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O88466 (ZN106_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 106

Short name=Zfp-106
Alternative name(s):
H3a minor histocompatibility antigen
Son of insulin receptor mutant
Zinc finger protein 474
Gene names
Name:Znf106
Synonyms:H3a, Sh3bp3, Sirm, Zfp106, Znf474
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1888 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in modulating tissue specificity to insulin (isoform 3) Ref.4

Subunit structure

Interacts with KNOP1. Isoform 3 interacts with the SH3 domains of FYN and GRB2. Ref.4 Ref.6

Subcellular location

Nucleusnucleolus Ref.4 Ref.6.

Isoform 3: Cytoplasm Ref.4 Ref.6.

Tissue specificity

Widely expressed, including lymphocytes. Isoform 3 is most abundant in insulin-sensitive tissues such as skeletal muscle, heart, fat, kidney and liver. Ref.1 Ref.4

Induction

Expression is regulated by insulin (isoform 3) Ref.4

Sequence similarities

Contains 3 C2H2-type zinc fingers.

Contains 6 WD repeats.

Sequence caution

The sequence AAB96870.1 differs from that shown. Reason: Frameshift at positions 805 and 816.

The sequence BAC26389.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O88466-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O88466-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1245-1246: RV → SK
     1247-1888: Missing.
Note: May be due to an intron retention. No experimental confirmation available.
Isoform 3 (identifier: O88466-3)

The sequence of this isoform differs from the canonical sequence as follows:
     829-839: FGIEMVPLVQN → CVPLIPVLGFF
     840-1888: Missing.
Note: May be due to an intron retention. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18881888Zinc finger protein 106
PRO_0000051468

Regions

Repeat1534 – 157340WD 1
Repeat1575 – 161844WD 2
Repeat1659 – 170042WD 3
Repeat1703 – 174240WD 4
Repeat1743 – 178038WD 5
Repeat1783 – 182038WD 6
Zinc finger5 – 2925C2H2-type 1; atypical
Zinc finger43 – 6725C2H2-type 2; atypical
Zinc finger1818 – 184326C2H2-type 3; atypical

Amino acid modifications

Modified residue8761Phosphoserine By similarity
Modified residue8781Phosphoserine By similarity
Modified residue8811Phosphoserine By similarity
Modified residue9091Phosphoserine By similarity
Modified residue9531Phosphoserine By similarity
Modified residue10361Phosphothreonine By similarity
Modified residue10401Phosphoserine By similarity
Modified residue10411Phosphoserine By similarity
Modified residue10461Phosphoserine By similarity
Modified residue12911Phosphoserine By similarity
Modified residue12931Phosphoserine Ref.7
Modified residue12961Phosphoserine By similarity
Modified residue13131Phosphoserine By similarity
Modified residue13391Phosphoserine By similarity
Modified residue13811Phosphoserine By similarity
Modified residue13831Phosphothreonine By similarity

Natural variations

Alternative sequence829 – 83911FGIEMVPLVQN → CVPLIPVLGFF in isoform 3.
VSP_011438
Alternative sequence840 – 18881049Missing in isoform 3.
VSP_011439
Alternative sequence1245 – 12462RV → SK in isoform 2.
VSP_011440
Alternative sequence1247 – 1888642Missing in isoform 2.
VSP_011441
Natural variant2531G → S in strain: C57BL/6 and Swiss Webster.
Natural variant2621L → P in strain: C57BL/6 and Swiss Webster.
Natural variant2691G → D in strain: Swiss Webster.
Natural variant2931S → T in strain: Swiss Webster.
Natural variant4471A → P in strain: C57BL/6 and Swiss Webster.
Natural variant4511S → P in strain: C57BL/6 and Swiss Webster.
Natural variant5261L → R in strain: C57BL/6 and Swiss Webster.
Natural variant5521N → S in strain: C57BL/6.
Natural variant5791M → T in strain: C57BL/6.
Natural variant6211S → M in strain: 129/J.
Natural variant6561T → A in strain: C57BL/10.
Natural variant6591R → C in strain: C57BL/10.
Natural variant6851D → N in strain: C57BL/10.
Natural variant7061E → G in strain: Swiss Webster.
Natural variant7111E → G in strain: Swiss Webster.
Natural variant7171T → A in strain: C57BL/10.
Natural variant7781S → C in strain: 129/J.
Natural variant9961S → T in strain: C57BL/6.
Natural variant11881P → S in strain: C57BL/6. Ref.2
Natural variant1196 – 11994MSTF → TCTL in strain: C57BL/6.

