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O88512

- AP1G2_MOUSE

UniProt

O88512 - AP1G2_MOUSE

Protein

AP-1 complex subunit gamma-like 2

Gene

Ap1g2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May function in protein sorting in late endosomes or multivesucular bodies (MVBs).

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: MGI
    2. vesicle-mediated transport Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-1 complex subunit gamma-like 2
    Alternative name(s):
    Gamma2-adaptin
    Short name:
    G2ad
    Gene namesi
    Name:Ap1g2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1328307. Ap1g2.

    Subcellular locationi

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. endosome membrane Source: UniProtKB-SubCell
    4. Golgi-associated vesicle Source: UniProtKB
    5. Golgi membrane Source: UniProtKB-SubCell
    6. membrane Source: UniProtKB
    7. trans-Golgi network Source: MGI
    8. transport vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 791791AP-1 complex subunit gamma-like 2PRO_0000193761Add
    BLAST

    Proteomic databases

    MaxQBiO88512.
    PaxDbiO88512.
    PRIDEiO88512.

    PTM databases

    PhosphoSiteiO88512.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiO88512.
    BgeeiO88512.
    CleanExiMM_AP1G2.
    GenevestigatoriO88512.

    Interactioni

    Subunit structurei

    Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Binds ubiquitin By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000043996.

    Structurei

    3D structure databases

    ProteinModelPortaliO88512.
    SMRiO88512. Positions 6-590, 671-791.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini671 – 786116GAEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GAE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG303101.
    GeneTreeiENSGT00390000012618.
    HOGENOMiHOG000210271.
    HOVERGENiHBG067473.
    InParanoidiQ2YDV3.
    KOiK12391.
    OMAiPCAQLLH.
    OrthoDBiEOG7S7SD7.
    TreeFamiTF300367.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1230. 2 hits.
    InterProiIPR017107. AP1_complex_gsu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR008153. Clathrin_g-adaptin_app.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037094. AP1_complex_gamma. 1 hit.
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    PROSITEiPS50180. GAE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88512-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVHSLRLQD LIEEIRGAKT QAQEREVIQK ECAQIRASFR DGDPLQRHRQ    50
    LAKLLYVHML GYPAHFGQME CLKLIASPRF TDKRVGYLGA MLLLDERHDS 100
    HLLITNSIKN DLSQGNQPVQ GLALCTLSTM GSAEMCRDLA PEVEKLLLQP 150
    SPYVRKKAIL TAVHMIRKDP ELSGIFLPPC TKLLRERHHG IQLGTVTLIT 200
    ELCERNPAAL RHFRKVVPQL VQILRTLVTT GYSTEHSISG VSDPFLQVQI 250
    LRLLRILGRN HEESSETMND LLAQVATNTD TSRNAGNAVL LETVLTIMAI 300
    HSAAGLRVLA VNILGRFLLN NDKNIRYVAL TSLLQLVQSD HSAVQRHRST 350
    VVECLQETDA SLSRRALELS LALVNSSNVR AMMQELQAFL ESCPPDLRAD 400
    CASGILLAAE RFAPSKRWHI DTILHVLTTA GAHVRDDAVA NLTQLIGEAE 450
    ELHTYSVRRL YSALAEDISQ QPLVQVAAWC IGEYGDLLLE GNCEETEPFQ 500
    VEEEDVLALL EKVLQSHMSL PATRGYAITA LMKLSTRLRG DNNRIRQVVS 550
    IYGSCVDLEL QQRAVEYNTL FQKYDHMRAA ILEKMPLVER GDPHVKEGGK 600
    EKQTEAQPLE VTAPAPTEPQ ATKLLDLLDL LGDTSEPLSS GHAQHLPPQT 650
    PSPGEALIHL LDLPCTPPPP APIPSVRVFE REGLQLDLSF MRPLETPALL 700
    LVTATTTNSS KEDVTHFVCQ AAVPKSFQLQ LQAPSGNTIP AQGGLPITQV 750
    FRILNPNQAP LRLKLRLTYN HSGQPVQEIF EVDNLPVETW Q 791
    Length:791
    Mass (Da):87,863
    Last modified:July 27, 2011 - v2
    Checksum:i21F744FC8EEFB932
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191K → E in AAC67391. (PubMed:9762922)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068707 mRNA. Translation: AAC67391.1.
    CH466535 Genomic DNA. Translation: EDL36306.1.
    CH466535 Genomic DNA. Translation: EDL36307.1.
    BC108374 mRNA. Translation: AAI08375.1.
    CCDSiCCDS36929.1.
    RefSeqiNP_031481.2. NM_007455.4.
    UniGeneiMm.238879.

    Genome annotation databases

    EnsembliENSMUST00000036041; ENSMUSP00000043996; ENSMUSG00000040701.
    ENSMUST00000170285; ENSMUSP00000128427; ENSMUSG00000040701.
    GeneIDi11766.
    KEGGimmu:11766.
    UCSCiuc007tyd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068707 mRNA. Translation: AAC67391.1 .
    CH466535 Genomic DNA. Translation: EDL36306.1 .
    CH466535 Genomic DNA. Translation: EDL36307.1 .
    BC108374 mRNA. Translation: AAI08375.1 .
    CCDSi CCDS36929.1.
    RefSeqi NP_031481.2. NM_007455.4.
    UniGenei Mm.238879.

    3D structure databases

    ProteinModelPortali O88512.
    SMRi O88512. Positions 6-590, 671-791.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000043996.

    PTM databases

    PhosphoSitei O88512.

    Proteomic databases

    MaxQBi O88512.
    PaxDbi O88512.
    PRIDEi O88512.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036041 ; ENSMUSP00000043996 ; ENSMUSG00000040701 .
    ENSMUST00000170285 ; ENSMUSP00000128427 ; ENSMUSG00000040701 .
    GeneIDi 11766.
    KEGGi mmu:11766.
    UCSCi uc007tyd.2. mouse.

    Organism-specific databases

    CTDi 8906.
    MGIi MGI:1328307. Ap1g2.

    Phylogenomic databases

    eggNOGi NOG303101.
    GeneTreei ENSGT00390000012618.
    HOGENOMi HOG000210271.
    HOVERGENi HBG067473.
    InParanoidi Q2YDV3.
    KOi K12391.
    OMAi PCAQLLH.
    OrthoDBi EOG7S7SD7.
    TreeFami TF300367.

    Miscellaneous databases

    NextBioi 279529.
    PROi O88512.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88512.
    Bgeei O88512.
    CleanExi MM_AP1G2.
    Genevestigatori O88512.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1230. 2 hits.
    InterProi IPR017107. AP1_complex_gsu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR008153. Clathrin_g-adaptin_app.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037094. AP1_complex_gamma. 1 hit.
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    PROSITEi PS50180. GAE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and localization of a novel gamma-adaptin-like molecule."
      Lewin D.A., Sheff D., Ooi C.E., Whitney J.A., Yamamoto E., Chicione L.M., Webster P., Bonifacino J.S., Mellman I.
      FEBS Lett. 435:263-268(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NMRI.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiAP1G2_MOUSE
    AccessioniPrimary (citable) accession number: O88512
    Secondary accession number(s): Q2YDV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3