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Protein

COP9 signalosome complex subunit 6

Gene

Cops6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets, including SFN (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.

Protein family/group databases

MEROPSiM67.972.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 6
Short name:
SGN6
Short name:
Signalosome subunit 6
Alternative name(s):
JAB1-containing signalosome subunit 6
Gene namesi
Name:Cops6
Synonyms:Csn6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1349439. Cops6.

Subcellular locationi

GO - Cellular componenti

  • COP9 signalosome Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324COP9 signalosome complex subunit 6PRO_0000194861Add
BLAST

Proteomic databases

EPDiO88545.
PaxDbiO88545.
PRIDEiO88545.

PTM databases

iPTMnetiO88545.
PhosphoSiteiO88545.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019494.
ExpressionAtlasiO88545. baseline and differential.
GenevisibleiO88545. MM.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS4, COPS5 and COPS7 (COPS7A or COPS7B). Interacts with the translation initiation factor EIF3S6. Interacts weakly with RBX1 (By similarity). Directly interacts with RFWD2 and 14-3-3 protein sigma/SFN (By similarity).By similarity

Protein-protein interaction databases

BioGridi205044. 12 interactions.
IntActiO88545. 2 interactions.
MINTiMINT-4092182.
STRINGi10090.ENSMUSP00000019638.

Structurei

3D structure databases

ProteinModelPortaliO88545.
SMRiO88545. Positions 26-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 145110MPNAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M67A family. CSN6 subfamily.Curated
Contains 1 MPN (JAB/Mov34) domain.Curated

Phylogenomic databases

eggNOGiKOG3050. Eukaryota.
COG1310. LUCA.
HOGENOMiHOG000253002.
HOVERGENiHBG107770.
InParanoidiO88545.
KOiK12179.
OMAiDFLGWYT.
OrthoDBiEOG091G0AZ5.
PhylomeDBiO88545.
TreeFamiTF101148.

Family and domain databases

InterProiIPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGAN GSGGSSGMEV DAAVPSVMAS GVTGSVSVAL HPLVILNISD
60 70 80 90 100
HWIRMRSQEG RPMQVIGALI GKQEGRNIEV MNSFELLSHT VEEKIIIDKE
110 120 130 140 150
YYYTKEEQFK QVFKELEFLG WYTTGGPPDP SDIHVHKQVC EIIESPLFLK
160 170 180 190 200
LNPMTKHTDL PVSVFESVID IINGEATMLF AELTYTLATE EAERIGVDHV
210 220 230 240 250
ARMTATGSGE NSTVAEHLIA QHSAIKMLHS RVKLILEYVK ASEAGEVPFN
260 270 280 290 300
HEILREAYAL CHCLPVLSTD KFKTDFYDQC NDVGLMAYLG TITKTCNTMN
310 320
QFVNKFNVLY DRQGIGRRMR GLFF
Length:324
Mass (Da):35,880
Last modified:November 1, 1998 - v1
Checksum:i8F8B7EC5DF67C721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071315 mRNA. Translation: AAC33902.1.
BC004664 mRNA. Translation: AAH04664.1.
BC014286 mRNA. Translation: AAH14286.1.
CCDSiCCDS19792.1.
RefSeqiNP_036132.1. NM_012002.3.
UniGeneiMm.3981.

Genome annotation databases

EnsembliENSMUST00000019638; ENSMUSP00000019638; ENSMUSG00000019494.
GeneIDi26893.
KEGGimmu:26893.
UCSCiuc009aer.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071315 mRNA. Translation: AAC33902.1.
BC004664 mRNA. Translation: AAH04664.1.
BC014286 mRNA. Translation: AAH14286.1.
CCDSiCCDS19792.1.
RefSeqiNP_036132.1. NM_012002.3.
UniGeneiMm.3981.

3D structure databases

ProteinModelPortaliO88545.
SMRiO88545. Positions 26-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205044. 12 interactions.
IntActiO88545. 2 interactions.
MINTiMINT-4092182.
STRINGi10090.ENSMUSP00000019638.

Protein family/group databases

MEROPSiM67.972.

PTM databases

iPTMnetiO88545.
PhosphoSiteiO88545.

Proteomic databases

EPDiO88545.
PaxDbiO88545.
PRIDEiO88545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019638; ENSMUSP00000019638; ENSMUSG00000019494.
GeneIDi26893.
KEGGimmu:26893.
UCSCiuc009aer.1. mouse.

Organism-specific databases

CTDi10980.
MGIiMGI:1349439. Cops6.

Phylogenomic databases

eggNOGiKOG3050. Eukaryota.
COG1310. LUCA.
HOGENOMiHOG000253002.
HOVERGENiHBG107770.
InParanoidiO88545.
KOiK12179.
OMAiDFLGWYT.
OrthoDBiEOG091G0AZ5.
PhylomeDBiO88545.
TreeFamiTF101148.

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.

Miscellaneous databases

PROiO88545.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019494.
ExpressionAtlasiO88545. baseline and differential.
GenevisibleiO88545. MM.

Family and domain databases

InterProiIPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSN6_MOUSE
AccessioniPrimary (citable) accession number: O88545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.