Experimental info

Sequence conflict191Missing in AAH25424. Ref.3
Sequence conflict12631S → P in AAD04329. Ref.1
Sequence conflict16081I → V in AAD04327. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 73C37BF7A188A061

FASTA1,888208,964
        10         20         30         40         50         60 
MVRERKCILC HIVYGSKKEM DEHMRSMLHH RELENLKGRD ISHECRVCRV TEVGLSAYAK 

        70         80         90        100        110        120 
HISGQLHKDN VDAQEREDDG KEEEEEEYFD KELVQLIQER KEQSRQDEPP SNSQEVNSDD 

       130        140        150        160        170        180 
RQPQWRREDR IPYQDRESYS QPPRHHRGPP QRDWKWEKDG FNSTRKNSFP HSLRNSGGPR 

       190        200        210        220        230        240 
GSSVWHKGAT RGSSTWFLNH SNSGGGWHSN NGMVDWNYNG TGRNSSWHSE GTGGFPSWHM 

       250        260        270        280        290        300 
NNSNGNWKSS VRGTNSWNYN GLGDKFQQGR NRNPNYQMED MTKMWNKKSN KPSKYSQERC 

       310        320        330        340        350        360 
KWQRQDRDKA AKYRSPPEGY ASDTFPSEGL LEFNFEQRES QTTKQTDTAA SKINGKNGTK 

       370        380        390        400        410        420 
ARDKFRRWTP YPSQKTLDLQ SALKEVIGSK SDTLEKPLFN FSLITAGLRK PVDKTSNPPV 

       430        440        450        460        470        480 
IKTQKAGPPG SPSHKAISDG TAFCEVARAC SITEQSEPHQ KSNKIPLLKS PLLPLPTPKS 

       490        500        510        520        530        540 
GPHKQNLKNR SKNKETKSFP SGDHSHLLNT STLEGSHGSS YTSKSLGLCP RVLKENKTVS 

       550        560        570        580        590        600 
GTQKEPDEKL NNTSQKAQDT VLQCPKTLQN PLPTTPKRME NDAKESSVEE SAKDSLSIES 

       610        620        630        640        650        660 
QPHSAGNSAM TSDAENHGIK SEGVASLTTE VVSCSTHTVD KEQGSQIPGT PENLSTSPRN 

       670        680        690        700        710        720 
STVLQKEAEV QVSAATSPHS GLLLDLKTSL EDAQDNNLVK SDGPFETESF EDTSLDTELQ 

       730        740        750        760        770        780 
KPDLNNQPPG TLLPELSKLG FPASLQRDLS RHISLKSKTG THLPEPNLNS ARRIRNVSGH 

       790        800        810        820        830        840 
RKNETEKESG LKPTLRQILN ASRRNVNWEQ VIQQVTKKKQ ELGKGLPRFG IEMVPLVQNE 

       850        860        870        880        890        900 
QEVLDLDEEP DLSSLEGFQW EGVSIPSSSG LARKRSLSES SVVMDRAPVY SFFTGEGTGK 

       910        920        930        940        950        960 
ENEAQQSPSP NTALSAAQSQ KTAMYLEQEV APLTPSVGTG ERVGNIPTQR RHSAQLPSGH 

       970        980        990       1000       1010       1020 
IMPVMHSARD LHSQERSTPL SERHAQESTG EGNSLSSNAS SGHAVSSLAD AATDSSCTSG 

      1030       1040       1050       1060       1070       1080 
AEQTDGHSIR KKRRATGDGS SPELPSLERK NKRRKIKGKK ERSQVDQLLT ISLREEELSK 

      1090       1100       1110       1120       1130       1140 
SLQCMDNKLL QARAALQTAY VEVQRLLVLK QQITVEMSAL RTHRIQILQG LQETYEPPEH 

      1150       1160       1170       1180       1190       1200 
PDQAPCSLIS REQRNSRSQT SFETALLPAP FFPGFLDPPP SHASLPSPGN PLQITMSTFQ 

      1210       1220       1230       1240       1250       1260 
AHGTAPDSSV QIKQEPMSPE QEGNMNALPQ GCASNVSKEL LQTNRVVDDG SSVYPAIPAV 

      1270       1280       1290       1300       1310       1320 
IASESTENCQ EVSKDLNFSV EQGNSRSKGN SPSCQSPDLP GINRGEETAK GSSGSEACSS 

      1330       1340       1350       1360       1370       1380 
SFLRLSFTPE TPAEKETQSP ADQPEQQAES TLASAETRGS KKKKKLRKKK TLRATHVPEN 

      1390       1400       1410       1420       1430       1440 
SDTEQDVFTA KPARKVKTAK AAKGAKVTTS QTGQEQGTAR DEPDSDSSLE VLEVTNPQLE 

      1450       1460       1470       1480       1490       1500 
VVAIDTSESG DEKPDSPSKK DAWIAAEQNP IETSRSGCDE VSSTSELGTR YKDGVPVSVA 

      1510       1520       1530       1540       1550       1560 
ETQTVISIKA SKHSSEISSE PGDDEEPTEG SFEGHQAAVN AIQIFGNFLY TCSADTTVRV 

      1570       1580       1590       1600       1610       1620 
YNLVSRKCVG VFEGHTSKVN CLLVTHTSGK SSVLYTGSSD HTIRCYNIKT RECMEQLQLE 

      1630       1640       1650       1660       1670       1680 
DRVLCLHNRW RTLYAGLANG TVVTFDIKNN KRQEIFECHG PRAVSCLATA QEGARKLLVV 

      1690       1700       1710       1720       1730       1740 
GSYDCTISVR DARNGLLLRT LEGHSKTVLC MKVVNDLVFS GSSDQSVHAH NIHTGELVRI 

      1750       1760       1770       1780       1790       1800 
YKGHNHAVTV VNILGKVMVT ACLDKFVRVY ELQSHDRLQV YGGHKDMIMC MTIHKSVIYT 

      1810       1820       1830       1840       1850       1860 
GCYDGSIQAV RLNLMQNYRC WWYGCTLIFG VVDHLKQHLL TDHTNPNFQT LKCRWRNCDA 

      1870       1880 
FFTARKGSKQ DVAGHIERHA EDDSKIDS 

« Hide

Isoform 2 [UniParc].

Checksum: 91B70BC748EB0E44
Show »

FASTA1,246138,487
Isoform 3 [UniParc].

Checksum: 5FC8D1DC7BCF2503
Show »

FASTA83994,224

References

« Hide 'large scale' references
[1]"Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex."
Zuberi A.R., Christianson G.J., Mendoza L.M., Shastri N., Roopenian D.C.
Immunity 9:687-698(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS.
Strain: 129/J, BALB/cJ, C57BL/10, C57BL/6 and C57BL/6 X DBA/2.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-1188.
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Mammary gland.
[4]"Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN."
Salvatore P., Hanash C.R., Kido Y., Imai Y., Accili D.
J. Biol. Chem. 273:6989-6997(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 186-1888 (ISOFORM 3), FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH FYN AND GRB2, VARIANTS.
Strain: Swiss Webster.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1567-1888 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Head.
[6]"Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway."
Grasberger H., Bell G.I.
Int. J. Biochem. Cell Biol. 37:1421-1437(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KNOP1, SUBCELLULAR LOCATION.
[7]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF067397 Genomic DNA. Translation: AAD04340.1.
AF067398 Genomic DNA. Translation: AAD04341.1.
AF067399 Genomic DNA. Translation: AAD04342.1.
AL772299, AL935121 Genomic DNA. Translation: CAM15725.1.
AL935121, AL772299 Genomic DNA. Translation: CAM24138.1.
AF060243, AF060242 Genomic DNA. Translation: AAG27479.1.
AF060244 mRNA. Translation: AAD04327.1.
AF060245 mRNA. Translation: AAD04328.1.
AF060246 mRNA. Translation: AAD04329.1.
AF060247 mRNA. Translation: AAD04330.1.
BC025424 mRNA. Translation: AAH25424.1.
U59739 mRNA. Translation: AAB96870.1. Frameshift.
AK029313 mRNA. Translation: BAC26389.1. Different initiation.
PIRT14273.
RefSeqNP_035873.2. NM_011743.2.
UniGeneMm.485295.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203204. 4 interactions.
IntActO88466. 1 interaction.
MINTMINT-4140536.
STRING10090.ENSMUSP00000055602.

PTM databases

PhosphoSiteO88466.

Proteomic databases

PaxDbO88466.
PRIDEO88466.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID20402.
KEGGmmu:20402.

Organism-specific databases

CTD20402.
MGIMGI:1270153. Zfp106.

Phylogenomic databases

eggNOGCOG2319.
HOVERGENHBG079376.
InParanoidA2AKH3.
TreeFamTF105569.

Gene expression databases

ArrayExpressO88466.
BgeeO88466.
CleanExMM_ZFP106.
GenevestigatorO88466.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR018391. PQQ_beta_propeller_repeat.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamPF00400. WD40. 6 hits.
[Graphical view]
SMARTSM00564. PQQ. 4 hits.
SM00320. WD40. 6 hits.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZFP106. mouse.
NextBio298364.
PROO88466.
SOURCESearch...

Entry information

Entry nameZN106_MOUSE
AccessionPrimary (citable) accession number: O88466
Secondary accession number(s): A2AKH3 expand/collapse secondary AC list , O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot