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Protein
Submitted name:

Caspase 7, isoform CRA_c

Gene

Casp7

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • apoptotic process Source: RGD
  • execution phase of apoptosis Source: Ensembl
  • heart development Source: Ensembl
  • neuron apoptotic process Source: Ensembl
  • protein processing Source: Ensembl
  • proteolysis Source: RGD
  • response to UV Source: Ensembl

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-111459 Activation of caspases through apoptosome-mediated cleavage
R-RNO-111463 SMAC binds to IAPs
R-RNO-111464 SMAC-mediated dissociation of IAP:caspase complexes
R-RNO-111465 Apoptotic cleavage of cellular proteins
R-RNO-264870 Caspase-mediated cleavage of cytoskeletal proteins

Protein family/group databases

MEROPSiC14.004

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 7, isoform CRA_cImported
Submitted name:
Caspase-7Imported
Gene namesi
Name:Casp7Imported
ORF Names:rCG_57538Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620944 Casp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiO88550

Expressioni

Gene expression databases

BgeeiENSRNOG00000056216

Interactioni

Protein-protein interaction databases

IntActiO88550, 1 interactor
STRINGi10116.ENSRNOP00000022693

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 190CASPASE_P20InterPro annotationAdd BLAST125
Domaini209 – 303CASPASE_P10InterPro annotationAdd BLAST95

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912
HOGENOMiHOG000231878
HOVERGENiHBG050802
KOiK04397
OMAiSGSWFVQ
OrthoDBiEOG091G05YD
TreeFamiTF102023

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

O88550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDQDCAAE LEMADSSTED GVDAKPDRST IISSLLWKKK KNASMCPVST
60 70 80 90 100
TRDRVPTYLY RMDFEKMGKC IIINNKNFDK ATGMDVRNGT DKDAEALFKC
110 120 130 140 150
FRSLGFEVTV YNDCSCAKMQ DLLRRASEED HSNSACFACV LLSHGEENLI
160 170 180 190 200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG
210 220 230 240 250
PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRNPGKGSW FVQALCSILN
260 270 280 290 300
EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP RFNEKKQIPC MVSMLTKELY

FGR
Length:303
Mass (Da):34,324
Last modified:November 1, 1998 - v1
Checksum:iA71728754BF199DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07007019 Genomic DNA No translation available.
AABR07007020 Genomic DNA No translation available.
AABR07007021 Genomic DNA No translation available.
AF072124 mRNA Translation: AAC24011.1
BC070936 mRNA Translation: AAH70936.1
CH473986 Genomic DNA Translation: EDL94495.1
RefSeqiNP_071596.1, NM_022260.3
XP_008758768.1, XM_008760546.2
UniGeneiRn.53995

Genome annotation databases

EnsembliENSRNOT00000080511; ENSRNOP00000075193; ENSRNOG00000056216
GeneIDi64026
KEGGirno:64026
UCSCiRGD:620944 rat

Similar proteinsi

Entry informationi

Entry nameiO88550_RAT
AccessioniPrimary (citable) accession number: O88550
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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