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O88488

- PTPRQ_RAT

UniProt

O88488 - PTPRQ_RAT

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Protein

Phosphatidylinositol phosphatase PTPRQ

Gene

Ptprq

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 PublicationPROSITE-ProRule annotation

Kineticsi

  1. KM=125 µM for diC8-PI(3,4,5)P31 Publication

Vmax=18.3 nmol/min/mg enzyme with diC8-PI(3,4,5)P3 as substrate1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2203 – 22031Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of fat cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
Alternative name(s):
Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1
Short name:
rPTP-GMC1
Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
Short name:
PTP-RQ
Short name:
R-PTP-Q
Gene namesi
Name:Ptprq
Synonyms:Ptpgmc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620779. Ptprq.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: A small isoform that lacks the N-terminal part and starts after the transmembrane region localizes in the cytoplasm.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 19081890ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1909 – 192921HelicalSequence AnalysisAdd
BLAST
Topological domaini1930 – 2302373CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2171 – 21711E → D: Enhances the tyrosine-protein phosphatase activity but abolishes the phosphatidylinositol phosphatase activity. 1 Publication
Mutagenesisi2203 – 22031C → S: Abolishes the weak tyrosine-protein phosphatase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 23022284Phosphatidylinositol phosphatase PTPRQPRO_5000054322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi746 – 7461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi904 – 9041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi998 – 9981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1010 – 10101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1040 – 10401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1251 – 12511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1256 – 12561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1805 – 18051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88488.
PRIDEiO88488.

Expressioni

Inductioni

Up-regulated during the period of mesangial cell migration and proliferation that follows mesangial cell injury.1 Publication

Gene expression databases

GenevestigatoriO88488.

Structurei

3D structure databases

ProteinModelPortaliO88488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 15596Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini159 – 25496Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini310 – 39889Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 501101Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini474 – 56693Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 66596Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini670 – 75990Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini764 – 85491Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini859 – 94890Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini953 – 1053101Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1058 – 115194Fibronectin type-III 11PROSITE-ProRule annotationAdd
BLAST
Domaini1156 – 124388Fibronectin type-III 12PROSITE-ProRule annotationAdd
BLAST
Domaini1248 – 134194Fibronectin type-III 13PROSITE-ProRule annotationAdd
BLAST
Domaini1345 – 143187Fibronectin type-III 14PROSITE-ProRule annotationAdd
BLAST
Domaini1435 – 1539105Fibronectin type-III 15PROSITE-ProRule annotationAdd
BLAST
Domaini1544 – 164299Fibronectin type-III 16PROSITE-ProRule annotationAdd
BLAST
Domaini1647 – 1748102Fibronectin type-III 17PROSITE-ProRule annotationAdd
BLAST
Domaini2006 – 2262257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000214125.
HOVERGENiHBG108308.
InParanoidiO88488.
KOiK16910.
PhylomeDBiO88488.

Family and domain databases

Gene3Di2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced.

