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Protein

Leucine-rich repeat protein SHOC-2

Gene

Shoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat protein SHOC-2
Alternative name(s):
Protein soc-2 homolog
Protein sur-8 homolog
Gene namesi
Name:Shoc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1927197. Shoc2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates from cytoplasm to nucleus upon growth factor stimulation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Leucine-rich repeat protein SHOC-2PRO_0000097738Add
BLAST

Proteomic databases

EPDiO88520.
MaxQBiO88520.
PaxDbiO88520.
PRIDEiO88520.

PTM databases

iPTMnetiO88520.
PhosphoSiteiO88520.

Expressioni

Gene expression databases

BgeeiO88520.
CleanExiMM_SHOC2.
GenevisibleiO88520. MM.

Interactioni

Subunit structurei

Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBB2IP; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207949. 50 interactions.
IntActiO88520. 49 interactions.
STRINGi10090.ENSMUSP00000025932.

Structurei

3D structure databases

ProteinModelPortaliO88520.
SMRiO88520. Positions 73-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati101 – 12222LRR 1Add
BLAST
Repeati124 – 14522LRR 2Add
BLAST
Repeati147 – 16923LRR 3Add
BLAST
Repeati170 – 19122LRR 4Add
BLAST
Repeati193 – 21523LRR 5Add
BLAST
Repeati216 – 23722LRR 6Add
BLAST
Repeati239 – 26022LRR 7Add
BLAST
Repeati262 – 28322LRR 8Add
BLAST
Repeati285 – 30723LRR 9Add
BLAST
Repeati308 – 32922LRR 10Add
BLAST
Repeati332 – 35322LRR 11Add
BLAST
Repeati356 – 37722LRR 12Add
BLAST
Repeati380 – 40021LRR 13Add
BLAST
Repeati403 – 42422LRR 14Add
BLAST
Repeati426 – 44823LRR 15Add
BLAST
Repeati449 – 47022LRR 16Add
BLAST
Repeati472 – 49423LRR 17Add
BLAST
Repeati495 – 51622LRR 18Add
BLAST
Repeati518 – 54023LRR 19Add
BLAST
Repeati542 – 56322LRR 20Add
BLAST

Sequence similaritiesi

Belongs to the SHOC2 family.Curated
Contains 20 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
HOVERGENiHBG055661.
InParanoidiO88520.
KOiK19613.
OMAiNDNPHLH.
OrthoDBiEOG773XFV.
PhylomeDBiO88520.
TreeFamiTF315742.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 16 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLGKEKD SKEKDPKVPS AKEREKESKA SGGFGKESKE KEPKAKGKDA
60 70 80 90 100
KDGKKESSAA QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE
110 120 130 140 150
NSMRLDLSKR SIHILPPSVK ELTQLTELYL YSNKLQSLPA EVGCLVNLMT
160 170 180 190 200
LALSENSLTS LPDSLDNLKK LRMLDLRHNK LREIPSVVYR LDSLTTLYLR
210 220 230 240 250
FNRITTVEKD IKNLPKLSML SIRENKIKQL PAEIGELCNL ITLDVAHNQL
260 270 280 290 300
EHLPKEIGNC TQITNLDLQH NDLLDLPDTI GNLSSLNRLG LRYNRLSAIP
310 320 330 340 350
RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG
360 370 380 390 400
PSQFSTIYSL NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT
410 420 430 440 450
WTSMVELNLA TNQLTKIPED VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL
460 470 480 490 500
RELDLEENKL ESLPNEIAYL KDLQKLVLTN NQLSTLPRGI GHLTNLTHLG
510 520 530 540 550
LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC SKLSIMSIEN
560 570 580
CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV
Length:582
Mass (Da):64,893
Last modified:August 16, 2004 - v2
Checksum:i154B38C4909FB0AD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111S → F in AAC40175 (PubMed:9674433).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068921 mRNA. Translation: AAC40175.1.
DQ479926 Genomic DNA. Translation: ABF48505.1.
AK077798 mRNA. Translation: BAC37016.1.
AK146447 mRNA. Translation: BAE27179.1.
BC013722 mRNA. Translation: AAH13722.1.
BC049775 mRNA. Translation: AAH49775.1.
BC083060 mRNA. Translation: AAH83060.1.
CCDSiCCDS29904.1.
RefSeqiNP_001161977.1. NM_001168505.1.
NP_062632.2. NM_019658.6.
XP_006527290.1. XM_006527227.2.
XP_006527291.1. XM_006527228.2.
XP_011245601.1. XM_011247299.1.
UniGeneiMm.228669.

Genome annotation databases

EnsembliENSMUST00000025932; ENSMUSP00000025932; ENSMUSG00000024976.
ENSMUST00000169861; ENSMUSP00000127932; ENSMUSG00000024976.
GeneIDi56392.
KEGGimmu:56392.
UCSCiuc008hxg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068921 mRNA. Translation: AAC40175.1.
DQ479926 Genomic DNA. Translation: ABF48505.1.
AK077798 mRNA. Translation: BAC37016.1.
AK146447 mRNA. Translation: BAE27179.1.
BC013722 mRNA. Translation: AAH13722.1.
BC049775 mRNA. Translation: AAH49775.1.
BC083060 mRNA. Translation: AAH83060.1.
CCDSiCCDS29904.1.
RefSeqiNP_001161977.1. NM_001168505.1.
NP_062632.2. NM_019658.6.
XP_006527290.1. XM_006527227.2.
XP_006527291.1. XM_006527228.2.
XP_011245601.1. XM_011247299.1.
UniGeneiMm.228669.

3D structure databases

ProteinModelPortaliO88520.
SMRiO88520. Positions 73-563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207949. 50 interactions.
IntActiO88520. 49 interactions.
STRINGi10090.ENSMUSP00000025932.

PTM databases

iPTMnetiO88520.
PhosphoSiteiO88520.

Proteomic databases

EPDiO88520.
MaxQBiO88520.
PaxDbiO88520.
PRIDEiO88520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025932; ENSMUSP00000025932; ENSMUSG00000024976.
ENSMUST00000169861; ENSMUSP00000127932; ENSMUSG00000024976.
GeneIDi56392.
KEGGimmu:56392.
UCSCiuc008hxg.2. mouse.

Organism-specific databases

CTDi8036.
MGIiMGI:1927197. Shoc2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
HOVERGENiHBG055661.
InParanoidiO88520.
KOiK19613.
OMAiNDNPHLH.
OrthoDBiEOG773XFV.
PhylomeDBiO88520.
TreeFamiTF315742.

Miscellaneous databases

PROiO88520.
SOURCEiSearch...

Gene expression databases

BgeeiO88520.
CleanExiMM_SHOC2.
GenevisibleiO88520. MM.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 16 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans."
    Sieburth D.S., Sun Q., Han M.
    Cell 94:119-130(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Limb and Mammary gland.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSHOC2_MOUSE
AccessioniPrimary (citable) accession number: O88520
Secondary accession number(s): Q3UJH6, Q8BVL0, Q91VH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.