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O88488

- PTPRQ_RAT

UniProt

O88488 - PTPRQ_RAT

Protein

Phosphatidylinositol phosphatase PTPRQ

Gene

Ptprq

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 PublicationPROSITE-ProRule annotation

    Kineticsi

    1. KM=125 µM for diC8-PI(3,4,5)P31 Publication

    Vmax=18.3 nmol/min/mg enzyme with diC8-PI(3,4,5)P3 as substrate1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2203 – 22031Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of fat cell differentiation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
    Alternative name(s):
    Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1
    Short name:
    rPTP-GMC1
    Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
    Short name:
    PTP-RQ
    Short name:
    R-PTP-Q
    Gene namesi
    Name:Ptprq
    Synonyms:Ptpgmc1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620779. Ptprq.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: A small isoform that lacks the N-terminal part and starts after the transmembrane region localizes in the cytoplasm.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi2171 – 21711E → D: Enhances the tyrosine-protein phosphatase activity but abolishes the phosphatidylinositol phosphatase activity. 1 Publication
    Mutagenesisi2203 – 22031C → S: Abolishes the weak tyrosine-protein phosphatase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 23022284Phosphatidylinositol phosphatase PTPRQPRO_5000054322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi746 – 7461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi904 – 9041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi998 – 9981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1010 – 10101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1040 – 10401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1251 – 12511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1256 – 12561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1805 – 18051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO88488.
    PRIDEiO88488.

    Expressioni

    Inductioni

    Up-regulated during the period of mesangial cell migration and proliferation that follows mesangial cell injury.1 Publication

    Gene expression databases

    GenevestigatoriO88488.

    Structurei

    3D structure databases

    ProteinModelPortaliO88488.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 19081890ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1930 – 2302373CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1909 – 192921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 15596Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini159 – 25496Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini310 – 39889Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 501101Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini474 – 56693Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini570 – 66596Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini670 – 75990Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini764 – 85491Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini859 – 94890Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini953 – 1053101Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1058 – 115194Fibronectin type-III 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1156 – 124388Fibronectin type-III 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1248 – 134194Fibronectin type-III 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1345 – 143187Fibronectin type-III 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1435 – 1539105Fibronectin type-III 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1544 – 164299Fibronectin type-III 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1647 – 1748102Fibronectin type-III 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini2006 – 2262257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 17 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000214125.
    HOVERGENiHBG108308.
    KOiK16910.
    PhylomeDBiO88488.

    Family and domain databases

    Gene3Di2.60.40.10. 18 hits.
    3.90.190.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 14 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 16 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 11 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS50853. FN3. 16 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced.

    Isoform 1 (identifier: O88488-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMDFHFSFLF LLIGTSESQV DVSSSFDGTG YDITLSSVSA TTYSSPVSRT     50
    LATNVTKPGP PVFLAGERVG SAGILLSWNT PPNPNGRIIS YVVKYKEVCP 100
    WMQTAYTRAR AKPDSLEVLL TNLNPGTTYE IKVAAENNAG IGVFSDPFLF 150
    QTAESAPGKV VNLTVEALNY SAVNLIWYLP RQPNGKITSF KISVKHARSG 200
    IVVKDVSLRV EDILSGKLPE CNENSESFLW STTSPSPTLG RVTPTVRTTQ 250
    SSSTAARSKI SSVWKEPISF VVTHLRPYTT YLFEVSAVTT EAGYIDSTIV 300
    RTPESVPEGP PQNCIMGNVT GKAFSISWDP PTIVTGKFSY RVELYGPSGR 350
    ILDNSTKDLR FAFTHLTPFT MYDVYVAAET SAGVGPKSNL SVFTPPDVPG 400
    AVFDLQIAEV EATEIRITWR KPRQPNGIIS QYRVKVSVLE TGVVLENTLL 450
    TGQDESISNP MSPEIMNLVD PMIGFYEGSG EMSSDLHSPA SFIYNSHPHN 500
    DFPASTRAEE QSSPVVTTRN QYMTDITAEQ LSYVVRRLVP FTEHTISVSA 550
    FTIMGEGPPT VLTVRTREQV PSSIQIINYK NISSSSILLY WDPPEYPNGK 600
    ITHYTIYATE LDTNRAFQMT TVDNSFLITG LKKYTRYKMR VAASTHVGES 650
    SLSEENDIFV RTPEDEPESS PQDVQVTGVS PSELRLKWSP PEKPNGIIIA 700
    YEVLYQNADT LFVKNTSTTD IIISDLKPYT LYNISIRSYT RLGHGNQSSS 750
    LLSVRTSETV PDSAPENITY KNISSGEIEI SFLPPRSPNG IIQKYTIYLK 800
    RSNSHEARTI NTTSLTQTIG GLKKYTHYVI EVSASTLKGE GIRSRPISIL 850
    TEEDAPDSPP QNFSVKQLSG VTVMLSWQPP LEPNGIILYY TVYVWDKSSL 900
    RAINATEASL VLSDLDYNVD YGACVTASTR FGDGNARSSI INFRTPEGEP 950
    SDPPNDVHYV NLSSSSIILF WTPPVKPNGI IQYYSVYYQN TSGTFVQNFT 1000
    LLQVTKESDN VTVSARIYRL AIFSYYTFWL TASTSVGNGN KSSDIIHVYT 1050
    DQDIPEGPVG NLTFESISST AIHVSWEPPS QPNGLVFYYL SLNLQQSPPR 1100
    HMIPPLVTYE NSIDFDDLEK YTDYIFKITP STEKGFSETY TTQLHIKTEE 1150
    DVPDTPPIIN TFKNLSSTSI LLSWDPPLKP NGAILGYHLT LQGPHANHTF 1200
    VTSGNHIVLE ELSPFTLYSF FAAARTMKGL GPSSILFFYT DESAPLAPPQ 1250
    NLTLINYTSD FVWLTWSPSP LPGGIVKVYS FKIHEHETDT VFYKNISGLQ 1300
    TDAKLEGLEP VSTYSVSVSA FTKVGNGNQY SNVVEFTTQE SVPEAVRNIE 1350
    CVARDWQSVS VRWDPPRKTN GIIIHYMITV GGNSTKVSPR DPTYTFTKLL 1400
    PNTSYVFEVR ASTSAGEGNE SRCDISTLPE TVPSAPTNVA FSNVQSTSAT 1450
    LTWTKPDTIF GYFQNYKITT QLRAQKCREW EPEECIEHQK DQYLYEANQT 1500
    EETVHGLKKF RWYRFQVAAS TNVGYSNASE WISTQTLPGP PDGPPENVHV 1550
    VATSPFGINI SWSEPAVITG PTFYLIDVKS VDDDDFNISF LKSNEENKTT 1600
    EINNLEVFTR YSVVITAFVG NVSRAYTDGK SSAEVIITTL ESVPKDPPNN 1650
    MTFQKIPDEV TKFQLTFLPP SQPNGNIRVY QALVYREDDP TAVQIHNFSI 1700
    IQKTDTSIIA MLEGLKGGHT YNISVYAINS AGAGPKVQMR ITMDIKAPAR 1750
    PKSKPIPIRD ATGKLLVTST TITIRMPICY YNDDHGPIRN VQVLVAETGA 1800
    QQDGNVTKWY DAYFNKARPY FTNEGFPNPP CIEGKTKFSG NEEIYVIGAD 1850
    NACMIPGNEE KICNGPLKPK KQYLFKFRAT NVMGQFTDSE YSDPIKTLGE 1900
    GLSERTVEII LSVTLCILSI ILLGTAIFAF VRIRQKQKEG GTYSPRDAEI 1950
    IDTKFKLDQL ITVADLELKD ERLTRLLSYR KSIKPISKKS FLQHVEELCT 2000
    NSNLKFQEEF SELPKFLQDL SSTDADLPWN RAKNRFPNIK PYNNNRVKLI 2050
    ADVSLPGSDY INASYVSGYL CPNEFIATQG PLPGTVGDFW RMVWETRTKT 2100
    LVMLTQCFEK GRIRCHQYWP EDNKPVTVFG DIVITKLMED IQIDWTIRDL 2150
    KIERHGDCMT VRQCNFTGWP EHGVPENTTP LIHFVKLVRT SRAHDTTPMV 2200
    VHCSAGVGRT GVFIALDHLT QHINNHDFVD IYGLVAELRS ERMCMVQNLA 2250
    QYIFLHQCIL DLLSNKGGHQ PVCFVNYSTL QKMDSLDAME GDVELEWEET 2300
    TM 2302
    Length:2,302
    Mass (Da):256,824
    Last modified:November 1, 1998 - v1
    Checksum:iF0FA703022EB25D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063249 mRNA. Translation: AAC34801.1.
    PIRiT14328.
    RefSeqiNP_075214.1. NM_022925.1. [O88488-1]
    UniGeneiRn.30011.

    Genome annotation databases

    GeneIDi360417.
    KEGGirno:360417.
    UCSCiRGD:620779. rat. [O88488-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063249 mRNA. Translation: AAC34801.1 .
    PIRi T14328.
    RefSeqi NP_075214.1. NM_022925.1. [O88488-1 ]
    UniGenei Rn.30011.

    3D structure databases

    ProteinModelPortali O88488.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi O88488.
    PRIDEi O88488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 360417.
    KEGGi rno:360417.
    UCSCi RGD:620779. rat. [O88488-1 ]

    Organism-specific databases

    CTDi 374462.
    RGDi 620779. Ptprq.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000214125.
    HOVERGENi HBG108308.
    KOi K16910.
    PhylomeDBi O88488.

    Miscellaneous databases

    NextBioi 672803.
    PROi O88488.

    Gene expression databases

    Genevestigatori O88488.

    Family and domain databases

    Gene3Di 2.60.40.10. 18 hits.
    3.90.190.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 14 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 16 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 11 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS50853. FN3. 16 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis."
      Wright M.B., Hugo C., Seifert R., Disteche C.M., Bowen-Pope D.F.
      J. Biol. Chem. 273:23929-23937(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Strain: Wistar.
    2. "Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation."
      Oganesian A., Poot M., Daum G., Coats S.A., Wright M.B., Seifert R.A., Bowen-Pope D.F.
      Proc. Natl. Acad. Sci. U.S.A. 100:7563-7568(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF GLU-2171 AND CYS-2203.
    3. "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."
      Seifert R.A., Coats S.A., Oganesian A., Wright M.B., Dishmon M., Booth C.J., Johnson R.J., Alpers C.E., Bowen-Pope D.F.
      Exp. Cell Res. 287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.

    Entry informationi

    Entry nameiPTPRQ_RAT
    AccessioniPrimary (citable) accession number: O88488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3