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Protein
Submitted name:

Type VI collagen alpha 3 subunit

Gene

Col6a3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiI02.968.

Names & Taxonomyi

Protein namesi
Submitted name:
Type VI collagen alpha 3 subunitImported
Gene namesi
Name:Col6a3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88461. Col6a3.

Subcellular locationi

  • Secretedextracellular space SAAS annotation

GO - Cellular componenti

  • collagen trimer Source: MGI
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • extracellular space Source: MGI
  • extracellular vesicle Source: MGI
  • proteinaceous extracellular matrix Source: MGI
  • sarcolemma Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 26572632Sequence analysisPRO_5004160531Add
BLAST

Proteomic databases

PaxDbiO88493.
PeptideAtlasiO88493.
PRIDEiO88493.

PTM databases

iPTMnetiO88493.
PhosphoSiteiO88493.

Interactioni

Protein-protein interaction databases

IntActiO88493. 1 interaction.
MINTiMINT-4105570.
STRINGi10090.ENSMUSP00000137585.

Structurei

3D structure databases

ProteinModelPortaliO88493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 212176VWFAInterPro annotationAdd
BLAST
Domaini229 – 401173VWFAInterPro annotationAdd
BLAST
Domaini419 – 595177VWFAInterPro annotationAdd
BLAST
Domaini623 – 794172VWFAInterPro annotationAdd
BLAST
Domaini826 – 999174VWFAInterPro annotationAdd
BLAST
Domaini1029 – 1206178VWFAInterPro annotationAdd
BLAST
Domaini1228 – 1414187VWFAInterPro annotationAdd
BLAST
Domaini1792 – 1971180VWFAInterPro annotationAdd
BLAST
Domaini2009 – 2205197VWFAInterPro annotationAdd
BLAST
Domaini2480 – 257192Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2601 – 265151BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Keywords - Domaini

CollagenImported, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG41103QR. LUCA.
HOGENOMiHOG000168250.
HOVERGENiHBG051052.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.410. 9 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 8 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF53300. SSF53300. 9 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 1 hit.
PS50234. VWFA. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKHRHLPLV AVFSLLFSGI AMTRAQQHGV MEVNKRDIVF LVDGSSSLGP
60 70 80 90 100
SNFNAIRDFV TRVIQRLEIG QDLVQVSVAQ YADTVSPEFY LNSYTNKRDA
110 120 130 140 150
VTAVRKMRAL NGSALYTGSS LDFVRNNLFT SSAGHRAAEG VPKLLVLITG
160 170 180 190 200
GKSLDEVSQP ARELKRGSIM ALAVGSKAAD EDELKEIAFD SSLVFIPAEF
210 220 230 240 250
RPAPLQNMLP SLMAPLRTLT GTTEGSKRDI LFLFDGSVNV LGQFPAVRDF
260 270 280 290 300
LYRFIEELDV KPDGTRVAIA QFSDDVRLES RFSEHQTKAE ILNLVKKMKL
310 320 330 340 350
KTGKALNLGY ALDYALRNIF VRSAGSRIED NVQQFLVLLV AGRSSDAVAG
360 370 380 390 400
PASSLKQRGV VPFIFQAKNA NPSELEQIVL SPAFILAAES LPKIGDLQSQ
410 420 430 440 450
IVSLLKAEQG SGPVSGEKDV VFLIDGSEGV RSGFPLLKDF VQRVVESLDV
460 470 480 490 500
GPDRVRVALV QYSDRTRPEF YLNSHMDQQG VISAIRRLTL LGGTTPNTGA
510 520 530 540 550
ALEFVLRNIL TSSTGSRIAE GVPQLLIVLT AEPSGDDVRG PSVVLKQGGA
560 570 580 590 600
VPIGIGIGNA DISEMQTISF IPDFAVAIPT FRELGTIQRV ISERVIQLNR
610 620 630 640 650
EELSSLKPIL TPSTGAGVGS KKDVVFLIDG SRNAGPEFQY IRTQIERIVE
660 670 680 690 700
YLDIGFDTTR VAVIQFSEDS KMEFPLNAHF SKDEVQNTVR RLRPKGGSQV
710 720 730 740 750
YIGNALEYVL KNIFQRPLGS RIEEGVPQFL VLISSGKYDD EVDDSAVELK
760 770 780 790 800
QFGVAPLTIA RHTDQEELVK ISLSPEYVYS VSTFRELPRL EQKLLTPITT
810 820 830 840 850
LTSQQIHQIL ASTRYPPSVV ESDAADIVFL IDSSDAVKPD GIAHIRDFVS
860 870 880 890 900
RIVRRLNIGP SKVRIGVVQF SNDVFPEFYL KTHKSQSSVL EAIRRLRFKG
910 920 930 940 950
GSPLNTGRAL EFVARNLFVK SAGSRIEDGV PQHLVLFLGG KSQDDVARHA
960 970 980 990 1000
QVISSSGIVS LGIGDRNIDR TDLQTITNDP RLVFTVREFR ELPNIEERVM
1010 1020 1030 1040 1050
LSFGPSGATP QPPGVDLPSP SRPEKKKADI VFLLDGSINF RRDSFQEVLR
1060 1070 1080 1090 1100
FASVIVDTVY EDGDSIRVGL VQYNSDPTDE FFLRDFSTKR QIIDAINKVV
1110 1120 1130 1140 1150
YKGGRHANTR VGIEHLLRNH FVPEAGSRLD VRVPQIAFVI TGGKSVEDAQ
1160 1170 1180 1190 1200
DVSLALTQKG VKVFAVGVRN IDSEEVGKIA SNSATAFRVG SVQELSELSE
1210 1220 1230 1240 1250
TVLETLHDAM HETLCPGVTD VSKACNLEVI LGFDGSRDQN VFVSQKGLES
1260 1270 1280 1290 1300
KVDIILNRTS QIQRISCSGN QLPTVRVSVM ANTPSGPVEA FDFAEYQPEL
1310 1320 1330 1340 1350
FEKFRNMRSQ RPYVLTADTL KLYQNKFRQS SPDTVKVVIH FTDGADGDMA
1360 1370 1380 1390 1400
DLYRASEELR QAGAQALILV GLERVANLER LMHLEFGRGF MYDRPLRLNL
1410 1420 1430 1440 1450
LDLDYELAEQ LDNIAEKACC GVPCKCSGER GDRGPIGSIG PKGISGEDGY
1460 1470 1480 1490 1500
RGYPGDEGDP GERGPPGVNG TQGFQGCPGQ RGVKGSRGFP GEKGELGEIG
1510 1520 1530 1540 1550
LDGLDGEEGD KGLPGSSGEK GSPGRRGDKG PKGDKGERGD VGIRGDPGDS
1560 1570 1580 1590 1600
GRDSQQRGPK GETGDIGPMG LPGRDGIPGS PGDPGKDGGS GRRGPAGAKG
1610 1620 1630 1640 1650
NRGGPGQPGF EGEQGTRGSQ GPPGPIGPPG LIGEQGFPGP RGGGGTAGAP
1660 1670 1680 1690 1700
GERGRTGPLG RKGEPGEPGP KGSIGNRGPR GETGDDGRDG VGSEGRRGKK
1710 1720 1730 1740 1750
GERGFPGYPG PKGTPGEPGA DGPPGPKGIR GRRGNSGPPG ATGQKGDPGY
1760 1770 1780 1790 1800
PGPSGHKGNR GDSVDQCALI QSIRDKCPCC YGPLECPVLP TELAFALDTS
1810 1820 1830 1840 1850
EGVTQDTFSR MREVLLGIVG DLTIAESNCP RGARVAVVTY NNEVTTEIRF
1860 1870 1880 1890 1900
ASSKKKSALL DSIQNLQVAL TSKQQSLETA MSFVARNTFK RVRSGFPMRK
1910 1920 1930 1940 1950
VAVFFSNKPT RASPQLREAV LKLSDAGITP LFLTSQEDRQ LINALQINNT
1960 1970 1980 1990 2000
AVGHALVLPA RRDLTDFLKN VLTCHVCLDI CNIDPSCGFG SWRPSFRDRR
2010 2020 2030 2040 2050
AAGSDVDIDL AFILDSSEAT TLFQFNEMKK YIGYVIRQLD LSPDPKASQH
2060 2070 2080 2090 2100
FARVAVVQQS TYESVDNASV PPVKVEFSLT DYGAKEKLLD FLSRRMTQLQ
2110 2120 2130 2140 2150
GTMGLGNAIE YTIENIFESA PNPRDLKIMV LMLTGDMQRQ QLEEAQRAIL
2160 2170 2180 2190 2200
QAKCKGYFLV VLGIGRKVNI KEVYSFASEP NDVFFKFVDK STELNEEPLM
2210 2220 2230 2240 2250
RFGRLLPSFV SSENAFYLPP DFRKQCDWFQ GDQPVKNGVK FGHKQINPPH
2260 2270 2280 2290 2300
TANSSLTSKV VTTIKPSNSS KPTAIVNLTP AKPAPARPAP AQPVLAKPDP
2310 2320 2330 2340 2350
AKPAQARPAP AKPASAKLVP PQPVHVQPAP AQTASVRPAP AKPAPPQPAA
2360 2370 2380 2390 2400
AKPVPAKPAV PAQPAPPQPA AAKPVPAKPA VPAQPAAAQP MPAQPVLTKS
2410 2420 2430 2440 2450
AAVKPASANK PVAAKPVATN TATATARPAL AAKPAAAKPA ATRDPLAAAV
2460 2470 2480 2490 2500
RPVATKPEAP RQQAKPAATK PATTKPLARV SREVQVSEVT ENSARLHWER
2510 2520 2530 2540 2550
PEPSSSFFYD LTVTSAHDQS LVLRQNLTVT DRVIGGLLAG QLYHVVVVSY
2560 2570 2580 2590 2600
LQSQVRAIYQ GSFNTKKTQP PPLQAAHRAS SSTINLMVNT EPLFLTKTDI
2610 2620 2630 2640 2650
CKLSRDAGTC VDFKLLWHYD LESKSCKRFW YGGCGGNENR FHSQEECEKM

CSPELTV
Length:2,657
Mass (Da):286,883
Last modified:November 1, 1998 - v1
Checksum:i15D63345AF87942C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064749 mRNA. Translation: AAC23667.1.
UniGeneiMm.7562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064749 mRNA. Translation: AAC23667.1.
UniGeneiMm.7562.

3D structure databases

ProteinModelPortaliO88493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88493. 1 interaction.
MINTiMINT-4105570.
STRINGi10090.ENSMUSP00000137585.

Protein family/group databases

MEROPSiI02.968.

PTM databases

iPTMnetiO88493.
PhosphoSiteiO88493.

Proteomic databases

PaxDbiO88493.
PeptideAtlasiO88493.
PRIDEiO88493.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88461. Col6a3.

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG41103QR. LUCA.
HOGENOMiHOG000168250.
HOVERGENiHBG051052.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.410. 9 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 8 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF53300. SSF53300. 9 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 1 hit.
PS50234. VWFA. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of cell-specific secreted and surface proteins by subtractive antibody screening."
    Scherer P.E., Bickel P.E., Kotler M., Lodish H.F.
    Nat. Biotechnol. 16:581-586(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO88493_MOUSE
AccessioniPrimary (citable) accession number: O88493
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.