O88537 (FPRS3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formyl peptide receptor-related sequence 3

Gene names

Name:

Fpr-rs3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have an olfactory function associated with the identification of pathogens or of pathogenic states. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed exclusively in vomeronasal neurons (Ref.4 and Ref.5). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Localized in sensory somata as well as dendritic cells. Each neuron appears to express only one receptor gene. Ref.4 Ref.5
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	N-formyl peptide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Formyl peptide receptor-related sequence 3		PRO_0000382023
Regions
	Topological domain	1 – 29	29	Extracellular Potential
	Transmembrane	30 – 50	21	Helical; Name=1; Potential
	Topological domain	51 – 66	16	Cytoplasmic Potential
	Transmembrane	67 – 87	21	Helical; Name=2; Potential
	Topological domain	88 – 99	12	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 144	24	Cytoplasmic Potential
	Transmembrane	145 – 165	21	Helical; Name=4; Potential
	Topological domain	166 – 202	37	Extracellular Potential
	Transmembrane	203 – 223	21	Helical; Name=5; Potential
	Topological domain	224 – 241	18	Cytoplasmic Potential
	Transmembrane	242 – 262	21	Helical; Name=6; Potential
	Topological domain	263 – 280	18	Extracellular Potential
	Transmembrane	281 – 301	21	Helical; Name=7; Potential
	Topological domain	302 – 343	42	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 178		By similarity
Experimental info
	Sequence conflict	208 – 209	2	IG → NC in AAC34586. Ref.1
	Sequence conflict	208 – 209	2	IG → NC in AAI34353. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O88537 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: B130B0F190D923FF	FASTA	343	38,064
	10 20 30 40 50 60 MEANSSIPLN GSEVVFYDST TSRVLWILSV IVLSITFVLG VLGNGLVIWV AGFRMAHTVT 70 80 90 100 110 120 TICYLNLALG DFSFMVTLPL HIISMVMKGK WLFGWFLCKF VLSIVHINLF VSVFLITLIA 130 140 150 160 170 180 MDRCTCVLHP VWVQNHRTVS LARKVIVGAW ILSLLLTLPH FLFLTTVRDA RGEVHCTCNF 190 200 210 220 230 240 ESVVANPEEQ LKVSITVSTA TGIISFIIGF SLPMSFIAVC YGLMAAKICR KGFLNSSRPL 250 260 270 280 290 300 RVLTAVAISF FMCWFPFQLI ILLGNIWNKE TPSSIHILLN PASTLASFNS CLNPILYVFL 310 320 330 340 GQEFREKLIY SLSASLERAL REDSVLSSGK SSNFSSCPAD SEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse." Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M. Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors." Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I. Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION.
[5]	"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ." Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071181 Genomic DNA. Translation: AAC34586.1. AC166351 Genomic DNA. No translation available. BC134352 mRNA. Translation: AAI34353.1.
IPI	IPI00131821.
RefSeq	NP_032066.2. NM_008040.2.
UniGene	Mm.455334.
3D structure databases
ProteinModelPortal	O88537.
SMR	O88537. Positions 32-305.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	O88537.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000071189; ENSMUSP00000071179; ENSMUSG00000060701.
GeneID	14290.
KEGG	mmu:14290.
UCSC	uc012alk.1. mouse.
Organism-specific databases
CTD	14290.
MGI	MGI:1278318. Fpr-rs3.
Phylogenomic databases
eggNOG	NOG150376.
GeneTree	ENSGT00630000089620.
HOGENOM	HOG000234122.
InParanoid	O88537.
OMA	CPADSEL.
OrthoDB	EOG4NGGPK.
Gene expression databases
Genevestigator	O88537.
Family and domain databases
InterPro	IPR000826. Formyl_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24225. PTHR24225. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285685.
SOURCE	Search...

Entry information

Entry name

FPRS3_MOUSE

Accession

Primary (citable) accession number: O88537
Secondary accession number(s): A4IF56, E9QL30

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program