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Protein

AF4/FMR2 family member 1

Gene

Aff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
AF4/FMR2 family member 1
Alternative name(s):
Proto-oncogene AF4
Short name:
Protein AF-4
Gene namesi
Name:Aff1
Synonyms:Mllt2, Mllt2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1100819. Aff1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
  • transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12161216AF4/FMR2 family member 1PRO_0000215911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831PhosphoserineCombined sources
Modified residuei191 – 1911PhosphoserineCombined sources
Modified residuei197 – 1971PhosphoserineCombined sources
Modified residuei682 – 6821N6-acetyllysineBy similarity
Modified residuei755 – 7551PhosphoserineCombined sources
Modified residuei760 – 7601PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO88573.
PaxDbiO88573.
PRIDEiO88573.

PTM databases

iPTMnetiO88573.
PhosphoSiteiO88573.

Expressioni

Gene expression databases

CleanExiMM_AFF1.

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3).By similarity

Protein-protein interaction databases

IntActiO88573. 2 interactions.
MINTiMINT-1790645.
STRINGi10090.ENSMUSP00000031256.

Structurei

3D structure databases

ProteinModelPortaliO88573.
SMRiO88573. Positions 40-74, 743-800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi261 – 2666Poly-Pro
Compositional biasi467 – 47610Poly-Ser
Compositional biasi477 – 4837Poly-Glu
Compositional biasi840 – 8445Poly-Ser
Compositional biasi870 – 88011Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the AF4 family.Curated

Phylogenomic databases

eggNOGiENOG410IGJB. Eukaryota.
ENOG410XRXU. LUCA.
HOGENOMiHOG000246991.
HOVERGENiHBG004189.
InParanoidiO88573.

Family and domain databases

InterProiIPR007797. TF_AF4/FMR2.
[Graphical view]
PANTHERiPTHR10528. PTHR10528. 2 hits.
PfamiPF05110. AF-4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHSSLYNE DRNLLRIREK ERRNQEAHQE KEAFPEKAPL FPEPYKTAKG
60 70 80 90 100
DELSSRIQTM LGDYEEMKEF LSSKSHPHRL DGSEDRPGKP RYPLGHDRGN
110 120 130 140 150
GAASSSLRTH VYHQPIHTSA PGSRPVGNIS HSPKMAQPRM EPSLHTKIYD
160 170 180 190 200
GPRLTQDHLS QGHCSRKCDR RAEGDSAPER KLSPLISSLP SPVPPLSPVH
210 220 230 240 250
SRLQGTSKAH SSGVSSKSCC VAKSSKDLVA KAQDKETPHD GLVAVTSLGS
260 270 280 290 300
APPQPPCQTF PPPPLPSKSA AMQQKPTAYV RPMDGQDQAP SESPELKLPL
310 320 330 340 350
EDYGQQSFEK PDLKVPAKAK LTRLRMPSQS VEQPYSNEVH CVEEILKEMT
360 370 380 390 400
HSWPPPLTAI HTPSTAEPSR FPFPTKDPLH VSPATQSQKQ YDTPSKTHPN
410 420 430 440 450
PQQGTSMLED DLQLSDSEDS DTEQATEKPP SPPAPPSAPQ TLPEPVASAH
460 470 480 490 500
SSSGESESSE SDSSSDSESE SSSSDSEEEE ENEPLETRAP EPEPPTTNKW
510 520 530 540 550
QLDNWLTKVN QPSVPLDGRG STESPQWRQE SKGVAEGSSD QQHPDSKDPL
560 570 580 590 600
PKSSSKTLRG PSEGPSLGRG AVRNPPLNRN PHLGKPWAAN NPGNPPRLRP
610 620 630 640 650
GRAQASSQAE SEVGPLPYGS KEQTSKDRPK VKTKGRPRAV GSREPKPEVP
660 670 680 690 700
APTPQAAVPR PKPPVPTPSE KRKHKSSTAP SKAPSAPQPP KDSAGDRNPE
710 720 730 740 750
HSALVSLTQS QGPSHSSRGS SGSVRTSGCR QAVIAQGDGC KDKLLLPLRD
760 770 780 790 800
TKLLSPLRDS PPPTSLVVKI TLDLLTRIPQ PLGKGSRPRK AEDKQLSAGK
810 820 830 840 850
KQDSETKSCD SSSRVTKKRK VTQKKSTVTR DTNWISRRAS SSSSHTESSR
860 870 880 890 900
TKAPRSSSEN SRKEMLPPAS ASSVSSSSSS QKPSRPAQKR PRPDEDTCSQ
910 920 930 940 950
EPPRSASSTK SSSTDPPAPK HRKVQARGSE HKGSSGDAAN AANPFPVPSL
960 970 980 990 1000
PNGNAKPGKP QVKSDRQQAD FHMKEAKKLK CKAETMVDKA GKAFKYLEAV
1010 1020 1030 1040 1050
LSFIECGMAS ESESSAKSAY AVYSETIDLI RYVMSLKCFS DNTMPAQEKI
1060 1070 1080 1090 1100
FAVLCLRCQS LLNMAMFRCK KDTVMKYSRT LSEHFKSTSK VAQAPSPCTA
1110 1120 1130 1140 1150
RSTGVPSPLS PMPSPASSVG SQSSAGSSMG SVGVTATVST PVSIQNMTSS
1160 1170 1180 1190 1200
YVTITSHVLT AFSLWEQAEA LTRKNKEFFA QLSTKVRVLA LNSSLVDLVH
1210
YTRQGLQRLK QSPKGP
Length:1,216
Mass (Da):131,558
Last modified:October 3, 2012 - v2
Checksum:i4CCA54DBB4992E8B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti378 – 3781P → L in AAD08668 (PubMed:9880680).Curated
Sequence conflicti619 – 6191G → R in AAD08668 (PubMed:9880680).Curated
Sequence conflicti820 – 8201K → R in AAD08668 (PubMed:9880680).Curated
Sequence conflicti838 – 8381R → KT in AAD08668 (PubMed:9880680).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074266 mRNA. Translation: AAD08668.1.
AL713989 Genomic DNA. No translation available.
AL731554 Genomic DNA. No translation available.
PIRiT42625.
UniGeneiMm.6949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074266 mRNA. Translation: AAD08668.1.
AL713989 Genomic DNA. No translation available.
AL731554 Genomic DNA. No translation available.
PIRiT42625.
UniGeneiMm.6949.

3D structure databases

ProteinModelPortaliO88573.
SMRiO88573. Positions 40-74, 743-800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88573. 2 interactions.
MINTiMINT-1790645.
STRINGi10090.ENSMUSP00000031256.

PTM databases

iPTMnetiO88573.
PhosphoSiteiO88573.

Proteomic databases

MaxQBiO88573.
PaxDbiO88573.
PRIDEiO88573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1100819. Aff1.

Phylogenomic databases

eggNOGiENOG410IGJB. Eukaryota.
ENOG410XRXU. LUCA.
HOGENOMiHOG000246991.
HOVERGENiHBG004189.
InParanoidiO88573.

Miscellaneous databases

ChiTaRSiAff1. mouse.
PROiO88573.
SOURCEiSearch...

Gene expression databases

CleanExiMM_AFF1.

Family and domain databases

InterProiIPR007797. TF_AF4/FMR2.
[Graphical view]
PANTHERiPTHR10528. PTHR10528. 2 hits.
PfamiPF05110. AF-4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, expression and chromosomal localization of the murine AF-4 gene involved in human leukemia."
    Isnard P., Depetris D., Mattei M.-G., Ferrier P., Djabali M.
    Mamm. Genome 9:1065-1068(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-191; SER-197; SER-755 AND SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiAFF1_MOUSE
AccessioniPrimary (citable) accession number: O88573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: January 20, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.