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O88470

- FOXL2_MOUSE

UniProt

O88470 - FOXL2_MOUSE

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Protein
Forkhead box protein L2
Gene
Foxl2, Pfrk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi50 – 14495Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. DNA binding, bending Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. cysteine-type endopeptidase regulator activity involved in apoptotic process Source: UniProtKB
  5. double-stranded DNA binding Source: RefGenome
  6. estrogen receptor binding Source: UniProtKB
  7. protein binding Source: MGI
  8. sequence-specific DNA binding Source: InterPro
  9. sequence-specific DNA binding transcription factor activity Source: MGI
  10. transcription factor binding Source: RefGenome
  11. ubiquitin conjugating enzyme binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. apoptotic DNA fragmentation Source: UniProtKB
  2. embryonic eye morphogenesis Source: MGI
  3. extraocular skeletal muscle development Source: UniProtKB
  4. female somatic sex determination Source: MGI
  5. granulosa cell differentiation Source: MGI
  6. menstruation Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. negative regulation of transcription, DNA-templated Source: MGI
  9. ovarian follicle development Source: UniProtKB
  10. pattern specification process Source: RefGenome
  11. positive regulation of apoptotic process Source: UniProtKB
  12. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  14. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  15. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein L2
Alternative name(s):
Pituitary forkhead factor
Short name:
P-Frk
Gene namesi
Name:Foxl2
Synonyms:Pfrk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1349428. Foxl2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Forkhead box protein L2
PRO_0000091862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki25 – 25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Post-translational modificationi

Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity By similarity.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiO88470.

PTM databases

PhosphoSiteiO88470.

Expressioni

Tissue specificityi

Expressed in the mesenchyme of developing eyelids. Expressed in ovaries throughout development and adulthood, localized to the undifferentiated granulosa cells in small and medium follicles as well as cumulus cells of preovulatory follicles. Expressed in the pituitary.2 Publications

Gene expression databases

BgeeiO88470.
CleanExiMM_FOXL2.
GenevestigatoriO88470.

Interactioni

Subunit structurei

Interacts with ESR1. Interacts with UBE2I/UBC9 By similarity. Interacts with SMAD3. Interacts with DDX20.4 Publications

Protein-protein interaction databases

IntActiO88470. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO88470.
SMRiO88470. Positions 50-139.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi217 – 23014Poly-Ala
Add
BLAST
Compositional biasi280 – 2878Poly-Pro
Compositional biasi300 – 3034Poly-Ala

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000218632.
HOVERGENiHBG051651.
InParanoidiO88470.
KOiK09405.
OMAiELSMMHC.
OrthoDBiEOG7C8GHD.
PhylomeDBiO88470.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88470-1 [UniParc]FASTAAdd to Basket

« Hide

MMASYPEPED TAGTLLAPES GRAVKEAEAS PPSPGKGGGT TPEKPDPAQK    50
PPYSYVALIA MAIRESAEKR LTLSGIYQYI IAKFPFYEKN KKGWQNSIRH 100
NLSLNECFIK VPREGGGERK GNYWTLDPAC EDMFEKGNYR RRRRMKRPFR 150
PPPAHFQPGK GLFGSGGAAG GCGVPGAGAD GYGYLAPPKY LQSGFLNNSW 200
PLPQPPSPMP YASCQMAAAA AAAAAAAAAA GPGSPGAAAV VKGLAGPAAS 250
YGPYSRVQSM ALPPGVVNSY NGLGGPPAAP PPPPPPPHPH PHPHAHHLHA 300
AAAPPPAPPH HGAAAPPPGQ LSPASPATAA PPAPAPTSAP GLQFACARQP 350
ELAMMHCSYW DHDSKTGALH SRLDL 375
Length:375
Mass (Da):38,887
Last modified:March 15, 2005 - v2
Checksum:iF920C8407686C4B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF522275 Genomic DNA. Translation: AAN04088.1.
AF060873 mRNA. Translation: AAC27508.1.
CCDSiCCDS23430.1.
RefSeqiNP_036150.1. NM_012020.2.
UniGeneiMm.151239.

Genome annotation databases

EnsembliENSMUST00000051312; ENSMUSP00000053297; ENSMUSG00000050397.
GeneIDi26927.
KEGGimmu:26927.
UCSCiuc009rdr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF522275 Genomic DNA. Translation: AAN04088.1 .
AF060873 mRNA. Translation: AAC27508.1 .
CCDSi CCDS23430.1.
RefSeqi NP_036150.1. NM_012020.2.
UniGenei Mm.151239.

3D structure databases

ProteinModelPortali O88470.
SMRi O88470. Positions 50-139.
ModBasei Search...

Protein-protein interaction databases

IntActi O88470. 2 interactions.

PTM databases

PhosphoSitei O88470.

Proteomic databases

PRIDEi O88470.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051312 ; ENSMUSP00000053297 ; ENSMUSG00000050397 .
GeneIDi 26927.
KEGGi mmu:26927.
UCSCi uc009rdr.2. mouse.

Organism-specific databases

CTDi 668.
MGIi MGI:1349428. Foxl2.

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000218632.
HOVERGENi HBG051651.
InParanoidi O88470.
KOi K09405.
OMAi ELSMMHC.
OrthoDBi EOG7C8GHD.
PhylomeDBi O88470.
TreeFami TF316127.

Miscellaneous databases

NextBioi 304821.
PROi O88470.
SOURCEi Search...

Gene expression databases

Bgeei O88470.
CleanExi MM_FOXL2.
Genevestigatori O88470.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-139.
  3. "Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene."
    Pisarska M.D., Bae J., Klein C., Hsueh A.J.
    Endocrinology 145:3424-3433(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS TRANSCRIPTIONAL REPRESSOR OF STAR, TISSUE SPECIFICITY.
  4. "Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis."
    Lee K., Pisarska M.D., Ko J.J., Kang Y., Yoon S., Ryou S.M., Cha K.Y., Bae J.
    Biochem. Biophys. Res. Commun. 336:876-881(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDX20/DP103.
  5. Cited for: FUNCTION IN OVARY DIFFERENTIATION.
  6. Cited for: ROLE IN OVARY MAINTENANCE, FUNCTION AS TRANSCRIPTIONAL REPRESSOR OF SOX9, INTERACTION WITH ESR1.
  7. "Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha."
    Kim S.Y., Weiss J., Tong M., Laronda M.M., Lee E.J., Jameson J.L.
    Endocrinology 150:5085-5093(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS TRANSCRIPTIONAL REPRESSOR OF PTGS2, INTERACTION WITH ESR1, SUBCELLULAR LOCATION.
  8. "FoxL2 and Smad3 coordinately regulate follistatin gene transcription."
    Blount A.L., Schmidt K., Justice N.J., Vale W.W., Fischer W.H., Bilezikjian L.M.
    J. Biol. Chem. 284:7631-7645(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS TRANSCRIPTIONAL REGULATOR OF FST, INTERACTION WITH SMAD3, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFOXL2_MOUSE
AccessioniPrimary (citable) accession number: O88470
Secondary accession number(s): Q8K3X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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