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Protein

Calpain-6

Gene

Capn6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiC02.971

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-6
Gene namesi
Name:Capn6
Synonyms:Capa6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70960 Capn6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077191 – 641Calpain-6Add BLAST641

Proteomic databases

PaxDbiO88501
PRIDEiO88501

Interactioni

Subunit structurei

Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006638

Structurei

3D structure databases

ProteinModelPortaliO88501
SMRiO88501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 343Calpain catalyticPROSITE-ProRule annotationAdd BLAST318
Domaini518 – 620C2Add BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 495Domain IIIAdd BLAST152

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
HOGENOMiHOG000232036
HOVERGENiHBG001095
InParanoidiO88501
KOiK08575
PhylomeDBiO88501

Family and domain databases

CDDicd04046 C2_Calpain, 1 hit
cd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR033884 C2_Calpain
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR029540 CAPN6
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF381 PTHR10183:SF381, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

Sequencei

Sequence statusi: Complete.

O88501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPLKLFKN QKYQELKQDC MKDGRLFCDP TFLPENDSLF FNRLLPGKVV
60 70 80 90 100
WKRPQDISDD PHLIVGNISN HQLIQGRLGN KAMISAFSCL AVQESHWTKA
110 120 130 140 150
IPNHKEQEWD PRKPEKYAGI FRFRFWHFGE WTEVVIDDLL PTINGDLVFS
160 170 180 190 200
FSTSMNEFWN ALLEKAYAKL LGCYEALDGL TITDIIMDFT GTLAEIIDMQ
210 220 230 240 250
KGRYTDLVEE KYKLFGELYK TFTKGGLISC SIESPSQEEQ EVETDWGLLK
260 270 280 290 300
GYTYTMTDIR KLRLGERLVE VFSTEKLYMV RLRNPLGRQE WSGPWSEISE
310 320 330 340 350
EWQQLTVTDR KNLGLVMSDD GEFWMSLEDF CHNFHKLNVC RNVNNPVFGR
360 370 380 390 400
KELESVVGCW TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM
410 420 430 440 450
SLQQKDLRTY RRMGRPDNYI IGFELFKVEM NRRFRLHHLY IQERAGTSTY
460 470 480 490 500
IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS EFLLRIFSEV PVQLRELTLD
510 520 530 540 550
MPKMSCWNLA RGYPKVVTQI TVHSAEGLEK KYANETVNPY LTIKCGKEEV
560 570 580 590 600
RSPVQKNTVH AIFDTQAIFY RRTTDIPIII QVWNSRKFCD QFLGQVTLDA
610 620 630 640
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L
Length:641
Mass (Da):74,560
Last modified:November 1, 1998 - v1
Checksum:i3D9286F8B54369A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067793 mRNA Translation: AAC19367.1
RefSeqiNP_113996.1, NM_031808.1
UniGeneiRn.2862

Genome annotation databases

GeneIDi83685
KEGGirno:83685

Similar proteinsi

Entry informationi

Entry nameiCAN6_RAT
AccessioniPrimary (citable) accession number: O88501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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