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O88537

- FPRS3_MOUSE

UniProt

O88537 - FPRS3_MOUSE

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Protein

Formyl peptide receptor-related sequence 3

Gene

Fpr-rs3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: MGI

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 3
Gene namesi
Name:Fpr-rs3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1278318. Fpr-rs3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Formyl peptide receptor-related sequence 3PRO_0000382023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO88537.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Localized in sensory somata as well as dendritic cells. Each neuron appears to express only one receptor gene.2 Publications

Gene expression databases

GenevestigatoriO88537.

Structurei

3D structure databases

ProteinModelPortaliO88537.
SMRiO88537. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Topological domaini51 – 6616CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini88 – 9912ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 14424CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini166 – 20237ExtracellularSequence AnalysisAdd
BLAST
Topological domaini224 – 24118CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
BLAST
Topological domaini302 – 34342CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiO88537.
OMAiCPADSEL.
OrthoDBiEOG7PGDQQ.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88537-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEANSSIPLN GSEVVFYDST TSRVLWILSV IVLSITFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMAHTVT TICYLNLALG DFSFMVTLPL HIISMVMKGK WLFGWFLCKF
110 120 130 140 150
VLSIVHINLF VSVFLITLIA MDRCTCVLHP VWVQNHRTVS LARKVIVGAW
160 170 180 190 200
ILSLLLTLPH FLFLTTVRDA RGEVHCTCNF ESVVANPEEQ LKVSITVSTA
210 220 230 240 250
TGIISFIIGF SLPMSFIAVC YGLMAAKICR KGFLNSSRPL RVLTAVAISF
260 270 280 290 300
FMCWFPFQLI ILLGNIWNKE TPSSIHILLN PASTLASFNS CLNPILYVFL
310 320 330 340
GQEFREKLIY SLSASLERAL REDSVLSSGK SSNFSSCPAD SEL
Length:343
Mass (Da):38,064
Last modified:July 27, 2011 - v2
Checksum:iB130B0F190D923FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2092IG → NC in AAC34586. (PubMed:9722950)Curated
Sequence conflicti208 – 2092IG → NC in AAI34353. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071181 Genomic DNA. Translation: AAC34586.1.
AC166351 Genomic DNA. No translation available.
BC134352 mRNA. Translation: AAI34353.1.
CCDSiCCDS49989.1.
RefSeqiNP_032066.2. NM_008040.2.
UniGeneiMm.455334.

Genome annotation databases

EnsembliENSMUST00000071189; ENSMUSP00000071179; ENSMUSG00000060701.
GeneIDi14290.
KEGGimmu:14290.
UCSCiuc012alk.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071181 Genomic DNA. Translation: AAC34586.1 .
AC166351 Genomic DNA. No translation available.
BC134352 mRNA. Translation: AAI34353.1 .
CCDSi CCDS49989.1.
RefSeqi NP_032066.2. NM_008040.2.
UniGenei Mm.455334.

3D structure databases

ProteinModelPortali O88537.
SMRi O88537. Positions 32-305.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi O88537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071189 ; ENSMUSP00000071179 ; ENSMUSG00000060701 .
GeneIDi 14290.
KEGGi mmu:14290.
UCSCi uc012alk.1. mouse.

Organism-specific databases

CTDi 14290.
MGIi MGI:1278318. Fpr-rs3.

Phylogenomic databases

eggNOGi NOG150376.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000234122.
InParanoidi O88537.
OMAi CPADSEL.
OrthoDBi EOG7PGDQQ.
TreeFami TF330976.

Miscellaneous databases

NextBioi 285685.
PROi O88537.
SOURCEi Search...

Gene expression databases

Genevestigatori O88537.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
    Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
    Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
    Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
    Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPRS3_MOUSE
AccessioniPrimary (citable) accession number: O88537
Secondary accession number(s): A4IF56, E9QL30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3