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Protein

COP9 signalosome complex subunit 6

Gene

Cops6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity).By similarity

Caution

Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity.Curated

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Protein family/group databases

MEROPSiM67.972

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 6
Short name:
SGN6
Short name:
Signalosome subunit 6
Alternative name(s):
JAB1-containing signalosome subunit 6
Gene namesi
Name:Cops6
Synonyms:Csn6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1349439 Cops6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948611 – 324COP9 signalosome complex subunit 6Add BLAST324

Proteomic databases

EPDiO88545
PaxDbiO88545
PRIDEiO88545

PTM databases

iPTMnetiO88545
PhosphoSitePlusiO88545

Expressioni

Gene expression databases

BgeeiENSMUSG00000019494
ExpressionAtlasiO88545 baseline and differential
GenevisibleiO88545 MM

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS2, COPS4, COPS5, COPS7 (COPS7A or COPS7B) and COPS9. Interacts with the translation initiation factor EIF3S6. Interacts weakly with RBX1. Directly interacts with COP1 and 14-3-3 protein sigma/SFN (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi205044, 14 interactors
CORUMiO88545
IntActiO88545, 2 interactors
MINTiO88545
STRINGi10090.ENSMUSP00000019638

Structurei

3D structure databases

ProteinModelPortaliO88545
SMRiO88545
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 171MPNPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the peptidase M67A family. CSN6 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3050 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00530000063075
HOGENOMiHOG000253002
HOVERGENiHBG107770
InParanoidiO88545
KOiK12179
OMAiQQNGREI
OrthoDBiEOG091G0AZ5
PhylomeDBiO88545
TreeFamiTF101148

Family and domain databases

CDDicd08063 MPN_CSN6, 1 hit
InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR033859 MPN_CSN6
IPR024969 Rpn11/EIF3F_C
PANTHERiPTHR10540:SF8 PTHR10540:SF8, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

O88545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGAN GSGGSSGMEV DAAVPSVMAS GVTGSVSVAL HPLVILNISD
60 70 80 90 100
HWIRMRSQEG RPMQVIGALI GKQEGRNIEV MNSFELLSHT VEEKIIIDKE
110 120 130 140 150
YYYTKEEQFK QVFKELEFLG WYTTGGPPDP SDIHVHKQVC EIIESPLFLK
160 170 180 190 200
LNPMTKHTDL PVSVFESVID IINGEATMLF AELTYTLATE EAERIGVDHV
210 220 230 240 250
ARMTATGSGE NSTVAEHLIA QHSAIKMLHS RVKLILEYVK ASEAGEVPFN
260 270 280 290 300
HEILREAYAL CHCLPVLSTD KFKTDFYDQC NDVGLMAYLG TITKTCNTMN
310 320
QFVNKFNVLY DRQGIGRRMR GLFF
Length:324
Mass (Da):35,880
Last modified:November 1, 1998 - v1
Checksum:i8F8B7EC5DF67C721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071315 mRNA Translation: AAC33902.1
BC004664 mRNA Translation: AAH04664.1
BC014286 mRNA Translation: AAH14286.1
CCDSiCCDS19792.1
RefSeqiNP_036132.1, NM_012002.3
UniGeneiMm.3981

Genome annotation databases

EnsembliENSMUST00000019638; ENSMUSP00000019638; ENSMUSG00000019494
GeneIDi26893
KEGGimmu:26893
UCSCiuc009aer.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCSN6_MOUSE
AccessioniPrimary (citable) accession number: O88545
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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