Cytoplasmic dynein 1 intermediate chain 2

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O88487 (DC1I2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytoplasmic dynein 1 intermediate chain 2

Alternative name(s):
Cytoplasmic dynein intermediate chain 2
Dynein intermediate chain 2, cytosolic
Short name=DH IC-2

Gene names

Name:	Dync1i2
Synonyms:	Dnci2, Dncic2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	612 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes By similarity.
Subunit structure	Homodimer By similarity. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Post-translational modification	The phosphorylation status of Ser-84 appears to be involved in dynactin-dependent target binding By similarity.
Sequence similarities	Belongs to the dynein intermediate chain family. Contains 7 WD repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm Cytoskeleton Dynein Microtubule
Domain	Repeat WD repeat
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasmic dynein complex Inferred from electronic annotation. Source: InterPro microtubule Inferred from electronic annotation. Source: UniProtKB-KW vesicle Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	motor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 612

612

Cytoplasmic dynein 1 intermediate chain 2

PRO_0000114656

Regions

Repeat

251 – 300

WD 1

Repeat

304 – 344

WD 2

Repeat

353 – 394

WD 3

Repeat

403 – 443

WD 4

Repeat

448 – 493

WD 5

Repeat

496 – 536

WD 6

Repeat

542 – 581

WD 7

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

O88487 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 1D14CEECF62A5E33
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FASTA

612

68,394

        10         20         30         40         50         60 
MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAAVSVQEE SDLEKKRREA 

        70         80         90        100        110        120 
EALLQSMGLT TDSPIVPPPM SPSSKSVSTP SEAGSQDSGD GAVGSRRGPI KLGMAKITQV 

       130        140        150        160        170        180 
DFPPREIVTY TKETQTPVTA QPKEDEEEED DVATPKPPVE PEEEKTLKKD EENDSKAPPH 

       190        200        210        220        230        240 
ELTEEEKQQI LHSEEFLSFF DHSTRIVERA LSEQINIFFD YSGRDLEDKE GEIQAGAKLS 

       250        260        270        280        290        300 
LNRQFFDERW SKHRVVSCLD WSSQYPELLV ASYNNNEEAP HEPDGVALVW NMKYKKTTPE 

       310        320        330        340        350        360 
YVFHCQSAVM SATFAKFHPN LVVGGTYSGQ IVLWDNRSNK RTPVQRTPLS AAAHTHPVYC 

       370        380        390        400        410        420 
VNVVGTQNAH NLISISTDGK ICSWSLDMLS HPQDSMELVH KQSKAVAVTS MSFPVGDVNN 

       430        440        450        460        470        480 
FVVGSEEGSV YTACRHGSKA GISEMFEGHQ GPITGIHCHA AVGAVDFSHL FVTSSFDWTV 

       490        500        510        520        530        540 
KLWTTKNNKP LYSFEDNSDY VYDVMWSPTH PALFACVDGM GRLDLWNLNN DTEVPTASIS 

       550        560        570        580        590        600 
VEGNPALNRV RWTHSGREIA VGDSEGQIVI YDVGEQIAVP RNDEWARFGR TLAEINANRA 

       610 
DAEEEAATRI PA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human." Crackower M.A., Sinasac D.S., Xia J., Motoyama J., Prochazka M., Rommens J.M., Scherer S.W., Tsui L.-C. Genomics 55:257-267(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Eye, Heart and Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF063231 mRNA. Translation: AAC33446.1. AK088015 mRNA. Translation: BAC40097.1. AK164437 mRNA. Translation: BAE37788.1. AK168730 mRNA. Translation: BAE40571.1.
IPI	IPI00131086.
RefSeq	NP_001185805.1. NM_001198876.1. NP_001185806.1. NM_001198877.1. NP_001185807.1. NM_001198878.1. NP_034194.1. NM_010064.4.
UniGene	Mm.249479.
3D structure databases
ProteinModelPortal	O88487.
SMR	O88487. Positions 110-138, 353-386, 470-557.
ModBase	Search...
Protein-protein interaction databases
IntAct	O88487. 9 interactions.
PTM databases
PhosphoSite	O88487.
2D gel databases
REPRODUCTION-2DPAGE	O88487.
Proteomic databases
PaxDb	O88487.
PRIDE	O88487.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000081710; ENSMUSP00000080410; ENSMUSG00000027012. ENSMUST00000112138; ENSMUSP00000107766; ENSMUSG00000027012.
GeneID	13427.
KEGG	mmu:13427.
Organism-specific databases
CTD	1781.
MGI	MGI:107750. Dync1i2.
Phylogenomic databases
eggNOG	NOG308180.
GeneTree	ENSGT00690000101848.
HOVERGEN	HBG004083.
KO	K10415.
OrthoDB	EOG4RBQJ5.
Gene expression databases
ArrayExpress	O88487.
Bgee	O88487.
CleanEx	MM_DYNC1I2.
Genevestigator	O88487.
GermOnline	ENSMUSG00000027012. Mus musculus.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR025956. Dynein_IC_1/2. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF11540. Dynein_IC2. 1 hit. PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283847.
SOURCE	Search...

Entry information

Entry name

DC1I2_MOUSE

Accession

Primary (citable) accession number: O88487
Secondary accession number(s): Q3TGH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents