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Protein

Myosin-binding protein H

Gene

Mybph

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein H
Short name:
MyBP-H
Alternative name(s):
H-protein
Gene namesi
Name:Mybph
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620287. Mybph.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000727001 – 484Myosin-binding protein HAdd BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphothreonineCombined sources1
Modified residuei6PhosphothreonineCombined sources1
Modified residuei26PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88599.
PRIDEiO88599.

PTM databases

iPTMnetiO88599.
PhosphoSitePlusiO88599.

Expressioni

Tissue specificityi

Skeletal muscle.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044331.

Structurei

3D structure databases

ProteinModelPortaliO88599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 175Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini179 – 267Ig-like C2-type 1Add BLAST89
Domaini276 – 371Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini389 – 479Ig-like C2-type 2Add BLAST91

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF9Q. Eukaryota.
ENOG410YAE6. LUCA.
HOGENOMiHOG000290713.
HOVERGENiHBG056788.
InParanoidiO88599.
PhylomeDBiO88599.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKATPEAS VSTSEGTAPE PAKVPTPEPS GQVAASESTG QEQAPEPQKQ
60 70 80 90 100
PQAQDPAAHE APATPATTKP EAPSEDVPSA PLQLTLEDVS HSSLTVSWEP
110 120 130 140 150
PEDLGSWGSR AMCWSSVREG ASEWVPVNPR PVMVTQQTVR NLALGDKFFL
160 170 180 190 200
RVTAVNSAGA GPPAVLDQPV HIQEITEAPK IRVPRHLRQT YIRQVGESVN
210 220 230 240 250
LQIPFQGKPK PQASWTHNGH ALDSQRVNVR SGDQDSILFI RSAQRSDSGR
260 270 280 290 300
YELTVRLEGL EAKAAIDILV IEKPGPPSSI KLLDVWGCNA ALEWMPPQDT
310 320 330 340 350
GNTELLGYTV QKADKKTGQW FTVLERYHPT TCTVSDLIIG NSYSFRVFSE
360 370 380 390 400
NLCGLSDLAT TTKELAHIHK AAITAKPREF TERDFSEPPS FTQPVADRTS
410 420 430 440 450
TPGYSTQLFC SVRASPKPKI IWMKNKMSIQ GDPKYRAVSE QGVCTLEIRK
460 470 480
PSPFDSGVYT CKAINVLGEP AVDCRLEVKA SATH
Length:484
Mass (Da):52,656
Last modified:November 1, 1998 - v1
Checksum:i42875199AAF8A6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077338 mRNA. Translation: AAC27526.1.
RefSeqiNP_114001.1. NM_031813.1.
UniGeneiRn.23666.

Genome annotation databases

GeneIDi83708.
KEGGirno:83708.
UCSCiRGD:620287. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077338 mRNA. Translation: AAC27526.1.
RefSeqiNP_114001.1. NM_031813.1.
UniGeneiRn.23666.

3D structure databases

ProteinModelPortaliO88599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044331.

PTM databases

iPTMnetiO88599.
PhosphoSitePlusiO88599.

Proteomic databases

PaxDbiO88599.
PRIDEiO88599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83708.
KEGGirno:83708.
UCSCiRGD:620287. rat.

Organism-specific databases

CTDi4608.
RGDi620287. Mybph.

Phylogenomic databases

eggNOGiENOG410IF9Q. Eukaryota.
ENOG410YAE6. LUCA.
HOGENOMiHOG000290713.
HOVERGENiHBG056788.
InParanoidiO88599.
PhylomeDBiO88599.

Miscellaneous databases

PROiO88599.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYBPH_RAT
AccessioniPrimary (citable) accession number: O88599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.