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O88561

- S27A3_MOUSE

UniProt

O88561 - S27A3_MOUSE

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Protein

Long-chain fatty acid transport protein 3

Gene

Slc27a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi269 – 28012AMPSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. fatty-acyl-CoA synthase activity Source: MGI
  2. long-chain fatty acid-CoA ligase activity Source: MGI
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. acyl-CoA metabolic process Source: MGI
  2. long-chain fatty acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 3 (EC:6.2.1.-)
Short name:
FATP-3
Short name:
Fatty acid transport protein 3
Alternative name(s):
Solute carrier family 27 member 3
Gene namesi
Name:Slc27a3
Synonyms:Acsvl3, Fatp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1347358. Slc27a3.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Mitochondrion 1 Publication
Note: Mitochondrial in MA-10 Leydig cell line and Neuro-2a neuroblastoma.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Long-chain fatty acid transport protein 3PRO_0000193208Add
BLAST

Proteomic databases

MaxQBiO88561.
PaxDbiO88561.
PRIDEiO88561.

PTM databases

PhosphoSiteiO88561.

Expressioni

Tissue specificityi

Expressed at high levels in adrenal gland, testis and ovary. Expressed at lower levels in adult brain. Found in adrenal cortical cells, spermatocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and cerebellar Purkinje cells (at protein level).1 Publication

Developmental stagei

Expressed at higher levels in embryonic brain (embryonic days 12-14) than in newborn or adult.1 Publication

Gene expression databases

GenevestigatoriO88561.

Structurei

3D structure databases

ProteinModelPortaliO88561.
SMRiO88561. Positions 148-628.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiO88561.
KOiK08772.
PhylomeDBiO88561.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88561-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALLLLLPL LLLLPLLLKL DVWPQLRWLP ADLAFTVRAL RCKRALRARA
60 70 80 90 100
LAAAAADPES SESGCSLAWR LAYLAREQPT HTFLIHGAQR FSYAEAERES
110 120 130 140 150
NRIARAFLRA RGWTGGRRGS GRGSTEEGAR VAPPAGDAAA RGTTAPPLAP
160 170 180 190 200
GATVALLLPA GPDFLWIWFG LAKAGLRTAF VPTALRRGPL LHCLRSCGAS
210 220 230 240 250
ALVLATEFLE SLEPDLPALR AMGLHLWATG PETNVAGISN LLSEAADQVD
260 270 280 290 300
EPVPGYLSAP QNIMDTCLYI FTSGTTGLPK AARISHLKVL QCQGFYHLCG
310 320 330 340 350
VHQEDVIYLA LPLYHMSGSL LGIVGCLGIG ATVVLKPKFS ASQFWDDCQK
360 370 380 390 400
HRVTVFQYIG ELCRYLVNQP PSKAECDHKV RLAVGSGLRP DTWERFLRRF
410 420 430 440 450
GPLQILETYG MTEGNVATFN YTGRQGAVGR ASWLYKHIFP FSLIRYDVMT
460 470 480 490 500
GEPIRNAQGH CMTTSPGEPG LLVAPVSQQS PFLGYAGAPE LAKDKLLKDV
510 520 530 540 550
FWSGDVFFNT GDLLVCDEQG FLHFHDRTGD TIRWKGENVA TTEVAEVLET
560 570 580 590 600
LDFLQEVNIY GVTVPGHEGR AGMAALALRP PQALNLVQLY SHVSENLPPY
610 620 630 640 650
ARPRFLRLQE SLATTETFKQ QKVRMANEGF DPSVLSDPLY VLDQDIGAYL
660
PLTPARYSAL LSGDLRI
Length:667
Mass (Da):72,965
Last modified:November 22, 2005 - v2
Checksum:i0F343D14952075E7
GO
Isoform 2 (identifier: O88561-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-528: HIFPFSLIRY...QGFLHFHDRT → VRDRVDRRTP...VGAEPRGSGK
     529-667: Missing.

Show »
Length:528
Mass (Da):57,181
Checksum:i910A0B14CC41CFB3
GO

Sequence cautioni

The sequence AAH60052.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC36120.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3021Missing in AAH60052. (PubMed:15489334)Curated
Sequence conflicti376 – 3761C → F in AAC40187. (PubMed:16141072)Curated
Sequence conflicti532 – 5321I → F(PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei437 – 52892HIFPF…FHDRT → VRDRVDRRTPGAEGGMARAG APGANDAVWLSLPAHLPLLL DSIRCHDRGAYSECPGALHD HISRFVLGGVQSWQTRLNLA PEVGAEPRGSGK in isoform 2. 1 PublicationVSP_016219Add
BLAST
Alternative sequencei529 – 667139Missing in isoform 2. 1 PublicationVSP_016220Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060052 mRNA. Translation: AAH60052.1. Different initiation.
AK076014 mRNA. Translation: BAC36120.1. Different initiation.
AF072758 mRNA. Translation: AAC40187.1.
CCDSiCCDS17527.1. [O88561-1]
RefSeqiNP_036118.2. NM_011988.2.
UniGeneiMm.45519.

Genome annotation databases

GeneIDi26568.
KEGGimmu:26568.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060052 mRNA. Translation: AAH60052.1 . Different initiation.
AK076014 mRNA. Translation: BAC36120.1 . Different initiation.
AF072758 mRNA. Translation: AAC40187.1 .
CCDSi CCDS17527.1. [O88561-1 ]
RefSeqi NP_036118.2. NM_011988.2.
UniGenei Mm.45519.

3D structure databases

ProteinModelPortali O88561.
SMRi O88561. Positions 148-628.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O88561.

Proteomic databases

MaxQBi O88561.
PaxDbi O88561.
PRIDEi O88561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 26568.
KEGGi mmu:26568.

Organism-specific databases

CTDi 11000.
MGIi MGI:1347358. Slc27a3.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000044189.
HOVERGENi HBG005642.
InParanoidi O88561.
KOi K08772.
PhylomeDBi O88561.

Enzyme and pathway databases

BRENDAi 6.2.1.3. 3474.

Miscellaneous databases

NextBioi 304647.
PROi O88561.
SOURCEi Search...

Gene expression databases

Genevestigatori O88561.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-667 (ISOFORM 1).
    Strain: C57BL/6J.
  3. "A family of fatty acid transporters conserved from mycobacterium to man."
    Hirsch D., Stahl A., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 95:8625-8629(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-667 (ISOFORM 1).
  4. "Mouse very long-chain acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells."
    Pei Z., Fraisl P., Berger J., Jia Z., Forss-Petter S., Watkins P.A.
    J. Biol. Chem. 279:54454-54462(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS27A3_MOUSE
AccessioniPrimary (citable) accession number: O88561
Secondary accession number(s): Q6PAU1, Q8BK70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3