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Protein

Sodium- and chloride-dependent transporter XTRP3B

Gene

Slc6a20b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Does not show transporter activity with a range of tested amino acids including proline, glutamine, glutamic acid, leucine, alanine, histidine, glycine and arginine.1 Publication

GO - Molecular functioni

  • glycine:sodium symporter activity Source: GO_Central
  • neurotransmitter:sodium symporter activity Source: InterPro
  • transporter activity Source: MGI

GO - Biological processi

  • glycine import Source: GO_Central
  • synaptic transmission, glycinergic Source: GO_Central
  • transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent transporter XTRP3B
Alternative name(s):
IMINO-K
Solute carrier family 6 member 20B
Gene namesi
Name:Slc6a20b
Synonyms:Slc6a20, Xt3, Xtrp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1336891. Slc6a20b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini78 – 858ExtracellularSequence analysis
Transmembranei86 – 10621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini107 – 12721CytoplasmicSequence analysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini149 – 20860ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini230 – 2378CytoplasmicSequence analysis
Transmembranei238 – 25821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini259 – 28426ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini306 – 31914CytoplasmicSequence analysisAdd
BLAST
Transmembranei320 – 34021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini341 – 43292ExtracellularSequence analysisAdd
BLAST
Transmembranei433 – 45321Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini454 – 47421CytoplasmicSequence analysisAdd
BLAST
Transmembranei475 – 49521Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini496 – 50813ExtracellularSequence analysisAdd
BLAST
Transmembranei509 – 52921Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini530 – 54718CytoplasmicSequence analysisAdd
BLAST
Transmembranei548 – 56821Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini569 – 59729ExtracellularSequence analysisAdd
BLAST
Transmembranei598 – 61821Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini619 – 63517CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • brush border membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Sodium- and chloride-dependent transporter XTRP3BPRO_0000214813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO88575.
PaxDbiO88575.

PTM databases

iPTMnetiO88575.

Expressioni

Tissue specificityi

Detected only in kidney and lung.2 Publications

Gene expression databases

BgeeiO88575.
ExpressionAtlasiO88575. baseline and differential.
GenevisibleiO88575. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-60422N.
STRINGi10090.ENSMUSP00000026273.

Structurei

3D structure databases

ProteinModelPortaliO88575.
SMRiO88575. Positions 48-633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO88575.
KOiK05048.
OMAiRPRSTEC.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPSAHAVS LPEDEELQPW GGAGGPGQHP GRPRSTECAH PGVVEKVRPK
60 70 80 90 100
WDNPLQFLLV CISYAVGLGN VWRFPYLCQM YGGGNFLVPY IIMLIVEGMP
110 120 130 140 150
LLYLELAVGQ RMRQGSIGAW RTISPYLSGV GIASLVVSFL ASVYFNVINT
160 170 180 190 200
WALWYLFHSF QDPLPWSVCP LNSNHTGYDE ECEKASSTQY FWYRKTLNIS
210 220 230 240 250
PSIQENGGVQ WEPALCLTLA WLMVYLCILR GTESTGKVVY FTTSLPYFVL
260 270 280 290 300
IIYLVRGLTL HGATNGLAYM FTPKIEQLAN PKAWINAATQ IFFSLGLGCG
310 320 330 340 350
GLIAFASYNE PSNDCQKHAL IVSVINSTTA IFSSIVTFSI YGFKATFNYE
360 370 380 390 400
NCLNKVILLL TNSFDLEDGF LTVSNLEEVK NYLASTYPNK YSEVFPHIRN
410 420 430 440 450
CSLESELDTA VQGTGLAFIV YTEAIKNMEV SQLWSVLYFF MLLTLGMGSM
460 470 480 490 500
VGTGTAILTP LTDSKIISSY LPKEAISGLV CLLNCAIGMV FTMEAGNYWF
510 520 530 540 550
DLFNDYTATL SLLLIVLVET IAVCYVYGLK RFESDLRAMT GRTLSWYWKV
560 570 580 590 600
MWAFVSPLLI VGLFIFYLSD YILTGTLQYQ AWDATQGHVV TKDYPTYALA
610 620 630
VIGLLVASST MCIPLVALGT FVTRHFKIRE QFSAA
Length:635
Mass (Da):70,687
Last modified:July 27, 2011 - v3
Checksum:i465AD54AA807EBE3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851N → S in AAC27756 (PubMed:9932288).Curated
Sequence conflicti85 – 851N → S in BAE25668 (PubMed:16141072).Curated
Sequence conflicti85 – 851N → S in BAE37885 (PubMed:16141072).Curated
Sequence conflicti85 – 851N → S in AAH13484 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075261 mRNA. Translation: AAC27756.1.
AK144038 mRNA. Translation: BAE25668.1.
AK164706 mRNA. Translation: BAE37885.1.
AC132852 Genomic DNA. No translation available.
BC013484 mRNA. Translation: AAH13484.1.
CCDSiCCDS23661.1.
RefSeqiNP_035861.2. NM_011731.3.
UniGeneiMm.41963.

Genome annotation databases

EnsembliENSMUST00000026273; ENSMUSP00000026273; ENSMUSG00000025243.
GeneIDi22599.
KEGGimmu:22599.
UCSCiuc009sgi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075261 mRNA. Translation: AAC27756.1.
AK144038 mRNA. Translation: BAE25668.1.
AK164706 mRNA. Translation: BAE37885.1.
AC132852 Genomic DNA. No translation available.
BC013484 mRNA. Translation: AAH13484.1.
CCDSiCCDS23661.1.
RefSeqiNP_035861.2. NM_011731.3.
UniGeneiMm.41963.

3D structure databases

ProteinModelPortaliO88575.
SMRiO88575. Positions 48-633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60422N.
STRINGi10090.ENSMUSP00000026273.

PTM databases

iPTMnetiO88575.

Proteomic databases

MaxQBiO88575.
PaxDbiO88575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026273; ENSMUSP00000026273; ENSMUSG00000025243.
GeneIDi22599.
KEGGimmu:22599.
UCSCiuc009sgi.2. mouse.

Organism-specific databases

CTDi22599.
MGIiMGI:1336891. Slc6a20b.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO88575.
KOiK05048.
OMAiRPRSTEC.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiO88575.
SOURCEiSearch...

Gene expression databases

BgeeiO88575.
ExpressionAtlasiO88575. baseline and differential.
GenevisibleiO88575. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms."
    Nash S.R., Giros B., Kingsmore S.F., Kim K.M., El-Mestikawy S., Dong Q., Fumagalli F., Seldin M.F., Caron M.G.
    Recept. Channels 6:113-128(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter."
    Kowalczuk S., Broeer A., Munzinger M., Tietze N., Klingel K., Broeer S.
    Biochem. J. 386:417-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus."
    Romeo E., Dave M.H., Bacic D., Ristic Z., Camargo S.M.R., Loffing J., Wagner C.A., Verrey F.
    Am. J. Physiol. 290:F376-F383(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiS620B_MOUSE
AccessioniPrimary (citable) accession number: O88575
Secondary accession number(s): E9QNK3, Q3TP52, Q91WT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.