Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-1 complex subunit gamma-like 2

Gene

Ap1g2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).By similarity

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-432720. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit gamma-like 2
Alternative name(s):
Gamma2-adaptin
Short name:
G2ad
Gene namesi
Name:Ap1g2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1328307. Ap1g2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937611 – 791AP-1 complex subunit gamma-like 2Add BLAST791

Proteomic databases

EPDiO88512.
MaxQBiO88512.
PaxDbiO88512.
PeptideAtlasiO88512.
PRIDEiO88512.

PTM databases

iPTMnetiO88512.
PhosphoSitePlusiO88512.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000040701.
CleanExiMM_AP1G2.
ExpressionAtlasiO88512. baseline and differential.
GenevisibleiO88512. MM.

Interactioni

Subunit structurei

Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner. Binds ubiquitin.By similarity

Protein-protein interaction databases

BioGridi198124. 1 interactor.
STRINGi10090.ENSMUSP00000043996.

Structurei

3D structure databases

ProteinModelPortaliO88512.
SMRiO88512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini671 – 786GAEPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1062. Eukaryota.
ENOG410XPKK. LUCA.
GeneTreeiENSGT00390000012618.
HOGENOMiHOG000210271.
HOVERGENiHBG067473.
InParanoidiO88512.
KOiK12391.
OMAiQPSPYVR.
OrthoDBiEOG091G01RV.
TreeFamiTF300367.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR017107. AP1_complex_gsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008153. GAE_dom.
PfamiView protein in Pfam
PF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
PIRSFiPIRSF037094. AP1_complex_gamma. 1 hit.
SMARTiView protein in SMART
SM00809. Alpha_adaptinC2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiView protein in PROSITE
PS50180. GAE. 1 hit.

Sequencei

Sequence statusi: Complete.

O88512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVHSLRLQD LIEEIRGAKT QAQEREVIQK ECAQIRASFR DGDPLQRHRQ
60 70 80 90 100
LAKLLYVHML GYPAHFGQME CLKLIASPRF TDKRVGYLGA MLLLDERHDS
110 120 130 140 150
HLLITNSIKN DLSQGNQPVQ GLALCTLSTM GSAEMCRDLA PEVEKLLLQP
160 170 180 190 200
SPYVRKKAIL TAVHMIRKDP ELSGIFLPPC TKLLRERHHG IQLGTVTLIT
210 220 230 240 250
ELCERNPAAL RHFRKVVPQL VQILRTLVTT GYSTEHSISG VSDPFLQVQI
260 270 280 290 300
LRLLRILGRN HEESSETMND LLAQVATNTD TSRNAGNAVL LETVLTIMAI
310 320 330 340 350
HSAAGLRVLA VNILGRFLLN NDKNIRYVAL TSLLQLVQSD HSAVQRHRST
360 370 380 390 400
VVECLQETDA SLSRRALELS LALVNSSNVR AMMQELQAFL ESCPPDLRAD
410 420 430 440 450
CASGILLAAE RFAPSKRWHI DTILHVLTTA GAHVRDDAVA NLTQLIGEAE
460 470 480 490 500
ELHTYSVRRL YSALAEDISQ QPLVQVAAWC IGEYGDLLLE GNCEETEPFQ
510 520 530 540 550
VEEEDVLALL EKVLQSHMSL PATRGYAITA LMKLSTRLRG DNNRIRQVVS
560 570 580 590 600
IYGSCVDLEL QQRAVEYNTL FQKYDHMRAA ILEKMPLVER GDPHVKEGGK
610 620 630 640 650
EKQTEAQPLE VTAPAPTEPQ ATKLLDLLDL LGDTSEPLSS GHAQHLPPQT
660 670 680 690 700
PSPGEALIHL LDLPCTPPPP APIPSVRVFE REGLQLDLSF MRPLETPALL
710 720 730 740 750
LVTATTTNSS KEDVTHFVCQ AAVPKSFQLQ LQAPSGNTIP AQGGLPITQV
760 770 780 790
FRILNPNQAP LRLKLRLTYN HSGQPVQEIF EVDNLPVETW Q
Length:791
Mass (Da):87,863
Last modified:July 27, 2011 - v2
Checksum:i21F744FC8EEFB932
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19K → E in AAC67391 (PubMed:9762922).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068707 mRNA. Translation: AAC67391.1.
CH466535 Genomic DNA. Translation: EDL36306.1.
CH466535 Genomic DNA. Translation: EDL36307.1.
BC108374 mRNA. Translation: AAI08375.1.
CCDSiCCDS36929.1.
RefSeqiNP_031481.2. NM_007455.5.
UniGeneiMm.238879.

Genome annotation databases

EnsembliENSMUST00000036041; ENSMUSP00000043996; ENSMUSG00000040701.
ENSMUST00000170285; ENSMUSP00000128427; ENSMUSG00000040701.
GeneIDi11766.
KEGGimmu:11766.
UCSCiuc007tyd.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiAP1G2_MOUSE
AccessioniPrimary (citable) accession number: O88512
Secondary accession number(s): Q2YDV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families