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O88576

- S6A18_MOUSE

UniProt

O88576 - S6A18_MOUSE

Protein

Sodium-dependent neutral amino acid transporter B(0)AT3

Gene

Slc6a18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Functions as a sodium and chloride-dependent neutral amino acid transporter.

    GO - Molecular functioni

    1. neurotransmitter:sodium symporter activity Source: InterPro
    2. protein binding Source: MGI
    3. transporter activity Source: MGI

    GO - Biological processi

    1. amino acid transmembrane transport Source: MGI
    2. transport Source: MGI

    Keywords - Biological processi

    Amino-acid transport, Neurotransmitter transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent neutral amino acid transporter B(0)AT3
    Alternative name(s):
    Sodium- and chloride-dependent transporter XTRP2
    Solute carrier family 6 member 18
    System B(0) neutral amino acid transporter AT3
    Gene namesi
    Name:Slc6a18
    Synonyms:Xt2, Xtrp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1336892. Slc6a18.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: MGI
    2. integral component of plasma membrane Source: InterPro
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Animals lacking this protein exhibit no gross abnormalities and grow to adulthood, although they do exhibit hypertension. The elevated blood pressure appears to be attributable to a decreased level of renal glycine. High-affinity renal reabsorption of glycine is eliminated and intrarenal glycine concentration is reduced.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 615615Sodium-dependent neutral amino acid transporter B(0)AT3PRO_0000214807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO88576.
    PRIDEiO88576.

    PTM databases

    PhosphoSiteiO88576.

    Expressioni

    Tissue specificityi

    Expressed predominantly in kidney.1 Publication

    Gene expression databases

    BgeeiO88576.
    GenevestigatoriO88576.

    Interactioni

    Subunit structurei

    Associates with TMEM27. TMEM27 association is required for functional expression in kidney.

    Protein-protein interaction databases

    DIPiDIP-60421N.

    Structurei

    3D structure databases

    ProteinModelPortaliO88576.
    SMRiO88576. Positions 15-592.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini48 – 525ExtracellularSequence Analysis
    Topological domaini74 – 10532CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini127 – 17751ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini199 – 2068CytoplasmicSequence Analysis
    Topological domaini228 – 25528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini277 – 28812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 39788ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini419 – 44123CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini463 – 47210ExtracellularSequence Analysis
    Topological domaini494 – 52027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini542 – 57029ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini592 – 61524CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei442 – 46221Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei473 – 49321Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei571 – 59121Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00750000117287.
    HOVERGENiHBG071421.
    InParanoidiO88576.
    KOiK05048.
    OMAiRNDCERD.
    OrthoDBiEOG793B71.
    PhylomeDBiO88576.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002438. Na/ntran_symport_orphan.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01206. ORPHTRNSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88576-1) [UniParc]FASTAAdd to Basket

    Also known as: A12

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCQTH    50
    GGGAFLIPYF IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG 100
    LGCFSVSFLV SLYYNTVLLW VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE 150
    CQSSGTVSYF WYRQTLNITS DISNTGTIQW KLFLCLVACW STVYLCVIRG 200
    IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLIYLF TPNMKTLQNP 250
    RVWLDAATQI FFSLSLAFGG HIAFASYNPP RNNCEKDAVI IALVNSMTSL 300
    YASIAIFSVM GFKASNDYGR CLDRNILSLI NEFDLPELSI SRDEYPSVLM 350
    YLNATQTARV AQLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV 400
    WSVLFFGMLF TLGLSSMFGN MEGVITPLLD MGILPKGIPK EVMTGVICFA 450
    CFLSAICFTL QSGGYWLEIF DSFAASLNLI IFAFMEVVGV IHIYGMKRFC 500
    DDIEWMTGRR PGLYWQVTWR VVSPMLLFGI FLSYIVLLIQ TPPSYKAWNP 550
    QYEHFPSREE KFYPGWVQVT CVLLSFLPSL WVPGVALAQL LSQYKQRWKA 600
    THLESGLKLQ ESRGC 615
    Length:615
    Mass (Da):69,229
    Last modified:November 1, 1998 - v1
    Checksum:iA7925C0397FC63F8
    GO
    Isoform 2 (identifier: O88576-2) [UniParc]FASTAAdd to Basket

    Also known as: A11

    The sequence of this isoform differs from the canonical sequence as follows:
         445-454: Missing.

    Show »
    Length:605
    Mass (Da):68,188
    Checksum:iE86342EE242445BF
    GO
    Isoform 3 (identifier: O88576-3) [UniParc]FASTAAdd to Basket

    Also known as: B11

    The sequence of this isoform differs from the canonical sequence as follows:
         377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP

    Show »
    Length:577
    Mass (Da):65,254
    Checksum:i5F84F7C5CF1B14E3
    GO
    Isoform 4 (identifier: O88576-4) [UniParc]FASTAAdd to Basket

    Also known as: A10

    The sequence of this isoform differs from the canonical sequence as follows:
         499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
         553-615: Missing.

    Show »
    Length:552
    Mass (Da):61,513
    Checksum:i8DEE83992276B575
    GO
    Isoform 5 (identifier: O88576-5) [UniParc]FASTAAdd to Basket

    Also known as: B9

    The sequence of this isoform differs from the canonical sequence as follows:
         377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP
         499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
         553-615: Missing.

    Show »
    Length:514
    Mass (Da):57,538
    Checksum:i3743C2342ECE0610
    GO
    Isoform 6 (identifier: O88576-6) [UniParc]FASTAAdd to Basket

    Also known as: A8

    The sequence of this isoform differs from the canonical sequence as follows:
         377-422: SASGPGLAFI...GLSSMFGNME → VLLCGLCSSL...SYPKVYPRRS
         423-615: Missing.

    Show »
    Length:422
    Mass (Da):47,619
    Checksum:i6A794BDE016C00C3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei377 – 44468SASGP…KEVMT → PTWKQISGARVLGEGCARLT SRVCEASVLP in isoform 3 and isoform 5. 2 PublicationsVSP_050364Add
    BLAST
    Alternative sequencei377 – 42246SASGP…FGNME → VLLCGLCSSLGCCLPWVCPP CLGTWRVSLHHYWTWGSYPK VYPRRS in isoform 6. 1 PublicationVSP_050363Add
    BLAST
    Alternative sequencei423 – 615193Missing in isoform 6. 1 PublicationVSP_050697Add
    BLAST
    Alternative sequencei445 – 45410Missing in isoform 2. 1 PublicationVSP_050365
    Alternative sequencei499 – 55254FCDDI…WNPQY → NIFPQERRSSTQAGCRSPVC SCPSCPHCGSLELLWLSYCP STNRGGRLRIWKVV in isoform 4 and isoform 5. 1 PublicationVSP_050366Add
    BLAST
    Alternative sequencei553 – 61563Missing in isoform 4 and isoform 5. 1 PublicationVSP_050367Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075262 mRNA. Translation: AAC27757.1.
    AF075263 mRNA. Translation: AAC27758.1.
    AF075264 mRNA. Translation: AAC27759.1.
    AF075265 mRNA. Translation: AAC27760.1.
    AF075266 mRNA. Translation: AAC27761.1.
    AF075267 mRNA. Translation: AAC27762.1.
    BC010748 mRNA. Translation: AAH10748.1.
    CCDSiCCDS36727.1. [O88576-1]
    CCDS49311.1. [O88576-3]
    CCDS49312.1. [O88576-4]
    RefSeqiNP_001035782.1. NM_001040692.3. [O88576-1]
    NP_001129559.1. NM_001136087.2. [O88576-3]
    NP_001162115.1. NM_001168644.1. [O88576-4]
    NP_001162116.1. NM_001168645.1. [O88576-5]
    NP_001162117.1. NM_001168646.1. [O88576-2]
    UniGeneiMm.30370.

    Genome annotation databases

    EnsembliENSMUST00000022105; ENSMUSP00000022105; ENSMUSG00000021612. [O88576-1]
    ENSMUST00000109679; ENSMUSP00000105301; ENSMUSG00000021612. [O88576-4]
    ENSMUST00000109680; ENSMUSP00000105302; ENSMUSG00000021612. [O88576-3]
    GeneIDi22598.
    KEGGimmu:22598.
    UCSCiuc007rds.2. mouse. [O88576-1]
    uc007rdt.2. mouse. [O88576-2]
    uc007rdu.2. mouse. [O88576-3]
    uc007rdv.2. mouse. [O88576-4]
    uc007rdw.2. mouse. [O88576-5]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075262 mRNA. Translation: AAC27757.1 .
    AF075263 mRNA. Translation: AAC27758.1 .
    AF075264 mRNA. Translation: AAC27759.1 .
    AF075265 mRNA. Translation: AAC27760.1 .
    AF075266 mRNA. Translation: AAC27761.1 .
    AF075267 mRNA. Translation: AAC27762.1 .
    BC010748 mRNA. Translation: AAH10748.1 .
    CCDSi CCDS36727.1. [O88576-1 ]
    CCDS49311.1. [O88576-3 ]
    CCDS49312.1. [O88576-4 ]
    RefSeqi NP_001035782.1. NM_001040692.3. [O88576-1 ]
    NP_001129559.1. NM_001136087.2. [O88576-3 ]
    NP_001162115.1. NM_001168644.1. [O88576-4 ]
    NP_001162116.1. NM_001168645.1. [O88576-5 ]
    NP_001162117.1. NM_001168646.1. [O88576-2 ]
    UniGenei Mm.30370.

    3D structure databases

    ProteinModelPortali O88576.
    SMRi O88576. Positions 15-592.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60421N.

    PTM databases

    PhosphoSitei O88576.

    Proteomic databases

    PaxDbi O88576.
    PRIDEi O88576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022105 ; ENSMUSP00000022105 ; ENSMUSG00000021612 . [O88576-1 ]
    ENSMUST00000109679 ; ENSMUSP00000105301 ; ENSMUSG00000021612 . [O88576-4 ]
    ENSMUST00000109680 ; ENSMUSP00000105302 ; ENSMUSG00000021612 . [O88576-3 ]
    GeneIDi 22598.
    KEGGi mmu:22598.
    UCSCi uc007rds.2. mouse. [O88576-1 ]
    uc007rdt.2. mouse. [O88576-2 ]
    uc007rdu.2. mouse. [O88576-3 ]
    uc007rdv.2. mouse. [O88576-4 ]
    uc007rdw.2. mouse. [O88576-5 ]

    Organism-specific databases

    CTDi 348932.
    MGIi MGI:1336892. Slc6a18.

    Phylogenomic databases

    eggNOGi COG0733.
    GeneTreei ENSGT00750000117287.
    HOVERGENi HBG071421.
    InParanoidi O88576.
    KOi K05048.
    OMAi RNDCERD.
    OrthoDBi EOG793B71.
    PhylomeDBi O88576.
    TreeFami TF343812.

    Miscellaneous databases

    NextBioi 302949.
    PROi O88576.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88576.
    Genevestigatori O88576.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002438. Na/ntran_symport_orphan.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PR01206. ORPHTRNSPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms."
      Nash S.R., Giros B., Kingsmore S.F., Kim K.M., El-Mestikawy S., Dong Q., Fumagalli F., Seldin M.F., Caron M.G.
      Recept. Channels 6:113-128(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Kidney.
    3. "Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2."
      Quan H., Athirakul K., Wetsel W.C., Torres G.E., Stevens R., Chen Y.T., Coffman T.M., Caron M.G.
      Mol. Cell. Biol. 24:4166-4173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    4. Cited for: PROBABLE FUNCTION, ASSOCIATION WITH TMEM27.

    Entry informationi

    Entry nameiS6A18_MOUSE
    AccessioniPrimary (citable) accession number: O88576
    Secondary accession number(s): O88577
    , O88578, O88579, O88580, O88581, Q91XG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3