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Protein

Suppressor of cytokine signaling 2

Gene

Socs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 2
Short name:
SOCS-2
Alternative name(s):
Cytokine-inducible SH2 protein 2
Gene namesi
Name:Socs2
Synonyms:Cish2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69273. Socs2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Suppressor of cytokine signaling 2PRO_0000181240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88582.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008965.
GenevisibleiO88582. RN.

Interactioni

Subunit structurei

Associates with the Elongin BC complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250034. 4 interactions.
STRINGi10116.ENSRNOP00000011948.

Structurei

3D structure databases

ProteinModelPortaliO88582.
SMRiO88582. Positions 32-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 156109SH2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 19747SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOGENOMiHOG000236320.
HOVERGENiHBG002457.
InParanoidiO88582.
KOiK04695.
OrthoDBiEOG091G0J75.
PhylomeDBiO88582.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028410. SOCS2.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF75. PTHR24369:SF75. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRCLEPSG NGADRTRSQW GTAGSPEDQS PEAARLAKAL RELSQTGWYW
60 70 80 90 100
GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ
110 120 130 140 150
DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL
160 170 180 190
YLTKPLYTSA PTLQHFCRLS INKCTGTIRG LPLPTRLKDY LEEYKFQV
Length:198
Mass (Da):22,380
Last modified:November 1, 1998 - v1
Checksum:iDD6160D3899122E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075382 mRNA. Translation: AAC26222.1.
RefSeqiNP_478115.1. NM_058208.1.
UniGeneiRn.205056.

Genome annotation databases

GeneIDi84607.
KEGGirno:84607.
UCSCiRGD:69273. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075382 mRNA. Translation: AAC26222.1.
RefSeqiNP_478115.1. NM_058208.1.
UniGeneiRn.205056.

3D structure databases

ProteinModelPortaliO88582.
SMRiO88582. Positions 32-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250034. 4 interactions.
STRINGi10116.ENSRNOP00000011948.

Proteomic databases

PaxDbiO88582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84607.
KEGGirno:84607.
UCSCiRGD:69273. rat.

Organism-specific databases

CTDi8835.
RGDi69273. Socs2.

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOGENOMiHOG000236320.
HOVERGENiHBG002457.
InParanoidiO88582.
KOiK04695.
OrthoDBiEOG091G0J75.
PhylomeDBiO88582.
TreeFamiTF321368.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiO88582.

Gene expression databases

BgeeiENSRNOG00000008965.
GenevisibleiO88582. RN.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028410. SOCS2.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF75. PTHR24369:SF75. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS2_RAT
AccessioniPrimary (citable) accession number: O88582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.