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O88488

- PTPRQ_RAT

UniProt

O88488 - PTPRQ_RAT

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Protein
Phosphatidylinositol phosphatase PTPRQ
Gene
Ptprq, Ptpgmc1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells By similarity.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication

Kineticsi

  1. KM=125 µM for diC8-PI(3,4,5)P31 Publication

Vmax=18.3 nmol/min/mg enzyme with diC8-PI(3,4,5)P3 as substrate

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2203 – 22031Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of fat cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
Alternative name(s):
Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1
Short name:
rPTP-GMC1
Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
Short name:
PTP-RQ
Short name:
R-PTP-Q
Gene namesi
Name:Ptprq
Synonyms:Ptpgmc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620779. Ptprq.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity
Note: A small isoform that lacks the N-terminal part and starts after the transmembrane region localizes in the cytoplasm.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 19081890Extracellular Reviewed prediction
Add
BLAST
Transmembranei1909 – 192921Helical; Reviewed prediction
Add
BLAST
Topological domaini1930 – 2302373Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2171 – 21711E → D: Enhances the tyrosine-protein phosphatase activity but abolishes the phosphatidylinositol phosphatase activity. 1 Publication
Mutagenesisi2203 – 22031C → S: Abolishes the weak tyrosine-protein phosphatase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 23022284Phosphatidylinositol phosphatase PTPRQ
PRO_5000054322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi389 – 3891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi733 – 7331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi746 – 7461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi904 – 9041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi998 – 9981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1010 – 10101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1040 – 10401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1251 – 12511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1256 – 12561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1805 – 18051N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88488.
PRIDEiO88488.

Expressioni

Inductioni

Up-regulated during the period of mesangial cell migration and proliferation that follows mesangial cell injury.1 Publication

Gene expression databases

GenevestigatoriO88488.

Structurei

3D structure databases

ProteinModelPortaliO88488.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 15596Fibronectin type-III 1
Add
BLAST
Domaini159 – 25496Fibronectin type-III 2
Add
BLAST
Domaini310 – 39889Fibronectin type-III 3
Add
BLAST
Domaini401 – 501101Fibronectin type-III 4
Add
BLAST
Domaini474 – 56693Fibronectin type-III 5
Add
BLAST
Domaini570 – 66596Fibronectin type-III 6
Add
BLAST
Domaini670 – 75990Fibronectin type-III 7
Add
BLAST
Domaini764 – 85491Fibronectin type-III 8
Add
BLAST
Domaini859 – 94890Fibronectin type-III 9
Add
BLAST
Domaini953 – 1053101Fibronectin type-III 10
Add
BLAST
Domaini1058 – 115194Fibronectin type-III 11
Add
BLAST
Domaini1156 – 124388Fibronectin type-III 12
Add
BLAST
Domaini1248 – 134194Fibronectin type-III 13
Add
BLAST
Domaini1345 – 143187Fibronectin type-III 14
Add
BLAST
Domaini1435 – 1539105Fibronectin type-III 15
Add
BLAST
Domaini1544 – 164299Fibronectin type-III 16
Add
BLAST
Domaini1647 – 1748102Fibronectin type-III 17
Add
BLAST
Domaini2006 – 2262257Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000214125.
HOVERGENiHBG108308.
KOiK16910.
PhylomeDBiO88488.

Family and domain databases

Gene3Di2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced.

Isoform 1 (identifier: O88488-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MMDFHFSFLF LLIGTSESQV DVSSSFDGTG YDITLSSVSA TTYSSPVSRT     50
LATNVTKPGP PVFLAGERVG SAGILLSWNT PPNPNGRIIS YVVKYKEVCP 100
WMQTAYTRAR AKPDSLEVLL TNLNPGTTYE IKVAAENNAG IGVFSDPFLF 150
QTAESAPGKV VNLTVEALNY SAVNLIWYLP RQPNGKITSF KISVKHARSG 200
IVVKDVSLRV EDILSGKLPE CNENSESFLW STTSPSPTLG RVTPTVRTTQ 250
SSSTAARSKI SSVWKEPISF VVTHLRPYTT YLFEVSAVTT EAGYIDSTIV 300
RTPESVPEGP PQNCIMGNVT GKAFSISWDP PTIVTGKFSY RVELYGPSGR 350
ILDNSTKDLR FAFTHLTPFT MYDVYVAAET SAGVGPKSNL SVFTPPDVPG 400
AVFDLQIAEV EATEIRITWR KPRQPNGIIS QYRVKVSVLE TGVVLENTLL 450
TGQDESISNP MSPEIMNLVD PMIGFYEGSG EMSSDLHSPA SFIYNSHPHN 500
DFPASTRAEE QSSPVVTTRN QYMTDITAEQ LSYVVRRLVP FTEHTISVSA 550
FTIMGEGPPT VLTVRTREQV PSSIQIINYK NISSSSILLY WDPPEYPNGK 600
ITHYTIYATE LDTNRAFQMT TVDNSFLITG LKKYTRYKMR VAASTHVGES 650
SLSEENDIFV RTPEDEPESS PQDVQVTGVS PSELRLKWSP PEKPNGIIIA 700
YEVLYQNADT LFVKNTSTTD IIISDLKPYT LYNISIRSYT RLGHGNQSSS 750
LLSVRTSETV PDSAPENITY KNISSGEIEI SFLPPRSPNG IIQKYTIYLK 800
RSNSHEARTI NTTSLTQTIG GLKKYTHYVI EVSASTLKGE GIRSRPISIL 850
TEEDAPDSPP QNFSVKQLSG VTVMLSWQPP LEPNGIILYY TVYVWDKSSL 900
RAINATEASL VLSDLDYNVD YGACVTASTR FGDGNARSSI INFRTPEGEP 950
SDPPNDVHYV NLSSSSIILF WTPPVKPNGI IQYYSVYYQN TSGTFVQNFT 1000
LLQVTKESDN VTVSARIYRL AIFSYYTFWL TASTSVGNGN KSSDIIHVYT 1050
DQDIPEGPVG NLTFESISST AIHVSWEPPS QPNGLVFYYL SLNLQQSPPR 1100
HMIPPLVTYE NSIDFDDLEK YTDYIFKITP STEKGFSETY TTQLHIKTEE 1150
DVPDTPPIIN TFKNLSSTSI LLSWDPPLKP NGAILGYHLT LQGPHANHTF 1200
VTSGNHIVLE ELSPFTLYSF FAAARTMKGL GPSSILFFYT DESAPLAPPQ 1250
NLTLINYTSD FVWLTWSPSP LPGGIVKVYS FKIHEHETDT VFYKNISGLQ 1300
TDAKLEGLEP VSTYSVSVSA FTKVGNGNQY SNVVEFTTQE SVPEAVRNIE 1350
CVARDWQSVS VRWDPPRKTN GIIIHYMITV GGNSTKVSPR DPTYTFTKLL 1400
PNTSYVFEVR ASTSAGEGNE SRCDISTLPE TVPSAPTNVA FSNVQSTSAT 1450
LTWTKPDTIF GYFQNYKITT QLRAQKCREW EPEECIEHQK DQYLYEANQT 1500
EETVHGLKKF RWYRFQVAAS TNVGYSNASE WISTQTLPGP PDGPPENVHV 1550
VATSPFGINI SWSEPAVITG PTFYLIDVKS VDDDDFNISF LKSNEENKTT 1600
EINNLEVFTR YSVVITAFVG NVSRAYTDGK SSAEVIITTL ESVPKDPPNN 1650
MTFQKIPDEV TKFQLTFLPP SQPNGNIRVY QALVYREDDP TAVQIHNFSI 1700
IQKTDTSIIA MLEGLKGGHT YNISVYAINS AGAGPKVQMR ITMDIKAPAR 1750
PKSKPIPIRD ATGKLLVTST TITIRMPICY YNDDHGPIRN VQVLVAETGA 1800
QQDGNVTKWY DAYFNKARPY FTNEGFPNPP CIEGKTKFSG NEEIYVIGAD 1850
NACMIPGNEE KICNGPLKPK KQYLFKFRAT NVMGQFTDSE YSDPIKTLGE 1900
GLSERTVEII LSVTLCILSI ILLGTAIFAF VRIRQKQKEG GTYSPRDAEI 1950
IDTKFKLDQL ITVADLELKD ERLTRLLSYR KSIKPISKKS FLQHVEELCT 2000
NSNLKFQEEF SELPKFLQDL SSTDADLPWN RAKNRFPNIK PYNNNRVKLI 2050
ADVSLPGSDY INASYVSGYL CPNEFIATQG PLPGTVGDFW RMVWETRTKT 2100
LVMLTQCFEK GRIRCHQYWP EDNKPVTVFG DIVITKLMED IQIDWTIRDL 2150
KIERHGDCMT VRQCNFTGWP EHGVPENTTP LIHFVKLVRT SRAHDTTPMV 2200
VHCSAGVGRT GVFIALDHLT QHINNHDFVD IYGLVAELRS ERMCMVQNLA 2250
QYIFLHQCIL DLLSNKGGHQ PVCFVNYSTL QKMDSLDAME GDVELEWEET 2300
TM 2302
Length:2,302
Mass (Da):256,824
Last modified:November 1, 1998 - v1
Checksum:iF0FA703022EB25D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063249 mRNA. Translation: AAC34801.1.
PIRiT14328.
RefSeqiNP_075214.1. NM_022925.1. [O88488-1]
UniGeneiRn.30011.

Genome annotation databases

GeneIDi360417.
KEGGirno:360417.
UCSCiRGD:620779. rat. [O88488-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063249 mRNA. Translation: AAC34801.1 .
PIRi T14328.
RefSeqi NP_075214.1. NM_022925.1. [O88488-1 ]
UniGenei Rn.30011.

3D structure databases

ProteinModelPortali O88488.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi O88488.
PRIDEi O88488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 360417.
KEGGi rno:360417.
UCSCi RGD:620779. rat. [O88488-1 ]

Organism-specific databases

CTDi 374462.
RGDi 620779. Ptprq.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000214125.
HOVERGENi HBG108308.
KOi K16910.
PhylomeDBi O88488.

Miscellaneous databases

NextBioi 672803.
PROi O88488.

Gene expression databases

Genevestigatori O88488.

Family and domain databases

Gene3Di 2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis."
    Wright M.B., Hugo C., Seifert R., Disteche C.M., Bowen-Pope D.F.
    J. Biol. Chem. 273:23929-23937(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: Wistar.
  2. "Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation."
    Oganesian A., Poot M., Daum G., Coats S.A., Wright M.B., Seifert R.A., Bowen-Pope D.F.
    Proc. Natl. Acad. Sci. U.S.A. 100:7563-7568(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF GLU-2171 AND CYS-2203.
  3. "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."
    Seifert R.A., Coats S.A., Oganesian A., Wright M.B., Dishmon M., Booth C.J., Johnson R.J., Alpers C.E., Bowen-Pope D.F.
    Exp. Cell Res. 287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.

Entry informationi

Entry nameiPTPRQ_RAT
AccessioniPrimary (citable) accession number: O88488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi