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Protein

Sodium-dependent neutral amino acid transporter B(0)AT3

Gene

Slc6a18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium and chloride-dependent neutral amino acid transporter.

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane transport Source: MGI
  • transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT3
Alternative name(s):
Sodium- and chloride-dependent transporter XTRP2
Solute carrier family 6 member 18
System B(0) neutral amino acid transporter AT3
Gene namesi
Name:Slc6a18
Synonyms:Xt2, Xtrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1336892. Slc6a18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 52ExtracellularSequence analysis5
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 105CytoplasmicSequence analysisAdd BLAST32
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 177ExtracellularSequence analysisAdd BLAST51
Transmembranei178 – 198Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini199 – 206CytoplasmicSequence analysis8
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 255ExtracellularSequence analysisAdd BLAST28
Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini277 – 288CytoplasmicSequence analysisAdd BLAST12
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 397ExtracellularSequence analysisAdd BLAST88
Transmembranei398 – 418Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini419 – 441CytoplasmicSequence analysisAdd BLAST23
Transmembranei442 – 462Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini463 – 472ExtracellularSequence analysis10
Transmembranei473 – 493Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini494 – 520CytoplasmicSequence analysisAdd BLAST27
Transmembranei521 – 541Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini542 – 570ExtracellularSequence analysisAdd BLAST29
Transmembranei571 – 591Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini592 – 615CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • brush border membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Animals lacking this protein exhibit no gross abnormalities and grow to adulthood, although they do exhibit hypertension. The elevated blood pressure appears to be attributable to a decreased level of renal glycine. High-affinity renal reabsorption of glycine is eliminated and intrarenal glycine concentration is reduced.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002148071 – 615Sodium-dependent neutral amino acid transporter B(0)AT3Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88576.
PRIDEiO88576.

PTM databases

iPTMnetiO88576.
PhosphoSitePlusiO88576.

Expressioni

Tissue specificityi

Expressed predominantly in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000021612.
GenevisibleiO88576. MM.

Interactioni

Subunit structurei

Associates with TMEM27. TMEM27 association is required for functional expression in kidney.

Protein-protein interaction databases

DIPiDIP-60421N.
STRINGi10090.ENSMUSP00000022105.

Structurei

3D structure databases

ProteinModelPortaliO88576.
SMRiO88576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOVERGENiHBG071421.
InParanoidiO88576.
KOiK05048.
OMAiPIQGERI.
OrthoDBiEOG091G08PX.
PhylomeDBiO88576.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88576-1) [UniParc]FASTAAdd to basket
Also known as: A12

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCQTH
60 70 80 90 100
GGGAFLIPYF IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG
110 120 130 140 150
LGCFSVSFLV SLYYNTVLLW VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE
160 170 180 190 200
CQSSGTVSYF WYRQTLNITS DISNTGTIQW KLFLCLVACW STVYLCVIRG
210 220 230 240 250
IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLIYLF TPNMKTLQNP
260 270 280 290 300
RVWLDAATQI FFSLSLAFGG HIAFASYNPP RNNCEKDAVI IALVNSMTSL
310 320 330 340 350
YASIAIFSVM GFKASNDYGR CLDRNILSLI NEFDLPELSI SRDEYPSVLM
360 370 380 390 400
YLNATQTARV AQLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV
410 420 430 440 450
WSVLFFGMLF TLGLSSMFGN MEGVITPLLD MGILPKGIPK EVMTGVICFA
460 470 480 490 500
CFLSAICFTL QSGGYWLEIF DSFAASLNLI IFAFMEVVGV IHIYGMKRFC
510 520 530 540 550
DDIEWMTGRR PGLYWQVTWR VVSPMLLFGI FLSYIVLLIQ TPPSYKAWNP
560 570 580 590 600
QYEHFPSREE KFYPGWVQVT CVLLSFLPSL WVPGVALAQL LSQYKQRWKA
610
THLESGLKLQ ESRGC
Length:615
Mass (Da):69,229
Last modified:November 1, 1998 - v1
Checksum:iA7925C0397FC63F8
GO
Isoform 2 (identifier: O88576-2) [UniParc]FASTAAdd to basket
Also known as: A11

The sequence of this isoform differs from the canonical sequence as follows:
     445-454: Missing.

Show »
Length:605
Mass (Da):68,188
Checksum:iE86342EE242445BF
GO
Isoform 3 (identifier: O88576-3) [UniParc]FASTAAdd to basket
Also known as: B11

The sequence of this isoform differs from the canonical sequence as follows:
     377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP

Show »
Length:577
Mass (Da):65,254
Checksum:i5F84F7C5CF1B14E3
GO
Isoform 4 (identifier: O88576-4) [UniParc]FASTAAdd to basket
Also known as: A10

The sequence of this isoform differs from the canonical sequence as follows:
     499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
     553-615: Missing.

Show »
Length:552
Mass (Da):61,513
Checksum:i8DEE83992276B575
GO
Isoform 5 (identifier: O88576-5) [UniParc]FASTAAdd to basket
Also known as: B9

The sequence of this isoform differs from the canonical sequence as follows:
     377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP
     499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
     553-615: Missing.

