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Protein

Calpain-6

Gene

Capn6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC02.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-6
Gene namesi
Name:Capn6
Synonyms:Capa6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70960. Capn6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641Calpain-6PRO_0000207719Add
BLAST

Proteomic databases

PaxDbiO88501.
PRIDEiO88501.

Interactioni

Subunit structurei

Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006638.

Structurei

3D structure databases

ProteinModelPortaliO88501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 343318Calpain catalyticPROSITE-ProRule annotationAdd
BLAST
Domaini518 – 620103C2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 495152Domain IIIAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 C2 domain.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiO88501.
KOiK08575.
PhylomeDBiO88501.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029540. CAPN6.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF281. PTHR10183:SF281. 1 hit.
PfamiPF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPLKLFKN QKYQELKQDC MKDGRLFCDP TFLPENDSLF FNRLLPGKVV
60 70 80 90 100
WKRPQDISDD PHLIVGNISN HQLIQGRLGN KAMISAFSCL AVQESHWTKA
110 120 130 140 150
IPNHKEQEWD PRKPEKYAGI FRFRFWHFGE WTEVVIDDLL PTINGDLVFS
160 170 180 190 200
FSTSMNEFWN ALLEKAYAKL LGCYEALDGL TITDIIMDFT GTLAEIIDMQ
210 220 230 240 250
KGRYTDLVEE KYKLFGELYK TFTKGGLISC SIESPSQEEQ EVETDWGLLK
260 270 280 290 300
GYTYTMTDIR KLRLGERLVE VFSTEKLYMV RLRNPLGRQE WSGPWSEISE
310 320 330 340 350
EWQQLTVTDR KNLGLVMSDD GEFWMSLEDF CHNFHKLNVC RNVNNPVFGR
360 370 380 390 400
KELESVVGCW TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM
410 420 430 440 450
SLQQKDLRTY RRMGRPDNYI IGFELFKVEM NRRFRLHHLY IQERAGTSTY
460 470 480 490 500
IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS EFLLRIFSEV PVQLRELTLD
510 520 530 540 550
MPKMSCWNLA RGYPKVVTQI TVHSAEGLEK KYANETVNPY LTIKCGKEEV
560 570 580 590 600
RSPVQKNTVH AIFDTQAIFY RRTTDIPIII QVWNSRKFCD QFLGQVTLDA
610 620 630 640
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L
Length:641
Mass (Da):74,560
Last modified:November 1, 1998 - v1
Checksum:i3D9286F8B54369A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067793 mRNA. Translation: AAC19367.1.
RefSeqiNP_113996.1. NM_031808.1.
UniGeneiRn.2862.

Genome annotation databases

GeneIDi83685.
KEGGirno:83685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067793 mRNA. Translation: AAC19367.1.
RefSeqiNP_113996.1. NM_031808.1.
UniGeneiRn.2862.

3D structure databases

ProteinModelPortaliO88501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006638.

Protein family/group databases

MEROPSiC02.971.

Proteomic databases

PaxDbiO88501.
PRIDEiO88501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83685.
KEGGirno:83685.

Organism-specific databases

CTDi827.
RGDi70960. Capn6.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiO88501.
KOiK08575.
PhylomeDBiO88501.

Miscellaneous databases

PROiO88501.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029540. CAPN6.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF281. PTHR10183:SF281. 1 hit.
PfamiPF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cellular genes modulated by a transactivator Tax of HTLV-1."
    Shimizu T.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.

Entry informationi

Entry nameiCAN6_RAT
AccessioniPrimary (citable) accession number: O88501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.