Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol dehydrogenase 7

Gene

Rdh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities.1 Publication

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei163 – 1631SubstrateBy similarity
Active sitei175 – 1751Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 5725NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • catalytic activity Source: MGI
  • retinol dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BRENDAi1.1.1.315. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 7 (EC:1.1.1.105)
Alternative name(s):
Cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2
Cis-retinol/androgen dehydrogenase type 2
Short name:
CRAD-2
Gene namesi
Name:Rdh7
Synonyms:Crad2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1860517. Rdh7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Retinol dehydrogenase 7PRO_0000054761Add
BLAST

Proteomic databases

EPDiO88451.
MaxQBiO88451.
PaxDbiO88451.
PeptideAtlasiO88451.
PRIDEiO88451.

PTM databases

iPTMnetiO88451.
PhosphoSiteiO88451.
SwissPalmiO88451.

Expressioni

Tissue specificityi

Highly expressed in liver. Also expressed in lung, eye, kidney, and brain.1 Publication

Gene expression databases

BgeeiO88451.
CleanExiMM_RDH7.
GenevisibleiO88451. MM.

Interactioni

Protein-protein interaction databases

IntActiO88451. 1 interaction.
MINTiMINT-1862586.
STRINGi10090.ENSMUSP00000039252.

Structurei

3D structure databases

ProteinModelPortaliO88451.
SMRiO88451. Positions 25-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
HOVERGENiHBG005482.
InParanoidiO88451.
OMAiYSASWDA.
OrthoDBiEOG7FXZZX.
PhylomeDBiO88451.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLVALVG LWTLLRFFRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR NKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNRGLWGLV NNAGICVFAI NEWLKKEDFA NILDVNLLGM IEVTLSMLPL
160 170 180 190 200
VRKARGRVVN ISSSMGRVSL CGGGYCISKY GVEAFSDSLR REISYFGVKV
210 220 230 240 250
AIIEPGGFRT NVSNYERLSH SIEKLWDQTS SEVKEVYDKN FLDSYIKAIQ
260 270 280 290 300
SLTDTCSDDL SVVTDCMEHA LTACHPRTRY SAGWDAKLFY LPLSYMPTFL
310
VDAMLYWSSV KPAQAL
Length:316
Mass (Da):35,660
Last modified:November 1, 1998 - v1
Checksum:i0BFB9A1C2DDE3C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056194 mRNA. Translation: AAC40159.1.
AB015165 mRNA. Translation: BAB03717.1.
AB032058 mRNA. Translation: BAB03718.1.
AB032057 Genomic DNA. Translation: BAB03719.1.
BC024603 mRNA. Translation: AAH24603.1.
BC092255 mRNA. Translation: AAH92255.1.
BC093514 mRNA. Translation: AAH93514.1.
CCDSiCCDS24255.1.
RefSeqiNP_001144221.1. NM_001150749.1.
NP_059501.1. NM_017473.4.
UniGeneiMm.6696.

Genome annotation databases

EnsembliENSMUST00000047199; ENSMUSP00000039252; ENSMUSG00000040134.
GeneIDi54150.
KEGGimmu:54150.
UCSCiuc007hkv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056194 mRNA. Translation: AAC40159.1.
AB015165 mRNA. Translation: BAB03717.1.
AB032058 mRNA. Translation: BAB03718.1.
AB032057 Genomic DNA. Translation: BAB03719.1.
BC024603 mRNA. Translation: AAH24603.1.
BC092255 mRNA. Translation: AAH92255.1.
BC093514 mRNA. Translation: AAH93514.1.
CCDSiCCDS24255.1.
RefSeqiNP_001144221.1. NM_001150749.1.
NP_059501.1. NM_017473.4.
UniGeneiMm.6696.

3D structure databases

ProteinModelPortaliO88451.
SMRiO88451. Positions 25-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88451. 1 interaction.
MINTiMINT-1862586.
STRINGi10090.ENSMUSP00000039252.

PTM databases

iPTMnetiO88451.
PhosphoSiteiO88451.
SwissPalmiO88451.

Proteomic databases

EPDiO88451.
MaxQBiO88451.
PaxDbiO88451.
PeptideAtlasiO88451.
PRIDEiO88451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047199; ENSMUSP00000039252; ENSMUSG00000040134.
GeneIDi54150.
KEGGimmu:54150.
UCSCiuc007hkv.2. mouse.

Organism-specific databases

CTDi54150.
MGIiMGI:1860517. Rdh7.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
HOVERGENiHBG005482.
InParanoidiO88451.
OMAiYSASWDA.
OrthoDBiEOG7FXZZX.
PhylomeDBiO88451.
TreeFamiTF325617.

Enzyme and pathway databases

UniPathwayiUPA00912.
BRENDAi1.1.1.315. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Miscellaneous databases

ChiTaRSiRdh7. mouse.
PROiO88451.
SOURCEiSearch...

Gene expression databases

BgeeiO88451.
CleanExiMM_RDH7.
GenevisibleiO88451. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, tissue distribution, and substrate characteristics of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme."
    Su J., Chai X., Kahn B., Napoli J.L.
    J. Biol. Chem. 273:17910-17916(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "Gene structure and promoter for Crad2 encoding mouse cis-retinol/3-hydroxysterol short-chain dehydrogenase isozyme."
    Tomita K., Sato M., Kajiwara K., Tanaka M., Tamiya G., Makino S., Tomizawa M., Mizutani A., Kuwano Y., Shiina T., Ishii H., Kimura M.
    Gene 251:175-186(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRDH7_MOUSE
AccessioniPrimary (citable) accession number: O88451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.