Isoform 1 (identifier: O88488-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDFHFSFLF LLIGTSESQV DVSSSFDGTG YDITLSSVSA TTYSSPVSRT
60 70 80 90 100
LATNVTKPGP PVFLAGERVG SAGILLSWNT PPNPNGRIIS YVVKYKEVCP
110 120 130 140 150
WMQTAYTRAR AKPDSLEVLL TNLNPGTTYE IKVAAENNAG IGVFSDPFLF
160 170 180 190 200
QTAESAPGKV VNLTVEALNY SAVNLIWYLP RQPNGKITSF KISVKHARSG
210 220 230 240 250
IVVKDVSLRV EDILSGKLPE CNENSESFLW STTSPSPTLG RVTPTVRTTQ
260 270 280 290 300
SSSTAARSKI SSVWKEPISF VVTHLRPYTT YLFEVSAVTT EAGYIDSTIV
310 320 330 340 350
RTPESVPEGP PQNCIMGNVT GKAFSISWDP PTIVTGKFSY RVELYGPSGR
360 370 380 390 400
ILDNSTKDLR FAFTHLTPFT MYDVYVAAET SAGVGPKSNL SVFTPPDVPG
410 420 430 440 450
AVFDLQIAEV EATEIRITWR KPRQPNGIIS QYRVKVSVLE TGVVLENTLL
460 470 480 490 500
TGQDESISNP MSPEIMNLVD PMIGFYEGSG EMSSDLHSPA SFIYNSHPHN
510 520 530 540 550
DFPASTRAEE QSSPVVTTRN QYMTDITAEQ LSYVVRRLVP FTEHTISVSA
560 570 580 590 600
FTIMGEGPPT VLTVRTREQV PSSIQIINYK NISSSSILLY WDPPEYPNGK
610 620 630 640 650
ITHYTIYATE LDTNRAFQMT TVDNSFLITG LKKYTRYKMR VAASTHVGES
660 670 680 690 700
SLSEENDIFV RTPEDEPESS PQDVQVTGVS PSELRLKWSP PEKPNGIIIA
710 720 730 740 750
YEVLYQNADT LFVKNTSTTD IIISDLKPYT LYNISIRSYT RLGHGNQSSS
760 770 780 790 800
LLSVRTSETV PDSAPENITY KNISSGEIEI SFLPPRSPNG IIQKYTIYLK
810 820 830 840 850
RSNSHEARTI NTTSLTQTIG GLKKYTHYVI EVSASTLKGE GIRSRPISIL
860 870 880 890 900
TEEDAPDSPP QNFSVKQLSG VTVMLSWQPP LEPNGIILYY TVYVWDKSSL
910 920 930 940 950
RAINATEASL VLSDLDYNVD YGACVTASTR FGDGNARSSI INFRTPEGEP
960 970 980 990 1000
SDPPNDVHYV NLSSSSIILF WTPPVKPNGI IQYYSVYYQN TSGTFVQNFT
1010 1020 1030 1040 1050
LLQVTKESDN VTVSARIYRL AIFSYYTFWL TASTSVGNGN KSSDIIHVYT
1060 1070 1080 1090 1100
DQDIPEGPVG NLTFESISST AIHVSWEPPS QPNGLVFYYL SLNLQQSPPR
1110 1120 1130 1140 1150
HMIPPLVTYE NSIDFDDLEK YTDYIFKITP STEKGFSETY TTQLHIKTEE
1160 1170 1180 1190 1200
DVPDTPPIIN TFKNLSSTSI LLSWDPPLKP NGAILGYHLT LQGPHANHTF
1210 1220 1230 1240 1250
VTSGNHIVLE ELSPFTLYSF FAAARTMKGL GPSSILFFYT DESAPLAPPQ
1260 1270 1280 1290 1300
NLTLINYTSD FVWLTWSPSP LPGGIVKVYS FKIHEHETDT VFYKNISGLQ
1310 1320 1330 1340 1350
TDAKLEGLEP VSTYSVSVSA FTKVGNGNQY SNVVEFTTQE SVPEAVRNIE
1360 1370 1380 1390 1400
CVARDWQSVS VRWDPPRKTN GIIIHYMITV GGNSTKVSPR DPTYTFTKLL
1410 1420 1430 1440 1450
PNTSYVFEVR ASTSAGEGNE SRCDISTLPE TVPSAPTNVA FSNVQSTSAT
1460 1470 1480 1490 1500
LTWTKPDTIF GYFQNYKITT QLRAQKCREW EPEECIEHQK DQYLYEANQT
1510 1520 1530 1540 1550
EETVHGLKKF RWYRFQVAAS TNVGYSNASE WISTQTLPGP PDGPPENVHV
1560 1570 1580 1590 1600
VATSPFGINI SWSEPAVITG PTFYLIDVKS VDDDDFNISF LKSNEENKTT
1610 1620 1630 1640 1650
EINNLEVFTR YSVVITAFVG NVSRAYTDGK SSAEVIITTL ESVPKDPPNN
1660 1670 1680 1690 1700
MTFQKIPDEV TKFQLTFLPP SQPNGNIRVY QALVYREDDP TAVQIHNFSI
1710 1720 1730 1740 1750
IQKTDTSIIA MLEGLKGGHT YNISVYAINS AGAGPKVQMR ITMDIKAPAR
1760 1770 1780 1790 1800
PKSKPIPIRD ATGKLLVTST TITIRMPICY YNDDHGPIRN VQVLVAETGA
1810 1820 1830 1840 1850
QQDGNVTKWY DAYFNKARPY FTNEGFPNPP CIEGKTKFSG NEEIYVIGAD
1860 1870 1880 1890 1900
NACMIPGNEE KICNGPLKPK KQYLFKFRAT NVMGQFTDSE YSDPIKTLGE
1910 1920 1930 1940 1950
GLSERTVEII LSVTLCILSI ILLGTAIFAF VRIRQKQKEG GTYSPRDAEI
1960 1970 1980 1990 2000
IDTKFKLDQL ITVADLELKD ERLTRLLSYR KSIKPISKKS FLQHVEELCT
2010 2020 2030 2040 2050
NSNLKFQEEF SELPKFLQDL SSTDADLPWN RAKNRFPNIK PYNNNRVKLI
2060 2070 2080 2090 2100
ADVSLPGSDY INASYVSGYL CPNEFIATQG PLPGTVGDFW RMVWETRTKT
2110 2120 2130 2140 2150
LVMLTQCFEK GRIRCHQYWP EDNKPVTVFG DIVITKLMED IQIDWTIRDL
2160 2170 2180 2190 2200
KIERHGDCMT VRQCNFTGWP EHGVPENTTP LIHFVKLVRT SRAHDTTPMV
2210 2220 2230 2240 2250
VHCSAGVGRT GVFIALDHLT QHINNHDFVD IYGLVAELRS ERMCMVQNLA
2260 2270 2280 2290 2300
QYIFLHQCIL DLLSNKGGHQ PVCFVNYSTL QKMDSLDAME GDVELEWEET

