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Protein

Peptidoglycan recognition protein 1

Gene

Pglyrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. May function in intracellular killing of bacteria. The soluble form triggers apoptosis in vitro.3 Publications

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • defense response to Gram-positive bacterium Source: MGI
  • detection of bacterium Source: MGI
  • growth of symbiont in host Source: MGI
  • innate immune response Source: UniProtKB-KW
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of interferon-gamma production Source: MGI
  • negative regulation of natural killer cell differentiation involved in immune response Source: MGI
  • pattern recognition receptor signaling pathway Source: MGI
  • peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Cytokine

Keywords - Biological processi

Apoptosis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 1
Alternative name(s):
Cytokine tag7
Peptidoglycan recognition protein short
Short name:
PGRP-S
Gene namesi
Name:Pglyrp1
Synonyms:Pglyrp, Pgrp, Pgrps, Tag7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1345092. Pglyrp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 182164Peptidoglycan recognition protein 1PRO_0000023902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi17 ↔ 141By similarity
Disulfide bondi33 ↔ 78By similarity
Disulfide bondi54 ↔ 60By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO88593.
PRIDEiO88593.

PTM databases

PhosphoSiteiO88593.

Expressioni

Tissue specificityi

Strongly expressed in spleen and lung. Also detected in brain and thymus. In the lung, expressed in the intraalveolar space, in the brain, expressed in the Purkinje cells of the cerebellum and in certain layers of neurons in the hippocampus. Also detected in cells filling the space within the intestinal villus.1 Publication

Gene expression databases

BgeeiO88593.
CleanExiMM_PGLYRP1.
ExpressionAtlasiO88593. baseline and differential.
GenevisibleiO88593. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032573.

Structurei

3D structure databases

ProteinModelPortaliO88593.
SMRiO88593. Positions 16-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
HOGENOMiHOG000267017.
HOVERGENiHBG007406.
InParanoidiO88593.
KOiK01446.
OMAiLWNPMSI.
OrthoDBiEOG757CZ5.
PhylomeDBiO88593.
TreeFamiTF323898.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFACALLAL LGLATSCSFI VPRSEWRALP SECSSRLGHP VRYVVISHTA
60 70 80 90 100
GSFCNSPDSC EQQARNVQHY HKNELGWCDV AYNFLIGEDG HVYEGRGWNI
110 120 130 140 150
KGDHTGPIWN PMSIGITFMG NFMDRVPAKR ALRAALNLLE CGVSRGFLRS
160 170 180
NYEVKGHRDV QSTLSPGDQL YQVIQSWEHY RE
Length:182
Mass (Da):20,489
Last modified:November 1, 1998 - v1
Checksum:i9844E2137F047F14
GO

Sequence cautioni

The sequence CAA60133.1 differs from that shown. Reason: Frameshift at position 127. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411C → S in CAA60133 (PubMed:9660837).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076482 mRNA. Translation: AAC31821.1.
X86374 mRNA. Translation: CAA60133.1. Frameshift.
Y12088 Genomic DNA. Translation: CAA72803.1.
AF193843 mRNA. Translation: AAF06335.1.
AY144361, AY144360 Genomic DNA. Translation: AAN52146.1.
AK008335 mRNA. Translation: BAB25611.1.
BC005582 mRNA. Translation: AAH05582.1.
CCDSiCCDS20881.1.
RefSeqiNP_033428.1. NM_009402.2.
UniGeneiMm.21855.

Genome annotation databases

EnsembliENSMUST00000032573; ENSMUSP00000032573; ENSMUSG00000030413.
GeneIDi21946.
KEGGimmu:21946.
UCSCiuc009fjv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076482 mRNA. Translation: AAC31821.1.
X86374 mRNA. Translation: CAA60133.1. Frameshift.
Y12088 Genomic DNA. Translation: CAA72803.1.
AF193843 mRNA. Translation: AAF06335.1.
AY144361, AY144360 Genomic DNA. Translation: AAN52146.1.
AK008335 mRNA. Translation: BAB25611.1.
BC005582 mRNA. Translation: AAH05582.1.
CCDSiCCDS20881.1.
RefSeqiNP_033428.1. NM_009402.2.
UniGeneiMm.21855.

3D structure databases

ProteinModelPortaliO88593.
SMRiO88593. Positions 16-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032573.

PTM databases

PhosphoSiteiO88593.

Proteomic databases

PaxDbiO88593.
PRIDEiO88593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032573; ENSMUSP00000032573; ENSMUSG00000030413.
GeneIDi21946.
KEGGimmu:21946.
UCSCiuc009fjv.1. mouse.

Organism-specific databases

CTDi8993.
MGIiMGI:1345092. Pglyrp1.

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
HOGENOMiHOG000267017.
HOVERGENiHBG007406.
InParanoidiO88593.
KOiK01446.
OMAiLWNPMSI.
OrthoDBiEOG757CZ5.
PhylomeDBiO88593.
TreeFamiTF323898.

Miscellaneous databases

NextBioi301596.
PROiO88593.
SOURCEiSearch...

Gene expression databases

BgeeiO88593.
CleanExiMM_PGLYRP1.
ExpressionAtlasiO88593. baseline and differential.
GenevisibleiO88593. MM.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A peptidoglycan recognition protein in innate immunity conserved from insects to humans."
    Kang D., Liu G., Lundstroem A., Gelius E., Steiner H.
    Proc. Natl. Acad. Sci. U.S.A. 95:10078-10082(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Spleen.
  2. "Molecular cloning and characterization of the mouse tag7 gene encoding a novel cytokine."
    Kiselev S.L., Kustikova O.S., Korobko E.V., Prokhortchouk E.B., Kabishev A.A., Lukanidin E.M., Georgiev G.P.
    J. Biol. Chem. 273:18633-18639(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "Granulocyte-colony stimulating factor up-regulates expression of murine tag7 during myeloid differentiation."
    Slayton W.B., Rigaa A., Hancock J.D., Zaugg J.K., Le T.V., Trautman M.S., Spangrude G.J., Carroll W.L., Schibler K.R.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic Gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice."
    Dziarski R., Platt K.A., Gelius E., Steiner H., Gupta D.
    Blood 102:689-697(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: 129/Sv.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiPGRP1_MOUSE
AccessioniPrimary (citable) accession number: O88593
Secondary accession number(s): Q62185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.