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O88533

- DDC_MOUSE

UniProt

O88533 - DDC_MOUSE

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Protein

Aromatic-L-amino-acid decarboxylase

Gene

Ddc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activityi

L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821SubstrateBy similarity
Binding sitei148 – 1481PLP; via amide nitrogenBy similarity
Binding sitei149 – 1491PLPBy similarity
Binding sitei192 – 1921SubstrateBy similarity
Binding sitei246 – 2461PLP; via carbonyl oxygenBy similarity
Binding sitei300 – 3001PLPBy similarity

GO - Molecular functioni

  1. amino acid binding Source: Ensembl
  2. aromatic-L-amino-acid decarboxylase activity Source: MGI
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
  2. cellular response to alkaloid Source: Ensembl
  3. cellular response to drug Source: Ensembl
  4. cellular response to growth factor stimulus Source: Ensembl
  5. circadian rhythm Source: Ensembl
  6. dopamine biosynthetic process Source: UniProtKB-UniPathway
  7. isoquinoline alkaloid metabolic process Source: Ensembl
  8. multicellular organismal aging Source: Ensembl
  9. phytoalexin metabolic process Source: Ensembl
  10. response to pyrethroid Source: Ensembl
  11. response to toxic substance Source: MGI
  12. serotonin biosynthetic process Source: Ensembl
  13. synaptic vesicle amine transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_217777. Catecholamine biosynthesis.
REACT_218437. Serotonin and melatonin biosynthesis.
UniPathwayiUPA00747; UER00734.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
Short name:
AADC
Alternative name(s):
DOPA decarboxylase
Short name:
DDC
Gene namesi
Name:Ddc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:94876. Ddc.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. neuronal cell body Source: Ensembl
  5. synaptic vesicle Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Aromatic-L-amino-acid decarboxylasePRO_0000146940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei303 – 3031N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO88533.
PaxDbiO88533.
PRIDEiO88533.

PTM databases

PhosphoSiteiO88533.

Expressioni

Gene expression databases

BgeeiO88533.
CleanExiMM_DDC.
ExpressionAtlasiO88533. baseline and differential.
GenevestigatoriO88533.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO88533. 2 interactions.
MINTiMINT-1869726.

Structurei

3D structure databases

ProteinModelPortaliO88533.
SMRiO88533. Positions 1-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 115581Add
BLAST
Repeati118 – 178612Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 1781212 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiO88533.
KOiK01593.
OMAiPICNKED.
OrthoDBiEOG75B851.
PhylomeDBiO88533.
TreeFamiTF313863.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88533-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRP LIPATAPQEP
60 70 80 90 100
ETYEDIIKDI EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC
110 120 130 140 150
IGFSWAASPA CTELETVMMD WLGKMLELPE AFLAGRAGEG GGVIQGSASE
160 170 180 190 200
ATLVALLAAR TKVIRQLQAA SPEFTQAAIM EKLVAYTSDQ AHSSVERAGL
210 220 230 240 250
IGGIKLKAVP SDGNFSMRAS ALREALERDK AAGLIPFFVV ATLGTTSCCS
260 270 280 290 300
FDNLLEVGPI CNQEGVWLHI DAAYAGSAFI CPEFRYLLNG VEFADSFNFN
310 320 330 340 350
PHKWLLVNFD CSAMWVKRRT DLTGAFNMDP VYLKHSHQDS GFITDYRHWQ
360 370 380 390 400
IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVELSHEFES LVRQDPRFEI
410 420 430 440 450
CTEVILGLVC FRLKGSNELN ETLLQRINSA KKIHLVPCRL RDKFVLRFAV
460 470 480
CARTVESAHV QLAWEHISDL ASSVLRAEKE
Length:480
Mass (Da):53,874
Last modified:November 1, 1998 - v1
Checksum:iD6C1CA504AC2D10E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071068 mRNA. Translation: AAC25566.1.
CCDSiCCDS24439.1.
RefSeqiNP_001177377.1. NM_001190448.1.
NP_057881.1. NM_016672.4.
XP_006514550.1. XM_006514487.1.
XP_006514551.1. XM_006514488.1.
XP_006514552.1. XM_006514489.1.
XP_006514553.1. XM_006514490.1.
UniGeneiMm.12906.

Genome annotation databases

EnsembliENSMUST00000066237; ENSMUSP00000068525; ENSMUSG00000020182.
ENSMUST00000109659; ENSMUSP00000105286; ENSMUSG00000020182.
ENSMUST00000178704; ENSMUSP00000136467; ENSMUSG00000020182.
GeneIDi13195.
KEGGimmu:13195.
UCSCiuc007iaw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071068 mRNA. Translation: AAC25566.1 .
CCDSi CCDS24439.1.
RefSeqi NP_001177377.1. NM_001190448.1.
NP_057881.1. NM_016672.4.
XP_006514550.1. XM_006514487.1.
XP_006514551.1. XM_006514488.1.
XP_006514552.1. XM_006514489.1.
XP_006514553.1. XM_006514490.1.
UniGenei Mm.12906.

3D structure databases

ProteinModelPortali O88533.
SMRi O88533. Positions 1-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O88533. 2 interactions.
MINTi MINT-1869726.

Chemistry

BindingDBi O88533.
ChEMBLi CHEMBL4230.

PTM databases

PhosphoSitei O88533.

Proteomic databases

MaxQBi O88533.
PaxDbi O88533.
PRIDEi O88533.

Protocols and materials databases

DNASUi 13195.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066237 ; ENSMUSP00000068525 ; ENSMUSG00000020182 .
ENSMUST00000109659 ; ENSMUSP00000105286 ; ENSMUSG00000020182 .
ENSMUST00000178704 ; ENSMUSP00000136467 ; ENSMUSG00000020182 .
GeneIDi 13195.
KEGGi mmu:13195.
UCSCi uc007iaw.2. mouse.

Organism-specific databases

CTDi 1644.
MGIi MGI:94876. Ddc.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000121941.
HOVERGENi HBG000944.
InParanoidi O88533.
KOi K01593.
OMAi PICNKED.
OrthoDBi EOG75B851.
PhylomeDBi O88533.
TreeFami TF313863.

Enzyme and pathway databases

UniPathwayi UPA00747 ; UER00734 .
Reactomei REACT_217777. Catecholamine biosynthesis.
REACT_218437. Serotonin and melatonin biosynthesis.

Miscellaneous databases

NextBioi 283324.
PROi O88533.
SOURCEi Search...

Gene expression databases

Bgeei O88533.
CleanExi MM_DDC.
ExpressionAtlasi O88533. baseline and differential.
Genevestigatori O88533.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
PRINTSi PR00800. YHDCRBOXLASE.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of mouse brain aromatic-L-amino-acid decarboxylase cDNA."
    Duchemin A.M., Quach T.T., Gudehithlu K.F., Hadjiconstantinou M., Neff N.H.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.

Entry informationi

Entry nameiDDC_MOUSE
AccessioniPrimary (citable) accession number: O88533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3