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Protein

Retinol dehydrogenase 7

Gene

Rdh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities.1 Publication

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei163SubstrateBy similarity1
Active sitei175Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • catalytic activity Source: MGI
  • retinol dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

BRENDAi1.1.1.315. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 7 (EC:1.1.1.105)
Alternative name(s):
Cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2
Cis-retinol/androgen dehydrogenase type 2
Short name:
CRAD-2
Gene namesi
Name:Rdh7
Synonyms:Crad2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1860517. Rdh7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547611 – 316Retinol dehydrogenase 7Add BLAST316

Proteomic databases

MaxQBiO88451.
PaxDbiO88451.
PeptideAtlasiO88451.
PRIDEiO88451.

PTM databases

iPTMnetiO88451.
PhosphoSitePlusiO88451.
SwissPalmiO88451.

Expressioni

Tissue specificityi

Highly expressed in liver. Also expressed in lung, eye, kidney, and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000040134.
CleanExiMM_RDH7.
GenevisibleiO88451. MM.

Interactioni

Protein-protein interaction databases

IntActiO88451. 1 interactor.
MINTiMINT-1862586.
STRINGi10090.ENSMUSP00000039252.

Structurei

3D structure databases

ProteinModelPortaliO88451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00900000140775.
HOVERGENiHBG005482.
InParanoidiO88451.
OMAiRRELTYF.
OrthoDBiEOG091G0LMI.
PhylomeDBiO88451.
TreeFamiTF325617.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

O88451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLVALVG LWTLLRFFRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR NKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNRGLWGLV NNAGICVFAI NEWLKKEDFA NILDVNLLGM IEVTLSMLPL
160 170 180 190 200
VRKARGRVVN ISSSMGRVSL CGGGYCISKY GVEAFSDSLR REISYFGVKV
210 220 230 240 250
AIIEPGGFRT NVSNYERLSH SIEKLWDQTS SEVKEVYDKN FLDSYIKAIQ
260 270 280 290 300
SLTDTCSDDL SVVTDCMEHA LTACHPRTRY SAGWDAKLFY LPLSYMPTFL
310
VDAMLYWSSV KPAQAL
Length:316
Mass (Da):35,660
Last modified:November 1, 1998 - v1
Checksum:i0BFB9A1C2DDE3C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056194 mRNA. Translation: AAC40159.1.
AB015165 mRNA. Translation: BAB03717.1.
AB032058 mRNA. Translation: BAB03718.1.
AB032057 Genomic DNA. Translation: BAB03719.1.
BC024603 mRNA. Translation: AAH24603.1.
BC092255 mRNA. Translation: AAH92255.1.
BC093514 mRNA. Translation: AAH93514.1.
CCDSiCCDS24255.1.
RefSeqiNP_001144221.1. NM_001150749.1.
NP_059501.1. NM_017473.4.
UniGeneiMm.6696.

Genome annotation databases

EnsembliENSMUST00000047199; ENSMUSP00000039252; ENSMUSG00000040134.
GeneIDi54150.
KEGGimmu:54150.
UCSCiuc007hkv.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRDH7_MOUSE
AccessioniPrimary (citable) accession number: O88451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families