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Protein

Vitamin K-dependent gamma-carboxylase

Gene

Ggcx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Catalytic activityi

[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O = [peptidyl]-glutamate + CO2 + O2 + phylloquinol.

GO - Molecular functioni

  • gamma-glutamyl carboxylase activity Source: RGD
  • peptide binding Source: RGD
  • vitamin binding Source: RGD

GO - Biological processi

  • lung growth Source: RGD
  • peptidyl-glutamic acid carboxylation Source: RGD
  • response to dexamethasone Source: RGD
  • response to manganese ion Source: RGD
  • response to oxygen levels Source: RGD
  • response to parathyroid hormone Source: RGD
  • response to Thyroglobulin triiodothyronine Source: RGD
  • response to vitamin D Source: RGD
  • response to vitamin K Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BRENDAi4.1.1.90. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K-dependent gamma-carboxylase (EC:4.1.1.90)
Alternative name(s):
Gamma-glutamyl carboxylase
Peptidyl-glutamate 4-carboxylase
Vitamin K gamma glutamyl carboxylase
Gene namesi
Name:Ggcx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68383. Ggcx.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6059CytoplasmicSequence analysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Topological domaini82 – 11332LumenalSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Topological domaini135 – 1362CytoplasmicSequence analysis
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Topological domaini158 – 292135LumenalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Topological domaini314 – 36148CytoplasmicSequence analysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence analysisAdd
BLAST
Topological domaini383 – 758376LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 758757Vitamin K-dependent gamma-carboxylasePRO_0000191826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Disulfide bondi99 ↔ 450By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiO88496.
PRIDEiO88496.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with CALU.By similarity1 Publication

Protein-protein interaction databases

MINTiMINT-4567226.
STRINGi10116.ENSRNOP00000017928.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHG2. Eukaryota.
ENOG410XR5Q. LUCA.
HOGENOMiHOG000007593.
HOVERGENiHBG012798.
InParanoidiO88496.
KOiK10106.
PhylomeDBiO88496.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR011020. HTTM.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR007782. VKG_COase.
[Graphical view]
PANTHERiPTHR12639. PTHR12639. 1 hit.
PfamiPF05090. VKG_Carbox. 1 hit.
[Graphical view]
SMARTiSM00752. HTTM. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVHRGSARA APASDKVQKN KPAQTSGLEQ GSRMARIFGF EWADLSSWQS
60 70 80 90 100
VVTLLNRPTD PANLAVFRFL FAFLMLLDIP QERGLSSLDR KYLDGLDVCR
110 120 130 140 150
FPLLDALRPL PLDWMYLVYT IMFLGALGMM LGLWYRLSCM LFLLPYWYVF
160 170 180 190 200
LLDKTSWNNH SYLYGLLAFQ LTFMDANHYW SVDGLLSAQK KNAHVPLWNY
210 220 230 240 250
TVLRGQIFIV YFIAGVKKLD ADWVEGYSME HLSRHWLFSP FKLVLSEELT
260 270 280 290 300
SLLVVHWCGL LLDLSAGFLL FFDASRPIGL VFVSYFHCMN SQLFSIGMFP
310 320 330 340 350
YVMLASSPLF CSAEWPRKLV ARCPKRLQEL LPAKAAPRPS ASCVYKRARA
360 370 380 390 400
KAGQKPGLRH HLGTVFTLLY LLEQLFLPYS HFLTQGYNNW TNGLYGYSWD
410 420 430 440 450
MMVHSRSHQH VKITYRDGLT GELGYLNPGV FTQSRRWKDH ADMLKQYATC
460 470 480 490 500
LSLLLPKYNV TEPQIYFDIW VSINDRFQQR LFDPRVDIVQ AVWSPFRRTP
510 520 530 540 550
WVQPLLMDLS PWRTKLQDIK SSLDNHTEVV FIADFPGLHL ENFVSEDLGN
560 570 580 590 600
TSIQLLQGEV TVELVAEQKN QTLREGEKMQ LPAGEYHKVY TVSSSPSCYM
610 620 630 640 650
YIYVNTTEVA LEQDLAYLQE LKEKVENGSE TGPLPPELQP LLEGEVKGGP
660 670 680 690 700
EPTPLVQTFL RRQRKLQEIE RRRNSPLHER FLRFVLRKLY VFRRSFLMTR
710 720 730 740 750
ISLRNLLFGR PSLEQLAQEV TYANLRPFEP VDESSASNTD SSDPHPSEPD

SEHVHSEL
Length:758
Mass (Da):87,479
Last modified:November 1, 1998 - v1
Checksum:i6CF2FC8DC96A71A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065387 mRNA. Translation: AAC82374.1.
RefSeqiNP_113944.1. NM_031756.1.
UniGeneiRn.22410.

Genome annotation databases

GeneIDi81716.
KEGGirno:81716.
UCSCiRGD:68383. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065387 mRNA. Translation: AAC82374.1.
RefSeqiNP_113944.1. NM_031756.1.
UniGeneiRn.22410.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4567226.
STRINGi10116.ENSRNOP00000017928.

Chemistry

ChEMBLiCHEMBL2744.

Proteomic databases

PaxDbiO88496.
PRIDEiO88496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81716.
KEGGirno:81716.
UCSCiRGD:68383. rat.

Organism-specific databases

CTDi2677.
RGDi68383. Ggcx.

Phylogenomic databases

eggNOGiENOG410IHG2. Eukaryota.
ENOG410XR5Q. LUCA.
HOGENOMiHOG000007593.
HOVERGENiHBG012798.
InParanoidiO88496.
KOiK10106.
PhylomeDBiO88496.

Enzyme and pathway databases

BRENDAi4.1.1.90. 5301.

Miscellaneous databases

PROiO88496.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR011020. HTTM.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR007782. VKG_COase.
[Graphical view]
PANTHERiPTHR12639. PTHR12639. 1 hit.
PfamiPF05090. VKG_Carbox. 1 hit.
[Graphical view]
SMARTiSM00752. HTTM. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVKGC_RAT
AccessioniPrimary (citable) accession number: O88496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO2, O2 and reduced vitamin K are cosubstrates.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.