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O88454

- KCNK4_MOUSE

UniProt

O88454 - KCNK4_MOUSE

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Protein

Potassium channel subfamily K member 4

Gene

Kcnk4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K+ concentrations.

GO - Molecular functioni

  1. potassium channel activity Source: UniProtKB-KW
  2. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199083. TWIK related potassium channel (TREK).

Protein family/group databases

TCDBi1.A.1.9.3. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 4
Alternative name(s):
TWIK-related arachidonic acid-stimulated potassium channel protein
Short name:
TRAAK
Gene namesi
Name:Kcnk4
Synonyms:Traak
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1298234. Kcnk4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Potassium channel subfamily K member 4PRO_0000101748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 – 52InterchainBy similarity
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO88454.

PTM databases

PhosphoSiteiO88454.

Expressioni

Tissue specificityi

Expressed in brain, spinal cord and eye. Not detected in heart, skeletal muscle, liver, lungs, kidney and testis.

Gene expression databases

BgeeiO88454.
CleanExiMM_KCNK4.
ExpressionAtlasiO88454. baseline.
GenevestigatoriO88454.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025908.

Structurei

3D structure databases

ProteinModelPortaliO88454.
SMRiO88454. Positions 2-259.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence Analysis
Topological domaini140 – 17132CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini256 – 398143CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei89 – 11325Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Intramembranei198 – 22225Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280717.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
InParanoidiO88454.
KOiK04915.
OMAiAYQPLVW.
OrthoDBiEOG77M8NK.
PhylomeDBiO88454.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR008074. 2pore_dom_K_chnl_TRAAK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01691. TRAAKCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88454-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSTTLLALL ALVLLYLVSG ALVFQALEQP HEQQAQKKMD HGRDQFLRDH
60 70 80 90 100
PCVSQKSLED FIKLLVEALG GGANPETSWT NSSNHSSAWN LGSAFFFSGT
110 120 130 140 150
IITTIGYGNI VLHTDAGRLF CIFYALVGIP LFGMLLAGVG DRLGSSLRRG
160 170 180 190 200
IGHIEAIFLK WHVPPGLVRS LSAVLFLLIG CLLFVLTPTF VFSYMESWSK
210 220 230 240 250
LEAIYFVIVT LTTVGFGDYV PGDGTGQNSP AYQPLVWFWI LFGLAYFASV
260 270 280 290 300
LTTIGNWLRA VSRRTRAEMG GLTAQAASWT GTVTARVTQR TGPSAPPPEK
310 320 330 340 350
EQPLLPSSLP APPAVVEPAG RPGSPAPAEK VETPSPPTAS ALDYPSENLA
360 370 380 390
FIDESSDTQS ERGCALPRAP RGRRRPNPSK KPSRPRGPGR LRDKAVPV
Length:398
Mass (Da):43,052
Last modified:November 1, 1998 - v1
Checksum:i478A834B7B7AEC92
GO
Isoform 2 (identifier: O88454-2) [UniParc]FASTAAdd to Basket

Also known as: TRAAKT, Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     63-67: KLLVE → KAMAI
     68-398: Missing.

Show »
Length:67
Mass (Da):7,594
Checksum:i797A27D595231704
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei63 – 675KLLVE → KAMAI in isoform 2. CuratedVSP_006690
Alternative sequencei68 – 398331Missing in isoform 2. CuratedVSP_006691Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF056492 mRNA. Translation: AAC40181.1.
CCDSiCCDS29511.1. [O88454-1]
RefSeqiNP_032457.1. NM_008431.2. [O88454-1]
XP_006526783.1. XM_006526720.1. [O88454-1]
UniGeneiMm.12894.

Genome annotation databases

EnsembliENSMUST00000025908; ENSMUSP00000025908; ENSMUSG00000024957. [O88454-1]
GeneIDi16528.
KEGGimmu:16528.
UCSCiuc008gjj.1. mouse. [O88454-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF056492 mRNA. Translation: AAC40181.1 .
CCDSi CCDS29511.1. [O88454-1 ]
RefSeqi NP_032457.1. NM_008431.2. [O88454-1 ]
XP_006526783.1. XM_006526720.1. [O88454-1 ]
UniGenei Mm.12894.

3D structure databases

ProteinModelPortali O88454.
SMRi O88454. Positions 2-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025908.

Protein family/group databases

TCDBi 1.A.1.9.3. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei O88454.

Proteomic databases

PRIDEi O88454.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025908 ; ENSMUSP00000025908 ; ENSMUSG00000024957 . [O88454-1 ]
GeneIDi 16528.
KEGGi mmu:16528.
UCSCi uc008gjj.1. mouse. [O88454-1 ]

Organism-specific databases

CTDi 50801.
MGIi MGI:1298234. Kcnk4.

Phylogenomic databases

eggNOGi NOG280717.
HOGENOMi HOG000013106.
HOVERGENi HBG052234.
InParanoidi O88454.
KOi K04915.
OMAi AYQPLVW.
OrthoDBi EOG77M8NK.
PhylomeDBi O88454.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_199083. TWIK related potassium channel (TREK).

Miscellaneous databases

NextBioi 289931.
PROi O88454.
SOURCEi Search...

Gene expression databases

Bgeei O88454.
CleanExi MM_KCNK4.
ExpressionAtlasi O88454. baseline.
Genevestigatori O88454.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR008074. 2pore_dom_K_chnl_TRAAK.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PRINTSi PR01333. 2POREKCHANEL.
PR01691. TRAAKCHANNEL.
ProtoNeti Search...

Publicationsi

  1. "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids."
    Fink M., Lesage F., Duprat F., Heurteaux C., Reyes R., Fosset M., Lazdunski M.
    EMBO J. 17:3297-3308(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Inhalational anesthetics activate two-pore-domain background K+ channels."
    Patel A.J., Honore E., Lesage F., Fink M., Romey G., Lazdunski M.
    Nat. Neurosci. 2:422-426(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVATION.

Entry informationi

Entry nameiKCNK4_MOUSE
AccessioniPrimary (citable) accession number: O88454
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Activated by arachidonic acid and other unsaturated fatty acids. Not affected by volatile general anaesthetics such as chloroform, diethyl ether, halothane and isoflurane.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3