Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O88533 (DDC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatic-L-amino-acid decarboxylase

Short name=AADC
EC=4.1.1.28
Alternative name(s):
DOPA decarboxylase
Short name=DDC
Gene names
Name:Ddc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activity

L-dopa = dopamine + CO2.

5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactor

Pyridoxal phosphate.

Pathway

Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the group II decarboxylase family.

Ontologies

Keywords
   Biological processCatecholamine biosynthesis
   DomainRepeat
   LigandPyridoxal phosphate
   Molecular functionDecarboxylase
Lyase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

cellular response to alkaloid

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from electronic annotation. Source: Ensembl

cellular response to growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

circadian rhythm

Inferred from electronic annotation. Source: Ensembl

dopamine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

isoquinoline alkaloid metabolic process

Inferred from electronic annotation. Source: Ensembl

multicellular organismal aging

Inferred from electronic annotation. Source: Ensembl

phytoalexin metabolic process

Inferred from electronic annotation. Source: Ensembl

response to pyrethroid

Inferred from electronic annotation. Source: Ensembl

response to toxic substance

Inferred from direct assay PubMed 7904615. Source: MGI

serotonin biosynthetic process

Inferred from electronic annotation. Source: Ensembl

synaptic vesicle amine transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 23010799. Source: MGI

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

synaptic vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionamino acid binding

Inferred from electronic annotation. Source: Ensembl

aromatic-L-amino-acid decarboxylase activity

Inferred from direct assay PubMed 23863468. Source: MGI

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Aromatic-L-amino-acid decarboxylase
PRO_0000146940

Regions

Repeat58 – 115581
Repeat118 – 178612
Region58 – 1781212 X approximate tandem repeats

Sites

Binding site821Substrate By similarity
Binding site1481PLP; via amide nitrogen By similarity
Binding site1491PLP By similarity
Binding site1921Substrate By similarity
Binding site2461PLP; via carbonyl oxygen By similarity
Binding site3001PLP By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue3031N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O88533 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: D6C1CA504AC2D10E

FASTA48053,874
        10         20         30         40         50         60 
MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRP LIPATAPQEP ETYEDIIKDI 

        70         80         90        100        110        120 
EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD 

       130        140        150        160        170        180 
WLGKMLELPE AFLAGRAGEG GGVIQGSASE ATLVALLAAR TKVIRQLQAA SPEFTQAAIM 

       190        200        210        220        230        240 
EKLVAYTSDQ AHSSVERAGL IGGIKLKAVP SDGNFSMRAS ALREALERDK AAGLIPFFVV 

       250        260        270        280        290        300 
ATLGTTSCCS FDNLLEVGPI CNQEGVWLHI DAAYAGSAFI CPEFRYLLNG VEFADSFNFN 

       310        320        330        340        350        360 
PHKWLLVNFD CSAMWVKRRT DLTGAFNMDP VYLKHSHQDS GFITDYRHWQ IPLGRRFRSL 

       370        380        390        400        410        420 
KMWFVFRMYG VKGLQAYIRK HVELSHEFES LVRQDPRFEI CTEVILGLVC FRLKGSNELN 

       430        440        450        460        470        480 
ETLLQRINSA KKIHLVPCRL RDKFVLRFAV CARTVESAHV QLAWEHISDL ASSVLRAEKE 

« Hide

References

[1]"Cloning of mouse brain aromatic-L-amino-acid decarboxylase cDNA."
Duchemin A.M., Quach T.T., Gudehithlu K.F., Hadjiconstantinou M., Neff N.H.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071068 mRNA. Translation: AAC25566.1.
CCDSCCDS24439.1.
RefSeqNP_001177377.1. NM_001190448.1.
NP_057881.1. NM_016672.4.
XP_006514550.1. XM_006514487.1.
XP_006514551.1. XM_006514488.1.
XP_006514552.1. XM_006514489.1.
XP_006514553.1. XM_006514490.1.
UniGeneMm.12906.

3D structure databases

ProteinModelPortalO88533.
SMRO88533. Positions 1-475.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO88533. 2 interactions.
MINTMINT-1869726.

Chemistry

BindingDBO88533.
ChEMBLCHEMBL4230.

PTM databases

PhosphoSiteO88533.

Proteomic databases

MaxQBO88533.
PaxDbO88533.
PRIDEO88533.

Protocols and materials databases

DNASU13195.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000066237; ENSMUSP00000068525; ENSMUSG00000020182.
ENSMUST00000109659; ENSMUSP00000105286; ENSMUSG00000020182.
ENSMUST00000178704; ENSMUSP00000136467; ENSMUSG00000020182.
GeneID13195.
KEGGmmu:13195.
UCSCuc007iaw.2. mouse.

Organism-specific databases

CTD1644.
MGIMGI:94876. Ddc.

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000121941.
HOVERGENHBG000944.
InParanoidO88533.
KOK01593.
OMAPICNKED.
OrthoDBEOG75B851.
PhylomeDBO88533.
TreeFamTF313863.

Enzyme and pathway databases

UniPathwayUPA00747; UER00734.

Gene expression databases

ArrayExpressO88533.
BgeeO88533.
CleanExMM_DDC.
GenevestigatorO88533.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSPR00800. YHDCRBOXLASE.
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283324.
PROO88533.
SOURCESearch...

Entry information

Entry nameDDC_MOUSE
AccessionPrimary (citable) accession number: O88533
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot