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Protein

Zinc finger RNA-binding protein

Gene

Zfr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA. Involved in the nucleocytoplasmic shuttling of STAU2 (By similarity).By similarity1 Publication

Miscellaneous

Knockout mice form mesoderm but are delayed in their development and fail to form normal anterior embryonic structures. Show both an increase in programmed cell death and a decrease in mitotic index, especially in the region of the distal tip of the embryonic ectoderm. Show also a reduction in apical vacuoles in the columnar visceral endoderm cells in the extraembryonic region. Knockout mice die by 8 to 9 days of gestation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger RNA-binding protein
Gene namesi
Name:Zfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1341890 Zfr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127201 – 1074Zinc finger RNA-binding proteinAdd BLAST1074

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei509N6-acetyllysine; alternateCombined sources1
Cross-linki509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei516N6-acetyllysineCombined sources1
Cross-linki541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki623Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1054PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO88532
MaxQBiO88532
PaxDbiO88532
PeptideAtlasiO88532
PRIDEiO88532

PTM databases

iPTMnetiO88532
PhosphoSitePlusiO88532

Expressioni

Tissue specificityi

Expressed in Sertoli cells, spermatocytes, primary and growing oocytes and granulosa cells (at protein level). Expressed in testis, ovary and brain.2 Publications

Developmental stagei

Expressed in embryos at 5.5, 6.5 and 7 dpc (at protein level). Expressed in the trophoectoderm cells and inner cell mass of blastocysts (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000022201
CleanExiMM_ZFR
ExpressionAtlasiO88532 baseline and differential
GenevisibleiO88532 MM

Interactioni

Subunit structurei

Found in a cytoplasmic mRNP complex with STAU2. Does not interact with STAU1 (By similarity). Interacts with STAU2.By similarity1 Publication

Protein-protein interaction databases

BioGridi204689, 5 interactors
IntActiO88532, 6 interactors
MINTiO88532
STRINGi10090.ENSMUSP00000118911

Structurei

3D structure databases

ProteinModelPortaliO88532
SMRiO88532
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini703 – 1073DZFPROSITE-ProRule annotationAdd BLAST371

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 302Ala-richAdd BLAST267

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3792 Eukaryota
ENOG410XPBY LUCA
GeneTreeiENSGT00550000074528
HOGENOMiHOG000232147
HOVERGENiHBG108765
InParanoidiO88532
KOiK13203
OMAiNNCTVNT
OrthoDBiEOG091G022L
PhylomeDBiO88532
TreeFamiTF320194

Family and domain databases

InterProiView protein in InterPro
IPR006561 DZF_dom
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00572 DZF, 1 hit
SM00355 ZnF_C2H2, 3 hits
SM00451 ZnF_U1, 3 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51703 DZF, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits

Sequencei

Sequence statusi: Complete.

O88532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPICPVVSF TYVPSRLGED AKMATGNYFG FTHSGAAAAA AAAQYSQQPA
60 70 80 90 100
SGVAYSHPTT VASYTVHQAP VAAHTVTAAY APAAATVAVA RPAPVAVAAA
110 120 130 140 150
ATAAAYGGYP TAHTATDYGY TQRQQEAPPP PPPATTQNYQ DSYSYVRSTA
160 170 180 190 200
PAVAYDSKQY YQQPTATAAA VAAAAQPQPS VAETYYQTAP KAGYSQGATQ
210 220 230 240 250
YTQAQQARQV TAIKPATPSP ATTTFSIYPV SSTVQPVAAA ATVVPSYTQS
260 270 280 290 300
ATYSTTAVTY SGTSYSGYEA AVYSAASSYY QQQQQQQKQA AAAAAAAAAT
310 320 330 340 350
AAWTGTTFTK KTPFQNKQLK PKQPPKPPQI HYCDVCKISC AGPQTYKEHL
360 370 380 390 400
EGQKHKKKEA ALKASQNTSS SNNSTRGTQN QLRCELCDVS CTGADAYAAH
410 420 430 440 450
IRGAKHQKVV KLHTKLGKPI PSTEPNVVSQ ATSSTAASAS KPTASPSSIG
460 470 480 490 500
ASNCTLNTSS IATSSVKGLS TTGNSSLNST SNTKVSAIPT NMAAKKTSTP
510 520 530 540 550
KINFVGGNKL QSTGNKTEDL KGIDCVKNTP AASAVQIPEV KQDAGSEPVT
560 570 580 590 600
PASLAALQSD VQPVGHDYVE EVRNDEGKVI RFHCKLCECS FNDPNAKEMH
610 620 630 640 650
LKGRRHRLQY KKKVNPDLQV EVKPSIRARK IQEEKMRKQM QKEEYWRRRE
660 670 680 690 700
EEERWRMEIR RYEEDMYWRR MEEEQHHWDD RRRMPDGGYP HGPPGPLGLL
710 720 730 740 750
GVRPGMPPQP QGPAPLRRPD SSDDRYVMTK HATIYPTEEE LQAVQKIVSI
760 770 780 790 800
TERALKLVSD SLSEHEKSKN KEGDDKKEGG KDRALKGVLR VGVLAKGLLL
810 820 830 840 850
RGDRNVNLVL LCSEKPSKSL LSRIAENLPK QLAVISPEKY DIKCAVSEAA
860 870 880 890 900
IILNSCVEPK MQVTITLTSP IIREENMREG DVTSGMVKDP PDVLDRQKCL
910 920 930 940 950
DALAALRHAK WFQARANGLQ SCVIIIRILR DLCQRVPTWS DFPSWAMELL
960 970 980 990 1000
VEKAISSASS PQSPGDALRR VFECISSGII LKGSPGLLDP CEKDPFDTLA
1010 1020 1030 1040 1050
TMTDQQREDI TSSAQFALRL LAFRQIHKVL GMDPLPQMNQ RFNIHNNRKR
1060 1070
RRDSDGVDGF EAEGKKDKKD YDNF
Length:1,074
Mass (Da):116,859
Last modified:December 4, 2007 - v2
Checksum:iF0CE7B9F84A79A07
GO

Sequence cautioni

The sequence AAC25762 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH06962 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH38599 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH38599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH58570 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH58570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC28897 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355H → K in AAH58570 (PubMed:15489334).Curated1
Sequence conflicti355H → K in AAH38599 (PubMed:15489334).Curated1
Sequence conflicti458T → S in BAC28897 (PubMed:16141072).Curated1
Sequence conflicti877M → I in BAB27548 (PubMed:16141072).Curated1
Sequence conflicti1016F → K in AAC25762 (PubMed:10072773).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071059 mRNA Translation: AAC25762.1 Different initiation.
BC006962 mRNA Translation: AAH06962.1 Different initiation.
BC038599 mRNA Translation: AAH38599.1 Sequence problems.
BC058570 mRNA Translation: AAH58570.1 Sequence problems.
AK011329 mRNA Translation: BAB27548.1
AK034963 mRNA Translation: BAC28897.1 Different initiation.
AK158938 mRNA Translation: BAE34733.1
CCDSiCCDS37044.2
PIRiT14343
RefSeqiNP_035897.2, NM_011767.2
UniGeneiMm.273496

Genome annotation databases

EnsembliENSMUST00000122941; ENSMUSP00000118911; ENSMUSG00000022201
GeneIDi22763
KEGGimmu:22763
UCSCiuc007vhk.3 mouse

Similar proteinsi

Entry informationi

Entry nameiZFR_MOUSE
AccessioniPrimary (citable) accession number: O88532
Secondary accession number(s): Q3TY30
, Q8BS85, Q8CGG5, Q91VZ0, Q9CT34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health