TM
Length:2,302
Mass (Da):256,824
Last modified:November 1, 1998 - v1
Checksum:iF0FA703022EB25D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063249 mRNA. Translation: AAC34801.1.
PIRiT14328.
RefSeqiNP_075214.1. NM_022925.1. [O88488-1]
UniGeneiRn.30011.

Genome annotation databases

GeneIDi360417.
KEGGirno:360417.
UCSCiRGD:620779. rat. [O88488-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063249 mRNA. Translation: AAC34801.1 .
PIRi T14328.
RefSeqi NP_075214.1. NM_022925.1. [O88488-1 ]
UniGenei Rn.30011.

3D structure databases

ProteinModelPortali O88488.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi O88488.
PRIDEi O88488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 360417.
KEGGi rno:360417.
UCSCi RGD:620779. rat. [O88488-1 ]

Organism-specific databases

CTDi 374462.
RGDi 620779. Ptprq.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000214125.
HOVERGENi HBG108308.
InParanoidi O88488.
KOi K16910.
PhylomeDBi O88488.

Miscellaneous databases

NextBioi 672803.
PROi O88488.

Gene expression databases

Genevestigatori O88488.

Family and domain databases

Gene3Di 2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis."
    Wright M.B., Hugo C., Seifert R., Disteche C.M., Bowen-Pope D.F.
    J. Biol. Chem. 273:23929-23937(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: Wistar.
  2. "Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation."
    Oganesian A., Poot M., Daum G., Coats S.A., Wright M.B., Seifert R.A., Bowen-Pope D.F.
    Proc. Natl. Acad. Sci. U.S.A. 100:7563-7568(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF GLU-2171 AND CYS-2203.
  3. "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."
    Seifert R.A., Coats S.A., Oganesian A., Wright M.B., Dishmon M., Booth C.J., Johnson R.J., Alpers C.E., Bowen-Pope D.F.
    Exp. Cell Res. 287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.

Entry informationi

Entry nameiPTPRQ_RAT
AccessioniPrimary (citable) accession number: O88488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3