.
GeneIDi12300.
KEGGimmu:12300.
UCSCiuc007wop.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077739 mRNA. Translation: AAC40201.1 .
CCDSi CCDS27608.1.
RefSeqi NP_031609.1. NM_007583.2.
UniGenei Mm.277338.
Mm.400802.

3D structure databases

ProteinModelPortali O88602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198444. 2 interactions.
DIPi DIP-32457N.
IntActi O88602. 2 interactions.
STRINGi 10090.ENSMUSP00000019290.

PTM databases

PhosphoSitei O88602.

Proteomic databases

PaxDbi O88602.
PRIDEi O88602.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019290 ; ENSMUSP00000019290 ; ENSMUSG00000019146 .
GeneIDi 12300.
KEGGi mmu:12300.
UCSCi uc007wop.2. mouse.

Organism-specific databases

CTDi 10369.
MGIi MGI:1316660. Cacng2.

Phylogenomic databases

eggNOGi NOG43469.
HOGENOMi HOG000233440.
HOVERGENi HBG003682.
InParanoidi O88602.
KOi K04867.
OMAi SMSENET.
OrthoDBi EOG7TQV1Q.
PhylomeDBi O88602.
TreeFami TF327980.

Enzyme and pathway databases

Reactomei REACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Miscellaneous databases

NextBioi 280822.
PROi O88602.
SOURCEi Search...

Gene expression databases

Bgeei O88602.
ExpressionAtlasi O88602. baseline and differential.
Genevestigatori O88602.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR005422. VDCC_g2su.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
PR01602. VDCCGAMMA2.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95."
    Choi J., Ko J., Park E., Lee J.-R., Yoon J., Lim S., Kim E.
    J. Biol. Chem. 277:12359-12363(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-321, INTERACTION WITH DLG1 AND DLG4, MUTAGENESIS OF THR-321 AND VAL-323.
  3. "Microtubule-associated protein light chain 2 is a stargazin-AMPA receptor complex-interacting protein in vivo."
    Ives J.H., Fung S., Tiwari P., Payne H.L., Thompson C.L.
    J. Biol. Chem. 279:31002-31009(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-271, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCCG2_MOUSE
AccessioniPrimary (citable) accession number: O88602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3