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O88455

- DHCR7_MOUSE

UniProt

O88455 - DHCR7_MOUSE

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Protein
7-dehydrocholesterol reductase
Gene
Dhcr7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi

GO - Molecular functioni

  1. 7-dehydrocholesterol reductase activity Source: MGI

GO - Biological processi

  1. blood vessel development Source: MGI
  2. cell differentiation Source: MGI
  3. cholesterol biosynthetic process Source: UniProtKB-UniPathway
  4. lung development Source: MGI
  5. multicellular organism growth Source: MGI
  6. post-embryonic development Source: MGI
  7. regulation of cell proliferation Source: MGI
  8. regulation of cholesterol biosynthetic process Source: Ensembl
  9. sterol biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.
UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:Dhcr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1298378. Dhcr7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST
Transmembranei416 – 43621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear outer membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4714717-dehydrocholesterol reductase
PRO_0000207503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88455.
PRIDEiO88455.

PTM databases

PhosphoSiteiO88455.

Expressioni

Gene expression databases

ArrayExpressiO88455.
BgeeiO88455.
CleanExiMM_DHCR7.
GenevestigatoriO88455.

Structurei

3D structure databases

ProteinModelPortaliO88455.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72042.
GeneTreeiENSGT00390000000417.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiO88455.
KOiK00213.
OMAiFYIIYMT.
PhylomeDBiO88455.
TreeFamiTF101180.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88455-1 [UniParc]FASTAAdd to Basket

« Hide

MASKSQHNAP KVKSPNGKAG SQGQWGRAWE VDWFSLASII FLLLFAPFIV    50
YYFIMACDQY SCSLTAPALD IATGHASLAD IWAKTPPVTA KAAQLYALWV 100
SFQVLLYSWL PDFCHRFLPG YVGGVQEGAI TPAGVVNKYE VNGLQAWLIT 150
HILWFVNAYL LSWFSPTIIF DNWIPLLWCA NILGYAVSTF AMIKGYLFPT 200
SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG IVAWTLINLS 250
FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW 300
YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGILLLG LVGYYIFRMT 350
NHQKDLFRRT DGRCLIWGKK PKAIECSYTS ADGLKHHSKL LVSGFWGVAR 400
HFNYTGDLMG SLAYCLACGG GHLLPYFYII YMTILLTHRC LRDEHRCANK 450
YGRDWERYTA AVPYRLLPGI F 471
Length:471
Mass (Da):53,919
Last modified:November 1, 1998 - v1
Checksum:i6B1BC356CC539290
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057368 mRNA. Translation: AAC40164.1.
BC006854 mRNA. Translation: AAH06854.1.
CCDSiCCDS22048.1.
RefSeqiNP_031882.1. NM_007856.2.
XP_006508541.1. XM_006508478.1.
XP_006508542.1. XM_006508479.1.
XP_006508543.1. XM_006508480.1.
XP_006508544.1. XM_006508481.1.
UniGeneiMm.249342.

Genome annotation databases

EnsembliENSMUST00000073878; ENSMUSP00000073541; ENSMUSG00000058454.
ENSMUST00000124340; ENSMUSP00000117659; ENSMUSG00000058454.
ENSMUST00000141916; ENSMUSP00000121782; ENSMUSG00000058454.
GeneIDi13360.
KEGGimmu:13360.
UCSCiuc009kqc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057368 mRNA. Translation: AAC40164.1 .
BC006854 mRNA. Translation: AAH06854.1 .
CCDSi CCDS22048.1.
RefSeqi NP_031882.1. NM_007856.2.
XP_006508541.1. XM_006508478.1.
XP_006508542.1. XM_006508479.1.
XP_006508543.1. XM_006508480.1.
XP_006508544.1. XM_006508481.1.
UniGenei Mm.249342.

3D structure databases

ProteinModelPortali O88455.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O88455.

Proteomic databases

PaxDbi O88455.
PRIDEi O88455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073878 ; ENSMUSP00000073541 ; ENSMUSG00000058454 .
ENSMUST00000124340 ; ENSMUSP00000117659 ; ENSMUSG00000058454 .
ENSMUST00000141916 ; ENSMUSP00000121782 ; ENSMUSG00000058454 .
GeneIDi 13360.
KEGGi mmu:13360.
UCSCi uc009kqc.1. mouse.

Organism-specific databases

CTDi 1717.
MGIi MGI:1298378. Dhcr7.

Phylogenomic databases

eggNOGi NOG72042.
GeneTreei ENSGT00390000000417.
HOGENOMi HOG000193296.
HOVERGENi HBG007825.
InParanoidi O88455.
KOi K00213.
OMAi FYIIYMT.
PhylomeDBi O88455.
TreeFami TF101180.

Enzyme and pathway databases

UniPathwayi UPA00063 .
Reactomei REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.

Miscellaneous databases

NextBioi 283692.
PROi O88455.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88455.
Bgeei O88455.
CleanExi MM_DHCR7.
Genevestigatori O88455.

Family and domain databases

InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view ]
Pfami PF01222. ERG4_ERG24. 1 hit.
[Graphical view ]
PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in the delta7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome."
    Fitzky B.U., Witsch-Baumgartner M., Erdel M., Lee J.N., Paik Y.-K., Glossmann H., Utermann G., Moebius F.F.
    Proc. Natl. Acad. Sci. U.S.A. 95:8181-8186(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDHCR7_MOUSE
AccessioniPrimary (citable) accession number: O88455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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