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O88457

- SCNBA_RAT

UniProt

O88457 - SCNBA_RAT

Protein

Sodium channel protein type 11 subunit alpha

Gene

Scn11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: BHF-UCL
    2. voltage-gated sodium channel activity Source: RefGenome

    GO - Biological processi

    1. membrane depolarization during action potential Source: RefGenome
    2. neuronal action potential Source: RefGenome
    3. regulation of sensory perception of pain Source: UniProtKB
    4. sodium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel protein type 11 subunit alpha
    Alternative name(s):
    NaN
    Sensory neuron sodium channel 2
    Sodium channel protein type XI subunit alpha
    Voltage-gated sodium channel subunit alpha Nav1.9
    Gene namesi
    Name:Scn11a
    Synonyms:Nan, Sns2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3630. Scn11a.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. plasma membrane Source: RefGenome
    2. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17651765Sodium channel protein type 11 subunit alphaPRO_0000048512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi660 – 6601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi723 – 7231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1187 – 11871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1202 – 12021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1207 – 12071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1210 – 12101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1547 – 15471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO88457.
    PRIDEiO88457.

    PTM databases

    PhosphoSiteiO88457.

    Expressioni

    Tissue specificityi

    Expressed (at protein level) in myenteric sensory neurons. Expressed in small sensory neurons of the dorsal root ganglia (C-fiber neurons) and trigeminal ganglia.3 Publications

    Developmental stagei

    Expressed in dorsal root ganglia at 17 dpc onwards.1 Publication

    Inductioni

    Down-regulated after axotomy and up-regulated following hind paw inflammation. Down-regulated in vitro by electrical stimulation and by deprivation of NGF.2 Publications

    Gene expression databases

    GenevestigatoriO88457.

    Interactioni

    Subunit structurei

    The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000033224.

    Structurei

    3D structure databases

    ProteinModelPortaliO88457.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei127 – 14822Helical; Name=S1 of repeat IBy similarityAdd
    BLAST
    Transmembranei158 – 17720Helical; Name=S2 of repeat IBy similarityAdd
    BLAST
    Transmembranei190 – 20920Helical; Name=S3 of repeat IBy similarityAdd
    BLAST
    Transmembranei217 – 23620Helical; Voltage-sensor; Name=S4 of repeat IBy similarityAdd
    BLAST
    Transmembranei253 – 26614Helical; Name=S5 of repeat IBy similarityAdd
    BLAST
    Transmembranei372 – 39726Helical; Name=S6 of repeat IBy similarityAdd
    BLAST
    Transmembranei568 – 59124Helical; Name=S1 of repeat IIBy similarityAdd
    BLAST
    Transmembranei603 – 62624Helical; Name=S2 of repeat IIBy similarityAdd
    BLAST
    Transmembranei635 – 65622Helical; Name=S3 of repeat IIBy similarityAdd
    BLAST
    Transmembranei663 – 68220Helical; Voltage-sensor; Name=S4 of repeat IIBy similarityAdd
    BLAST
    Transmembranei698 – 72023Helical; Name=S5 of repeat IIBy similarityAdd
    BLAST
    Transmembranei773 – 79826Helical; Name=S6 of repeat IIBy similarityAdd
    BLAST
    Transmembranei1030 – 105223Helical; Name=S1 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1067 – 109226Helical; Name=S2 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1099 – 111618Helical; Name=S3 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1118 – 113922Helical; Voltage-sensor; Name=S4 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1159 – 118022Helical; Name=S5 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1262 – 128827Helical; Name=S6 of repeat IIIBy similarityAdd
    BLAST
    Transmembranei1342 – 136524Helical; Name=S1 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1377 – 140024Helical; Name=S2 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1407 – 143024Helical; Name=S3 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1441 – 146323Helical; Voltage-sensor; Name=S4 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1479 – 150123Helical; Name=S5 of repeat IVBy similarityAdd
    BLAST
    Transmembranei1560 – 158425Helical; Name=S6 of repeat IVBy similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati126 – 398273IAdd
    BLAST
    Repeati567 – 799233IIAdd
    BLAST
    Repeati1029 – 1289261IIIAdd
    BLAST
    Repeati1341 – 1585245IVAdd
    BLAST

    Domaini

    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    InParanoidiO88457.
    KOiK04843.
    PhylomeDBiO88457.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR028821. Na_channel_a11su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PANTHERiPTHR10037:SF22. PTHR10037:SF22. 1 hit.
    PfamiPF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.

    Sequencei

    Sequence statusi: Complete.

