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Protein

Formyl peptide receptor-related sequence 3

Gene

Fpr-rs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 3
Gene namesi
Name:Fpr-rs3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1278318 Fpr-rs3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 66CytoplasmicSequence analysisAdd BLAST16
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 99ExtracellularSequence analysisAdd BLAST12
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 144CytoplasmicSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 202ExtracellularSequence analysisAdd BLAST37
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 241CytoplasmicSequence analysisAdd BLAST18
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 343CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003820231 – 343Formyl peptide receptor-related sequence 3Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88537
PRIDEiO88537

PTM databases

iPTMnetiO88537
PhosphoSitePlusiO88537

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Localized in sensory somata as well as dendritic cells. Each neuron appears to express only one receptor gene.2 Publications

Gene expression databases

BgeeiENSMUSG00000060701
GenevisibleiO88537 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071179

Structurei

3D structure databases

ProteinModelPortaliO88537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
InParanoidiO88537
OMAiVIWICGW
OrthoDBiEOG091G09ZK
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANSSIPLN GSEVVFYDST TSRVLWILSV IVLSITFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMAHTVT TICYLNLALG DFSFMVTLPL HIISMVMKGK WLFGWFLCKF
110 120 130 140 150
VLSIVHINLF VSVFLITLIA MDRCTCVLHP VWVQNHRTVS LARKVIVGAW
160 170 180 190 200
ILSLLLTLPH FLFLTTVRDA RGEVHCTCNF ESVVANPEEQ LKVSITVSTA
210 220 230 240 250
TGIISFIIGF SLPMSFIAVC YGLMAAKICR KGFLNSSRPL RVLTAVAISF
260 270 280 290 300
FMCWFPFQLI ILLGNIWNKE TPSSIHILLN PASTLASFNS CLNPILYVFL
310 320 330 340
GQEFREKLIY SLSASLERAL REDSVLSSGK SSNFSSCPAD SEL
Length:343
Mass (Da):38,064
Last modified:July 27, 2011 - v2
Checksum:iB130B0F190D923FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208 – 209IG → NC in AAC34586 (PubMed:9722950).Curated2
Sequence conflicti208 – 209IG → NC in AAI34353 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071181 Genomic DNA Translation: AAC34586.1
AC166351 Genomic DNA No translation available.
BC134352 mRNA Translation: AAI34353.1
CCDSiCCDS49989.1
RefSeqiNP_032066.2, NM_008040.2
UniGeneiMm.455334

Genome annotation databases

EnsembliENSMUST00000071189; ENSMUSP00000071179; ENSMUSG00000060701
GeneIDi14290
KEGGimmu:14290
UCSCiuc012alk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFPRS3_MOUSE
AccessioniPrimary (citable) accession number: O88537
Secondary accession number(s): A4IF56, E9QL30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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