Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formyl peptide receptor 2

Gene

Fpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.3 Publications

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: MGI
  • receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor 2
Alternative name(s):
Formylpeptide receptor-related sequence 2
Lipoxin A4 receptor-like protein
N-formylpeptide receptor-like 2
Gene namesi
Name:Fpr2
Synonyms:Fpr-rs2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1278319. Fpr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 99ExtracellularSequence analysisAdd BLAST17
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 144CytoplasmicSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 205ExtracellularSequence analysisAdd BLAST40
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 241CytoplasmicSequence analysisAdd BLAST15
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 282ExtracellularSequence analysisAdd BLAST20
Transmembranei283 – 305Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini306 – 351CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003820221 – 351Formyl peptide receptor 2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88536.
PRIDEiO88536.

PTM databases

PhosphoSitePlusiO88536.

Expressioni

Tissue specificityi

Primarily expressed in neutrophils. Not detected in vomeronasal neurons.5 Publications

Gene expression databases

BgeeiENSMUSG00000052270.
GenevisibleiO88536. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065799.

Structurei

3D structure databases

ProteinModelPortaliO88536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiO88536.
KOiK04173.
OMAiRSTHTED.
OrthoDBiEOG091G09ZK.
PhylomeDBiO88536.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNYSIHLN GSEVVVYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV
60 70 80 90 100
AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL
110 120 130 140 150
VHIVVDVNLF GSVFLIALIA LDRCICVLHP VWAQNHRTVS LARKVVVGPW
160 170 180 190 200
IFALILTLPI FIFLTTVRIP GGDVYCTFNF GSWAQTDEEK LNTAITFVTT
210 220 230 240 250
RGIIRFLIGF SMPMSIVAVC YGLIAVKINR RNLVNSSRPL RVLTAVVASF
260 270 280 290 300
FICWFPFQLV ALLGTVWFKE TLLSGSYKIL DMFVNPTSSL AYFNSCLNPM
310 320 330 340 350
LYVFMGQDFR ERFIHSLPYS LERALSEDSG QTSDSSTSST SPPADIELKA

P
Length:351
Mass (Da):39,422
Last modified:November 1, 1998 - v1
Checksum:iB16BCE7FA9AA8F43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071180 Genomic DNA. Translation: AAC34585.1.
AY138248 Genomic DNA. Translation: AAN06932.1.
CH466642 Genomic DNA. Translation: EDL20513.1.
BC117066 mRNA. Translation: AAI17067.1.
CCDSiCCDS28419.1.
RefSeqiNP_032065.1. NM_008039.2.
UniGeneiMm.378918.

Genome annotation databases

EnsembliENSMUST00000064068; ENSMUSP00000065799; ENSMUSG00000052270.
GeneIDi14289.
KEGGimmu:14289.
UCSCiuc008apu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071180 Genomic DNA. Translation: AAC34585.1.
AY138248 Genomic DNA. Translation: AAN06932.1.
CH466642 Genomic DNA. Translation: EDL20513.1.
BC117066 mRNA. Translation: AAI17067.1.
CCDSiCCDS28419.1.
RefSeqiNP_032065.1. NM_008039.2.
UniGeneiMm.378918.

3D structure databases

ProteinModelPortaliO88536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065799.

Chemistry databases

GuidetoPHARMACOLOGYi223.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO88536.

Proteomic databases

PaxDbiO88536.
PRIDEiO88536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064068; ENSMUSP00000065799; ENSMUSG00000052270.
GeneIDi14289.
KEGGimmu:14289.
UCSCiuc008apu.1. mouse.

Organism-specific databases

CTDi2358.
MGIiMGI:1278319. Fpr2.

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiO88536.
KOiK04173.
OMAiRSTHTED.
OrthoDBiEOG091G09ZK.
PhylomeDBiO88536.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO88536.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052270.
GenevisibleiO88536. MM.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPR2_MOUSE
AccessioniPrimary (citable) accession number: O88536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.