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Protein

Heat shock 70 kDa protein 4

Gene

Hspa4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • kidney development Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cell death Source: RGD
  • negative regulation of DNA binding Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of protein phosphorylation Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of protein binding Source: RGD
  • response to heat Source: RGD

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 4
Alternative name(s):
Ischemia responsive 94 kDa protein
Gene namesi
Name:Hspa4
Synonyms:Irp94
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628878 Hspa4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002559341 – 840Heat shock 70 kDa protein 4Add BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei76PhosphoserineCombined sources1
Modified residuei89PhosphotyrosineBy similarity1
Modified residuei336PhosphotyrosineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei430N6-acetyllysineBy similarity1
Modified residuei538PhosphothreonineCombined sources1
Modified residuei546PhosphoserineBy similarity1
Modified residuei660PhosphotyrosineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei773N6-methyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiO88600
PRIDEiO88600

2D gel databases

World-2DPAGEi0004:O88600

PTM databases

iPTMnetiO88600
PhosphoSitePlusiO88600

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in testis.1 Publication

Inductioni

Up-regulated in neuronal cells upon ischemia.1 Publication

Interactioni

Subunit structurei

Interacts with TJP1/ZO-1.By similarity

Protein-protein interaction databases

BioGridi251801, 15 interactors
IntActiO88600, 1 interactor
MINTiO88600
STRINGi10116.ENSRNOP00000023628

Structurei

3D structure databases

ProteinModelPortaliO88600
SMRiO88600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0103 Eukaryota
COG0443 LUCA
HOGENOMiHOG000228138
HOVERGENiHBG047955
InParanoidiO88600
KOiK09489
PhylomeDBiO88600

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 2 hits
SSF100934 SSF100934, 2 hits
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

O88600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSVGA
60 70 80 90 100
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG
110 120 130 140 150
IKVTYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPSFYTD
160 170 180 190 200
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF
210 220 230 240 250
VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK
260 270 280 290 300
KYKLDIKSKV RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT
310 320 330 340 350
MNRGKFLEMC DDLLARVEPP LRSILDQSKL KKEDIYAVEI VGGATRIPAV
360 370 380 390 400
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY
410 420 430 440 450
PISLRWNSPA EEGSSDCEVF PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ
460 470 480 490 500
DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSAALVEV
510 520 530 540 550
HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQPQTPA ENKAESEEME
560 570 580 590 600
TSQAGSKDKK MDQPPQAKKA KVKTSTVDLP IESQLLWQLD REMLGLYTEN
610 620 630 640 650
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNNFTL
660 670 680 690 700
KLEDTENWLY EDGEDQPKQV YVDKLAELRT LGQPIKTRFQ ESEERPKLFE
710 720 730 740 750
ELGKQIQQYM KVISSFKNKE DQYEHLDAAD MTKVEKSTNE AMEWMNSKLN
760 770 780 790 800
LQNKQSLTAD PVVKTKEIEA KIKELTNICS PIISKPKPKV EPPKEEPKHA
810 820 830 840
EQNGPVDGQG DNPGTQAAEH GADTAVPSDG DKKLPEMDID
Length:840
Mass (Da):94,057
Last modified:November 1, 1998 - v1
Checksum:i77BC00171669BF71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti627 – 628EM → DF AA sequence (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077354 mRNA Translation: AAC27937.1
RefSeqiNP_705893.1, NM_153629.1
UniGeneiRn.163092

Genome annotation databases

GeneIDi266759
KEGGirno:266759
UCSCiRGD:628878 rat

Similar proteinsi

Entry informationi

Entry nameiHSP74_RAT
AccessioniPrimary (citable) accession number: O88600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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