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O88512 (AP1G2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
AP-1 complex subunit gamma-like 2
Alternative name(s):
Gamma2-adaptin
Short name=G2ad
Gene names
Name:Ap1g2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length791 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function in protein sorting in late endosomes or multivesucular bodies (MVBs).

Subunit structure

Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Binds ubiquitin By similarity.

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the adaptor complexes large subunit family.

Contains 1 GAE domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 791791AP-1 complex subunit gamma-like 2
PRO_0000193761

Regions

Domain671 – 786116GAE

Experimental info

Sequence conflict191K → E in AAC67391. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O88512 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 21F744FC8EEFB932

FASTA79187,863
        10         20         30         40         50         60 
MVVHSLRLQD LIEEIRGAKT QAQEREVIQK ECAQIRASFR DGDPLQRHRQ LAKLLYVHML 

        70         80         90        100        110        120 
GYPAHFGQME CLKLIASPRF TDKRVGYLGA MLLLDERHDS HLLITNSIKN DLSQGNQPVQ 

       130        140        150        160        170        180 
GLALCTLSTM GSAEMCRDLA PEVEKLLLQP SPYVRKKAIL TAVHMIRKDP ELSGIFLPPC 

       190        200        210        220        230        240 
TKLLRERHHG IQLGTVTLIT ELCERNPAAL RHFRKVVPQL VQILRTLVTT GYSTEHSISG 

       250        260        270        280        290        300 
VSDPFLQVQI LRLLRILGRN HEESSETMND LLAQVATNTD TSRNAGNAVL LETVLTIMAI 

       310        320        330        340        350        360 
HSAAGLRVLA VNILGRFLLN NDKNIRYVAL TSLLQLVQSD HSAVQRHRST VVECLQETDA 

       370        380        390        400        410        420 
SLSRRALELS LALVNSSNVR AMMQELQAFL ESCPPDLRAD CASGILLAAE RFAPSKRWHI 

       430        440        450        460        470        480 
DTILHVLTTA GAHVRDDAVA NLTQLIGEAE ELHTYSVRRL YSALAEDISQ QPLVQVAAWC 

       490        500        510        520        530        540 
IGEYGDLLLE GNCEETEPFQ VEEEDVLALL EKVLQSHMSL PATRGYAITA LMKLSTRLRG 

       550        560        570        580        590        600 
DNNRIRQVVS IYGSCVDLEL QQRAVEYNTL FQKYDHMRAA ILEKMPLVER GDPHVKEGGK 

       610        620        630        640        650        660 
EKQTEAQPLE VTAPAPTEPQ ATKLLDLLDL LGDTSEPLSS GHAQHLPPQT PSPGEALIHL 

       670        680        690        700        710        720 
LDLPCTPPPP APIPSVRVFE REGLQLDLSF MRPLETPALL LVTATTTNSS KEDVTHFVCQ 

       730        740        750        760        770        780 
AAVPKSFQLQ LQAPSGNTIP AQGGLPITQV FRILNPNQAP LRLKLRLTYN HSGQPVQEIF 

       790 
EVDNLPVETW Q 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression, and localization of a novel gamma-adaptin-like molecule."
Lewin D.A., Sheff D., Ooi C.E., Whitney J.A., Yamamoto E., Chicione L.M., Webster P., Bonifacino J.S., Mellman I.
FEBS Lett. 435:263-268(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NMRI.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF068707 mRNA. Translation: AAC67391.1.
CH466535 Genomic DNA. Translation: EDL36306.1.
CH466535 Genomic DNA. Translation: EDL36307.1.
BC108374 mRNA. Translation: AAI08375.1.
CCDSCCDS36929.1.
RefSeqNP_031481.2. NM_007455.4.
UniGeneMm.238879.

3D structure databases

ProteinModelPortalO88512.
SMRO88512. Positions 6-590, 671-791.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000043996.

PTM databases

PhosphoSiteO88512.

Proteomic databases

MaxQBO88512.
PaxDbO88512.
PRIDEO88512.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036041; ENSMUSP00000043996; ENSMUSG00000040701.
ENSMUST00000170285; ENSMUSP00000128427; ENSMUSG00000040701.
GeneID11766.
KEGGmmu:11766.
UCSCuc007tyd.2. mouse.

Organism-specific databases

CTD8906.
MGIMGI:1328307. Ap1g2.

Phylogenomic databases

eggNOGNOG303101.
GeneTreeENSGT00390000012618.
HOGENOMHOG000210271.
HOVERGENHBG067473.
InParanoidQ2YDV3.
KOK12391.
OMAPCAQLLH.
OrthoDBEOG7S7SD7.
TreeFamTF300367.

Gene expression databases

ArrayExpressO88512.
BgeeO88512.
CleanExMM_AP1G2.
GenevestigatorO88512.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
2.60.40.1230. 2 hits.
InterProIPR017107. AP1_complex_gsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamPF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFPIRSF037094. AP1_complex_gamma. 1 hit.
SMARTSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEPS50180. GAE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279529.
PROO88512.
SOURCESearch...

Entry information

Entry nameAP1G2_MOUSE
AccessionPrimary (citable) accession number: O88512
Secondary accession number(s): Q2YDV3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot