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Protein

AP-1 complex subunit gamma-like 2

Gene

Ap1g2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function in protein sorting in late endosomes or multivesucular bodies (MVBs).

GO - Molecular functioni

  1. protein transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: MGI
  2. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit gamma-like 2
Alternative name(s):
Gamma2-adaptin
Short name:
G2ad
Gene namesi
Name:Ap1g2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1328307. Ap1g2.

Subcellular locationi

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  3. endosome membrane Source: UniProtKB-SubCell
  4. Golgi-associated vesicle Source: UniProtKB
  5. Golgi membrane Source: UniProtKB-SubCell
  6. membrane Source: UniProtKB
  7. trans-Golgi network Source: MGI
  8. transport vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 791791AP-1 complex subunit gamma-like 2PRO_0000193761Add
BLAST

Proteomic databases

MaxQBiO88512.
PaxDbiO88512.
PRIDEiO88512.

PTM databases

PhosphoSiteiO88512.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiO88512.
CleanExiMM_AP1G2.
ExpressionAtlasiO88512. baseline and differential.
GenevestigatoriO88512.

Interactioni

Subunit structurei

Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Binds ubiquitin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043996.

Structurei

3D structure databases

ProteinModelPortaliO88512.
SMRiO88512. Positions 6-589, 671-791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini671 – 786116GAEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GAE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG303101.
GeneTreeiENSGT00390000012618.
HOGENOMiHOG000210271.
HOVERGENiHBG067473.
InParanoidiO88512.
KOiK12391.
OMAiPCAQLLH.
OrthoDBiEOG7S7SD7.
TreeFamiTF300367.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1230. 2 hits.
InterProiIPR017107. AP1_complex_gsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037094. AP1_complex_gamma. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVHSLRLQD LIEEIRGAKT QAQEREVIQK ECAQIRASFR DGDPLQRHRQ
60 70 80 90 100
LAKLLYVHML GYPAHFGQME CLKLIASPRF TDKRVGYLGA MLLLDERHDS
110 120 130 140 150
HLLITNSIKN DLSQGNQPVQ GLALCTLSTM GSAEMCRDLA PEVEKLLLQP
160 170 180 190 200
SPYVRKKAIL TAVHMIRKDP ELSGIFLPPC TKLLRERHHG IQLGTVTLIT
210 220 230 240 250
ELCERNPAAL RHFRKVVPQL VQILRTLVTT GYSTEHSISG VSDPFLQVQI
260 270 280 290 300
LRLLRILGRN HEESSETMND LLAQVATNTD TSRNAGNAVL LETVLTIMAI
310 320 330 340 350
HSAAGLRVLA VNILGRFLLN NDKNIRYVAL TSLLQLVQSD HSAVQRHRST
360 370 380 390 400
VVECLQETDA SLSRRALELS LALVNSSNVR AMMQELQAFL ESCPPDLRAD
410 420 430 440 450
CASGILLAAE RFAPSKRWHI DTILHVLTTA GAHVRDDAVA NLTQLIGEAE
460 470 480 490 500
ELHTYSVRRL YSALAEDISQ QPLVQVAAWC IGEYGDLLLE GNCEETEPFQ
510 520 530 540 550
VEEEDVLALL EKVLQSHMSL PATRGYAITA LMKLSTRLRG DNNRIRQVVS
560 570 580 590 600
IYGSCVDLEL QQRAVEYNTL FQKYDHMRAA ILEKMPLVER GDPHVKEGGK
610 620 630 640 650
EKQTEAQPLE VTAPAPTEPQ ATKLLDLLDL LGDTSEPLSS GHAQHLPPQT
660 670 680 690 700
PSPGEALIHL LDLPCTPPPP APIPSVRVFE REGLQLDLSF MRPLETPALL
710 720 730 740 750
LVTATTTNSS KEDVTHFVCQ AAVPKSFQLQ LQAPSGNTIP AQGGLPITQV
760 770 780 790
FRILNPNQAP LRLKLRLTYN HSGQPVQEIF EVDNLPVETW Q
Length:791
Mass (Da):87,863
Last modified:July 27, 2011 - v2
Checksum:i21F744FC8EEFB932
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191K → E in AAC67391 (PubMed:9762922).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068707 mRNA. Translation: AAC67391.1.
CH466535 Genomic DNA. Translation: EDL36306.1.
CH466535 Genomic DNA. Translation: EDL36307.1.
BC108374 mRNA. Translation: AAI08375.1.
CCDSiCCDS36929.1.
RefSeqiNP_031481.2. NM_007455.5.
UniGeneiMm.238879.

Genome annotation databases

EnsembliENSMUST00000036041; ENSMUSP00000043996; ENSMUSG00000040701.
ENSMUST00000170285; ENSMUSP00000128427; ENSMUSG00000040701.
GeneIDi11766.
KEGGimmu:11766.
UCSCiuc007tyd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068707 mRNA. Translation: AAC67391.1.
CH466535 Genomic DNA. Translation: EDL36306.1.
CH466535 Genomic DNA. Translation: EDL36307.1.
BC108374 mRNA. Translation: AAI08375.1.
CCDSiCCDS36929.1.
RefSeqiNP_031481.2. NM_007455.5.
UniGeneiMm.238879.

3D structure databases

ProteinModelPortaliO88512.
SMRiO88512. Positions 6-589, 671-791.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043996.

PTM databases

PhosphoSiteiO88512.

Proteomic databases

MaxQBiO88512.
PaxDbiO88512.
PRIDEiO88512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036041; ENSMUSP00000043996; ENSMUSG00000040701.
ENSMUST00000170285; ENSMUSP00000128427; ENSMUSG00000040701.
GeneIDi11766.
KEGGimmu:11766.
UCSCiuc007tyd.2. mouse.

Organism-specific databases

CTDi8906.
MGIiMGI:1328307. Ap1g2.

Phylogenomic databases

eggNOGiNOG303101.
GeneTreeiENSGT00390000012618.
HOGENOMiHOG000210271.
HOVERGENiHBG067473.
InParanoidiO88512.
KOiK12391.
OMAiPCAQLLH.
OrthoDBiEOG7S7SD7.
TreeFamiTF300367.

Miscellaneous databases

NextBioi279529.
PROiO88512.
SOURCEiSearch...

Gene expression databases

BgeeiO88512.
CleanExiMM_AP1G2.
ExpressionAtlasiO88512. baseline and differential.
GenevestigatoriO88512.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1230. 2 hits.
InterProiIPR017107. AP1_complex_gsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037094. AP1_complex_gamma. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and localization of a novel gamma-adaptin-like molecule."
    Lewin D.A., Sheff D., Ooi C.E., Whitney J.A., Yamamoto E., Chicione L.M., Webster P., Bonifacino J.S., Mellman I.
    FEBS Lett. 435:263-268(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiAP1G2_MOUSE
AccessioniPrimary (citable) accession number: O88512
Secondary accession number(s): Q2YDV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.