Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase complex subunit SAP30

Gene

Sap30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri67 – 115AtypicalAdd BLAST49

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase complex subunit SAP30
Alternative name(s):
30 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP30
Sin3-associated polypeptide p30
Gene namesi
Name:Sap30Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1929129 Sap30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975831 – 220Histone deacetylase complex subunit SAP30Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei5PhosphothreonineBy similarity1
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei131PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei145PhosphothreonineBy similarity1
Cross-linki194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO88574
MaxQBiO88574
PaxDbiO88574
PeptideAtlasiO88574
PRIDEiO88574

PTM databases

iPTMnetiO88574
PhosphoSitePlusiO88574

Expressioni

Gene expression databases

BgeeiENSMUSG00000031609
GenevisibleiO88574 MM

Interactioni

Subunit structurei

Interacts with HCFC1 (By similarity). A component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with SIN3A, SIN3B, HDAC1, HDAC2, RBBP4 and NCOR1 (PubMed:9702189). Interacts directly with SAMSN1 (PubMed:20478393). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894).By similarity3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi208559, 4 interactors
CORUMiO88574
IntActiO88574, 7 interactors
MINTiO88574
STRINGi10090.ENSMUSP00000034022

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi135 – 138Combined sources4
Beta strandi151 – 153Combined sources3
Helixi155 – 164Combined sources10
Helixi175 – 186Combined sources12
Helixi193 – 206Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LD7NMR-A130-220[»]
ProteinModelPortaliO88574
SMRiO88574
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88574

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 129Interaction with NCOR11 PublicationAdd BLAST129
Regioni130 – 220Interaction with SIN3A1 PublicationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 59Ala-richSequence analysisAdd BLAST45

Sequence similaritiesi

Belongs to the SAP30 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri67 – 115AtypicalAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHMG Eukaryota
ENOG4111GVC LUCA
GeneTreeiENSGT00390000006633
HOGENOMiHOG000007811
HOVERGENiHBG057907
InParanoidiO88574
KOiK19202
OMAiKIDSGVH
OrthoDBiEOG091G0PSQ
PhylomeDBiO88574
TreeFamiTF324135

Family and domain databases

Gene3Di1.10.720.110, 1 hit
InterProiView protein in InterPro
IPR024145 His_deAcase_SAP30/SAP30L
IPR038291 SAP30_C_sf
IPR025718 SAP30_Sin3-bd
IPR025717 SAP30_zn-finger
PANTHERiPTHR13286 PTHR13286, 1 hit
PfamiView protein in Pfam
PF13867 SAP30_Sin3_bdg, 1 hit
PF13866 zf-SAP30, 1 hit

Sequencei

Sequence statusi: Complete.

O88574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGFTPEEMS RGGDAAAAVA AVVAAAAAAA SAGNGNAAGG GAEVPGAGAV
60 70 80 90 100
SASGPPGAAG PGPGQLCCLR EDGERCGRAA GNASFSKRIQ KSISQKKVKI
110 120 130 140 150
ELDKSARHLY ICDYHKNLIQ SVRNRRKRKG SDDDGGDSPV QDIDTPEVDL
160 170 180 190 200
YQLQVNTLRR YKRHFKLPTR PGLNKAQLVE IVGCHFKSIP VNEKDTLTCF
210 220
IYSVRNDKNK SDLKADSGVH
Length:220
Mass (Da):23,231
Last modified:November 1, 1998 - v1
Checksum:iA9D4CBDAB97BBD8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075136 mRNA Translation: AAC26007.1
AK010928 mRNA Translation: BAB27273.1
AK088745 mRNA Translation: BAC40543.1
CH466569 Genomic DNA Translation: EDL28616.1
BC132081 mRNA Translation: AAI32082.1
BC132087 mRNA Translation: AAI32088.1
AJ251216 Genomic DNA Translation: CAC24848.1
CCDSiCCDS22316.1
RefSeqiNP_068560.1, NM_021788.2
UniGeneiMm.118

Genome annotation databases

EnsembliENSMUST00000034022; ENSMUSP00000034022; ENSMUSG00000031609
GeneIDi60406
KEGGimmu:60406
UCSCiuc009lsu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSAP30_MOUSE
AccessioniPrimary (citable) accession number: O88574
Secondary accession number(s): A2RSE9, Q99JB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health