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O88472

- TNR17_MOUSE

UniProt

O88472 - TNR17_MOUSE

Protein

Tumor necrosis factor receptor superfamily member 17

Gene

Tnfrsf17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK By similarity.By similarity

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 17
    Alternative name(s):
    B-cell maturation protein
    CD_antigen: CD269
    Gene namesi
    Name:Tnfrsf17
    Synonyms:Bcm, Bcma
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1343050. Tnfrsf17.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Tumor necrosis factor receptor superfamily member 17PRO_0000058936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi5 ↔ 18By similarity
    Disulfide bondi21 ↔ 32By similarity
    Disulfide bondi25 ↔ 36By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO88472.

    PTM databases

    PhosphoSiteiO88472.

    Expressioni

    Tissue specificityi

    Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.

    Gene expression databases

    BgeeiO88472.
    GenevestigatoriO88472.

    Interactioni

    Subunit structurei

    Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023140.

    Structurei

    3D structure databases

    ProteinModelPortaliO88472.
    SMRiO88472. Positions 1-45.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini71 – 185115CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 3633TNFR-CysAdd
    BLAST

    Sequence similaritiesi

    Contains 1 TNFR-Cys repeat.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46220.
    GeneTreeiENSGT00390000011914.
    HOGENOMiHOG000129926.
    HOVERGENiHBG062796.
    InParanoidiO88472.
    KOiK05153.
    OMAiIEDIMES.
    OrthoDBiEOG7Z95NN.
    PhylomeDBiO88472.
    TreeFamiTF337842.

    Family and domain databases

    InterProiIPR015337. BCMA_Tall-1-bd.
    IPR022320. TNFR_17.
    [Graphical view]
    PfamiPF09257. BCMA-Tall_bind. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011859. BCMA_Tall-1_bd. 1 hit.
    PRINTSiPR01967. TNFACTORR17.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88472-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQQCFHSEY FDSLLHACKP CHLRCSNPPA TCQPYCDPSV TSSVKGTYTV    50
    LWIFLGLTLV LSLALFTISF LLRKMNPEAL KDEPQSPGQL DGSAQLDKAD 100
    TELTRIRAGD DRIFPRSLEY TVEECTCEDC VKSKPKGDSD HFFPLPAMEE 150
    GATILVTTKT GDYGKSSVPT ALQSVMGMEK PTHTR 185
    Length:185
    Mass (Da):20,442
    Last modified:November 1, 1998 - v1
    Checksum:i8806352B4FD26A8E
    GO
    Isoform 2 (identifier: O88472-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         87-91: Missing.

    Show »
    Length:180
    Mass (Da):19,932
    Checksum:iE774EEB8D12FF79F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei87 – 915Missing in isoform 2. 1 PublicationVSP_006507

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061505 mRNA. Translation: AAC23799.1.
    AK020247 mRNA. Translation: BAB32038.1.
    BC027519 mRNA. Translation: AAH27519.1.
    CCDSiCCDS27962.1. [O88472-1]
    RefSeqiNP_035738.1. NM_011608.1. [O88472-1]
    UniGeneiMm.12935.

    Genome annotation databases

    EnsembliENSMUST00000023140; ENSMUSP00000023140; ENSMUSG00000022496. [O88472-1]
    GeneIDi21935.
    KEGGimmu:21935.
    UCSCiuc007yfh.1. mouse. [O88472-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061505 mRNA. Translation: AAC23799.1 .
    AK020247 mRNA. Translation: BAB32038.1 .
    BC027519 mRNA. Translation: AAH27519.1 .
    CCDSi CCDS27962.1. [O88472-1 ]
    RefSeqi NP_035738.1. NM_011608.1. [O88472-1 ]
    UniGenei Mm.12935.

    3D structure databases

    ProteinModelPortali O88472.
    SMRi O88472. Positions 1-45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023140.

    Chemistry

    ChEMBLi CHEMBL1250345.

    PTM databases

    PhosphoSitei O88472.

    Proteomic databases

    PRIDEi O88472.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023140 ; ENSMUSP00000023140 ; ENSMUSG00000022496 . [O88472-1 ]
    GeneIDi 21935.
    KEGGi mmu:21935.
    UCSCi uc007yfh.1. mouse. [O88472-1 ]

    Organism-specific databases

    CTDi 608.
    MGIi MGI:1343050. Tnfrsf17.

    Phylogenomic databases

    eggNOGi NOG46220.
    GeneTreei ENSGT00390000011914.
    HOGENOMi HOG000129926.
    HOVERGENi HBG062796.
    InParanoidi O88472.
    KOi K05153.
    OMAi IEDIMES.
    OrthoDBi EOG7Z95NN.
    PhylomeDBi O88472.
    TreeFami TF337842.

    Miscellaneous databases

    NextBioi 301536.
    PROi O88472.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88472.
    Genevestigatori O88472.

    Family and domain databases

    InterProi IPR015337. BCMA_Tall-1-bd.
    IPR022320. TNFR_17.
    [Graphical view ]
    Pfami PF09257. BCMA-Tall_bind. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011859. BCMA_Tall-1_bd. 1 hit.
    PRINTSi PR01967. TNFACTORR17.
    ProtoNeti Search...

    Publicationsi

    1. "The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily."
      Madry C., Laabi Y., Callebaut I., Roussel J., Hatzoglou A., Le Coniat M., Mornon J.-P., Berger R., Tsapis A.
      Int. Immunol. 10:1693-1702(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: BALB/c.
      Tissue: Spleen.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Colon.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiTNR17_MOUSE
    AccessioniPrimary (citable) accession number: O88472
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3