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O88472 (TNR17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 17
Alternative name(s):
B-cell maturation protein
CD_antigen=CD269
Gene names
Name:Tnfrsf17
Synonyms:Bcm, Bcma
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK By similarity.

Subunit structure

Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 By similarity.

Subcellular location

Membrane; Single-pass type III membrane protein Probable.

Tissue specificity

Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.

Sequence similarities

Contains 1 TNFR-Cys repeat.

Ontologies

Keywords
   Biological processAdaptive immunity
Immunity
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O88472-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O88472-2)

The sequence of this isoform differs from the canonical sequence as follows:
     87-91: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Tumor necrosis factor receptor superfamily member 17
PRO_0000058936

Regions

Topological domain1 – 4949Extracellular Potential
Transmembrane50 – 7021Helical; Signal-anchor for type III membrane protein; Potential
Topological domain71 – 185115Cytoplasmic Potential
Repeat4 – 3633TNFR-Cys

Amino acid modifications

Disulfide bond5 ↔ 18 By similarity
Disulfide bond21 ↔ 32 By similarity
Disulfide bond25 ↔ 36 By similarity

Natural variations

Alternative sequence87 – 915Missing in isoform 2.
VSP_006507

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8806352B4FD26A8E

FASTA18520,442
        10         20         30         40         50         60 
MAQQCFHSEY FDSLLHACKP CHLRCSNPPA TCQPYCDPSV TSSVKGTYTV LWIFLGLTLV 

        70         80         90        100        110        120 
LSLALFTISF LLRKMNPEAL KDEPQSPGQL DGSAQLDKAD TELTRIRAGD DRIFPRSLEY 

       130        140        150        160        170        180 
TVEECTCEDC VKSKPKGDSD HFFPLPAMEE GATILVTTKT GDYGKSSVPT ALQSVMGMEK 


PTHTR

« Hide

Isoform 2 [UniParc].

Checksum: E774EEB8D12FF79F
Show »

FASTA18019,932

References

« Hide 'large scale' references
[1]"The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily."
Madry C., Laabi Y., Callebaut I., Roussel J., Hatzoglou A., Le Coniat M., Mornon J.-P., Berger R., Tsapis A.
Int. Immunol. 10:1693-1702(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: BALB/c.
Tissue: Spleen.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Colon.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF061505 mRNA. Translation: AAC23799.1.
AK020247 mRNA. Translation: BAB32038.1.
BC027519 mRNA. Translation: AAH27519.1.
IPIIPI00131048.
IPI00230206.
RefSeqNP_035738.1. NM_011608.1.
UniGeneMm.12935.

3D structure databases

ProteinModelPortalO88472.
SMRO88472. Positions 1-45.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000023140.

PTM databases

PhosphoSiteO88472.

Proteomic databases

PRIDEO88472.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023140; ENSMUSP00000023140; ENSMUSG00000022496.
GeneID21935.
KEGGmmu:21935.
UCSCuc007yfh.1. mouse.

Organism-specific databases

CTD608.
MGIMGI:1343050. Tnfrsf17.

Phylogenomic databases

eggNOGNOG46220.
GeneTreeENSGT00390000011914.
HOGENOMHOG000129926.
HOVERGENHBG062796.
InParanoidO88472.
KOK05153.
OMAFPLPAME.
OrthoDBEOG495ZT0.

Gene expression databases

BgeeO88472.
GenevestigatorO88472.
GermOnlineENSMUSG00000022496. Mus musculus.

Family and domain databases

InterProIPR015337. BCMA_Tall-1-bd.
IPR022320. TNFR_17.
[Graphical view]
PfamPF09257. BCMA-Tall_bind. 1 hit.
[Graphical view]
PIRSFPIRSF011859. BCMA_Tall-1_bd. 1 hit.
PRINTSPR01967. TNFACTORR17.
PROSITEPS00652. TNFR_NGFR_1. False negative.
PS50050. TNFR_NGFR_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

ChEMBLCHEMBL1250345.
NextBio301536.
SOURCESearch...

Entry information

Entry nameTNR17_MOUSE
AccessionPrimary (citable) accession number: O88472
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1998
Last modified: April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents