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Protein

Claudin-1

Gene

Cldn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.3 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: InterPro
  • virus receptor activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-1
Gene namesi
Name:Cldn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1276109 Cldn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicBy similarity7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 115CytoplasmicSequence analysisAdd BLAST13
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 163ExtracellularSequence analysisAdd BLAST27
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 211CytoplasmicBy similarityAdd BLAST27

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Disruption phenotypei

Complete perinatal lethality. Mice are born at the expected Mendelian rate, but die within one day after birth, due to severe defects in the skin barrier function, leading to rapid transepidermal water loss and dehydration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447301 – 211Claudin-1Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO88551
PRIDEiO88551

PTM databases

iPTMnetiO88551
PhosphoSitePlusiO88551

Miscellaneous databases

PMAP-CutDBiO88551

Expressioni

Tissue specificityi

Detected in epidermis and liver (at protein level). Widely expressed, with highest levels in liver and kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000022512
CleanExiMM_CLDN1
ExpressionAtlasiO88551 baseline and differential
GenevisibleiO88551 MM

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and PATJ. Interacts with OCLN, CD81, CLDN4, CLDN6 and CLDN9 (By similarity).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MpdzQ8VBX62EBI-7158428,EBI-8026435

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198743, 2 interactors
IntActiO88551, 2 interactors
MINTiO88551
STRINGi10090.ENSMUSP00000023154

Structurei

3D structure databases

ProteinModelPortaliO88551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 211Interactions with TJP1, TJP2, TJP3 and PATJ2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG63 Eukaryota
ENOG4111GMP LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiO88551
KOiK06087
OMAiIYEGLWM
OrthoDBiEOG091G0MX2
PhylomeDBiO88551
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003548 Claudin1
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF92 PTHR12002:SF92, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01377 CLAUDIN1
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

O88551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANAGLQLLG FILASLGWIG SIVSTALPQW KIYSYAGDNI VTAQAIYEGL
60 70 80 90 100
WMSCVSQSTG QIQCKVFDSL LNLNSTLQAT RALMVIGILL GLIAIFVSTI
110 120 130 140 150
GMKCMRCLED DEVQKMWMAV IGGIIFLISG LATLVATAWY GNRIVQEFYD
160 170 180 190 200
PLTPINARYE FGQALFTGWA AASLCLLGGV LLSCSCPRKT TSYPTPRPYP
210
KPTPSSGKDY V
Length:211
Mass (Da):22,881
Last modified:November 1, 1998 - v1
Checksum:iBEF896FA62DBB6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072127 mRNA Translation: AAC27078.1
AK028428 mRNA Translation: BAC25945.1
AK036762 mRNA Translation: BAC29567.1
AK036780 mRNA Translation: BAC29574.1
AK040604 mRNA Translation: BAC30640.1
AK054207 mRNA Translation: BAC35693.1
AK081601 mRNA Translation: BAC38267.1
BC002003 mRNA Translation: AAH02003.1
CCDSiCCDS28087.1
RefSeqiNP_057883.1, NM_016674.4
UniGeneiMm.289441

Genome annotation databases

EnsembliENSMUST00000023154; ENSMUSP00000023154; ENSMUSG00000022512
GeneIDi12737
KEGGimmu:12737
UCSCiuc007yuz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCLD1_MOUSE
AccessioniPrimary (citable) accession number: O88551
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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