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Protein

Aromatic-L-amino-acid decarboxylase

Gene

Ddc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activityi

L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

Pathway:idopamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (Th)
  2. Aromatic-L-amino-acid decarboxylase (Ddc)
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821SubstrateBy similarity
Binding sitei148 – 1481Pyridoxal phosphate; via amide nitrogenBy similarity
Binding sitei149 – 1491Pyridoxal phosphateBy similarity
Binding sitei192 – 1921SubstrateBy similarity
Binding sitei246 – 2461Pyridoxal phosphate; via carbonyl oxygenBy similarity
Binding sitei300 – 3001Pyridoxal phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.28. 3474.
ReactomeiREACT_295408. Catecholamine biosynthesis.
REACT_314546. Serotonin and melatonin biosynthesis.
UniPathwayiUPA00747; UER00734.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
Short name:
AADC
Alternative name(s):
DOPA decarboxylase
Short name:
DDC
Gene namesi
Name:Ddc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:94876. Ddc.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • neuronal cell body Source: Ensembl
  • synaptic vesicle Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Aromatic-L-amino-acid decarboxylasePRO_0000146940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei303 – 3031N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

MaxQBiO88533.
PaxDbiO88533.
PRIDEiO88533.

PTM databases

PhosphoSiteiO88533.

Expressioni

Gene expression databases

BgeeiO88533.
CleanExiMM_DDC.
ExpressionAtlasiO88533. baseline and differential.
GenevisibleiO88533. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO88533. 2 interactions.
MINTiMINT-1869726.
STRINGi10090.ENSMUSP00000068525.

Structurei

3D structure databases

ProteinModelPortaliO88533.
SMRiO88533. Positions 1-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 115581Add
BLAST
Repeati118 – 178612Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 1781212 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiO88533.
KOiK01593.
OMAiCSFDKLL.
OrthoDBiEOG75B851.
PhylomeDBiO88533.
TreeFamiTF313863.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRP LIPATAPQEP
60 70 80 90 100
ETYEDIIKDI EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC
110 120 130 140 150
IGFSWAASPA CTELETVMMD WLGKMLELPE AFLAGRAGEG GGVIQGSASE
160 170 180 190 200
ATLVALLAAR TKVIRQLQAA SPEFTQAAIM EKLVAYTSDQ AHSSVERAGL
210 220 230 240 250
IGGIKLKAVP SDGNFSMRAS ALREALERDK AAGLIPFFVV ATLGTTSCCS
260 270 280 290 300
FDNLLEVGPI CNQEGVWLHI DAAYAGSAFI CPEFRYLLNG VEFADSFNFN
310 320 330 340 350
PHKWLLVNFD CSAMWVKRRT DLTGAFNMDP VYLKHSHQDS GFITDYRHWQ
360 370 380 390 400
IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVELSHEFES LVRQDPRFEI
410 420 430 440 450
CTEVILGLVC FRLKGSNELN ETLLQRINSA KKIHLVPCRL RDKFVLRFAV
460 470 480
CARTVESAHV QLAWEHISDL ASSVLRAEKE
Length:480
Mass (Da):53,874
Last modified:November 1, 1998 - v1
Checksum:iD6C1CA504AC2D10E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071068 mRNA. Translation: AAC25566.1.
CCDSiCCDS24439.1.
RefSeqiNP_001177377.1. NM_001190448.1.
NP_057881.1. NM_016672.4.
XP_006514550.1. XM_006514487.2.
XP_006514551.1. XM_006514488.2.
XP_006514552.1. XM_006514489.2.
UniGeneiMm.12906.

Genome annotation databases

EnsembliENSMUST00000066237; ENSMUSP00000068525; ENSMUSG00000020182.
ENSMUST00000109659; ENSMUSP00000105286; ENSMUSG00000020182.
ENSMUST00000178704; ENSMUSP00000136467; ENSMUSG00000020182.
GeneIDi13195.
KEGGimmu:13195.
UCSCiuc007iaw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071068 mRNA. Translation: AAC25566.1.
CCDSiCCDS24439.1.
RefSeqiNP_001177377.1. NM_001190448.1.
NP_057881.1. NM_016672.4.
XP_006514550.1. XM_006514487.2.
XP_006514551.1. XM_006514488.2.
XP_006514552.1. XM_006514489.2.
UniGeneiMm.12906.

3D structure databases

ProteinModelPortaliO88533.
SMRiO88533. Positions 1-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88533. 2 interactions.
MINTiMINT-1869726.
STRINGi10090.ENSMUSP00000068525.

Chemistry

BindingDBiO88533.
ChEMBLiCHEMBL4230.

PTM databases

PhosphoSiteiO88533.

Proteomic databases

MaxQBiO88533.
PaxDbiO88533.
PRIDEiO88533.

Protocols and materials databases

DNASUi13195.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066237; ENSMUSP00000068525; ENSMUSG00000020182.
ENSMUST00000109659; ENSMUSP00000105286; ENSMUSG00000020182.
ENSMUST00000178704; ENSMUSP00000136467; ENSMUSG00000020182.
GeneIDi13195.
KEGGimmu:13195.
UCSCiuc007iaw.2. mouse.

Organism-specific databases

CTDi1644.
MGIiMGI:94876. Ddc.

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiO88533.
KOiK01593.
OMAiCSFDKLL.
OrthoDBiEOG75B851.
PhylomeDBiO88533.
TreeFamiTF313863.

Enzyme and pathway databases

UniPathwayiUPA00747; UER00734.
BRENDAi4.1.1.28. 3474.
ReactomeiREACT_295408. Catecholamine biosynthesis.
REACT_314546. Serotonin and melatonin biosynthesis.

Miscellaneous databases

ChiTaRSiDdc. mouse.
NextBioi283324.
PROiO88533.
SOURCEiSearch...

Gene expression databases

BgeeiO88533.
CleanExiMM_DDC.
ExpressionAtlasiO88533. baseline and differential.
GenevisibleiO88533. MM.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of mouse brain aromatic-L-amino-acid decarboxylase cDNA."
    Duchemin A.M., Quach T.T., Gudehithlu K.F., Hadjiconstantinou M., Neff N.H.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.

Entry informationi

Entry nameiDDC_MOUSE
AccessioniPrimary (citable) accession number: O88533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.