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O88561

- S27A3_MOUSE

UniProt

O88561 - S27A3_MOUSE

Protein

Long-chain fatty acid transport protein 3

Gene

Slc27a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi269 – 28012AMPSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. fatty-acyl-CoA synthase activity Source: MGI
    2. long-chain fatty acid-CoA ligase activity Source: MGI
    3. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. acyl-CoA metabolic process Source: MGI
    2. long-chain fatty acid metabolic process Source: MGI

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.2.1.3. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain fatty acid transport protein 3 (EC:6.2.1.-)
    Short name:
    FATP-3
    Short name:
    Fatty acid transport protein 3
    Alternative name(s):
    Solute carrier family 27 member 3
    Gene namesi
    Name:Slc27a3
    Synonyms:Acsvl3, Fatp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1347358. Slc27a3.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Mitochondrion 1 Publication
    Note: Mitochondrial in MA-10 Leydig cell line and Neuro-2a neuroblastoma.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 667667Long-chain fatty acid transport protein 3PRO_0000193208Add
    BLAST

    Proteomic databases

    PaxDbiO88561.
    PRIDEiO88561.

    PTM databases

    PhosphoSiteiO88561.

    Expressioni

    Tissue specificityi

    Expressed at high levels in adrenal gland, testis and ovary. Expressed at lower levels in adult brain. Found in adrenal cortical cells, spermatocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and cerebellar Purkinje cells (at protein level).1 Publication

    Developmental stagei

    Expressed at higher levels in embryonic brain (embryonic days 12-14) than in newborn or adult.1 Publication

    Gene expression databases

    GenevestigatoriO88561.

    Structurei

    3D structure databases

    ProteinModelPortaliO88561.
    SMRiO88561. Positions 148-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000044189.
    HOVERGENiHBG005642.
    InParanoidiO88561.
    KOiK08772.
    PhylomeDBiO88561.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88561-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALLLLLPL LLLLPLLLKL DVWPQLRWLP ADLAFTVRAL RCKRALRARA    50
    LAAAAADPES SESGCSLAWR LAYLAREQPT HTFLIHGAQR FSYAEAERES 100
    NRIARAFLRA RGWTGGRRGS GRGSTEEGAR VAPPAGDAAA RGTTAPPLAP 150
    GATVALLLPA GPDFLWIWFG LAKAGLRTAF VPTALRRGPL LHCLRSCGAS 200
    ALVLATEFLE SLEPDLPALR AMGLHLWATG PETNVAGISN LLSEAADQVD 250
    EPVPGYLSAP QNIMDTCLYI FTSGTTGLPK AARISHLKVL QCQGFYHLCG 300
    VHQEDVIYLA LPLYHMSGSL LGIVGCLGIG ATVVLKPKFS ASQFWDDCQK 350
    HRVTVFQYIG ELCRYLVNQP PSKAECDHKV RLAVGSGLRP DTWERFLRRF 400
    GPLQILETYG MTEGNVATFN YTGRQGAVGR ASWLYKHIFP FSLIRYDVMT 450
    GEPIRNAQGH CMTTSPGEPG LLVAPVSQQS PFLGYAGAPE LAKDKLLKDV 500
    FWSGDVFFNT GDLLVCDEQG FLHFHDRTGD TIRWKGENVA TTEVAEVLET 550
    LDFLQEVNIY GVTVPGHEGR AGMAALALRP PQALNLVQLY SHVSENLPPY 600
    ARPRFLRLQE SLATTETFKQ QKVRMANEGF DPSVLSDPLY VLDQDIGAYL 650
    PLTPARYSAL LSGDLRI 667
    Length:667
    Mass (Da):72,965
    Last modified:November 22, 2005 - v2
    Checksum:i0F343D14952075E7
    GO
    Isoform 2 (identifier: O88561-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         437-528: HIFPFSLIRY...QGFLHFHDRT → VRDRVDRRTP...VGAEPRGSGK
         529-667: Missing.

    Show »
    Length:528
    Mass (Da):57,181
    Checksum:i910A0B14CC41CFB3
    GO

    Sequence cautioni

    The sequence AAH60052.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC36120.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti302 – 3021Missing in AAH60052. (PubMed:15489334)Curated
    Sequence conflicti376 – 3761C → F in AAC40187. (PubMed:16141072)Curated
    Sequence conflicti532 – 5321I → F(PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei437 – 52892HIFPF…FHDRT → VRDRVDRRTPGAEGGMARAG APGANDAVWLSLPAHLPLLL DSIRCHDRGAYSECPGALHD HISRFVLGGVQSWQTRLNLA PEVGAEPRGSGK in isoform 2. 1 PublicationVSP_016219Add
    BLAST
    Alternative sequencei529 – 667139Missing in isoform 2. 1 PublicationVSP_016220Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060052 mRNA. Translation: AAH60052.1. Different initiation.
    AK076014 mRNA. Translation: BAC36120.1. Different initiation.
    AF072758 mRNA. Translation: AAC40187.1.
    CCDSiCCDS17527.1. [O88561-1]
    RefSeqiNP_036118.2. NM_011988.2.
    UniGeneiMm.45519.

    Genome annotation databases

    GeneIDi26568.
    KEGGimmu:26568.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060052 mRNA. Translation: AAH60052.1 . Different initiation.
    AK076014 mRNA. Translation: BAC36120.1 . Different initiation.
    AF072758 mRNA. Translation: AAC40187.1 .
    CCDSi CCDS17527.1. [O88561-1 ]
    RefSeqi NP_036118.2. NM_011988.2.
    UniGenei Mm.45519.

    3D structure databases

    ProteinModelPortali O88561.
    SMRi O88561. Positions 148-628.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O88561.

    Proteomic databases

    PaxDbi O88561.
    PRIDEi O88561.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 26568.
    KEGGi mmu:26568.

    Organism-specific databases

    CTDi 11000.
    MGIi MGI:1347358. Slc27a3.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000044189.
    HOVERGENi HBG005642.
    InParanoidi O88561.
    KOi K08772.
    PhylomeDBi O88561.

    Enzyme and pathway databases

    BRENDAi 6.2.1.3. 3474.

    Miscellaneous databases

    NextBioi 304647.
    PROi O88561.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori O88561.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-667 (ISOFORM 1).
      Strain: C57BL/6J.
    3. "A family of fatty acid transporters conserved from mycobacterium to man."
      Hirsch D., Stahl A., Lodish H.F.
      Proc. Natl. Acad. Sci. U.S.A. 95:8625-8629(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-667 (ISOFORM 1).
    4. "Mouse very long-chain acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells."
      Pei Z., Fraisl P., Berger J., Jia Z., Forss-Petter S., Watkins P.A.
      J. Biol. Chem. 279:54454-54462(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS27A3_MOUSE
    AccessioniPrimary (citable) accession number: O88561
    Secondary accession number(s): Q6PAU1, Q8BK70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3