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Protein

Zinc finger protein 37

Gene

Zfp37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30319C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33724C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri570 – 59223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: RGD
  • cell proliferation Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 37
Short name:
Zfp-37
Gene namesi
Name:Zfp37
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620723. Zfp37.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Zinc finger protein 37PRO_0000047295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31PhosphothreonineCombined sources
Modified residuei9 – 91PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO88553.

PTM databases

iPTMnetiO88553.

Expressioni

Tissue specificityi

Expressed in testes, brain, kidney, spleen, thymus, lung, and at low levels in liver.

Structurei

3D structure databases

ProteinModelPortaliO88553.
SMRiO88553. Positions 341-592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7070KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30319C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33724C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri570 – 59223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO88553.
PhylomeDBiO88553.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPEPAESD AEWEQLEPGQ RNLYKDTKLE TCSNPASMGN QDPKQGLVSK
60 70 80 90 100
LDGEEERWSS VRANKNSSSS LHRLKKTGTS AKVQQDGAQT EGKQKFQRKL
110 120 130 140 150
TSEVTFRKKS SNSKKSSECT LLEKKNVHSK HDPSEKRLHK SNLYGKNLNQ
160 170 180 190 200
NLDLPSQIKI SAKKKPDTAN EYRKSLSHSA SDVNRDEIST RKKCDKSPNN
210 220 230 240 250
KLFGKGDKNQ TGKKCEKVCR HTASHTKEDK IHTGEKRKSP CRSPSKSDKA
260 270 280 290 300
PGSGKPYECN QCGKVLSHKQ GLLDHQRTHA GEEPYECYEC GIAFSQKSHL
310 320 330 340 350
VVHQKTPTGE KAPYECVQCG KAHGHKHALT DHLRISHTGE KPYKCNECGK
360 370 380 390 400
TFRHSSNLMQ HIRSHTGEKP YECKECGKSF RYNSSFTEHV RTHTGEIPYE
410 420 430 440 450
CNECGKAFKY GSSLTKHMRI HTGEKPFECT ECGKTFSKKS HLVIHQRTHT
460 470 480 490 500
KEKPYKCKEC GKAFGHSSSL TYHMRTHTGD CPFECNKCGK AFKQIEGLTQ
510 520 530 540 550
HQRVHTGEKP YECVECGKAF SQKSHLIVHQ RTHTGEKPFE CYECGKAFNA
560 570 580 590 600
KSQLVIHQRS HTGEKPYKPY ECVECGKAFK QNASLTRHMK THSEEQSQEE

D
Length:601
Mass (Da):68,098
Last modified:November 1, 1998 - v1
Checksum:i1CFCB55B595B7C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072439 mRNA. Translation: AAC24590.1.
UniGeneiRn.29978.

Genome annotation databases

UCSCiRGD:620723. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072439 mRNA. Translation: AAC24590.1.
UniGeneiRn.29978.

3D structure databases

ProteinModelPortaliO88553.
SMRiO88553. Positions 341-592.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO88553.

Proteomic databases

PRIDEiO88553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620723. rat.

Organism-specific databases

RGDi620723. Zfp37.

Phylogenomic databases

HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO88553.
PhylomeDBiO88553.

Miscellaneous databases

PROiO88553.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37."
    Vanden Heuvel J.P., Holden P., Tugwood J., Ingle C., Yen W., Galjart N., Greenlee W.F.
    Toxicol. Appl. Pharmacol. 152:107-118(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3 AND SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZFP37_RAT
AccessioniPrimary (citable) accession number: O88553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: February 17, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.