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O88509

- DNM3B_MOUSE

UniProt

O88509 - DNM3B_MOUSE

Protein

DNA (cytosine-5)-methyltransferase 3B

Gene

Dnmt3b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Enzyme regulationi

    Activated by binding to the regulatory factor DNMT3L.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei611 – 6111S-adenosyl-L-methionineBy similarity
    Active sitei657 – 6571PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri439 – 46931GATA-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 53657PHD-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: MGI
    2. DNA binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW
    4. methyltransferase activity Source: UniProtKB
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. C-5 methylation of cytosine Source: GOC
    2. cellular response to amino acid stimulus Source: MGI
    3. DNA methylation Source: MGI
    4. DNA methylation involved in embryo development Source: UniProtKB
    5. methylation-dependent chromatin silencing Source: MGI
    6. negative regulation of gene expression, epigenetic Source: UniProtKB
    7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    8. protein complex localization Source: MGI
    9. regulation of gene expression by genetic imprinting Source: MGI

    Keywords - Molecular functioni

    Activator, Methyltransferase, Repressor, Transferase

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    BRENDAi2.1.1.37. 3474.
    ReactomeiREACT_200667. NoRC negatively regulates rRNA expression.
    REACT_214440. NoRC negatively regulates rRNA expression.
    REACT_222475. PRC2 methylates histones and DNA.

    Protein family/group databases

    REBASEi3748. M.MmuDnmt3B.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA (cytosine-5)-methyltransferase 3B (EC:2.1.1.37)
    Short name:
    Dnmt3b
    Alternative name(s):
    DNA methyltransferase MmuIIIB
    Short name:
    DNA MTase MmuIIIB
    Short name:
    M.MmuIIIB
    Gene namesi
    Name:Dnmt3b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1261819. Dnmt3b.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Accumulates in the major satellite repeats at pericentric heterochromatin.

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB
    2. heterochromatin Source: MGI
    3. nuclear heterochromatin Source: MGI
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi236 – 2372VW → RR: Prevents accumulation in pericentric heterochromatin.
    Mutagenesisi277 – 2771S → P: Prevents accumulation in pericentric heterochromatin. 1 Publication
    Mutagenesisi609 – 6091A → T: Significantly reduces activity. 1 Publication
    Mutagenesisi656 – 6572PC → GT: No effect on localization.
    Mutagenesisi669 – 6691G → S: Significantly reduces activity. 1 Publication
    Mutagenesisi670 – 6701L → T: Significantly reduces activity. 1 Publication
    Mutagenesisi725 – 7251V → G: Loss of activity. 1 Publication
    Mutagenesisi823 – 8231D → G: Significantly reduces activity. 1 Publication
    Mutagenesisi824 – 8241V → M: Significantly reduces activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859DNA (cytosine-5)-methyltransferase 3BPRO_0000088046Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei96 – 961PhosphoserineBy similarity
    Modified residuei112 – 1121PhosphothreonineBy similarity
    Modified residuei116 – 1161PhosphoserineBy similarity
    Modified residuei216 – 2161PhosphoserineBy similarity
    Modified residuei415 – 4151Citrulline1 Publication

    Post-translational modificationi

    Sumoylated.By similarity
    Citrullinated by PADI4.1 Publication

    Keywords - PTMi

    Citrullination, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO88509.
    PRIDEiO88509.

    PTM databases

    PhosphoSiteiO88509.

    Expressioni

    Developmental stagei

    Expressed in almost all blastocysts at embryonic day 3.0 (E3.0). Preferentially expressed in the trophectoderm (TE) in E3.5 and polar TE in E4.0 blastocysts. In E4.5 embryos, expressed in the polar TE and some inner cell mass (ICM) embryonic lineage cells. In post-implantation embryo at E5.5, expressed in the epiblast (embryonic lineage) derived from the ICM. Highly expressed, at E7.5, in the embryonic ectoderm, neural ectoderm, and chorionic ectoderm; a weak expression is also detected in mesodermal and endodermal cells. At later stages, the expression is detected predominantly in the forebrain and eyes but weakly throughout the embryo.2 Publications

    Gene expression databases

    ArrayExpressiO88509.
    BgeeiO88509.
    CleanExiMM_DNMT3B.
    GenevestigatoriO88509.

    Interactioni

    Subunit structurei

    Interacts with CBX4, DNMT1, DNMT3A, SETDB1, UBE2I9, UBL1 and ZHX1 By similarity. Interacts with SUV39H1 and BAZ2A/TIP5. Interacts with the PRC2/EED-EZH2 complex. Interacts with UHRF1.By similarity6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dnmt3lQ9CWR85EBI-7987547,EBI-3043871
    HellsQ608484EBI-7987547,EBI-3043887

    Protein-protein interaction databases

    BioGridi199262. 10 interactions.
    DIPiDIP-43736N.
    IntActiO88509. 5 interactions.
    MINTiMINT-2523761.

    Structurei

    Secondary structure

    1
    859
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi226 – 2294
    Beta strandi235 – 2406
    Turni241 – 2433
    Beta strandi244 – 2518
    Helixi253 – 2553
    Beta strandi265 – 2706
    Turni271 – 2733
    Beta strandi276 – 2805
    Helixi281 – 2833
    Helixi290 – 2934
    Helixi296 – 3016
    Helixi303 – 32018
    Helixi332 – 34413
    Turni348 – 3503
    Helixi351 – 3555

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KHCX-ray1.80A219-366[»]
    ProteinModelPortaliO88509.
    SMRiO88509. Positions 223-357, 421-858.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO88509.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini232 – 29059PWWPPROSITE-ProRule annotationAdd
    BLAST
    Domaini428 – 560133ADDPROSITE-ProRule annotationAdd
    BLAST
    Domaini581 – 859279SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 305305Interaction with DNMT1 and DNMT3ABy similarityAdd
    BLAST
    Regioni440 – 53293Interaction with the PRC2/EED-EZH2 complexAdd
    BLAST
    Regioni588 – 5925S-adenosyl-L-methionine bindingBy similarity
    Regioni633 – 6353S-adenosyl-L-methionine bindingBy similarity
    Regioni838 – 8403S-adenosyl-L-methionine bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi160 – 1656Poly-Arg

    Domaini

    The PWWP domain is essential for targeting to pericentric heterochromatin.

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 ADD domain.PROSITE-ProRule annotation
    Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PWWP domain.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri439 – 46931GATA-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 53657PHD-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG70699.
    GeneTreeiENSGT00390000008341.
    HOGENOMiHOG000230875.
    HOVERGENiHBG051381.
    KOiK17399.
    OrthoDBiEOG7MWGW6.
    TreeFamiTF329039.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025766. ADD.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025811. C5_MeTrfase_3.
    IPR000313. PWWP_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR011011. Znf_FYVE_PHD.
    [Graphical view]
    PfamiPF00145. DNA_methylase. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view]
    SMARTiSM00293. PWWP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51533. ADD. 1 hit.
    PS00094. C5_MTASE_1. 1 hit.
    PS50812. PWWP. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88509-1) [UniParc]FASTAAdd to Basket

    Also known as: 5

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGDSRHLNE EEGASGYEEC IIVNGNFSDQ SSDTKDAPSP PVLEAICTEP    50
    VCTPETRGRR SSSRLSKREV SSLLNYTQDM TGDGDRDDEV DDGNGSDILM 100
    PKLTRETKDT RTRSESPAVR TRHSNGTSSL ERQRASPRIT RGRQGRHHVQ 150
    EYPVEFPATR SRRRRASSSA STPWSSPASV DFMEEVTPKS VSTPSVDLSQ 200
    DGDQEGMDTT QVDAESRDGD STEYQDDKEF GIGDLVWGKI KGFSWWPAMV 250
    VSWKATSKRQ AMPGMRWVQW FGDGKFSEIS ADKLVALGLF SQHFNLATFN 300
    KLVSYRKAMY HTLEKARVRA GKTFSSSPGE SLEDQLKPML EWAHGGFKPT 350
    GIEGLKPNKK QPVVNKSKVR RSDSRNLEPR RRENKSRRRT TNDSAASESP 400
    PPKRLKTNSY GGKDRGEDEE SRERMASEVT NNKGNLEDRC LSCGKKNPVS 450
    FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ SYCTVCCEGR ELLLCSNTSC 500
    CRCFCVECLE VLVGAGTAED AKLQEPWSCY MCLPQRCHGV LRRRKDWNMR 550
    LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKEL 600
    GIKVEKYIAS EVCAESIAVG TVKHEGQIKY VNDVRKITKK NIEEWGPFDL 650
    VIGGSPCNDL SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW 700
    MFENVVAMKV NDKKDISRFL ACNPVMIDAI KVSAAHRARY FWGNLPGMNR 750
    PVMASKNDKL ELQDCLEFSR TAKLKKVQTI TTKSNSIRQG KNQLFPVVMN 800
    GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW SVPVIRHLFA 850
    PLKDYFACE 859
    Length:859
    Mass (Da):97,228
    Last modified:May 1, 2000 - v2
    Checksum:i93E334D9FBCC590E
    GO
    Isoform 2 (identifier: O88509-2) [UniParc]FASTAAdd to Basket

    Also known as: 6

    The sequence of this isoform differs from the canonical sequence as follows:
         363-382: Missing.

    Show »
    Length:839
    Mass (Da):94,793
    Checksum:i59BF48AB459A1298
    GO
    Isoform 3 (identifier: O88509-3) [UniParc]FASTAAdd to Basket

    Also known as: 8

    The sequence of this isoform differs from the canonical sequence as follows:
         363-382: Missing.
         750-812: Missing.

    Show »
    Length:776
    Mass (Da):87,586
    Checksum:i211E2DE8BF06C48E
    GO
    Isoform 4 (identifier: O88509-4) [UniParc]FASTAAdd to Basket

    Also known as: 7

    The sequence of this isoform differs from the canonical sequence as follows:
         750-812: Missing.

    Show »
    Length:796
    Mass (Da):90,021
    Checksum:i0B7D93B4D802744E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti217 – 2182RD → IY in AAF74515. (PubMed:12567489)Curated
    Sequence conflicti217 – 2182RD → IY in AAF74516. (PubMed:12567489)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei363 – 38220Missing in isoform 2 and isoform 3. 2 PublicationsVSP_005642Add
    BLAST
    Alternative sequencei750 – 81263Missing in isoform 3 and isoform 4. 2 PublicationsVSP_005643Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068626 mRNA. Translation: AAC40178.2.
    AF068627 mRNA. Translation: AAC40179.2.
    AF068628 mRNA. Translation: AAC40180.2.
    AF151969 mRNA. Translation: AAF74515.1.
    AF151970 mRNA. Translation: AAF74516.1.
    AF151971 mRNA. Translation: AAF74517.1.
    AF151972 mRNA. Translation: AAF74518.1.
    AF151973 mRNA. Translation: AAF74519.1.
    AF151974 mRNA. Translation: AAF74520.1.
    AF151975 mRNA. Translation: AAF74521.1.
    AF151976 mRNA. Translation: AAF74522.1.
    CCDSiCCDS16913.1. [O88509-2]
    CCDS16914.1. [O88509-1]
    CCDS16915.1. [O88509-4]
    CCDS16916.1. [O88509-3]
    RefSeqiNP_001003960.2. NM_001003960.4. [O88509-2]
    NP_001003961.2. NM_001003961.4. [O88509-1]
    NP_001258673.1. NM_001271744.1. [O88509-1]
    NP_001258674.1. NM_001271745.1. [O88509-2]
    NP_001258676.1. NM_001271747.1. [O88509-3]
    NP_034198.3. NM_010068.5. [O88509-3]
    UniGeneiMm.491804.
    Mm.89772.

