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Protein

Ciliary neurotrophic factor receptor subunit alpha

Gene

Cntfr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).By similarity

GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: MGI
  • cytokine binding Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • brainstem development Source: MGI
  • ciliary neurotrophic factor-mediated signaling pathway Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • sex differentiation Source: MGI
  • skeletal muscle organ development Source: MGI
  • suckling behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.
SABIO-RKO88507.

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name:
CNTF receptor subunit alpha
Short name:
CNTFR-alpha
Gene namesi
Name:Cntfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99605. Cntfr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 342320Ciliary neurotrophic factor receptor subunit alphaPRO_0000010993Add
BLAST
Propeptidei343 – 37230Removed in mature formSequence analysisPRO_0000010994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 89PROSITE-ProRule annotation
Glycosylationi60 – 601N-linked (GlcNAc...)1 Publication
Glycosylationi70 – 701N-linked (GlcNAc...)1 Publication
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Lipidationi342 – 3421GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO88507.
PaxDbiO88507.
PRIDEiO88507.

Expressioni

Gene expression databases

BgeeiO88507.
CleanExiMM_CNTFR.
ExpressionAtlasiO88507. baseline and differential.
GenevisibleiO88507. MM.

Interactioni

Subunit structurei

Heterotrimer of the alpha subunit, LIFR and IL6ST.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198796. 2 interactions.
IntActiO88507. 4 interactions.
MINTiMINT-4105586.
STRINGi10090.ENSMUSP00000100026.

Structurei

3D structure databases

ProteinModelPortaliO88507.
SMRiO88507. Positions 39-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10478Ig-like C2-typeAdd
BLAST
Domaini108 – 20598Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini206 – 306101Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi290 – 2945WSXWS motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH2U. Eukaryota.
ENOG4110HUW. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000171060.
HOVERGENiHBG051048.
InParanoidiO88507.
KOiK05059.
OMAiQETPHVQ.
OrthoDBiEOG72NRQF.
PhylomeDBiO88507.
TreeFamiTF331210.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVPWACC AVLAAAAAAV YTQKHSPQEA PHVQYERLGA DVTLPCGTAS
60 70 80 90 100
WDAAVTWRVN GTDLAPDLLN GSQLILRSLE LGHSGLYACF HRDSWHLRHQ
110 120 130 140 150
VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK
160 170 180 190 200
IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN TTAITFDEFT
210 220 230 240 250
IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI
260 270 280 290 300
LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
310 320 330 340 350
PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GSGGGPSILF
360 370
LTSVPVTLVL AAAAATANNL LI
Length:372
Mass (Da):40,801
Last modified:April 26, 2005 - v2
Checksum:i0704AA35CF1BBE12
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → T in AAC25711 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068615 mRNA. Translation: AAC25711.1.
BC046974 mRNA. Translation: AAH46974.1.
BC050928 mRNA. Translation: AAH50928.1.
CCDSiCCDS18067.1.
RefSeqiNP_001129528.1. NM_001136056.3.
NP_057882.2. NM_016673.2.
XP_006537660.1. XM_006537597.2.
XP_006537661.1. XM_006537598.2.
XP_006537662.1. XM_006537599.2.
XP_011248218.1. XM_011249916.1.
XP_011248219.1. XM_011249917.1.
UniGeneiMm.425178.

Genome annotation databases

EnsembliENSMUST00000102961; ENSMUSP00000100026; ENSMUSG00000028444.
ENSMUST00000102962; ENSMUSP00000100027; ENSMUSG00000028444.
GeneIDi12804.
KEGGimmu:12804.
UCSCiuc008sje.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068615 mRNA. Translation: AAC25711.1.
BC046974 mRNA. Translation: AAH46974.1.
BC050928 mRNA. Translation: AAH50928.1.
CCDSiCCDS18067.1.
RefSeqiNP_001129528.1. NM_001136056.3.
NP_057882.2. NM_016673.2.
XP_006537660.1. XM_006537597.2.
XP_006537661.1. XM_006537598.2.
XP_006537662.1. XM_006537599.2.
XP_011248218.1. XM_011249916.1.
XP_011248219.1. XM_011249917.1.
UniGeneiMm.425178.

3D structure databases

ProteinModelPortaliO88507.
SMRiO88507. Positions 39-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198796. 2 interactions.
IntActiO88507. 4 interactions.
MINTiMINT-4105586.
STRINGi10090.ENSMUSP00000100026.

Proteomic databases

MaxQBiO88507.
PaxDbiO88507.
PRIDEiO88507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102961; ENSMUSP00000100026; ENSMUSG00000028444.
ENSMUST00000102962; ENSMUSP00000100027; ENSMUSG00000028444.
GeneIDi12804.
KEGGimmu:12804.
UCSCiuc008sje.2. mouse.

Organism-specific databases

CTDi1271.
MGIiMGI:99605. Cntfr.

Phylogenomic databases

eggNOGiENOG410IH2U. Eukaryota.
ENOG4110HUW. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000171060.
HOVERGENiHBG051048.
InParanoidiO88507.
KOiK05059.
OMAiQETPHVQ.
OrthoDBiEOG72NRQF.
PhylomeDBiO88507.
TreeFamiTF331210.

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.
SABIO-RKO88507.

Miscellaneous databases

ChiTaRSiCntfr. mouse.
NextBioi282238.
PROiO88507.
SOURCEiSearch...

Gene expression databases

BgeeiO88507.
CleanExiMM_CNTFR.
ExpressionAtlasiO88507. baseline and differential.
GenevisibleiO88507. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homolog of human ciliary neurotrophic factor receptor."
    Maeda M., Yaguchi N., Hanyuu C., Nakata Y., Onoda N., Tulin E.E., Kojima T., Hasegawa M., Kikuchi Y., Nomura H.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Olfactory epithelium.
  3. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-60 AND ASN-70.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Brown adipose tissue.

Entry informationi

Entry nameiCNTFR_MOUSE
AccessioniPrimary (citable) accession number: O88507
Secondary accession number(s): Q80T01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.