Show »
Length:514
Mass (Da):57,538
Checksum:i3743C2342ECE0610
GO
Isoform 6 (identifier: O88576-6) [UniParc]FASTAAdd to basket
Also known as: A8

The sequence of this isoform differs from the canonical sequence as follows:
     377-422: SASGPGLAFI...GLSSMFGNME → VLLCGLCSSL...SYPKVYPRRS
     423-615: Missing.

Show »
Length:422
Mass (Da):47,619
Checksum:i6A794BDE016C00C3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050364377 – 444SASGP…KEVMT → PTWKQISGARVLGEGCARLT SRVCEASVLP in isoform 3 and isoform 5. 2 PublicationsAdd BLAST68
Alternative sequenceiVSP_050363377 – 422SASGP…FGNME → VLLCGLCSSLGCCLPWVCPP CLGTWRVSLHHYWTWGSYPK VYPRRS in isoform 6. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_050697423 – 615Missing in isoform 6. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_050365445 – 454Missing in isoform 2. 1 Publication10
Alternative sequenceiVSP_050366499 – 552FCDDI…WNPQY → NIFPQERRSSTQAGCRSPVC SCPSCPHCGSLELLWLSYCP STNRGGRLRIWKVV in isoform 4 and isoform 5. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_050367553 – 615Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075262 mRNA. Translation: AAC27757.1.
AF075263 mRNA. Translation: AAC27758.1.
AF075264 mRNA. Translation: AAC27759.1.
AF075265 mRNA. Translation: AAC27760.1.
AF075266 mRNA. Translation: AAC27761.1.
AF075267 mRNA. Translation: AAC27762.1.
BC010748 mRNA. Translation: AAH10748.1.
CCDSiCCDS36727.1. [O88576-1]
CCDS49311.1. [O88576-3]
CCDS49312.1. [O88576-4]
RefSeqiNP_001035782.1. NM_001040692.3. [O88576-1]
NP_001129559.1. NM_001136087.2. [O88576-3]
NP_001162115.1. NM_001168644.1. [O88576-4]
NP_001162116.1. NM_001168645.1. [O88576-5]
NP_001162117.1. NM_001168646.1. [O88576-2]
UniGeneiMm.30370.

Genome annotation databases

EnsembliENSMUST00000022105; ENSMUSP00000022105; ENSMUSG00000021612. [O88576-1]
ENSMUST00000109679; ENSMUSP00000105301; ENSMUSG00000021612. [O88576-4]
ENSMUST00000109680; ENSMUSP00000105302; ENSMUSG00000021612. [O88576-3]
GeneIDi22598.
KEGGimmu:22598.
UCSCiuc007rds.2. mouse. [O88576-1]
uc007rdt.2. mouse. [O88576-2]
uc007rdu.2. mouse. [O88576-3]
uc007rdv.2. mouse. [O88576-4]
uc007rdw.2. mouse. [O88576-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075262 mRNA. Translation: AAC27757.1.
AF075263 mRNA. Translation: AAC27758.1.
AF075264 mRNA. Translation: AAC27759.1.
AF075265 mRNA. Translation: AAC27760.1.
AF075266 mRNA. Translation: AAC27761.1.
AF075267 mRNA. Translation: AAC27762.1.
BC010748 mRNA. Translation: AAH10748.1.
CCDSiCCDS36727.1. [O88576-1]
CCDS49311.1. [O88576-3]
CCDS49312.1. [O88576-4]
RefSeqiNP_001035782.1. NM_001040692.3. [O88576-1]
NP_001129559.1. NM_001136087.2. [O88576-3]
NP_001162115.1. NM_001168644.1. [O88576-4]
NP_001162116.1. NM_001168645.1. [O88576-5]
NP_001162117.1. NM_001168646.1. [O88576-2]
UniGeneiMm.30370.

3D structure databases

ProteinModelPortaliO88576.
SMRiO88576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60421N.
STRINGi10090.ENSMUSP00000022105.

PTM databases

iPTMnetiO88576.
PhosphoSitePlusiO88576.

Proteomic databases

PaxDbiO88576.
PRIDEiO88576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022105; ENSMUSP00000022105; ENSMUSG00000021612. [O88576-1]
ENSMUST00000109679; ENSMUSP00000105301; ENSMUSG00000021612. [O88576-4]
ENSMUST00000109680; ENSMUSP00000105302; ENSMUSG00000021612. [O88576-3]
GeneIDi22598.
KEGGimmu:22598.
UCSCiuc007rds.2. mouse. [O88576-1]
uc007rdt.2. mouse. [O88576-2]
uc007rdu.2. mouse. [O88576-3]
uc007rdv.2. mouse. [O88576-4]
uc007rdw.2. mouse. [O88576-5]

Organism-specific databases

CTDi348932.
MGIiMGI:1336892. Slc6a18.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOVERGENiHBG071421.
InParanoidiO88576.
KOiK05048.
OMAiPIQGERI.
OrthoDBiEOG091G08PX.
PhylomeDBiO88576.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiO88576.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021612.
GenevisibleiO88576. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS6A18_MOUSE
AccessioniPrimary (citable) accession number: O88576
Secondary accession number(s): O88577
, O88578, O88579, O88580, O88581, Q91XG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.