    O88457-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEERYYPVIF PDERNFRPFT SDSLAAIEKR IAIQKERKKS KDKAAAEPQP     50
    RPQLDLKASR KLPKLYGDIP PELVAKPLED LDPFYKDHKT FMVLNKKRTI 100
    YRFSAKRALF ILGPFNPLRS LMIRISVHSV FSMFIICTVI INCMFMANSM 150
    ERSFDNDIPE YVFIGIYILE AVIKILARGF IVDEFSFLRD PWNWLDFIVI 200
    GTAIATCFPG SQVNLSALRT FRVFRALKAI SVISGLKVIV GALLRSVKKL 250
    VDVMVLTLFC LSIFALVGQQ LFMGILNQKC IKHNCGPNPA SNKDCFEKEK 300
    DSEDFIMCGT WLGSRPCPNG STCDKTTLNP DNNYTKFDNF GWSFLAMFRV 350
    MTQDSWERLY RQILRTSGIY FVFFFVVVIF LGSFYLLNLT LAVVTMAYEE 400
    QNRNVAAETE AKEKMFQEAQ QLLREEKEAL VAMGIDRSSL NSLQASSFSP 450
    KKRKFFGSKT RKSFFMRGSK TAQASASDSE DDASKNPQLL EQTKRLSQNL 500
    PVDLFDEHVD PLHRQRALSA VSILTITMQE QEKFQEPCFP CGKNLASKYL 550
    VWDCSPQWLC IKKVLRTIMT DPFTELAITI CIIINTVFLA VEHHNMDDNL 600
    KTILKIGNWV FTGIFIAEMC LKIIALDPYH YFRHGWNVFD SIVALLSLAD 650
    VLYNTLSDNN RSFLASLRVL RVFKLAKSWP TLNTLIKIIG HSVGALGNLT 700
    VVLTIVVFIF SVVGMRLFGT KFNKTAYATQ ERPRRRWHMD NFYHSFLVVF 750
    RILCGEWIEN MWGCMQDMDG SPLCIIVFVL IMVIGKLVVL NLFIALLLNS 800
    FSNEEKDGSL EGETRKTKVQ LALDRFRRAF SFMLHALQSF CCKKCRRKNS 850
    PKPKETTESF AGENKDSILP DARPWKEYDT DMALYTGQAG APLAPLAEVE 900
    DDVEYCGEGG ALPTSQHSAG VQAGDLPPET KQLTSPDDQG VEMEVFSEED 950
    LHLSIQSPRK KSDAVSMLSE CSTIDLNDIF RNLQKTVSPK KQPDRCFPKG 1000
    LSCHFLCHKT DKRKSPWVLW WNIRKTCYQI VKHSWFESFI IFVILLSSGA 1050
    LIFEDVNLPS RPQVEKLLRC TDNIFTFIFL LEMILKWVAF GFRRYFTSAW 1100
    CWLDFLIVVV SVLSLMNLPS LKSFRTLRAL RPLRALSQFE GMKVVVYALI 1150
    SAIPAILNVL LVCLIFWLVF CILGVNLFSG KFGRCINGTD INMYLDFTEV 1200
    PNRSQCNISN YSWKVPQVNF DNVGNAYLAL LQVATYKGWL EIMNAAVDSR 1250
    EKDEQPDFEA NLYAYLYFVV FIIFGSFFTL NLFIGVIIDN FNQQQKKLGG 1300
    QDIFMTEEQK KYYNAMKKLG TKKPQKPIPR PLNKCQAFVF DLVTSQVFDV 1350
    IILGLIVLNM IIMMAESADQ PKDVKKTFDI LNIAFVVIFT IECLIKVFAL 1400
    RQHYFTNGWN LFDCVVVVLS IISTLVSRLE DSDISFPPTL FRVVRLARIG 1450
    RILRLVRAAR GIRTLLFALM MSLPSLFNIG LLLFLVMFIY AIFGMSWFSK 1500
    VKKGSGIDDI FNFETFTGSM LCLFQITTSA GWDTLLNPML EAKEHCNSSS 1550
    QDSCQQPQIA VVYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE 1600
    DDFEIFYEVW EKFDPEASQF IQYSALSDFA DALPEPLRVA KPNKFQFLVM 1650
    DLPMVMGDRL HCMDVLFAFT TRVLGDSSGL DTMKTMMEEK FMEANPFKKL 1700
    YEPIVTTTKR KEEEQGAAVI QRAYRKHMEK MVKLRLKDRS SSSHQVFCNG 1750
    DLSSLDVAKV KVHND 1765
    Length:1,765
    Mass (Da):201,845
    Last modified:November 1, 1998 - v1
    Checksum:iAE8C67397CC60BD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059030 mRNA. Translation: AAC40199.1.
    AJ237852 mRNA. Translation: CAB41850.1.
    PIRiT42388.
    RefSeqiNP_062138.1. NM_019265.2.
    UniGeneiRn.30023.

    Genome annotation databases

    GeneIDi29701.
    KEGGirno:29701.
    UCSCiRGD:3630. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059030 mRNA. Translation: AAC40199.1 .
    AJ237852 mRNA. Translation: CAB41850.1 .
    PIRi T42388.
    RefSeqi NP_062138.1. NM_019265.2.
    UniGenei Rn.30023.

    3D structure databases

    ProteinModelPortali O88457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000033224.

    Chemistry

    BindingDBi O88457.
    GuidetoPHARMACOLOGYi 586.

    PTM databases

    PhosphoSitei O88457.

    Proteomic databases

    PaxDbi O88457.
    PRIDEi O88457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29701.
    KEGGi rno:29701.
    UCSCi RGD:3630. rat.

    Organism-specific databases

    CTDi 11280.
    RGDi 3630. Scn11a.

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    InParanoidi O88457.
    KOi K04843.
    PhylomeDBi O88457.

    Miscellaneous databases

    NextBioi 610107.
    PROi O88457.

    Gene expression databases

    Genevestigatori O88457.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR028821. Na_channel_a11su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    PANTHERi PTHR10037:SF22. PTHR10037:SF22. 1 hit.
    Pfami PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy."
      Dib-Hajj S.D., Tyrrell L., Black J.A., Waxman S.G.
      Proc. Natl. Acad. Sci. U.S.A. 95:8963-8968(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: Sprague-Dawley.
      Tissue: Spinal ganglion.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION, TISSUE SPECIFICITY, INDUCTION.
      Strain: Sprague-Dawley.
      Tissue: Spinal ganglion.
    3. "Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons."
      Benn S.C., Costigan M., Tate S., Fitzgerald M., Woolf C.J.
      J. Neurosci. 21:6077-6085(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    4. "Na+ channel Nav1.9: in search of a gating mechanism."
      Delmas P., Coste B.
      Trends Neurosci. 26:55-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiSCNBA_RAT
    AccessioniPrimary (citable) accession number: O88457
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3