Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Caspase 7, isoform CRA_c

Gene

Casp7

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-111459. Activation of caspases through apoptosome-mediated cleavage.
R-RNO-111465. Apoptotic cleavage of cellular proteins.
R-RNO-264870. Caspase-mediated cleavage of cytoskeletal proteins.

Protein family/group databases

MEROPSiC14.004.

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 7, isoform CRA_cImported
Submitted name:
Caspase-7Imported
Gene namesi
Name:Casp7Imported
ORF Names:rCG_57538Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620944. Casp7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000056216.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022693.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 190CASPASE_P20InterPro annotationAdd BLAST125
Domaini209 – 303CASPASE_P10InterPro annotationAdd BLAST95

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
KOiK04397.
OMAiSGSWFVQ.
OrthoDBiEOG091G05YD.
TreeFamiTF102023.

Family and domain databases

CDDicd00032. CASc. 1 hit.
InterProiView protein in InterPro
IPR029030. Caspase-like_dom_sf.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00115. CASc. 1 hit.
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.

Sequencei

Sequence statusi: Complete.

O88550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDQDCAAE LEMADSSTED GVDAKPDRST IISSLLWKKK KNASMCPVST
60 70 80 90 100
TRDRVPTYLY RMDFEKMGKC IIINNKNFDK ATGMDVRNGT DKDAEALFKC
110 120 130 140 150
FRSLGFEVTV YNDCSCAKMQ DLLRRASEED HSNSACFACV LLSHGEENLI
160 170 180 190 200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG
210 220 230 240 250
PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRNPGKGSW FVQALCSILN
260 270 280 290 300
EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP RFNEKKQIPC MVSMLTKELY

FGR
Length:303
Mass (Da):34,324
Last modified:November 1, 1998 - v1
Checksum:iA71728754BF199DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07007019 Genomic DNA. No translation available.
AABR07007020 Genomic DNA. No translation available.
AABR07007021 Genomic DNA. No translation available.
AF072124 mRNA. Translation: AAC24011.1.
BC070936 mRNA. Translation: AAH70936.1.
CH473986 Genomic DNA. Translation: EDL94495.1.
RefSeqiNP_071596.1. NM_022260.3.
XP_008758768.1. XM_008760546.2.
UniGeneiRn.53995.

Genome annotation databases

EnsembliENSRNOT00000080511; ENSRNOP00000075193; ENSRNOG00000056216.
GeneIDi64026.
KEGGirno:64026.
UCSCiRGD:620944. rat.

Similar proteinsi

Entry informationi

Entry nameiO88550_RAT
AccessioniPrimary (citable) accession number: O88550
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported