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Protein

Calcineurin-binding protein cabin-1

Gene

Cabin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin.By similarity1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein phosphatase 2B binding Source: RGD
  • protein phosphatase inhibitor activity Source: RGD

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • DNA replication-independent nucleosome assembly Source: InterPro
  • negative regulation of catalytic activity Source: GOC
  • negative regulation of cell death Source: RGD
  • response to activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin-binding protein cabin-1
Alternative name(s):
Calcineurin inhibitor
Short name:
CAIN
Gene namesi
Name:Cabin1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620263. Cabin1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21822182Calcineurin-binding protein cabin-1PRO_0000106276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1439 – 14391PhosphoserineBy similarity
Modified residuei2003 – 20031PhosphoserineCombined sources
Modified residuei2113 – 21131PhosphothreonineBy similarity
Modified residuei2116 – 21161PhosphothreonineBy similarity

Post-translational modificationi

Activated through PKC-mediated hyperphosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88480.
PRIDEiO88480.

PTM databases

iPTMnetiO88480.
PhosphoSiteiO88480.

Expressioni

Tissue specificityi

Widely expressed with prominent expression in neurons.1 Publication

Interactioni

Subunit structurei

Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1 (By similarity). Interacts with MEF2B (By similarity). Interacts with calcineurin.By similarity1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein phosphatase 2B binding Source: RGD

Protein-protein interaction databases

MINTiMINT-142046.
STRINGi10116.ENSRNOP00000001659.

Structurei

3D structure databases

ProteinModelPortaliO88480.
SMRiO88480. Positions 2121-2146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 6934TPR 1Add
BLAST
Repeati90 – 12334TPR 2Add
BLAST
Repeati125 – 15733TPR 3Add
BLAST
Repeati615 – 64834TPR 4Add
BLAST
Repeati1055 – 108834TPR 5Add
BLAST
Repeati1106 – 113934TPR 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2078 – 211538Required for interaction with calcineurinAdd
BLAST

Sequence similaritiesi

Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFFG. Eukaryota.
ENOG410XY91. LUCA.
HOGENOMiHOG000111281.
HOVERGENiHBG050758.
InParanoidiO88480.
KOiK17613.
PhylomeDBiO88480.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR033053. Hir3/CABIN1.
IPR015134. MEF2_binding.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR15502:SF7. PTHR15502:SF7. 4 hits.
PfamiPF09047. MEF2_binding. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRIAALNAS STIEDDHEGS FKSHKIQTKE AQEAEAFALY HKALDLQKHD
60 70 80 90 100
RFEESAKAYH ELLEARLLRE AVSSGDEKEG LKHPGLILKY STYKNLAQLA
110 120 130 140 150
AQREDLETAM EFYLEAVMLD STDVNLWYKI GHVALRLIRL PLARHAFEEG
160 170 180 190 200
LRCNPDHWPC LDNLITVLYT LSDYTTCLYF ICKALEKDCR YSKGLVLKEK
210 220 230 240 250
IFEEQPCLRK DSLRMFLKCD MSVHEVSVNA AETQAIVDEA LGLRKKRQAL
260 270 280 290 300
IVREKEPDLK LVQPIPFFTW KCLGESLLAM YNHLTTCEPP RPSLGKRIDL
310 320 330 340 350
SDYQDPSQLL APSIVVTPVS VVQPSPVCTN PTVAVAEPVL SYTSVTTTSF
360 370 380 390 400
PLHSPGLLDT GTPMGDVSGG DKSKKGVKRK KTLEESGETA KRRSARVRNT
410 420 430 440 450
KCKKEEKVDF QGLLVKFLPS RLRKLDPEEE DDPFNNYEVQ SEAKLESFSN
460 470 480 490 500
VGPHRLSFDS ATFMESEKQD VHAFLMENLT NGGVLELMMR YLKSMGHKFL
510 520 530 540 550
LKWPPGLAEV VLSVYHSWRR HSTSLPNPLL RDCSNKHIKD MMLMSLSCME
560 570 580 590 600
LQLDQWLLTK GRSSTVSPRN CPAGVVTGRF GPDFPGTHCL GDLLQLSFAS
610 620 630 640 650
SQRDLFEDGW LEFVVRVYWL KARFLALQGD MEQALENYDI CTEILQSSTA
660 670 680 690 700
LQAQAGAEQR DIVIRLPNLH NDSIVSLEEI DKNLKSLERC QSLEEIQRLF
710 720 730 740 750
EAGDYKAVVQ LLRPTLCTSG FDRAKHLEFM TSIPERPAQL LLLQDSLLRL
760 770 780 790 800
EEHRQCFECS DVALNEAVQQ MLNSSDSAAK EEWAATVTQL LLGMEQALSS
810 820 830 840 850
DSRGSILKES SSPTGLVRLT NNLIQVIDCS MAVQEEPKEP YVSSVLPWII
860 870 880 890 900
LHRIIWQEED TFRSLCHQQQ LQNPTEEGIS EMPMLPSSLM LLNTAHEYLG
910 920 930 940 950
RRSWCCNSDG ALLRFYVHVL QKELAASASE DTHPYKEELE TALEQCFYCL
960 970 980 990 1000
YSFPSKKSKA RYLEEHSAQQ VDLTWEDALF MFEYFKPKTL PEFDSYKTST
1010 1020 1030 1040 1050
VSADLANLLK RIATIVPRTE KPALSMDKVS AYIEGTSAEV PCLPDGADPA
1060 1070 1080 1090 1100
PPVLNELYYL LADYHFKNKE QSKAIKFYMH DICICPNRFD SWAGMALARA
1110 1120 1130 1140 1150
SRIQDKLNSN ELKSDGPIWR HATPVLNCFR RALEIDSSNL SLWIEYGTMS
1160 1170 1180 1190 1200
YALHSFASRQ LKQWRAELPP EVVQQMEDRR DSMLETARHC FTSAAHCEGD
1210 1220 1230 1240 1250
GDEEEWLIHY MLGKVAEKQQ QPPTVYLLHY RQAGHYLHEE AARYPKKIHY
1260 1270 1280 1290 1300
HNPPELAMEA LEVYFRLHAS ILKLLGKPDS GVSAEVLVSF MKEAAEGPFA
1310 1320 1330 1340 1350
RGEEKNTPKA SEKEKACLVD EDSHSSAGTL PGPGASLPSS SGPGLTSPPY
1360 1370 1380 1390 1400
TATPIDHDYV KCKKPRQQAT PDDRSQDSTA VALSDSSSTQ DFFNEPTSLL
1410 1420 1430 1440 1450
DGSRKLLPEK RISGLSAQAG PSGKDLPGPT EERGKTEESL ESTEAFRVVE
1460 1470 1480 1490 1500
PSVQKPVADS SASAYIPSKP AVSTPPPWDG KKRSDPLGEP VAFPQGLPAG
1510 1520 1530 1540 1550
AEEQRQFLTE QCIASFCLCL SRFPQHYKSL YRLAFLYTYS KTHRNLQWAR
1560 1570 1580 1590 1600
DVLLGSSIPW QQLQHMPAQG LFCERNKTNF FNGIWRIPVD EIDRPGSFAW
1610 1620 1630 1640 1650
HMNRSIVLLL KVLAQLRDHS TLLKVSSMLQ RTPDQGKKYL RDADRQVLAQ
1660 1670 1680 1690 1700
RAFILTVKVL EDTLSELAEG LEHPGSKACG LSGARMTTDV SHKASPEDGQ
1710 1720 1730 1740 1750
ESLPHPKKLP LADGSGPGPE PGGKVGPLHQ LPVATDTRDN TEQGGEPKDK
1760 1770 1780 1790 1800
ERPPVGPTEP MDTGETAARH PDLEPTPRLL PGRPPRDRGP ESRSAELSLE
1810 1820 1830 1840 1850
ELSISTRQQP APLVPSPVTP TTAAPTTMGA RAAGHPEEAP PRPNRKRKLL
1860 1870 1880 1890 1900
QDTESGKTLL LDAYRVWQQG QKAMAYDLSR IEKIMSETYM LIKQVDEETA
1910 1920 1930 1940 1950
LEQAVKFCQV HLGAAAQRQA SGDAPTTPKH PKDSRENFFP ATVAPSAPDT
1960 1970 1980 1990 2000
TAPDALQRPS DSHLKPGLAA AITCPPSASA STPDPGIPQP HRPEAVPSRA
2010 2020 2030 2040 2050
PLSPDGEEVS GVTEGPSFLS QEPRHSHQMK MAATGPLAEQ HCWPVEAACQ
2060 2070 2080 2090 2100
TGAEPTFSQA TSTKVPSSGS TQTPESHQGK TESSRAKSRL LPNMPKLVIP
2110 2120 2130 2140 2150
SATTKFPPEI TVTPPTPTLL SPKGSISEET KQKLKSAILS AQSAANVRKE
2160 2170 2180
SLCQPALEVL ETSSQESSLE SETDEDDDFM DV
Length:2,182
Mass (Da):242,813
Last modified:November 1, 1998 - v1
Checksum:i2904C335AB3F440A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061947 mRNA. Translation: AAC40176.1.
PIRiT14320.
RefSeqiNP_446027.2. NM_053575.2.
UniGeneiRn.4.

Genome annotation databases

GeneIDi94165.
KEGGirno:94165.
UCSCiRGD:620263. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061947 mRNA. Translation: AAC40176.1.
PIRiT14320.
RefSeqiNP_446027.2. NM_053575.2.
UniGeneiRn.4.

3D structure databases

ProteinModelPortaliO88480.
SMRiO88480. Positions 2121-2146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-142046.
STRINGi10116.ENSRNOP00000001659.

PTM databases

iPTMnetiO88480.
PhosphoSiteiO88480.

Proteomic databases

PaxDbiO88480.
PRIDEiO88480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi94165.
KEGGirno:94165.
UCSCiRGD:620263. rat.

Organism-specific databases

CTDi23523.
RGDi620263. Cabin1.

Phylogenomic databases

eggNOGiENOG410IFFG. Eukaryota.
ENOG410XY91. LUCA.
HOGENOMiHOG000111281.
HOVERGENiHBG050758.
InParanoidiO88480.
KOiK17613.
PhylomeDBiO88480.

Miscellaneous databases

PROiO88480.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR033053. Hir3/CABIN1.
IPR015134. MEF2_binding.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR15502:SF7. PTHR15502:SF7. 4 hits.
PfamiPF09047. MEF2_binding. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cain, a novel physiologic protein inhibitor of calcineurin."
    Lai M.M., Burnett P.E., Wolosker H., Blackshaw S., Snyder S.H.
    J. Biol. Chem. 273:18325-18331(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CALCINEURIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Hippocampus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCABIN_RAT
AccessioniPrimary (citable) accession number: O88480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.