    Genome annotation databases

    EnsembliENSMUST00000072997; ENSMUSP00000072761; ENSMUSG00000027478. [O88509-1]
    ENSMUST00000081628; ENSMUSP00000080334; ENSMUSG00000027478. [O88509-2]
    ENSMUST00000088976; ENSMUSP00000086370; ENSMUSG00000027478. [O88509-4]
    ENSMUST00000103150; ENSMUSP00000099439; ENSMUSG00000027478. [O88509-3]
    ENSMUST00000103151; ENSMUSP00000099440; ENSMUSG00000027478. [O88509-3]
    ENSMUST00000109772; ENSMUSP00000105394; ENSMUSG00000027478. [O88509-4]
    ENSMUST00000109773; ENSMUSP00000105395; ENSMUSG00000027478. [O88509-2]
    ENSMUST00000109774; ENSMUSP00000105396; ENSMUSG00000027478. [O88509-1]
    GeneIDi13436.
    KEGGimmu:13436.
    UCSCiuc008nib.2. mouse. [O88509-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068626 mRNA. Translation: AAC40178.2 .
    AF068627 mRNA. Translation: AAC40179.2 .
    AF068628 mRNA. Translation: AAC40180.2 .
    AF151969 mRNA. Translation: AAF74515.1 .
    AF151970 mRNA. Translation: AAF74516.1 .
    AF151971 mRNA. Translation: AAF74517.1 .
    AF151972 mRNA. Translation: AAF74518.1 .
    AF151973 mRNA. Translation: AAF74519.1 .
    AF151974 mRNA. Translation: AAF74520.1 .
    AF151975 mRNA. Translation: AAF74521.1 .
    AF151976 mRNA. Translation: AAF74522.1 .
    CCDSi CCDS16913.1. [O88509-2 ]
    CCDS16914.1. [O88509-1 ]
    CCDS16915.1. [O88509-4 ]
    CCDS16916.1. [O88509-3 ]
    RefSeqi NP_001003960.2. NM_001003960.4. [O88509-2 ]
    NP_001003961.2. NM_001003961.4. [O88509-1 ]
    NP_001258673.1. NM_001271744.1. [O88509-1 ]
    NP_001258674.1. NM_001271745.1. [O88509-2 ]
    NP_001258676.1. NM_001271747.1. [O88509-3 ]
    NP_034198.3. NM_010068.5. [O88509-3 ]
    UniGenei Mm.491804.
    Mm.89772.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KHC X-ray 1.80 A 219-366 [» ]
    ProteinModelPortali O88509.
    SMRi O88509. Positions 223-357, 421-858.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199262. 10 interactions.
    DIPi DIP-43736N.
    IntActi O88509. 5 interactions.
    MINTi MINT-2523761.

    Chemistry

    ChEMBLi CHEMBL2189115.

    Protein family/group databases

    REBASEi 3748. M.MmuDnmt3B.

    PTM databases

    PhosphoSitei O88509.

    Proteomic databases

    PaxDbi O88509.
    PRIDEi O88509.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072997 ; ENSMUSP00000072761 ; ENSMUSG00000027478 . [O88509-1 ]
    ENSMUST00000081628 ; ENSMUSP00000080334 ; ENSMUSG00000027478 . [O88509-2 ]
    ENSMUST00000088976 ; ENSMUSP00000086370 ; ENSMUSG00000027478 . [O88509-4 ]
    ENSMUST00000103150 ; ENSMUSP00000099439 ; ENSMUSG00000027478 . [O88509-3 ]
    ENSMUST00000103151 ; ENSMUSP00000099440 ; ENSMUSG00000027478 . [O88509-3 ]
    ENSMUST00000109772 ; ENSMUSP00000105394 ; ENSMUSG00000027478 . [O88509-4 ]
    ENSMUST00000109773 ; ENSMUSP00000105395 ; ENSMUSG00000027478 . [O88509-2 ]
    ENSMUST00000109774 ; ENSMUSP00000105396 ; ENSMUSG00000027478 . [O88509-1 ]
    GeneIDi 13436.
    KEGGi mmu:13436.
    UCSCi uc008nib.2. mouse. [O88509-1 ]

    Organism-specific databases

    CTDi 1789.
    MGIi MGI:1261819. Dnmt3b.

    Phylogenomic databases

    eggNOGi NOG70699.
    GeneTreei ENSGT00390000008341.
    HOGENOMi HOG000230875.
    HOVERGENi HBG051381.
    KOi K17399.
    OrthoDBi EOG7MWGW6.
    TreeFami TF329039.

    Enzyme and pathway databases

    BRENDAi 2.1.1.37. 3474.
    Reactomei REACT_200667. NoRC negatively regulates rRNA expression.
    REACT_214440. NoRC negatively regulates rRNA expression.
    REACT_222475. PRC2 methylates histones and DNA.

    Miscellaneous databases

    ChiTaRSi DNMT3B. mouse.
    EvolutionaryTracei O88509.
    NextBioi 283873.
    PROi O88509.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88509.
    Bgeei O88509.
    CleanExi MM_DNMT3B.
    Genevestigatori O88509.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025766. ADD.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025811. C5_MeTrfase_3.
    IPR000313. PWWP_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR011011. Znf_FYVE_PHD.
    [Graphical view ]
    Pfami PF00145. DNA_methylase. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view ]
    SMARTi SM00293. PWWP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51533. ADD. 1 hit.
    PS00094. C5_MTASE_1. 1 hit.
    PS50812. PWWP. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases."
      Okano M., Xie S., Li E.
      Nat. Genet. 19:219-220(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    2. "Cloning of full-length Dnmt3b cDNA and its alternative splicing isoforms in mouse embryo."
      Yin B., Chen Y., Zhu N., Wu G., Shen Y.
      Zhongguo Yi Xue Ke Xue Yuan Xue Bao 21:431-438(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Strain: KM.
      Tissue: Embryo.
    3. "DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development."
      Okano M., Bell D.W., Haber D.A., Li E.
      Cell 99:247-257(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    4. "Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases."
      Gowher H., Jeltsch A.
      J. Biol. Chem. 277:20409-20414(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ALA-609; GLY-669; LEU-670; VAL-725; ASP-823 AND VAL-824.
    5. Cited for: CITRULLINATION AT ARG-415.
    6. "Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin."
      Lehnertz B., Ueda Y., Derijck A.A.H.A., Braunschweig U., Perez-Burgos L., Kubicek S., Chen T., Li E., Jenuwein T., Peters A.H.F.M.
      Curr. Biol. 13:1192-1200(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SUV39H1.
    7. "The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing."
      Zhou Y., Grummt I.
      Curr. Biol. 15:1434-1438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BAZ2A.
    8. Cited for: INTERACTION WITH EED AND EZH2.
    9. "The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin."
      Chen T., Tsujimoto N., Li E.
      Mol. Cell. Biol. 24:9048-9058(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF 236-VAL-TRP-237; SER-277 AND 656-PRO-CYS-657.
    10. "Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L."
      Gowher H., Liebert K., Hermann A., Xu G., Jeltsch A.
      J. Biol. Chem. 280:13341-13348(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    11. "Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA."
      Takeshima H., Suetake I., Shimahara H., Ura K., Tate S., Tajima S.
      J. Biochem. 139:503-515(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing."
      Linhart H.G., Lin H., Yamada Y., Moran E., Steine E.J., Gokhale S., Lo G., Cantu E., Ehrich M., He T., Meissner A., Jaenisch R.
      Genes Dev. 21:3110-3122(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription."
      Kim S.-H., Park J., Choi M.-C., Park J.-H., Kim H.-P., Lee J.-H., Oh D.-Y., Im S.-A., Bang Y.-J., Kim T.-Y.
      Int. J. Biochem. Cell Biol. 40:2462-2471(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CBX4.
    14. "Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells."
      Meilinger D., Fellinger K., Bultmann S., Rothbauer U., Bonapace I.M., Klinkert W.E., Spada F., Leonhardt H.
      EMBO Rep. 10:1259-1264(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UHRF1.
    15. "Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos."
      Hirasawa R., Sasaki H.
      Gene Expr. Patterns 9:27-30(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    16. "The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds."
      Qiu C., Sawada K., Zhang X., Cheng X.
      Nat. Struct. Biol. 9:217-224(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 219-362, FUNCTION, INTERACTION WITH DNA.

    Entry informationi

    Entry nameiDNM3B_MOUSE
    AccessioniPrimary (citable) accession number: O88509
    Secondary accession number(s): O88510, O88511
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3