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Protein

Kinesin light chain 2

Gene

Klc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

GO - Molecular functioni

GO - Biological processi

  • axo-dendritic transport Source: MGI
  • microtubule-based movement Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 2
Short name:
KLC 2
Gene namesi
Name:Klc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107953. Klc2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • ciliary rootlet Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: HGNC
  • kinesin complex Source: HGNC
  • membrane Source: MGI
  • microtubule Source: UniProtKB-KW
  • neuron projection Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150961 – 599Kinesin light chain 2Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei505PhosphoserineCombined sources1
Modified residuei515PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei575PhosphoserineCombined sources1
Modified residuei582PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88448.
MaxQBiO88448.
PaxDbiO88448.
PeptideAtlasiO88448.
PRIDEiO88448.

PTM databases

iPTMnetiO88448.
PhosphoSitePlusiO88448.
SwissPalmiO88448.

Expressioni

Gene expression databases

CleanExiMM_KLC2.

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk8ip3Q9ESN96EBI-301558,EBI-301496
VACWR159P686193EBI-301558,EBI-7133540From a different organism.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: MGI
  • kinesin binding Source: BHF-UCL

Protein-protein interaction databases

DIPiDIP-31518N.
IntActiO88448. 14 interactors.
MINTiMINT-136135.
STRINGi10090.ENSMUSP00000112262.

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi236 – 251Combined sources16
Helixi255 – 272Combined sources18
Helixi278 – 293Combined sources16
Helixi297 – 314Combined sources18
Helixi320 – 334Combined sources15
Turni335 – 337Combined sources3
Helixi339 – 356Combined sources18
Helixi362 – 377Combined sources16
Helixi381 – 400Combined sources20
Helixi410 – 418Combined sources9
Helixi444 – 459Combined sources16
Helixi463 – 476Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZFWX-ray2.90A/B217-478[»]
5FJYX-ray4.00A/B/C160-478[»]
ProteinModelPortaliO88448.
SMRiO88448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati197 – 230TPR 1Add BLAST34
Repeati239 – 272TPR 2Add BLAST34
Repeati281 – 314TPR 3Add BLAST34
Repeati323 – 356TPR 4Add BLAST34
Repeati365 – 398TPR 5Add BLAST34
Repeati447 – 480TPR 6Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 143Sequence analysisAdd BLAST66

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated
Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOVERGENiHBG006217.
InParanoidiO88448.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS01160. KINESIN_LIGHT. 2 hits.
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMVLPREE KLSQDEIVLG TKAVIQGLET LRGEHRALLA PLASHEAGEA
60 70 80 90 100
EPGSQERCLL LRRSLEAIEL GLGEAQVILA LSSHLGAVES EKQKLRAQVR
110 120 130 140 150
RLVQENQWLR EELAGTQQKL QRSEQAVAQL EEEKQHLLFM SQIRKLDEML
160 170 180 190 200
PQEEKGDVPK DSLDDLFPNE DEQSPAPSPG GGDVAAQHGG YEIPARLRTL
210 220 230 240 250
HNLVIQYASQ GRYEVAVPLC KQALEDLEKT SGHDHPDVAT MLNILALVYR
260 270 280 290 300
DQNKYKDAAH LLNDALAIRE KTLGKDHPAV AATLNNLAVL YGKRGKYKEA
310 320 330 340 350
EPLCKRALEI REKVLGKFHP DVAKQLSNLA LLCQNQGKAE EVEYYYRRAL
360 370 380 390 400
EIYATRLGPD DPNVAKTKNN LASCYLKQGK YQDAETLYKE ILTRAHEKEF
410 420 430 440 450
GSVNGENKPI WMHAEEREES KDKRRDRRPM EYGSWYKACK VDSPTVNTTL
460 470 480 490 500
RTLGALYRPE GKLEAAHTLE DCASRSRKQG LDPASQTKVV ELLKDGSGRG
510 520 530 540 550
HRRGSRDVAG PQSESDLEES GPAAEWSGDG SGSLRRSGSF GKLRDALRRS
560 570 580 590
SEMLVRKLQG GGPQEPNSRM KRASSLNFLN KSVEEPVQPG GRVFLTAAL
Length:599
Mass (Da):66,662
Last modified:November 1, 1998 - v1
Checksum:iA5E6F9081609E1CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055666 mRNA. Translation: AAC27741.1.
UniGeneiMm.271648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055666 mRNA. Translation: AAC27741.1.
UniGeneiMm.271648.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZFWX-ray2.90A/B217-478[»]
5FJYX-ray4.00A/B/C160-478[»]
ProteinModelPortaliO88448.
SMRiO88448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-31518N.
IntActiO88448. 14 interactors.
MINTiMINT-136135.
STRINGi10090.ENSMUSP00000112262.

PTM databases

iPTMnetiO88448.
PhosphoSitePlusiO88448.
SwissPalmiO88448.

Proteomic databases

EPDiO88448.
MaxQBiO88448.
PaxDbiO88448.
PeptideAtlasiO88448.
PRIDEiO88448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107953. Klc2.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOVERGENiHBG006217.
InParanoidiO88448.

Miscellaneous databases

ChiTaRSiKlc2. mouse.
PROiO88448.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KLC2.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS01160. KINESIN_LIGHT. 2 hits.
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLC2_MOUSE
AccessioniPrimary (citable) accession number: O88448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.