Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium- and chloride-dependent transporter XTRP3B

Gene

Slc6a20b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Does not show transporter activity with a range of tested amino acids including proline, glutamine, glutamic acid, leucine, alanine, histidine, glycine and arginine.1 Publication

GO - Molecular functioni

  • glycine:sodium symporter activity Source: GO_Central
  • neurotransmitter:sodium symporter activity Source: InterPro
  • transporter activity Source: MGI

GO - Biological processi

  • glycine import Source: GO_Central
  • synaptic transmission, glycinergic Source: GO_Central
  • transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent transporter XTRP3B
Alternative name(s):
IMINO-K
Solute carrier family 6 member 20B
Gene namesi
Name:Slc6a20b
Synonyms:Slc6a20, Xt3, Xtrp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1336891. Slc6a20b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini78 – 85ExtracellularSequence analysis8
Transmembranei86 – 106Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini107 – 127CytoplasmicSequence analysisAdd BLAST21
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 208ExtracellularSequence analysisAdd BLAST60
Transmembranei209 – 229Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini230 – 237CytoplasmicSequence analysis8
Transmembranei238 – 258Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini259 – 284ExtracellularSequence analysisAdd BLAST26
Transmembranei285 – 305Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini306 – 319CytoplasmicSequence analysisAdd BLAST14
Transmembranei320 – 340Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini341 – 432ExtracellularSequence analysisAdd BLAST92
Transmembranei433 – 453Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini454 – 474CytoplasmicSequence analysisAdd BLAST21
Transmembranei475 – 495Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini496 – 508ExtracellularSequence analysisAdd BLAST13
Transmembranei509 – 529Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini530 – 547CytoplasmicSequence analysisAdd BLAST18
Transmembranei548 – 568Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini569 – 597ExtracellularSequence analysisAdd BLAST29
Transmembranei598 – 618Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini619 – 635CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • brush border membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002148131 – 635Sodium- and chloride-dependent transporter XTRP3BAdd BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO88575.
PaxDbiO88575.
PRIDEiO88575.

PTM databases

iPTMnetiO88575.
PhosphoSitePlusiO88575.

Expressioni

Tissue specificityi

Detected only in kidney and lung.2 Publications

Gene expression databases

BgeeiENSMUSG00000025243.
ExpressionAtlasiO88575. baseline and differential.
GenevisibleiO88575. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-60422N.
STRINGi10090.ENSMUSP00000026273.

Structurei

3D structure databases

ProteinModelPortaliO88575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO88575.
KOiK05048.
OMAiVINTWAL.
OrthoDBiEOG091G08PX.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPSAHAVS LPEDEELQPW GGAGGPGQHP GRPRSTECAH PGVVEKVRPK
60 70 80 90 100
WDNPLQFLLV CISYAVGLGN VWRFPYLCQM YGGGNFLVPY IIMLIVEGMP
110 120 130 140 150
LLYLELAVGQ RMRQGSIGAW RTISPYLSGV GIASLVVSFL ASVYFNVINT
160 170 180 190 200
WALWYLFHSF QDPLPWSVCP LNSNHTGYDE ECEKASSTQY FWYRKTLNIS
210 220 230 240 250
PSIQENGGVQ WEPALCLTLA WLMVYLCILR GTESTGKVVY FTTSLPYFVL
260 270 280 290 300
IIYLVRGLTL HGATNGLAYM FTPKIEQLAN PKAWINAATQ IFFSLGLGCG
310 320 330 340 350
GLIAFASYNE PSNDCQKHAL IVSVINSTTA IFSSIVTFSI YGFKATFNYE
360 370 380 390 400
NCLNKVILLL TNSFDLEDGF LTVSNLEEVK NYLASTYPNK YSEVFPHIRN
410 420 430 440 450
CSLESELDTA VQGTGLAFIV YTEAIKNMEV SQLWSVLYFF MLLTLGMGSM
460 470 480 490 500
VGTGTAILTP LTDSKIISSY LPKEAISGLV CLLNCAIGMV FTMEAGNYWF
510 520 530 540 550
DLFNDYTATL SLLLIVLVET IAVCYVYGLK RFESDLRAMT GRTLSWYWKV
560 570 580 590 600
MWAFVSPLLI VGLFIFYLSD YILTGTLQYQ AWDATQGHVV TKDYPTYALA
610 620 630
VIGLLVASST MCIPLVALGT FVTRHFKIRE QFSAA
Length:635
Mass (Da):70,687
Last modified:July 27, 2011 - v3
Checksum:i465AD54AA807EBE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85N → S in AAC27756 (PubMed:9932288).Curated1
Sequence conflicti85N → S in BAE25668 (PubMed:16141072).Curated1
Sequence conflicti85N → S in BAE37885 (PubMed:16141072).Curated1
Sequence conflicti85N → S in AAH13484 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075261 mRNA. Translation: AAC27756.1.
AK144038 mRNA. Translation: BAE25668.1.
AK164706 mRNA. Translation: BAE37885.1.
AC132852 Genomic DNA. No translation available.
BC013484 mRNA. Translation: AAH13484.1.
CCDSiCCDS23661.1.
RefSeqiNP_035861.2. NM_011731.3.
UniGeneiMm.41963.

Genome annotation databases

EnsembliENSMUST00000026273; ENSMUSP00000026273; ENSMUSG00000025243.
GeneIDi22599.
KEGGimmu:22599.
UCSCiuc009sgi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075261 mRNA. Translation: AAC27756.1.
AK144038 mRNA. Translation: BAE25668.1.
AK164706 mRNA. Translation: BAE37885.1.
AC132852 Genomic DNA. No translation available.
BC013484 mRNA. Translation: AAH13484.1.
CCDSiCCDS23661.1.
RefSeqiNP_035861.2. NM_011731.3.
UniGeneiMm.41963.

3D structure databases

ProteinModelPortaliO88575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60422N.
STRINGi10090.ENSMUSP00000026273.

PTM databases

iPTMnetiO88575.
PhosphoSitePlusiO88575.

Proteomic databases

MaxQBiO88575.
PaxDbiO88575.
PRIDEiO88575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026273; ENSMUSP00000026273; ENSMUSG00000025243.
GeneIDi22599.
KEGGimmu:22599.
UCSCiuc009sgi.2. mouse.

Organism-specific databases

CTDi22599.
MGIiMGI:1336891. Slc6a20b.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO88575.
KOiK05048.
OMAiVINTWAL.
OrthoDBiEOG091G08PX.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiO88575.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025243.
ExpressionAtlasiO88575. baseline and differential.
GenevisibleiO88575. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS620B_MOUSE
AccessioniPrimary (citable) accession number: O88575
Secondary accession number(s): E9QNK3, Q3TP52, Q91WT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.