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O88533

- DDC_MOUSE

UniProt

O88533 - DDC_MOUSE

Protein

Aromatic-L-amino-acid decarboxylase

Gene

Ddc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

    Catalytic activityi

    L-dopa = dopamine + CO2.
    5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821SubstrateBy similarity
    Binding sitei148 – 1481PLP; via amide nitrogenBy similarity
    Binding sitei149 – 1491PLPBy similarity
    Binding sitei192 – 1921SubstrateBy similarity
    Binding sitei246 – 2461PLP; via carbonyl oxygenBy similarity
    Binding sitei300 – 3001PLPBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: Ensembl
    2. aromatic-L-amino-acid decarboxylase activity Source: MGI
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro
    2. cellular response to alkaloid Source: Ensembl
    3. cellular response to drug Source: Ensembl
    4. cellular response to growth factor stimulus Source: Ensembl
    5. circadian rhythm Source: Ensembl
    6. dopamine biosynthetic process Source: UniProtKB-UniPathway
    7. isoquinoline alkaloid metabolic process Source: Ensembl
    8. multicellular organismal aging Source: Ensembl
    9. phytoalexin metabolic process Source: Ensembl
    10. response to pyrethroid Source: Ensembl
    11. response to toxic substance Source: MGI
    12. serotonin biosynthetic process Source: Ensembl
    13. synaptic vesicle amine transport Source: Ensembl

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Catecholamine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_217777. Catecholamine biosynthesis.
    REACT_218437. Serotonin and melatonin biosynthesis.
    UniPathwayiUPA00747; UER00734.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
    Short name:
    AADC
    Alternative name(s):
    DOPA decarboxylase
    Short name:
    DDC
    Gene namesi
    Name:Ddc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:94876. Ddc.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: MGI
    3. neuronal cell body Source: Ensembl
    4. synaptic vesicle Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Aromatic-L-amino-acid decarboxylasePRO_0000146940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei303 – 3031N6-(pyridoxal phosphate)lysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO88533.
    PaxDbiO88533.
    PRIDEiO88533.

    PTM databases

    PhosphoSiteiO88533.

    Expressioni

    Gene expression databases

    ArrayExpressiO88533.
    BgeeiO88533.
    CleanExiMM_DDC.
    GenevestigatoriO88533.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiO88533. 2 interactions.
    MINTiMINT-1869726.

    Structurei

    3D structure databases

    ProteinModelPortaliO88533.
    SMRiO88533. Positions 1-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati58 – 115581Add
    BLAST
    Repeati118 – 178612Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 1781212 X approximate tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000121941.
    HOVERGENiHBG000944.
    InParanoidiO88533.
    KOiK01593.
    OMAiPICNKED.
    OrthoDBiEOG75B851.
    PhylomeDBiO88533.
    TreeFamiTF313863.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    PRINTSiPR00800. YHDCRBOXLASE.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88533-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRP LIPATAPQEP    50
    ETYEDIIKDI EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC 100
    IGFSWAASPA CTELETVMMD WLGKMLELPE AFLAGRAGEG GGVIQGSASE 150
    ATLVALLAAR TKVIRQLQAA SPEFTQAAIM EKLVAYTSDQ AHSSVERAGL 200
    IGGIKLKAVP SDGNFSMRAS ALREALERDK AAGLIPFFVV ATLGTTSCCS 250
    FDNLLEVGPI CNQEGVWLHI DAAYAGSAFI CPEFRYLLNG VEFADSFNFN 300
    PHKWLLVNFD CSAMWVKRRT DLTGAFNMDP VYLKHSHQDS GFITDYRHWQ 350
    IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVELSHEFES LVRQDPRFEI 400
    CTEVILGLVC FRLKGSNELN ETLLQRINSA KKIHLVPCRL RDKFVLRFAV 450
    CARTVESAHV QLAWEHISDL ASSVLRAEKE 480
    Length:480
    Mass (Da):53,874
    Last modified:November 1, 1998 - v1
    Checksum:iD6C1CA504AC2D10E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071068 mRNA. Translation: AAC25566.1.
    CCDSiCCDS24439.1.
    RefSeqiNP_001177377.1. NM_001190448.1.
    NP_057881.1. NM_016672.4.
    XP_006514550.1. XM_006514487.1.
    XP_006514551.1. XM_006514488.1.
    XP_006514552.1. XM_006514489.1.
    XP_006514553.1. XM_006514490.1.
    UniGeneiMm.12906.

    Genome annotation databases

    EnsembliENSMUST00000066237; ENSMUSP00000068525; ENSMUSG00000020182.
    ENSMUST00000109659; ENSMUSP00000105286; ENSMUSG00000020182.
    ENSMUST00000178704; ENSMUSP00000136467; ENSMUSG00000020182.
    GeneIDi13195.
    KEGGimmu:13195.
    UCSCiuc007iaw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071068 mRNA. Translation: AAC25566.1 .
    CCDSi CCDS24439.1.
    RefSeqi NP_001177377.1. NM_001190448.1.
    NP_057881.1. NM_016672.4.
    XP_006514550.1. XM_006514487.1.
    XP_006514551.1. XM_006514488.1.
    XP_006514552.1. XM_006514489.1.
    XP_006514553.1. XM_006514490.1.
    UniGenei Mm.12906.

    3D structure databases

    ProteinModelPortali O88533.
    SMRi O88533. Positions 1-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88533. 2 interactions.
    MINTi MINT-1869726.

    Chemistry

    BindingDBi O88533.
    ChEMBLi CHEMBL4230.

    PTM databases

    PhosphoSitei O88533.

    Proteomic databases

    MaxQBi O88533.
    PaxDbi O88533.
    PRIDEi O88533.

    Protocols and materials databases

    DNASUi 13195.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066237 ; ENSMUSP00000068525 ; ENSMUSG00000020182 .
    ENSMUST00000109659 ; ENSMUSP00000105286 ; ENSMUSG00000020182 .
    ENSMUST00000178704 ; ENSMUSP00000136467 ; ENSMUSG00000020182 .
    GeneIDi 13195.
    KEGGi mmu:13195.
    UCSCi uc007iaw.2. mouse.

    Organism-specific databases

    CTDi 1644.
    MGIi MGI:94876. Ddc.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000121941.
    HOVERGENi HBG000944.
    InParanoidi O88533.
    KOi K01593.
    OMAi PICNKED.
    OrthoDBi EOG75B851.
    PhylomeDBi O88533.
    TreeFami TF313863.

    Enzyme and pathway databases

    UniPathwayi UPA00747 ; UER00734 .
    Reactomei REACT_217777. Catecholamine biosynthesis.
    REACT_218437. Serotonin and melatonin biosynthesis.

    Miscellaneous databases

    NextBioi 283324.
    PROi O88533.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88533.
    Bgeei O88533.
    CleanExi MM_DDC.
    Genevestigatori O88533.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR00800. YHDCRBOXLASE.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse brain aromatic-L-amino-acid decarboxylase cDNA."
      Duchemin A.M., Quach T.T., Gudehithlu K.F., Hadjiconstantinou M., Neff N.H.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.

    Entry informationi

    Entry nameiDDC_MOUSE
    AccessioniPrimary (citable) accession number: O88533
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3