O88582 (SOCS2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Suppressor of cytokine signaling 2
Short name=SOCS-2

Alternative name(s):
Cytokine-inducible SH2 protein 2

Gene names

Name:	Socs2
Synonyms:	Cish2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Associates with the Elongin BC complex By similarity.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities	Contains 1 SH2 domain. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Growth regulation Ubl conjugation pathway
Domain	SH2 domain
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aging Inferred from expression pattern. Source: RGD intracellular signal transduction Inferred from electronic annotation. Source: InterPro negative regulation of signal transduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	insulin-like growth factor receptor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Suppressor of cytokine signaling 2		PRO_0000181240
Regions
	Domain	48 – 156	109	SH2
	Domain	151 – 197	47	SOCS box

Sequences

	Sequence		Length	Mass (Da)
	O88582 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: DD6160D3899122E6	FASTA	198	22,380
	10 20 30 40 50 60 MTLRCLEPSG NGADRTRSQW GTAGSPEDQS PEAARLAKAL RELSQTGWYW GSMTVNEAKE 70 80 90 100 110 120 KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 130 140 150 160 170 180 SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PTLQHFCRLS INKCTGTIRG 190 LPLPTRLKDY LEEYKFQV

References

[1]	"Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo." Mao Y., Ling P.R., Fitzgibbons T.P., McCowen K.C., Frick G.P., Bistrian B.R., Smith R.J. Endocrinology 140:5505-5515(1999) [PubMed: 10579313] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF075382 mRNA. Translation: AAC26222.1.
IPI	IPI00210795.
RefSeq	NP_478115.1. NM_058208.1.
UniGene	Rn.205056.
3D structure databases
ProteinModelPortal	O88582.
SMR	O88582. Positions 32-198.
ModBase	Search...
Protein-protein interaction databases
STRING	O88582.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000011948; ENSRNOP00000011948; ENSRNOG00000008965.
GeneID	84607.
KEGG	rno:84607.
UCSC	NM_058208. rat.
Organism-specific databases
CTD	8835.
RGD	69273. Socs2.
Phylogenomic databases
eggNOG	roNOG12105.
HOVERGEN	HBG002457.
InParanoid	O88582.
OMA	EGTRSQW.
OrthoDB	EOG48WC31.
PhylomeDB	O88582.
Gene expression databases
ArrayExpress	O88582.
Genevestigator	O88582.
GermOnline	ENSRNOG00000008965. Rattus norvegicus.
Family and domain databases
InterPro	IPR000980. SH2. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
KO	K04695.
Pfam	PF00017. SH2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00253. SOCS. 1 hit. SM00969. SOCS_box. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	617252.

Entry information

Entry name

SOCS2_RAT

Accession

Primary (citable) accession number: O88582

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	November 1, 1998
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program