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O88602

- CCG2_MOUSE

UniProt

O88602 - CCG2_MOUSE

Protein

Voltage-dependent calcium channel gamma-2 subunit

Gene

Cacng2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.By similarity

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. membrane depolarization Source: MGI
    2. membrane hyperpolarization Source: MGI
    3. neurological system process Source: MGI
    4. neuromuscular junction development Source: MGI
    5. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    6. regulation of membrane potential Source: MGI
    7. transmission of nerve impulse Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-2 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-2 subunit
    Stargazin
    Transmembrane AMPAR regulatory protein gamma-2
    Short name:
    TARP gamma-2
    Gene namesi
    Name:Cacng2
    Synonyms:Stg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1316660. Cacng2.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. voltage-gated calcium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi321 – 3211T → A: Abolishes phosphorylation. 1 Publication
    Mutagenesisi321 – 3211T → D or E: No interaction with DLG1 and DLG4. 1 Publication
    Mutagenesisi323 – 3231V → A: No interaction with DLG1 and DLG4. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Voltage-dependent calcium channel gamma-2 subunitPRO_0000164674Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Modified residuei271 – 2711Phosphotyrosine1 Publication
    Modified residuei321 – 3211Phosphothreonine; by PKA1 Publication

    Post-translational modificationi

    Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO88602.
    PRIDEiO88602.

    PTM databases

    PhosphoSiteiO88602.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiO88602.
    GenevestigatoriO88602.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198444. 2 interactions.
    DIPiDIP-32457N.
    IntActiO88602. 2 interactions.
    STRINGi10090.ENSMUSP00000019290.

    Structurei

    3D structure databases

    ProteinModelPortaliO88602.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43469.
    HOGENOMiHOG000233440.
    HOVERGENiHBG003682.
    InParanoidiO88602.
    KOiK04867.
    OMAiSMSENET.
    OrthoDBiEOG7TQV1Q.
    PhylomeDBiO88602.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR005422. VDCC_g2su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01602. VDCCGAMMA2.

    Sequencei

    Sequence statusi: Complete.

    O88602-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KTKSVSENET    50
    SKKNEEVMTH SGLWRTCCLE GNFKGLCKQI DHFPEDADYE ADTAEYFLRA 100
    VRASSIFPIL SVILLFMGGL CIAASEFYKT RHNIILSAGI FFVSAGLSNI 150
    IGIIVYISAN AGDPSKSDSK KNSYSYGWSF YFGALSFIIA EMVGVLAVHM 200
    FIDRHKQLRA TARATDYLQA SAITRIPSYR YRYQRRSRSS SRSTEPSHSR 250
    DASPVGVKGF NTLPSTEISM YTLSRDPLKA ATTPTATYNS DRDNSFLQVH 300
    NCIQKDSKDS LHANTANRRT TPV 323
    Length:323
    Mass (Da):35,895
    Last modified:November 1, 1998 - v1
    Checksum:iAA9D475606A0FBA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077739 mRNA. Translation: AAC40201.1.
    CCDSiCCDS27608.1.
    RefSeqiNP_031609.1. NM_007583.2.
    UniGeneiMm.277338.
    Mm.400802.

    Genome annotation databases

    EnsembliENSMUST00000019290; ENSMUSP00000019290; ENSMUSG00000019146.
    GeneIDi12300.
    KEGGimmu:12300.
    UCSCiuc007wop.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077739 mRNA. Translation: AAC40201.1 .
    CCDSi CCDS27608.1.
    RefSeqi NP_031609.1. NM_007583.2.
    UniGenei Mm.277338.
    Mm.400802.

    3D structure databases

    ProteinModelPortali O88602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198444. 2 interactions.
    DIPi DIP-32457N.
    IntActi O88602. 2 interactions.
    STRINGi 10090.ENSMUSP00000019290.

    PTM databases

    PhosphoSitei O88602.

    Proteomic databases

    PaxDbi O88602.
    PRIDEi O88602.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019290 ; ENSMUSP00000019290 ; ENSMUSG00000019146 .
    GeneIDi 12300.
    KEGGi mmu:12300.
    UCSCi uc007wop.2. mouse.

    Organism-specific databases

    CTDi 10369.
    MGIi MGI:1316660. Cacng2.

    Phylogenomic databases

    eggNOGi NOG43469.
    HOGENOMi HOG000233440.
    HOVERGENi HBG003682.
    InParanoidi O88602.
    KOi K04867.
    OMAi SMSENET.
    OrthoDBi EOG7TQV1Q.
    PhylomeDBi O88602.
    TreeFami TF327980.

    Enzyme and pathway databases

    Reactomei REACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

    Miscellaneous databases

    NextBioi 280822.
    PROi O88602.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88602.
    Genevestigatori O88602.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR005422. VDCC_g2su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01602. VDCCGAMMA2.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.
    2. "Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95."
      Choi J., Ko J., Park E., Lee J.-R., Yoon J., Lim S., Kim E.
      J. Biol. Chem. 277:12359-12363(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-321, INTERACTION WITH DLG1 AND DLG4, MUTAGENESIS OF THR-321 AND VAL-323.
    3. "Microtubule-associated protein light chain 2 is a stargazin-AMPA receptor complex-interacting protein in vivo."
      Ives J.H., Fung S., Tiwari P., Payne H.L., Thompson C.L.
      J. Biol. Chem. 279:31002-31009(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GOPC.
    4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-271, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiCCG2_MOUSE
    AccessioniPrimary (citable) accession number: O88602
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3