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Protein

Melatonin-related receptor

Gene

Gpr50

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Does not bind melatonin.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin-related receptor
Alternative name(s):
G protein-coupled receptor 50
H9
Gene namesi
Name:Gpr50
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1333877. Gpr50.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini60 – 7213CytoplasmicSequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini94 – 11118ExtracellularSequence analysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini133 – 15119CytoplasmicSequence analysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini173 – 19624ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 24730CytoplasmicSequence analysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini269 – 28113ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 591289CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Melatonin-related receptorPRO_0000069879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi109 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO88495.
PRIDEiO88495.

PTM databases

PhosphoSiteiO88495.

Expressioni

Gene expression databases

BgeeiO88495.
CleanExiMM_GPR50.
GenevisibleiO88495. MM.

Interactioni

Subunit structurei

Homodimer, and heterodimer with MTNR1A and MTNR1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064608.

Structurei

3D structure databases

ProteinModelPortaliO88495.
SMRiO88495. Positions 4-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000133094.
HOVERGENiHBG052529.
InParanoidiO88495.
KOiK04287.
OMAiPASVHFK.
OrthoDBiEOG7MD4Q5.
PhylomeDBiO88495.
TreeFamiTF331693.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002280. Mel_rcpt_1X.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01151. MELATONIN1XR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPKSNMG PTKAVPTPFG CIGCKLPKPD YPPALIIFMF CAMVITVVVD
60 70 80 90 100
LIGNSMVILA VTKNKKLRNS GNIFVASLSV ADMLVAIYPY PLMLYAMSVG
110 120 130 140 150
GWDLSQLQCQ MVGLVTGLSV VGSIFNITAI AINRYCYICH SLQYKRIFSL
160 170 180 190 200
RNTCIYLVVT WVMTVLAVLP NMYIGTIEYD PRTYTCIFNY VNNPAFTVTI
210 220 230 240 250
VCIHFVLPLI IVGYCYTKIW IKVLAARDPA GQNPDNQFAE VRNFLTMFVI
260 270 280 290 300
FLLFAVCWCP VNVLTVLVAV IPKEMAGKIP NWLYLAAYCI AYFNSCLNAI
310 320 330 340 350
IYGILNESFR REYWTIFHAM RHPILFISHL ISDIRETWET RALTRARVRA
360 370 380 390 400
RDQVREQERA RACVAVEGTP RNVRNVLLPG DASAPHSDRA SVRPKPQTRS
410 420 430 440 450
TSVYRKPASI HHKSISGHPK SASVYPKPAS SVHCKPASVH FKPASVHFKG
460 470 480 490 500
DSVYFKGDTV HYRAASKLVT SHRISAGPST SHPTSMAGYI KSGTSHPATT
510 520 530 540 550
TVDYLEPATT SHSVLTAVDL PEVSASHCLE MTSTGHLRAD ISASVLPSVP
560 570 580 590
FELAATPPDT TAIPIASGDY RKVVLIDDDS DDSDCSDEMA V
Length:591
Mass (Da):65,130
Last modified:October 16, 2013 - v3
Checksum:i12576D50C20E216A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065145 mRNA. Translation: AAC21462.1.
AK132272 mRNA. Translation: BAE21072.1.
AL840624 Genomic DNA. No translation available.
CH466624 Genomic DNA. Translation: EDL26572.1.
BC137982 mRNA. Translation: AAI37983.1.
CCDSiCCDS30181.1.
RefSeqiNP_001295430.1. NM_001308501.1.
NP_034470.1. NM_010340.2.
UniGeneiMm.33336.

Genome annotation databases

EnsembliENSMUST00000070449; ENSMUSP00000064608; ENSMUSG00000056380.
GeneIDi14765.
KEGGimmu:14765.
UCSCiuc009tke.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065145 mRNA. Translation: AAC21462.1.
AK132272 mRNA. Translation: BAE21072.1.
AL840624 Genomic DNA. No translation available.
CH466624 Genomic DNA. Translation: EDL26572.1.
BC137982 mRNA. Translation: AAI37983.1.
CCDSiCCDS30181.1.
RefSeqiNP_001295430.1. NM_001308501.1.
NP_034470.1. NM_010340.2.
UniGeneiMm.33336.

3D structure databases

ProteinModelPortaliO88495.
SMRiO88495. Positions 4-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064608.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO88495.

Proteomic databases

PaxDbiO88495.
PRIDEiO88495.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070449; ENSMUSP00000064608; ENSMUSG00000056380.
GeneIDi14765.
KEGGimmu:14765.
UCSCiuc009tke.1. mouse.

Organism-specific databases

CTDi9248.
MGIiMGI:1333877. Gpr50.

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000133094.
HOVERGENiHBG052529.
InParanoidiO88495.
KOiK04287.
OMAiPASVHFK.
OrthoDBiEOG7MD4Q5.
PhylomeDBiO88495.
TreeFamiTF331693.

Miscellaneous databases

NextBioi286851.
PROiO88495.
SOURCEiSearch...

Gene expression databases

BgeeiO88495.
CleanExiMM_GPR50.
GenevisibleiO88495. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002280. Mel_rcpt_1X.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01151. MELATONIN1XR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)."
    Gubitz A.K., Reppert S.M.
    Genomics 55:248-251(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Extraembryonic tissue and Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMTR1L_MOUSE
AccessioniPrimary (citable) accession number: O88495
Secondary accession number(s): Q3V1S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 16, 2013
Last modified: May 11, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.