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O88561 (S27A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain fatty acid transport protein 3

Short name=FATP-3
Short name=Fatty acid transport protein 3
EC=6.2.1.-
Alternative name(s):
Solute carrier family 27 member 3
Gene names
Name:Slc27a3
Synonyms:Acsvl3, Fatp3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein Potential. Mitochondrion. Note: Mitochondrial in MA-10 Leydig cell line and Neuro-2a neuroblastoma. Ref.4

Tissue specificity

Expressed at high levels in adrenal gland, testis and ovary. Expressed at lower levels in adult brain. Found in adrenal cortical cells, spermatocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and cerebellar Purkinje cells (at protein level). Ref.4

Developmental stage

Expressed at higher levels in embryonic brain (embryonic days 12-14) than in newborn or adult. Ref.4

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence caution

The sequence AAH60052.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC36120.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O88561-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O88561-2)

The sequence of this isoform differs from the canonical sequence as follows:
     437-528: HIFPFSLIRY...QGFLHFHDRT → VRDRVDRRTP...VGAEPRGSGK
     529-667: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 667667Long-chain fatty acid transport protein 3
PRO_0000193208

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane315 – 33521Helical; Potential
Nucleotide binding269 – 28012AMP Potential

Natural variations

Alternative sequence437 – 52892HIFPF…FHDRT → VRDRVDRRTPGAEGGMARAG APGANDAVWLSLPAHLPLLL DSIRCHDRGAYSECPGALHD HISRFVLGGVQSWQTRLNLA PEVGAEPRGSGK in isoform 2.
VSP_016219
Alternative sequence529 – 667139Missing in isoform 2.
VSP_016220

Experimental info

Sequence conflict3021Missing in AAH60052. Ref.1
Sequence conflict3761C → F in AAC40187. Ref.2
Sequence conflict5321I → F Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: 0F343D14952075E7

FASTA66772,965
        10         20         30         40         50         60 
MAALLLLLPL LLLLPLLLKL DVWPQLRWLP ADLAFTVRAL RCKRALRARA LAAAAADPES 

        70         80         90        100        110        120 
SESGCSLAWR LAYLAREQPT HTFLIHGAQR FSYAEAERES NRIARAFLRA RGWTGGRRGS 

       130        140        150        160        170        180 
GRGSTEEGAR VAPPAGDAAA RGTTAPPLAP GATVALLLPA GPDFLWIWFG LAKAGLRTAF 

       190        200        210        220        230        240 
VPTALRRGPL LHCLRSCGAS ALVLATEFLE SLEPDLPALR AMGLHLWATG PETNVAGISN 

       250        260        270        280        290        300 
LLSEAADQVD EPVPGYLSAP QNIMDTCLYI FTSGTTGLPK AARISHLKVL QCQGFYHLCG 

       310        320        330        340        350        360 
VHQEDVIYLA LPLYHMSGSL LGIVGCLGIG ATVVLKPKFS ASQFWDDCQK HRVTVFQYIG 

       370        380        390        400        410        420 
ELCRYLVNQP PSKAECDHKV RLAVGSGLRP DTWERFLRRF GPLQILETYG MTEGNVATFN 

       430        440        450        460        470        480 
YTGRQGAVGR ASWLYKHIFP FSLIRYDVMT GEPIRNAQGH CMTTSPGEPG LLVAPVSQQS 

       490        500        510        520        530        540 
PFLGYAGAPE LAKDKLLKDV FWSGDVFFNT GDLLVCDEQG FLHFHDRTGD TIRWKGENVA 

       550        560        570        580        590        600 
TTEVAEVLET LDFLQEVNIY GVTVPGHEGR AGMAALALRP PQALNLVQLY SHVSENLPPY 

       610        620        630        640        650        660 
ARPRFLRLQE SLATTETFKQ QKVRMANEGF DPSVLSDPLY VLDQDIGAYL PLTPARYSAL 


LSGDLRI 

« Hide

Isoform 2 [UniParc].

Checksum: 910A0B14CC41CFB3
Show »

FASTA52857,181

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-667 (ISOFORM 1).
Strain: C57BL/6J.
[3]"A family of fatty acid transporters conserved from mycobacterium to man."
Hirsch D., Stahl A., Lodish H.F.
Proc. Natl. Acad. Sci. U.S.A. 95:8625-8629(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-667 (ISOFORM 1).
[4]"Mouse very long-chain acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells."
Pei Z., Fraisl P., Berger J., Jia Z., Forss-Petter S., Watkins P.A.
J. Biol. Chem. 279:54454-54462(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC060052 mRNA. Translation: AAH60052.1. Different initiation.
AK076014 mRNA. Translation: BAC36120.1. Different initiation.
AF072758 mRNA. Translation: AAC40187.1.
CCDSCCDS17527.1. [O88561-1]
RefSeqNP_036118.2. NM_011988.2.
UniGeneMm.45519.

3D structure databases

ProteinModelPortalO88561.
SMRO88561. Positions 148-628.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO88561.

Proteomic databases

PaxDbO88561.
PRIDEO88561.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID26568.
KEGGmmu:26568.

Organism-specific databases

CTD11000.
MGIMGI:1347358. Slc27a3.

Phylogenomic databases

eggNOGCOG0318.
HOGENOMHOG000044189.
HOVERGENHBG005642.
InParanoidO88561.
KOK08772.
PhylomeDBO88561.

Enzyme and pathway databases

BRENDA6.2.1.3. 3474.

Gene expression databases

GenevestigatorO88561.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304647.
PROO88561.
SOURCESearch...

Entry information

Entry nameS27A3_MOUSE
AccessionPrimary (citable) accession number: O88561
Secondary accession number(s): Q6PAU1, Q8BK70
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot