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Protein

Formyl peptide receptor-related sequence 3

Gene

Fpr-rs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 3
Gene namesi
Name:Fpr-rs3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1278318. Fpr-rs3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 66CytoplasmicSequence analysisAdd BLAST16
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 99ExtracellularSequence analysisAdd BLAST12
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 144CytoplasmicSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 202ExtracellularSequence analysisAdd BLAST37
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 241CytoplasmicSequence analysisAdd BLAST18
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 343CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003820231 – 343Formyl peptide receptor-related sequence 3Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88537.
PRIDEiO88537.

PTM databases

iPTMnetiO88537.
PhosphoSitePlusiO88537.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Localized in sensory somata as well as dendritic cells. Each neuron appears to express only one receptor gene.2 Publications

Gene expression databases

BgeeiENSMUSG00000060701.
GenevisibleiO88537. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071179.

Structurei

3D structure databases

ProteinModelPortaliO88537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiO88537.
OMAiCPADSEL.
OrthoDBiEOG091G09ZK.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANSSIPLN GSEVVFYDST TSRVLWILSV IVLSITFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMAHTVT TICYLNLALG DFSFMVTLPL HIISMVMKGK WLFGWFLCKF
110 120 130 140 150
VLSIVHINLF VSVFLITLIA MDRCTCVLHP VWVQNHRTVS LARKVIVGAW
160 170 180 190 200
ILSLLLTLPH FLFLTTVRDA RGEVHCTCNF ESVVANPEEQ LKVSITVSTA
210 220 230 240 250
TGIISFIIGF SLPMSFIAVC YGLMAAKICR KGFLNSSRPL RVLTAVAISF
260 270 280 290 300
FMCWFPFQLI ILLGNIWNKE TPSSIHILLN PASTLASFNS CLNPILYVFL
310 320 330 340
GQEFREKLIY SLSASLERAL REDSVLSSGK SSNFSSCPAD SEL
Length:343
Mass (Da):38,064
Last modified:July 27, 2011 - v2
Checksum:iB130B0F190D923FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208 – 209IG → NC in AAC34586 (PubMed:9722950).Curated2
Sequence conflicti208 – 209IG → NC in AAI34353 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071181 Genomic DNA. Translation: AAC34586.1.
AC166351 Genomic DNA. No translation available.
BC134352 mRNA. Translation: AAI34353.1.
CCDSiCCDS49989.1.
RefSeqiNP_032066.2. NM_008040.2.
UniGeneiMm.455334.

Genome annotation databases

EnsembliENSMUST00000071189; ENSMUSP00000071179; ENSMUSG00000060701.
GeneIDi14290.
KEGGimmu:14290.
UCSCiuc012alk.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071181 Genomic DNA. Translation: AAC34586.1.
AC166351 Genomic DNA. No translation available.
BC134352 mRNA. Translation: AAI34353.1.
CCDSiCCDS49989.1.
RefSeqiNP_032066.2. NM_008040.2.
UniGeneiMm.455334.

3D structure databases

ProteinModelPortaliO88537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071179.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO88537.
PhosphoSitePlusiO88537.

Proteomic databases

PaxDbiO88537.
PRIDEiO88537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071189; ENSMUSP00000071179; ENSMUSG00000060701.
GeneIDi14290.
KEGGimmu:14290.
UCSCiuc012alk.1. mouse.

Organism-specific databases

CTDi14290.
MGIiMGI:1278318. Fpr-rs3.

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiO88537.
OMAiCPADSEL.
OrthoDBiEOG091G09ZK.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO88537.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060701.
GenevisibleiO88537. MM.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRS3_MOUSE
AccessioniPrimary (citable) accession number: O88537
Secondary accession number(s): A4IF56, E9QL30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.