Reviewed, UniProtKB/Swiss-Prot O88451 (RDH7_MOUSE)

Names and origin

Protein names

Recommended name:
    Retinol dehydrogenase 7
    EC=1.1.1.105
Alternative name(s):
    Cis-retinol/androgen dehydrogenase type 2
      Short name=CRAD-2
    Cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2

Gene names

Name:	Rdh7
Synonyms:	Crad2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities. Ref.1
Catalytic activity	Retinol + NAD+ = retinal + NADH.
Pathway	Cofactor metabolism; retinol metabolism.
Subcellular location	Microsome By similarity. Endoplasmic reticulum By similarity.
Tissue specificity	Highly expressed in liver. Also expressed in lung, eye, kidney, and brain. Ref.1
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Ligand	NAD NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro retinol dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Retinol dehydrogenase 7		PRO_0000054761
Regions
	Nucleotide binding	33 – 57	25	NADP By similarity
Sites
	Active site	175	1	Proton acceptor By similarity
	Binding site	163	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O88451-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 0BFB9A1C2DDE3C17	FASTA	316	35,660
	10 20 30 40 50 60 MWLYLVALVG LWTLLRFFRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD RRGMRVLAAC 70 80 90 100 110 120 LTEKGAEQLR NKTSDRLETV ILDVTKTESI VAATQWVKER VGNRGLWGLV NNAGICVFAI 130 140 150 160 170 180 NEWLKKEDFA NILDVNLLGM IEVTLSMLPL VRKARGRVVN ISSSMGRVSL CGGGYCISKY 190 200 210 220 230 240 GVEAFSDSLR REISYFGVKV AIIEPGGFRT NVSNYERLSH SIEKLWDQTS SEVKEVYDKN 250 260 270 280 290 300 FLDSYIKAIQ SLTDTCSDDL SVVTDCMEHA LTACHPRTRY SAGWDAKLFY LPLSYMPTFL 310 VDAMLYWSSV KPAQAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, tissue distribution, and substrate characteristics of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme." Su J., Chai X., Kahn B., Napoli J.L. J. Biol. Chem. 273:17910-17916(1998) [PubMed: 9651397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"Gene structure and promoter for Crad2 encoding mouse cis-retinol/3-hydroxysterol short-chain dehydrogenase isozyme." Tomita K., Sato M., Kajiwara K., Tanaka M., Tamiya G., Makino S., Tomizawa M., Mizutani A., Kuwano Y., Shiina T., Ishii H., Kimura M. Gene 251:175-186(2000) [PubMed: 10876094] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Ola. Tissue: Liver.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF056194 mRNA. Translation: AAC40159.1. AB015165 mRNA. Translation: BAB03717.1. AB032058 mRNA. Translation: BAB03718.1. AB032057 Genomic DNA. Translation: BAB03719.1. BC024603 mRNA. Translation: AAH24603.1. BC092255 mRNA. Translation: AAH92255.1. BC093514 mRNA. Translation: AAH93514.1.
IPI	IPI00130985.
RefSeq	NP_001144221.1. NP_059501.1.
UniGene	Mm.6696
3D structure databases
HSSP	HSSP built from PDB template 1FDS based on UniProtKB P14061.
ModBase	Search...
Protein-protein interaction databases
STRING	O88451.
PTM databases
PhosphoSite	O88451.
Proteomic databases
PRIDE	O88451.
Genome annotation databases
Ensembl	ENSMUST00000047199; ENSMUSP00000039252; ENSMUSG00000040134; Mus musculus. [Genome view]
GeneID	54150.
KEGG	mmu:54150.
UCSC	uc007hkv.1. mouse.
Organism-specific databases
CTD	54150.
MGI	MGI:1860517. Rdh7.
Phylogenomic databases
HOGENOM	O88451.
HOVERGEN	O88451.
OMA	FGVTVHI.
Enzyme and pathway databases
BRENDA	1.1.1.105. 244.
Gene expression databases
ArrayExpress	O88451.
Bgee	O88451.
CleanEx	MM_RDH7.
Genevestigator	O88451.
GermOnline	ENSMUSG00000040134. Mus musculus.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	310969.
SOURCE	Search...

Entry information

Entry name

RDH7_MOUSE

Accession

Primary (citable) accession number: O88451

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 1, 1998
Last modified:	November 3, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)