SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O88472

- TNR17_MOUSE

UniProt

O88472 - TNR17_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tumor necrosis factor receptor superfamily member 17
Gene
Tnfrsf17, Bcm, Bcma
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK By similarity.

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 17
Alternative name(s):
B-cell maturation protein
CD_antigen: CD269
Gene namesi
Name:Tnfrsf17
Synonyms:Bcm, Bcma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1343050. Tnfrsf17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949Extracellular Reviewed prediction
Add
BLAST
Transmembranei50 – 7021Helical; Signal-anchor for type III membrane protein; Reviewed prediction
Add
BLAST
Topological domaini71 – 185115Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Tumor necrosis factor receptor superfamily member 17
PRO_0000058936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 18 By similarity
Disulfide bondi21 ↔ 32 By similarity
Disulfide bondi25 ↔ 36 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO88472.

PTM databases

PhosphoSiteiO88472.

Expressioni

Tissue specificityi

Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.

Gene expression databases

BgeeiO88472.
GenevestigatoriO88472.

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023140.

Structurei

3D structure databases

ProteinModelPortaliO88472.
SMRiO88472. Positions 1-45.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3633TNFR-Cys
Add
BLAST

Sequence similaritiesi

Contains 1 TNFR-Cys repeat.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46220.
GeneTreeiENSGT00390000011914.
HOGENOMiHOG000129926.
HOVERGENiHBG062796.
InParanoidiO88472.
KOiK05153.
OMAiIEDIMES.
OrthoDBiEOG7Z95NN.
PhylomeDBiO88472.
TreeFamiTF337842.

Family and domain databases

InterProiIPR015337. BCMA_Tall-1-bd.
IPR022320. TNFR_17.
[Graphical view]
PfamiPF09257. BCMA-Tall_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF011859. BCMA_Tall-1_bd. 1 hit.
PRINTSiPR01967. TNFACTORR17.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88472-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQQCFHSEY FDSLLHACKP CHLRCSNPPA TCQPYCDPSV TSSVKGTYTV    50
LWIFLGLTLV LSLALFTISF LLRKMNPEAL KDEPQSPGQL DGSAQLDKAD 100
TELTRIRAGD DRIFPRSLEY TVEECTCEDC VKSKPKGDSD HFFPLPAMEE 150
GATILVTTKT GDYGKSSVPT ALQSVMGMEK PTHTR 185
Length:185
Mass (Da):20,442
Last modified:November 1, 1998 - v1
Checksum:i8806352B4FD26A8E
GO
Isoform 2 (identifier: O88472-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-91: Missing.

Show »
Length:180
Mass (Da):19,932
Checksum:iE774EEB8D12FF79F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei87 – 915Missing in isoform 2.
VSP_006507

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061505 mRNA. Translation: AAC23799.1.
AK020247 mRNA. Translation: BAB32038.1.
BC027519 mRNA. Translation: AAH27519.1.
CCDSiCCDS27962.1. [O88472-1]
RefSeqiNP_035738.1. NM_011608.1. [O88472-1]
UniGeneiMm.12935.

Genome annotation databases

EnsembliENSMUST00000023140; ENSMUSP00000023140; ENSMUSG00000022496. [O88472-1]
GeneIDi21935.
KEGGimmu:21935.
UCSCiuc007yfh.1. mouse. [O88472-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061505 mRNA. Translation: AAC23799.1 .
AK020247 mRNA. Translation: BAB32038.1 .
BC027519 mRNA. Translation: AAH27519.1 .
CCDSi CCDS27962.1. [O88472-1 ]
RefSeqi NP_035738.1. NM_011608.1. [O88472-1 ]
UniGenei Mm.12935.

3D structure databases

ProteinModelPortali O88472.
SMRi O88472. Positions 1-45.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000023140.

Chemistry

ChEMBLi CHEMBL1250345.

PTM databases

PhosphoSitei O88472.

Proteomic databases

PRIDEi O88472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023140 ; ENSMUSP00000023140 ; ENSMUSG00000022496 . [O88472-1 ]
GeneIDi 21935.
KEGGi mmu:21935.
UCSCi uc007yfh.1. mouse. [O88472-1 ]

Organism-specific databases

CTDi 608.
MGIi MGI:1343050. Tnfrsf17.

Phylogenomic databases

eggNOGi NOG46220.
GeneTreei ENSGT00390000011914.
HOGENOMi HOG000129926.
HOVERGENi HBG062796.
InParanoidi O88472.
KOi K05153.
OMAi IEDIMES.
OrthoDBi EOG7Z95NN.
PhylomeDBi O88472.
TreeFami TF337842.

Miscellaneous databases

NextBioi 301536.
PROi O88472.
SOURCEi Search...

Gene expression databases

Bgeei O88472.
Genevestigatori O88472.

Family and domain databases

InterProi IPR015337. BCMA_Tall-1-bd.
IPR022320. TNFR_17.
[Graphical view ]
Pfami PF09257. BCMA-Tall_bind. 1 hit.
[Graphical view ]
PIRSFi PIRSF011859. BCMA_Tall-1_bd. 1 hit.
PRINTSi PR01967. TNFACTORR17.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily."
    Madry C., Laabi Y., Callebaut I., Roussel J., Hatzoglou A., Le Coniat M., Mornon J.-P., Berger R., Tsapis A.
    Int. Immunol. 10:1693-1702(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: BALB/c.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Colon.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTNR17_MOUSE
AccessioniPrimary (citable) accession number: O88472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi