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O88576

- S6A18_MOUSE

UniProt

O88576 - S6A18_MOUSE

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Protein
Sodium-dependent neutral amino acid transporter B(0)AT3
Gene
Slc6a18, Xt2, Xtrp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions as a sodium and chloride-dependent neutral amino acid transporter.1 Publication

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro
  2. protein binding Source: MGI
  3. transporter activity Source: MGI

GO - Biological processi

  1. amino acid transmembrane transport Source: MGI
  2. transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT3
Alternative name(s):
Sodium- and chloride-dependent transporter XTRP2
Solute carrier family 6 member 18
System B(0) neutral amino acid transporter AT3
Gene namesi
Name:Slc6a18
Synonyms:Xt2, Xtrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1336892. Slc6a18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei27 – 4721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini48 – 525Extracellular Reviewed prediction
Transmembranei53 – 7321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini74 – 10532Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini127 – 17751Extracellular Reviewed prediction
Add
BLAST
Transmembranei178 – 19821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini199 – 2068Cytoplasmic Reviewed prediction
Transmembranei207 – 22721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini228 – 25528Extracellular Reviewed prediction
Add
BLAST
Transmembranei256 – 27621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini277 – 28812Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini310 – 39788Extracellular Reviewed prediction
Add
BLAST
Transmembranei398 – 41821Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini419 – 44123Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei442 – 46221Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini463 – 47210Extracellular Reviewed prediction
Transmembranei473 – 49321Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini494 – 52027Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei521 – 54121Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini542 – 57029Extracellular Reviewed prediction
Add
BLAST
Transmembranei571 – 59121Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini592 – 61524Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. brush border membrane Source: MGI
  2. integral component of plasma membrane Source: InterPro
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Animals lacking this protein exhibit no gross abnormalities and grow to adulthood, although they do exhibit hypertension. The elevated blood pressure appears to be attributable to a decreased level of renal glycine. High-affinity renal reabsorption of glycine is eliminated and intrarenal glycine concentration is reduced.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Sodium-dependent neutral amino acid transporter B(0)AT3
PRO_0000214807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88576.
PRIDEiO88576.

PTM databases

PhosphoSiteiO88576.

Expressioni

Tissue specificityi

Expressed predominantly in kidney.1 Publication

Gene expression databases

BgeeiO88576.
GenevestigatoriO88576.

Interactioni

Subunit structurei

Associates with TMEM27. TMEM27 association is required for functional expression in kidney.

Protein-protein interaction databases

DIPiDIP-60421N.

Structurei

3D structure databases

ProteinModelPortaliO88576.
SMRiO88576. Positions 15-592.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00750000117287.
HOVERGENiHBG071421.
InParanoidiO88576.
KOiK05048.
OMAiRNDCERD.
OrthoDBiEOG793B71.
PhylomeDBiO88576.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88576-1) [UniParc]FASTAAdd to Basket

Also known as: A12

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCQTH    50
GGGAFLIPYF IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG 100
LGCFSVSFLV SLYYNTVLLW VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE 150
CQSSGTVSYF WYRQTLNITS DISNTGTIQW KLFLCLVACW STVYLCVIRG 200
IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLIYLF TPNMKTLQNP 250
RVWLDAATQI FFSLSLAFGG HIAFASYNPP RNNCEKDAVI IALVNSMTSL 300
YASIAIFSVM GFKASNDYGR CLDRNILSLI NEFDLPELSI SRDEYPSVLM 350
YLNATQTARV AQLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV 400
WSVLFFGMLF TLGLSSMFGN MEGVITPLLD MGILPKGIPK EVMTGVICFA 450
CFLSAICFTL QSGGYWLEIF DSFAASLNLI IFAFMEVVGV IHIYGMKRFC 500
DDIEWMTGRR PGLYWQVTWR VVSPMLLFGI FLSYIVLLIQ TPPSYKAWNP 550
QYEHFPSREE KFYPGWVQVT CVLLSFLPSL WVPGVALAQL LSQYKQRWKA 600
THLESGLKLQ ESRGC 615
Length:615
Mass (Da):69,229
Last modified:November 1, 1998 - v1
Checksum:iA7925C0397FC63F8
GO
Isoform 2 (identifier: O88576-2) [UniParc]FASTAAdd to Basket

Also known as: A11

The sequence of this isoform differs from the canonical sequence as follows:
     445-454: Missing.

Show »
Length:605
Mass (Da):68,188
Checksum:iE86342EE242445BF
GO
Isoform 3 (identifier: O88576-3) [UniParc]FASTAAdd to Basket

Also known as: B11

The sequence of this isoform differs from the canonical sequence as follows:
     377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP

Show »
Length:577
Mass (Da):65,254
Checksum:i5F84F7C5CF1B14E3
GO
Isoform 4 (identifier: O88576-4) [UniParc]FASTAAdd to Basket

Also known as: A10

The sequence of this isoform differs from the canonical sequence as follows:
     499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
     553-615: Missing.

Show »
Length:552
Mass (Da):61,513
Checksum:i8DEE83992276B575
GO
Isoform 5 (identifier: O88576-5) [UniParc]FASTAAdd to Basket

Also known as: B9

The sequence of this isoform differs from the canonical sequence as follows:
     377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP
     499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
     553-615: Missing.

Show »
Length:514
Mass (Da):57,538
Checksum:i3743C2342ECE0610
GO
Isoform 6 (identifier: O88576-6) [UniParc]FASTAAdd to Basket

Also known as: A8

The sequence of this isoform differs from the canonical sequence as follows:
     377-422: SASGPGLAFI...GLSSMFGNME → VLLCGLCSSL...SYPKVYPRRS
     423-615: Missing.

Show »
Length:422
Mass (Da):47,619
Checksum:i6A794BDE016C00C3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei377 – 44468SASGP…KEVMT → PTWKQISGARVLGEGCARLT SRVCEASVLP in isoform 3 and isoform 5.
VSP_050364Add
BLAST
Alternative sequencei377 – 42246SASGP…FGNME → VLLCGLCSSLGCCLPWVCPP CLGTWRVSLHHYWTWGSYPK VYPRRS in isoform 6.
VSP_050363Add
BLAST
Alternative sequencei423 – 615193Missing in isoform 6.
VSP_050697Add
BLAST
Alternative sequencei445 – 45410Missing in isoform 2.
VSP_050365
Alternative sequencei499 – 55254FCDDI…WNPQY → NIFPQERRSSTQAGCRSPVC SCPSCPHCGSLELLWLSYCP STNRGGRLRIWKVV in isoform 4 and isoform 5.
VSP_050366Add
BLAST
Alternative sequencei553 – 61563Missing in isoform 4 and isoform 5.
VSP_050367Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075262 mRNA. Translation: AAC27757.1.
AF075263 mRNA. Translation: AAC27758.1.
AF075264 mRNA. Translation: AAC27759.1.
AF075265 mRNA. Translation: AAC27760.1.
AF075266 mRNA. Translation: AAC27761.1.
AF075267 mRNA. Translation: AAC27762.1.
BC010748 mRNA. Translation: AAH10748.1.
CCDSiCCDS36727.1. [O88576-1]
CCDS49311.1. [O88576-3]
CCDS49312.1. [O88576-4]
RefSeqiNP_001035782.1. NM_001040692.3. [O88576-1]
NP_001129559.1. NM_001136087.2. [O88576-3]
NP_001162115.1. NM_001168644.1. [O88576-4]
NP_001162116.1. NM_001168645.1. [O88576-5]
NP_001162117.1. NM_001168646.1. [O88576-2]
UniGeneiMm.30370.

Genome annotation databases

EnsembliENSMUST00000022105; ENSMUSP00000022105; ENSMUSG00000021612. [O88576-1]
ENSMUST00000109679; ENSMUSP00000105301; ENSMUSG00000021612. [O88576-4]
ENSMUST00000109680; ENSMUSP00000105302; ENSMUSG00000021612. [O88576-3]
GeneIDi22598.
KEGGimmu:22598.
UCSCiuc007rds.2. mouse. [O88576-1]
uc007rdt.2. mouse. [O88576-2]
uc007rdu.2. mouse. [O88576-3]
uc007rdv.2. mouse. [O88576-4]
uc007rdw.2. mouse. [O88576-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075262 mRNA. Translation: AAC27757.1 .
AF075263 mRNA. Translation: AAC27758.1 .
AF075264 mRNA. Translation: AAC27759.1 .
AF075265 mRNA. Translation: AAC27760.1 .
AF075266 mRNA. Translation: AAC27761.1 .
AF075267 mRNA. Translation: AAC27762.1 .
BC010748 mRNA. Translation: AAH10748.1 .
CCDSi CCDS36727.1. [O88576-1 ]
CCDS49311.1. [O88576-3 ]
CCDS49312.1. [O88576-4 ]
RefSeqi NP_001035782.1. NM_001040692.3. [O88576-1 ]
NP_001129559.1. NM_001136087.2. [O88576-3 ]
NP_001162115.1. NM_001168644.1. [O88576-4 ]
NP_001162116.1. NM_001168645.1. [O88576-5 ]
NP_001162117.1. NM_001168646.1. [O88576-2 ]
UniGenei Mm.30370.

3D structure databases

ProteinModelPortali O88576.
SMRi O88576. Positions 15-592.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60421N.

PTM databases

PhosphoSitei O88576.

Proteomic databases

PaxDbi O88576.
PRIDEi O88576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022105 ; ENSMUSP00000022105 ; ENSMUSG00000021612 . [O88576-1 ]
ENSMUST00000109679 ; ENSMUSP00000105301 ; ENSMUSG00000021612 . [O88576-4 ]
ENSMUST00000109680 ; ENSMUSP00000105302 ; ENSMUSG00000021612 . [O88576-3 ]
GeneIDi 22598.
KEGGi mmu:22598.
UCSCi uc007rds.2. mouse. [O88576-1 ]
uc007rdt.2. mouse. [O88576-2 ]
uc007rdu.2. mouse. [O88576-3 ]
uc007rdv.2. mouse. [O88576-4 ]
uc007rdw.2. mouse. [O88576-5 ]

Organism-specific databases

CTDi 348932.
MGIi MGI:1336892. Slc6a18.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00750000117287.
HOVERGENi HBG071421.
InParanoidi O88576.
KOi K05048.
OMAi RNDCERD.
OrthoDBi EOG793B71.
PhylomeDBi O88576.
TreeFami TF343812.

Miscellaneous databases

NextBioi 302949.
PROi O88576.
SOURCEi Search...

Gene expression databases

Bgeei O88576.
Genevestigatori O88576.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms."
    Nash S.R., Giros B., Kingsmore S.F., Kim K.M., El-Mestikawy S., Dong Q., Fumagalli F., Seldin M.F., Caron M.G.
    Recept. Channels 6:113-128(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Kidney.
  3. "Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2."
    Quan H., Athirakul K., Wetsel W.C., Torres G.E., Stevens R., Chen Y.T., Coffman T.M., Caron M.G.
    Mol. Cell. Biol. 24:4166-4173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  4. Cited for: PROBABLE FUNCTION, ASSOCIATION WITH TMEM27.

Entry informationi

Entry nameiS6A18_MOUSE
AccessioniPrimary (citable) accession number: O88576
Secondary accession number(s): O88577
, O88578, O88579, O88580, O88581, Q91XG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi