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O88537

- FPRS3_MOUSE

UniProt

O88537 - FPRS3_MOUSE

Protein

Formyl peptide receptor-related sequence 3

Gene

Fpr-rs3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

    GO - Molecular functioni

    1. N-formyl peptide receptor activity Source: MGI

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formyl peptide receptor-related sequence 3
    Gene namesi
    Name:Fpr-rs3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1278318. Fpr-rs3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Formyl peptide receptor-related sequence 3PRO_0000382023Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 178PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO88537.

    Expressioni

    Tissue specificityi

    Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Localized in sensory somata as well as dendritic cells. Each neuron appears to express only one receptor gene.2 Publications

    Gene expression databases

    GenevestigatoriO88537.

    Structurei

    3D structure databases

    ProteinModelPortaliO88537.
    SMRiO88537. Positions 32-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 9912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 20237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 24118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 34342CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    GeneTreeiENSGT00730000110302.
    HOGENOMiHOG000234122.
    InParanoidiO88537.
    OMAiCPADSEL.
    OrthoDBiEOG7PGDQQ.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88537-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEANSSIPLN GSEVVFYDST TSRVLWILSV IVLSITFVLG VLGNGLVIWV    50
    AGFRMAHTVT TICYLNLALG DFSFMVTLPL HIISMVMKGK WLFGWFLCKF 100
    VLSIVHINLF VSVFLITLIA MDRCTCVLHP VWVQNHRTVS LARKVIVGAW 150
    ILSLLLTLPH FLFLTTVRDA RGEVHCTCNF ESVVANPEEQ LKVSITVSTA 200
    TGIISFIIGF SLPMSFIAVC YGLMAAKICR KGFLNSSRPL RVLTAVAISF 250
    FMCWFPFQLI ILLGNIWNKE TPSSIHILLN PASTLASFNS CLNPILYVFL 300
    GQEFREKLIY SLSASLERAL REDSVLSSGK SSNFSSCPAD SEL 343
    Length:343
    Mass (Da):38,064
    Last modified:July 27, 2011 - v2
    Checksum:iB130B0F190D923FF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2092IG → NC in AAC34586. (PubMed:9722950)Curated
    Sequence conflicti208 – 2092IG → NC in AAI34353. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071181 Genomic DNA. Translation: AAC34586.1.
    AC166351 Genomic DNA. No translation available.
    BC134352 mRNA. Translation: AAI34353.1.
    CCDSiCCDS49989.1.
    RefSeqiNP_032066.2. NM_008040.2.
    UniGeneiMm.455334.

    Genome annotation databases

    EnsembliENSMUST00000071189; ENSMUSP00000071179; ENSMUSG00000060701.
    GeneIDi14290.
    KEGGimmu:14290.
    UCSCiuc012alk.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A sickly smell - Issue 114 of February 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071181 Genomic DNA. Translation: AAC34586.1 .
    AC166351 Genomic DNA. No translation available.
    BC134352 mRNA. Translation: AAI34353.1 .
    CCDSi CCDS49989.1.
    RefSeqi NP_032066.2. NM_008040.2.
    UniGenei Mm.455334.

    3D structure databases

    ProteinModelPortali O88537.
    SMRi O88537. Positions 32-305.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi O88537.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071189 ; ENSMUSP00000071179 ; ENSMUSG00000060701 .
    GeneIDi 14290.
    KEGGi mmu:14290.
    UCSCi uc012alk.1. mouse.

    Organism-specific databases

    CTDi 14290.
    MGIi MGI:1278318. Fpr-rs3.

    Phylogenomic databases

    eggNOGi NOG150376.
    GeneTreei ENSGT00730000110302.
    HOGENOMi HOG000234122.
    InParanoidi O88537.
    OMAi CPADSEL.
    OrthoDBi EOG7PGDQQ.
    TreeFami TF330976.

    Miscellaneous databases

    NextBioi 285685.
    PROi O88537.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori O88537.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
      Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
      Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
      Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
      Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    5. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFPRS3_MOUSE
    AccessioniPrimary (citable) accession number: O88537
    Secondary accession number(s): A4IF56, E9QL30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3