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O88551 (CLD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-1
Gene names
Name:Cldn1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Ref.4

Subunit structure

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Widely expressed, with highest levels in liver and kidney. Ref.1

Sequence similarities

Belongs to the claudin family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MpdzQ8VBX62EBI-7158428,EBI-8026435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Claudin-1
PRO_0000144730

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Potential
Topological domain29 – 8153Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11513Cytoplasmic Potential
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 16327Extracellular Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 21127Cytoplasmic Potential
Region210 – 2112Interactions with TJP1, TJP2, TJP3 and INADL

Sequences

Sequence LengthMass (Da)Tools
O88551 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: BEF896FA62DBB6F0

FASTA21122,881
        10         20         30         40         50         60 
MANAGLQLLG FILASLGWIG SIVSTALPQW KIYSYAGDNI VTAQAIYEGL WMSCVSQSTG 

        70         80         90        100        110        120 
QIQCKVFDSL LNLNSTLQAT RALMVIGILL GLIAIFVSTI GMKCMRCLED DEVQKMWMAV 

       130        140        150        160        170        180 
IGGIIFLISG LATLVATAWY GNRIVQEFYD PLTPINARYE FGQALFTGWA AASLCLLGGV 

       190        200        210 
LLSCSCPRKT TSYPTPRPYP KPTPSSGKDY V 

« Hide

References

« Hide 'large scale' references
[1]"Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin."
Furuse M., Fujita K., Hiiragi T., Fujimoto K., Tsukita S.
J. Cell Biol. 141:1539-1550(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic head, Liver, Oviduct, Thymus and Vagina.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[4]"Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions."
Kubota K., Furuse M., Sasaki H., Sonoda N., Fujita K., Nagafuchi A., Tsukita S.
Curr. Biol. 9:1035-1038(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Manner of interaction of heterogeneous claudin species within and between tight junction strands."
Furuse M., Sasaki H., Tsukita S.
J. Cell Biol. 147:891-903(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLDN2 AND CLDN3.
[6]"Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."
Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.
J. Cell Biol. 147:1351-1363(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TJP1; TJP2 AND TJP3.
[7]"Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions."
Itoh M., Sasaki H., Furuse M., Ozaki H., Kita T., Tsukita S.
J. Cell Biol. 154:491-497(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MPDZ.
[8]"The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions."
Roh M.H., Liu C.-J., Laurinec S., Margolis B.
J. Biol. Chem. 277:27501-27509(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INADL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF072127 mRNA. Translation: AAC27078.1.
AK028428 mRNA. Translation: BAC25945.1.
AK036762 mRNA. Translation: BAC29567.1.
AK036780 mRNA. Translation: BAC29574.1.
AK040604 mRNA. Translation: BAC30640.1.
AK054207 mRNA. Translation: BAC35693.1.
AK081601 mRNA. Translation: BAC38267.1.
BC002003 mRNA. Translation: AAH02003.1.
RefSeqNP_057883.1. NM_016674.4.
UniGeneMm.289441.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198743. 3 interactions.
IntActO88551. 2 interactions.
MINTMINT-113174.
STRING10090.ENSMUSP00000023154.

PTM databases

PhosphoSiteO88551.

Proteomic databases

PaxDbO88551.
PRIDEO88551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023154; ENSMUSP00000023154; ENSMUSG00000022512.
GeneID12737.
KEGGmmu:12737.
UCSCuc007yuz.2. mouse.

Organism-specific databases

CTD9076.
MGIMGI:1276109. Cldn1.

Phylogenomic databases

eggNOGNOG47316.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidO88551.
KOK06087.
OMAIYEGLWM.
OrthoDBEOG76HQ2T.
TreeFamTF331936.

Gene expression databases

ArrayExpressO88551.
BgeeO88551.
CleanExMM_CLDN1.
GenevestigatorO88551.

Family and domain databases

InterProIPR006187. Claudin.
IPR003548. Claudin1.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF29. PTHR12002:SF29. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01377. CLAUDIN1.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282042.
PMAP-CutDBO88551.
PROO88551.
SOURCESearch...

Entry information

Entry nameCLD1_MOUSE
AccessionPrimary (citable) accession number: O88551
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 19, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot