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O88487

- DC1I2_MOUSE

UniProt

O88487 - DC1I2_MOUSE

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Protein
Cytoplasmic dynein 1 intermediate chain 2
Gene
Dync1i2, Dnci2, Dncic2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes By similarity.

GO - Molecular functioni

  1. motor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. microtubule-based movement Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 intermediate chain 2
Alternative name(s):
Cytoplasmic dynein intermediate chain 2
Dynein intermediate chain 2, cytosolic
Short name:
DH IC-2
Gene namesi
Name:Dync1i2
Synonyms:Dnci2, Dncic2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107750. Dync1i2.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasmic dynein complex Source: InterPro
  2. microtubule Source: UniProtKB-KW
  3. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 612611Cytoplasmic dynein 1 intermediate chain 2
PRO_0000114656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei84 – 841Phosphoserine By similarity
Modified residuei91 – 911Phosphoserine By similarity
Modified residuei95 – 951Phosphoserine By similarity
Modified residuei98 – 981Phosphoserine By similarity

Post-translational modificationi

The phosphorylation status of Ser-84 appears to be involved in dynactin-dependent target binding By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO88487.
PaxDbiO88487.
PRIDEiO88487.

2D gel databases

REPRODUCTION-2DPAGEO88487.

PTM databases

PhosphoSiteiO88487.

Expressioni

Gene expression databases

ArrayExpressiO88487.
BgeeiO88487.
CleanExiMM_DYNC1I2.
GenevestigatoriO88487.

Interactioni

Subunit structurei

Homodimer By similarity. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 By similarity.

Protein-protein interaction databases

BioGridi199256. 7 interactions.
IntActiO88487. 11 interactions.
MINTiMINT-3088834.

Structurei

3D structure databases

ProteinModelPortaliO88487.
SMRiO88487. Positions 110-138, 307-557.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati251 – 30050WD 1
Add
BLAST
Repeati304 – 34441WD 2
Add
BLAST
Repeati353 – 39442WD 3
Add
BLAST
Repeati403 – 44341WD 4
Add
BLAST
Repeati448 – 49346WD 5
Add
BLAST
Repeati496 – 53641WD 6
Add
BLAST
Repeati542 – 58140WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG308180.
GeneTreeiENSGT00730000110228.
HOVERGENiHBG004083.
KOiK10415.
OrthoDBiEOG7FR7FX.
TreeFamiTF300553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR025956. Dynein_IC_1/2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF11540. Dynein_IC2. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88487-1 [UniParc]FASTAAdd to Basket

« Hide

MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAAVSVQEE    50
SDLEKKRREA EALLQSMGLT TDSPIVPPPM SPSSKSVSTP SEAGSQDSGD 100
GAVGSRRGPI KLGMAKITQV DFPPREIVTY TKETQTPVTA QPKEDEEEED 150
DVATPKPPVE PEEEKTLKKD EENDSKAPPH ELTEEEKQQI LHSEEFLSFF 200
DHSTRIVERA LSEQINIFFD YSGRDLEDKE GEIQAGAKLS LNRQFFDERW 250
SKHRVVSCLD WSSQYPELLV ASYNNNEEAP HEPDGVALVW NMKYKKTTPE 300
YVFHCQSAVM SATFAKFHPN LVVGGTYSGQ IVLWDNRSNK RTPVQRTPLS 350
AAAHTHPVYC VNVVGTQNAH NLISISTDGK ICSWSLDMLS HPQDSMELVH 400
KQSKAVAVTS MSFPVGDVNN FVVGSEEGSV YTACRHGSKA GISEMFEGHQ 450
GPITGIHCHA AVGAVDFSHL FVTSSFDWTV KLWTTKNNKP LYSFEDNSDY 500
VYDVMWSPTH PALFACVDGM GRLDLWNLNN DTEVPTASIS VEGNPALNRV 550
RWTHSGREIA VGDSEGQIVI YDVGEQIAVP RNDEWARFGR TLAEINANRA 600
DAEEEAATRI PA 612
Length:612
Mass (Da):68,394
Last modified:November 1, 1998 - v1
Checksum:i1D14CEECF62A5E33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063231 mRNA. Translation: AAC33446.1.
AK088015 mRNA. Translation: BAC40097.1.
AK164437 mRNA. Translation: BAE37788.1.
AK168730 mRNA. Translation: BAE40571.1.
CCDSiCCDS16112.1.
RefSeqiNP_001185805.1. NM_001198876.1.
NP_001185806.1. NM_001198877.1.
NP_001185807.1. NM_001198878.1.
NP_034194.1. NM_010064.4.
UniGeneiMm.249479.

Genome annotation databases

EnsembliENSMUST00000081710; ENSMUSP00000080410; ENSMUSG00000027012.
ENSMUST00000112138; ENSMUSP00000107766; ENSMUSG00000027012.
GeneIDi13427.
KEGGimmu:13427.
UCSCiuc008kai.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063231 mRNA. Translation: AAC33446.1 .
AK088015 mRNA. Translation: BAC40097.1 .
AK164437 mRNA. Translation: BAE37788.1 .
AK168730 mRNA. Translation: BAE40571.1 .
CCDSi CCDS16112.1.
RefSeqi NP_001185805.1. NM_001198876.1.
NP_001185806.1. NM_001198877.1.
NP_001185807.1. NM_001198878.1.
NP_034194.1. NM_010064.4.
UniGenei Mm.249479.

3D structure databases

ProteinModelPortali O88487.
SMRi O88487. Positions 110-138, 307-557.
ModBasei Search...

Protein-protein interaction databases

BioGridi 199256. 7 interactions.
IntActi O88487. 11 interactions.
MINTi MINT-3088834.

PTM databases

PhosphoSitei O88487.

2D gel databases

REPRODUCTION-2DPAGE O88487.

Proteomic databases

MaxQBi O88487.
PaxDbi O88487.
PRIDEi O88487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081710 ; ENSMUSP00000080410 ; ENSMUSG00000027012 .
ENSMUST00000112138 ; ENSMUSP00000107766 ; ENSMUSG00000027012 .
GeneIDi 13427.
KEGGi mmu:13427.
UCSCi uc008kai.2. mouse.

Organism-specific databases

CTDi 1781.
MGIi MGI:107750. Dync1i2.

Phylogenomic databases

eggNOGi NOG308180.
GeneTreei ENSGT00730000110228.
HOVERGENi HBG004083.
KOi K10415.
OrthoDBi EOG7FR7FX.
TreeFami TF300553.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 283847.
PROi O88487.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88487.
Bgeei O88487.
CleanExi MM_DYNC1I2.
Genevestigatori O88487.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR025956. Dynein_IC_1/2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF11540. Dynein_IC2. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human."
    Crackower M.A., Sinasac D.S., Xia J., Motoyama J., Prochazka M., Rommens J.M., Scherer S.W., Tsui L.-C.
    Genomics 55:257-267(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Eye, Heart and Thymus.
  3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiDC1I2_MOUSE
AccessioniPrimary (citable) accession number: O88487
Secondary accession number(s): Q3TGH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi