ID   DHCR7_MOUSE             Reviewed;         471 AA.
AC   O88455;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 67.
DE   RecName: Full=7-dehydrocholesterol reductase;
DE            Short=7-DHC reductase;
DE            EC=1.3.1.21;
DE   AltName: Full=Sterol Delta(7)-reductase;
GN   Name=Dhcr7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   MEDLINE=98318632; PubMed=9653161; DOI=10.1073/pnas.95.14.8181;
RA   Fitzky B.U., Witsch-Baumgartner M., Erdel M., Lee J.N., Paik Y.-K.,
RA   Glossmann H., Utermann G., Moebius F.F.;
RT   "Mutations in the delta7-sterol reductase gene in patients with the
RT   Smith-Lemli-Opitz syndrome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:8181-8186(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Production of cholesterol by reduction of C7-C8 double
CC       bond of 7-dehydrocholesterol (7-DHC).
CC   -!- CATALYTIC ACTIVITY: Cholesterol + NADP(+) = cholesta-5,7-dien-3-
CC       beta-ol + NADPH.
CC   -!- PATHWAY: Steroid biosynthesis; cholesterol biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ERG4/ERG24 family.
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DR   EMBL; AF057368; AAC40164.1; -; mRNA.
DR   EMBL; BC006854; AAH06854.1; -; mRNA.
DR   IPI; IPI00130988; -.
DR   RefSeq; NP_031882.1; -.
DR   UniGene; Mm.249342; -.
DR   PhosphoSite; O88455; -.
DR   PRIDE; O88455; -.
DR   Ensembl; ENSMUSG00000058454; Mus musculus.
DR   GeneID; 13360; -.
DR   KEGG; mmu:13360; -.
DR   MGI; MGI:1298378; Dhcr7.
DR   HOGENOM; O88455; -.
DR   HOVERGEN; O88455; -.
DR   OMA; O88455; WAKTPPV.
DR   BRENDA; 1.3.1.21; 244.
DR   NextBio; 283692; -.
DR   ArrayExpress; O88455; -.
DR   Bgee; O88455; -.
DR   CleanEx; MM_DHCR7; -.
DR   GermOnline; ENSMUSG00000058454; Mus musculus.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0047598; F:7-dehydrocholesterol reductase activity; IDA:MGI.
DR   GO; GO:0001568; P:blood vessel development; IMP:MGI.
DR   GO; GO:0030154; P:cell differentiation; IMP:MGI.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0030324; P:lung development; IMP:MGI.
DR   GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR   GO; GO:0042127; P:regulation of cell proliferation; IMP:MGI.
DR   InterPro; IPR001171; Ergosterol_biosynth_ERG4_ERG24.
DR   InterPro; IPR018083; Sterol_reductase_CS.
DR   Pfam; PF01222; ERG4_ERG24; 1.
DR   PROSITE; PS01017; STEROL_REDUCT_1; 1.
DR   PROSITE; PS01018; STEROL_REDUCT_2; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol biosynthesis; Endoplasmic reticulum; Lipid synthesis;
KW   Membrane; NADP; Oxidoreductase; Phosphoprotein; Steroid biosynthesis;
KW   Sterol biosynthesis; Transmembrane.
FT   CHAIN         1    471       7-dehydrocholesterol reductase.
FT                                /FTId=PRO_0000207503.
FT   TRANSMEM     36     56       Potential.
FT   TRANSMEM     95    115       Potential.
FT   TRANSMEM    144    164       Potential.
FT   TRANSMEM    173    193       Potential.
FT   TRANSMEM    233    253       Potential.
FT   TRANSMEM    262    282       Potential.
FT   TRANSMEM    302    322       Potential.
FT   TRANSMEM    327    347       Potential.
FT   TRANSMEM    416    436       Potential.
FT   MOD_RES      14     14       Phosphoserine (By similarity).
SQ   SEQUENCE   471 AA;  53919 MW;  6B1BC356CC539290 CRC64;
     MASKSQHNAP KVKSPNGKAG SQGQWGRAWE VDWFSLASII FLLLFAPFIV YYFIMACDQY
     SCSLTAPALD IATGHASLAD IWAKTPPVTA KAAQLYALWV SFQVLLYSWL PDFCHRFLPG
     YVGGVQEGAI TPAGVVNKYE VNGLQAWLIT HILWFVNAYL LSWFSPTIIF DNWIPLLWCA
     NILGYAVSTF AMIKGYLFPT SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG
     IVAWTLINLS FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW
     YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGILLLG LVGYYIFRMT NHQKDLFRRT
     DGRCLIWGKK PKAIECSYTS ADGLKHHSKL LVSGFWGVAR HFNYTGDLMG SLAYCLACGG
     GHLLPYFYII YMTILLTHRC LRDEHRCANK YGRDWERYTA AVPYRLLPGI F
//